This term is obsolete.
Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.

GO:0008696 JSON

4-amino-4-deoxychorismate lyase activity

Molecular Function

Definition (GO:0008696 GONUTS page)

Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate.

Comments

Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.

9,781 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
para-aminobenzoic acid synthase related
para-aminobenzoic acid (PABA) synthase related
p-aminobenzoate synthetase related
ADC lyase activity related
enzyme X activity related
aminodeoxychorismate lyase activity exact
4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming) related
4-amino-4-deoxychorismate pyruvate-lyase activity related

Ancestor Chart

Ancestor chart for GO:0008696
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 4.1.3.38
InterPro IPR017824 Aminodeoxychorismate lyase, class IV
KEGG_REACTION R05553
MetaCyc ADCLY-RXN
RHEA 16201

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17836 4-aminobenzoate
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:58406 4-amino-4-deoxychorismate(1-)
has_participant CHEBI CHEBI:15361 pyruvate

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0008149 obsolete para-aminobenzoic acid (PABA) synthase consider GO:0008696
GO:0008950 obsolete p-aminobenzoate synthetase consider GO:0008696

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008696 based on ALL annotations
The top 81 of 81 co-occurring terms
Co-occurring Term PR S% #Together #Compared
4-amino-4-deoxychorismate lyase activity
19,952.79 100.00 9,770 9,770
4-aminobenzoate biosynthetic process
10,314.00 41.64 6,660 12,884
carboxylic acid biosynthetic process
2,689.75 13.35 9,108 67,564
folic acid biosynthetic process
989.16 4.87 7,126 143,742
carboxylic acid metabolic process
129.64 0.64 2,624 403,849
branched-chain amino acid biosynthetic process
98.14 0.47 1,149 233,599
4-amino-4-deoxychorismate synthase activity
116.17 0.46 208 35,725
pyridoxal phosphate binding
82.14 0.41 7,114 1,728,166
D-alanine-2-oxoglutarate aminotransferase activity
291.62 0.31 38 2,600
L-valine-2-oxoglutarate transaminase activity
57.63 0.21 77 26,661
Totals 67522 240093019
No co-occurrence statistics for GO:0008696 based on MANUAL annotations
The top 9 of 9 co-occurring terms
Co-occurring Term PR S% #Together #Compared
4-amino-4-deoxychorismate lyase activity
129,179.90 100.00 10 10
4-aminobenzoate biosynthetic process
12,736.05 9.46 7 71
folic acid biosynthetic process
10,334.39 6.06 2 25
carboxylic acid metabolic process
1,761.54 1.32 3 220
transaminase activity
138.46 0.11 1 933
pyridoxal phosphate binding
58.37 0.05 1 2,213
cytosol
12.27 0.01 8 84,217
cytoplasm
0.72 0.00 1 179,389
nucleus
0.67 0.00 1 192,276
Totals 34 459354

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate.
2022-09-01 Added DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate.
2020-10-08 Added SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase activity
2020-10-08 Deleted SYNONYM ADC lyase activity
2020-10-08 Deleted SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase activity
2020-10-08 Added SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)
2020-10-08 Added SYNONYM ADC lyase activity
2020-10-08 Deleted SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)
2019-06-20 Deleted XREF KEGG:R05553
2019-06-20 Added XREF KEGG_REACTION:R05553
Timestamp Action Category Detail
2003-03-19 Updated TERM 4-amino-4-deoxychorismate lyase activity
2002-02-06 Updated TERM 4-amino-4-deoxychorismate lyase
2001-04-03 Updated TERM 4-amino-4-deoxychorismate lyase
2001-03-30 Added TERM 4-amino-4-deoxychorismate lyase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate.
2022-09-01 Added DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate.
2020-10-08 Added SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase activity
2020-10-08 Deleted SYNONYM ADC lyase activity
2020-10-08 Deleted SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase activity
2020-10-08 Added SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)
2020-10-08 Added SYNONYM ADC lyase activity
2020-10-08 Deleted SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)
2010-10-11 Added DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate.
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate.
2008-05-13 Added DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate.
2007-11-08 Added SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)
2007-11-08 Deleted SYNONYM aminodeoxychorismate lyase
2007-11-08 Added SYNONYM aminodeoxychorismate lyase activity
2007-10-16 Deleted SYNONYM 4-amino-4-deoxychorismate lyase activity
2007-09-06 Added SYNONYM enzyme X activity
2007-09-06 Added SYNONYM ADC lyase activity
2007-09-06 Added SYNONYM 4-amino-4-deoxychorismate pyruvate-lyase activity
2007-09-06 Added SYNONYM 4-amino-4-deoxychorismate lyase activity
2007-09-06 Deleted SYNONYM ADC lyase
2007-08-09 Deleted SYNONYM ADC lyase
2007-08-09 Deleted SYNONYM aminodeoxychorismate lyase
2007-08-09 Deleted SYNONYM p-aminobenzoate synthetase
2007-08-09 Deleted SYNONYM para-aminobenzoic acid (PABA) synthase
2007-08-09 Deleted SYNONYM para-aminobenzoic acid synthase
2007-08-09 Added SYNONYM para-aminobenzoic acid synthase
2007-08-09 Added SYNONYM p-aminobenzoate synthetase
2007-08-09 Added SYNONYM para-aminobenzoic acid (PABA) synthase
2007-08-09 Added SYNONYM ADC lyase
2007-08-09 Added SYNONYM aminodeoxychorismate lyase
2005-08-10 Added SYNONYM para-aminobenzoic acid (PABA) synthase
2005-08-10 Added SYNONYM p-aminobenzoate synthetase
2005-03-10 Added SYNONYM aminodeoxychorismate lyase
2004-04-19 Added SYNONYM ADC lyase
2004-04-19 Added SYNONYM para-aminobenzoic acid synthase
2004-04-16 Deleted SYNONYM ADC lyase
2004-04-05 Deleted SYNONYM para-aminobenzoic acid synthase
2003-10-27 Added SYNONYM ADC lyase
2003-10-27 Added SYNONYM para-aminobenzoic acid synthase
2003-03-26 Added DEFINITION Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate.
Timestamp Action Category Detail
2009-01-12 Deleted RELATION is a GO:0016829 (lyase activity)
2009-01-12 Added RELATION is a GO:0016833 (oxo-acid-lyase activity)
2008-04-01 Updated RELATION is a GO:0016829 (lyase activity)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R05553
2019-06-20 Added XREF KEGG_REACTION:R05553
2018-07-13 Added XREF RHEA:16201
2018-07-13 Deleted XREF RHEA:16204
2010-10-11 Added XREF KEGG:R05553
2010-10-11 Added XREF RHEA:16204
2005-03-10 Added XREF EC:4.1.3.38
2005-03-10 Deleted XREF EC:4.-.-.-
2003-10-27 Added XREF MetaCyc:ADCLY-RXN
2003-01-04 Added XREF EC:4.-.-.-
Timestamp Action Category Detail
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