Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
GO:0008696
JSON
4-amino-4-deoxychorismate lyase activity
Molecular Function
Definition (GO:0008696 GONUTS page)
Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate.
Comments
Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
para-aminobenzoic acid synthase | related |
para-aminobenzoic acid (PABA) synthase | related |
p-aminobenzoate synthetase | related |
ADC lyase activity | related |
enzyme X activity | related |
aminodeoxychorismate lyase activity | exact |
4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) | related |
4-amino-4-deoxychorismate pyruvate-lyase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 4.1.3.38 | |
InterPro | IPR017824 | Aminodeoxychorismate lyase, class IV |
KEGG_REACTION | R05553 | |
MetaCyc | ADCLY-RXN | |
RHEA | 16201 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17836 | 4-aminobenzoate |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:58406 | 4-amino-4-deoxychorismate(1-) |
has_participant | CHEBI | CHEBI:15361 | pyruvate |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0008149 | obsolete para-aminobenzoic acid (PABA) synthase | consider GO:0008696 |
GO:0008950 | obsolete p-aminobenzoate synthetase | consider GO:0008696 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008696 based on ALL annotations
The top 81 of 81 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
4-amino-4-deoxychorismate lyase activity
|
19,952.79 | 100.00 | 9,770 | 9,770 |
4-aminobenzoate biosynthetic process
|
10,314.00 | 41.64 | 6,660 | 12,884 |
carboxylic acid biosynthetic process
|
2,689.75 | 13.35 | 9,108 | 67,564 |
folic acid biosynthetic process
|
989.16 | 4.87 | 7,126 | 143,742 |
carboxylic acid metabolic process
|
129.64 | 0.64 | 2,624 | 403,849 |
branched-chain amino acid biosynthetic process
|
98.14 | 0.47 | 1,149 | 233,599 |
4-amino-4-deoxychorismate synthase activity
|
116.17 | 0.46 | 208 | 35,725 |
pyridoxal phosphate binding
|
82.14 | 0.41 | 7,114 | 1,728,166 |
D-alanine-2-oxoglutarate aminotransferase activity
|
291.62 | 0.31 | 38 | 2,600 |
L-valine-2-oxoglutarate transaminase activity
|
57.63 | 0.21 | 77 | 26,661 |
Totals | 67522 | 240093019 |
No co-occurrence statistics for GO:0008696 based on MANUAL annotations
The top 9 of 9 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
4-amino-4-deoxychorismate lyase activity
|
129,179.90 | 100.00 | 10 | 10 |
4-aminobenzoate biosynthetic process
|
12,736.05 | 9.46 | 7 | 71 |
folic acid biosynthetic process
|
10,334.39 | 6.06 | 2 | 25 |
carboxylic acid metabolic process
|
1,761.54 | 1.32 | 3 | 220 |
transaminase activity
|
138.46 | 0.11 | 1 | 933 |
pyridoxal phosphate binding
|
58.37 | 0.05 | 1 | 2,213 |
cytosol
|
12.27 | 0.01 | 8 | 84,217 |
cytoplasm
|
0.72 | 0.00 | 1 | 179,389 |
nucleus
|
0.67 | 0.00 | 1 | 192,276 |
Totals | 34 | 459354 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate. |
2020-10-08 | Added | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase activity |
2020-10-08 | Deleted | SYNONYM | ADC lyase activity |
2020-10-08 | Deleted | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase activity |
2020-10-08 | Added | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) |
2020-10-08 | Added | SYNONYM | ADC lyase activity |
2020-10-08 | Deleted | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) |
2019-06-20 | Deleted | XREF | KEGG:R05553 |
2019-06-20 | Added | XREF | KEGG_REACTION:R05553 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | 4-amino-4-deoxychorismate lyase activity |
2002-02-06 | Updated | TERM | 4-amino-4-deoxychorismate lyase |
2001-04-03 | Updated | TERM | 4-amino-4-deoxychorismate lyase |
2001-03-30 | Added | TERM | 4-amino-4-deoxychorismate lyase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate. |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate. |
2020-10-08 | Added | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase activity |
2020-10-08 | Deleted | SYNONYM | ADC lyase activity |
2020-10-08 | Deleted | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase activity |
2020-10-08 | Added | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) |
2020-10-08 | Added | SYNONYM | ADC lyase activity |
2020-10-08 | Deleted | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate. |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate. |
2007-11-08 | Added | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) |
2007-11-08 | Deleted | SYNONYM | aminodeoxychorismate lyase |
2007-11-08 | Added | SYNONYM | aminodeoxychorismate lyase activity |
2007-10-16 | Deleted | SYNONYM | 4-amino-4-deoxychorismate lyase activity |
2007-09-06 | Added | SYNONYM | enzyme X activity |
2007-09-06 | Added | SYNONYM | ADC lyase activity |
2007-09-06 | Added | SYNONYM | 4-amino-4-deoxychorismate pyruvate-lyase activity |
2007-09-06 | Added | SYNONYM | 4-amino-4-deoxychorismate lyase activity |
2007-09-06 | Deleted | SYNONYM | ADC lyase |
2007-08-09 | Deleted | SYNONYM | ADC lyase |
2007-08-09 | Deleted | SYNONYM | aminodeoxychorismate lyase |
2007-08-09 | Deleted | SYNONYM | p-aminobenzoate synthetase |
2007-08-09 | Deleted | SYNONYM | para-aminobenzoic acid (PABA) synthase |
2007-08-09 | Deleted | SYNONYM | para-aminobenzoic acid synthase |
2007-08-09 | Added | SYNONYM | para-aminobenzoic acid synthase |
2007-08-09 | Added | SYNONYM | p-aminobenzoate synthetase |
2007-08-09 | Added | SYNONYM | para-aminobenzoic acid (PABA) synthase |
2007-08-09 | Added | SYNONYM | ADC lyase |
2007-08-09 | Added | SYNONYM | aminodeoxychorismate lyase |
2005-08-10 | Added | SYNONYM | para-aminobenzoic acid (PABA) synthase |
2005-08-10 | Added | SYNONYM | p-aminobenzoate synthetase |
2005-03-10 | Added | SYNONYM | aminodeoxychorismate lyase |
2004-04-19 | Added | SYNONYM | ADC lyase |
2004-04-19 | Added | SYNONYM | para-aminobenzoic acid synthase |
2004-04-16 | Deleted | SYNONYM | ADC lyase |
2004-04-05 | Deleted | SYNONYM | para-aminobenzoic acid synthase |
2003-10-27 | Added | SYNONYM | ADC lyase |
2003-10-27 | Added | SYNONYM | para-aminobenzoic acid synthase |
2003-03-26 | Added | DEFINITION | Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-01-12 | Deleted | RELATION | is a GO:0016829 (lyase activity) |
2009-01-12 | Added | RELATION | is a GO:0016833 (oxo-acid-lyase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016829 (lyase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R05553 |
2019-06-20 | Added | XREF | KEGG_REACTION:R05553 |
2018-07-13 | Added | XREF | RHEA:16201 |
2018-07-13 | Deleted | XREF | RHEA:16204 |
2010-10-11 | Added | XREF | KEGG:R05553 |
2010-10-11 | Added | XREF | RHEA:16204 |
2005-03-10 | Added | XREF | EC:4.1.3.38 |
2005-03-10 | Deleted | XREF | EC:4.-.-.- |
2003-10-27 | Added | XREF | MetaCyc:ADCLY-RXN |
2003-01-04 | Added | XREF | EC:4.-.-.- |
Timestamp | Action | Category | Detail |
---|
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