This term is obsolete.

GO:0008750 JSON

proton-translocating NAD(P)+ transhydrogenase activity

Molecular Function

Definition (GO:0008750 GONUTS page)

Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+.

41,536 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
NAD(P)+ transhydrogenase (AB-specific) activity related

Ancestor Chart

Ancestor chart for GO:0008750
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Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7MB71 9913 AT1B4_BOVIN GO:0098662 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein B4YDY0 10090 B4YDY0_MOUSE GO:0006811 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921
NOT-qualified manual protein D4ABB2 10116 D4ABB2_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q8CHM1 10116 AQP11_RAT GO:0006811 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:16650285
NOT-qualified manual protein Q8NBQ7 9606 AQP11_HUMAN GO:0006811 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16650285
NOT-qualified manual protein Q8VHK5 10090 MLC1_MOUSE GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15367490
NOT-qualified manual protein Q99ME6 10090 AT1B4_MOUSE GO:0098662 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9BDK6 9823 AT1B4_PIG GO:0098662 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9R193 10116 AT1B4_RAT GO:0098662 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096

Cross-references

Database ID Description
EC 7.1.1.1
InterPro IPR012136 NADP transhydrogenase, beta subunit
RHEA 47992

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:15378 hydron

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0008746 obsolete NAD(P)+ transhydrogenase activity consider GO:0008750

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008750 based on ALL annotations
The top 100 of 122 co-occurring terms
Co-occurring Term PR S% #Together #Compared
proton-translocating NAD(P)+ transhydrogenase activity
4,771.83 100.00 41,526 41,526
NADPH regeneration
1,609.08 24.67 19,888 58,979
NADP binding
213.94 4.47 39,640 884,170
proton transmembrane transport
79.28 1.66 41,524 2,499,177
nucleotide binding
21.60 0.45 8,717 1,925,949
plasma membrane
8.08 0.17 38,704 22,848,296
alanine dehydrogenase activity
17.04 0.16 115 32,203
L-alanine catabolic process
15.35 0.14 107 33,267
reactive oxygen species metabolic process
49.16 0.13 64 6,212
alanine catabolic process
12.71 0.12 97 36,423
Totals 228733 177598437
No co-occurrence statistics for GO:0008750 based on MANUAL annotations
The top 13 of 13 co-occurring terms
Co-occurring Term PR S% #Together #Compared
proton-translocating NAD(P)+ transhydrogenase activity
235,255.50 100.00 6 6
proton export across plasma membrane
117,627.75 33.33 3 6
NAD(P)+ transhydrogenase (Si-specific) activity
78,418.50 12.50 1 3
NADPH regeneration
6,358.26 2.70 6 222
NADH binding
4,568.07 1.87 2 103
protein dimerization activity
2,276.67 0.96 3 310
NADP binding
953.74 0.40 3 740
NAD binding
953.74 0.40 3 740
NADH oxidation
649.88 0.27 1 362
NAD+ binding
466.31 0.20 2 1,009
Totals 38 193117

Change Log

Timestamp Action Category Detail
2024-05-09 Added RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2024-05-09 Updated TERM proton-translocating NAD(P)+ transhydrogenase activity
2024-05-09 Added RELATION is a GO:0015078 (proton transmembrane transporter activity)
2024-05-09 Added RELATION is a GO:0015453 (oxidoreduction-driven active transmembrane transporter activity)
2024-05-09 Deleted RELATION is a GO:0008746 (obsolete NAD(P)+ transhydrogenase activity)
2024-05-09 Added DEFINITION Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+.
2024-05-09 Deleted DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.
2024-05-09 Added SYNONYM NAD(P)+ transhydrogenase (AB-specific) activity
2024-05-09 Deleted SYNONYM pyridine nucleotide transhydrogenase activity
2024-05-09 Deleted SYNONYM NAD(P) transhydrogenase (AB-specific) activity
Timestamp Action Category Detail
2024-05-09 Updated TERM proton-translocating NAD(P)+ transhydrogenase activity
2004-01-07 Updated TERM NAD(P)+ transhydrogenase (AB-specific) activity
2003-09-06 Updated TERM NAD(P) transhydrogenase (AB-specific) activity
2003-03-19 Updated TERM NAD(P)+ transhydrogenase (AB-specific) activity
2002-05-15 Updated TERM NAD(P)+ transhydrogenase (AB-specific)
2002-02-06 Updated TERM NAD(P)(+) transhydrogenase (AB-specific)
2001-04-03 Updated TERM NAD(P)(+) transhydrogenase (AB-specific)
2001-03-30 Added TERM NAD(P)(+) transhydrogenase (AB-specific)
Timestamp Action Category Detail
2024-05-09 Added DEFINITION Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+.
2024-05-09 Deleted DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.
2024-05-09 Added SYNONYM NAD(P)+ transhydrogenase (AB-specific) activity
2024-05-09 Deleted SYNONYM pyridine nucleotide transhydrogenase activity
2024-05-09 Deleted SYNONYM NAD(P) transhydrogenase (AB-specific) activity
2024-05-09 Deleted SYNONYM NADPH:NAD+ oxidoreductase (AB-specific)
2024-05-09 Deleted SYNONYM transhydrogenase activity
2020-10-08 Deleted SYNONYM NADPH:NAD+ oxidoreductase (AB-specific)
2020-10-08 Deleted SYNONYM NAD(P) transhydrogenase (AB-specific) activity
2020-10-08 Added SYNONYM NADPH:NAD+ oxidoreductase (AB-specific)
2020-10-08 Added SYNONYM NAD(P) transhydrogenase (AB-specific) activity
2008-05-13 Added DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.
2007-12-06 Added SYNONYM NADPH:NAD+ oxidoreductase (AB-specific)
2007-09-06 Added SYNONYM transhydrogenase activity
2007-09-06 Added SYNONYM pyridine nucleotide transhydrogenase activity
2007-08-09 Added SYNONYM NAD(P) transhydrogenase (AB-specific) activity
2007-08-09 Deleted SYNONYM NAD(P) transhydrogenase (AB-specific) activity
2007-05-27 Updated DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.
2004-04-19 Added SYNONYM NAD(P) transhydrogenase (AB-specific) activity
2004-04-16 Deleted SYNONYM NAD(P) transhydrogenase (AB-specific) activity
2004-01-07 Added SYNONYM NAD(P) transhydrogenase (AB-specific) activity
2002-11-27 Added DEFINITION Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.
Timestamp Action Category Detail
2024-05-09 Added RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2024-05-09 Added RELATION is a GO:0015078 (proton transmembrane transporter activity)
2024-05-09 Added RELATION is a GO:0015453 (oxidoreduction-driven active transmembrane transporter activity)
2024-05-09 Deleted RELATION is a GO:0008746 (obsolete NAD(P)+ transhydrogenase activity)
2008-04-01 Updated RELATION is a GO:0008746 (obsolete NAD(P)+ transhydrogenase activity)
Timestamp Action Category Detail
2024-05-09 Added XREF EC:7.1.1.1
2024-05-09 Deleted XREF MetaCyc:PYRNUTRANSHYDROGEN-RXN
2024-05-09 Deleted XREF EC:1.6.1.2
2024-05-09 Added XREF RHEA:47992
2023-08-11 Added XREF MetaCyc:PYRNUTRANSHYDROGEN-RXN
2023-08-11 Deleted XREF MetaCyc:1.6.1.2-RXN
2013-10-02 Deleted XREF RHEA:11695
2011-09-16 Added XREF RHEA:11695
2010-10-08 Deleted XREF KEGG:R00112
2010-09-03 Added XREF KEGG:R00112
2003-10-27 Added XREF MetaCyc:1.6.1.2-RXN
2001-03-30 Added XREF EC:1.6.1.2
Timestamp Action Category Detail
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