GO:0008750
JSON
proton-translocating NAD(P)+ transhydrogenase activity
Molecular Function
Definition (GO:0008750 GONUTS page)
Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
NAD(P)+ transhydrogenase (AB-specific) activity | related |
Ancestor Chart
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7MB71 | 9913 | AT1B4_BOVIN | GO:0098662 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | B4YDY0 | 10090 | B4YDY0_MOUSE | GO:0006811 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921 | |
NOT-qualified manual | protein | D4ABB2 | 10116 | D4ABB2_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q8CHM1 | 10116 | AQP11_RAT | GO:0006811 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:16650285 | |
NOT-qualified manual | protein | Q8NBQ7 | 9606 | AQP11_HUMAN | GO:0006811 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16650285 | |
NOT-qualified manual | protein | Q8VHK5 | 10090 | MLC1_MOUSE | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15367490 | |
NOT-qualified manual | protein | Q99ME6 | 10090 | AT1B4_MOUSE | GO:0098662 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9BDK6 | 9823 | AT1B4_PIG | GO:0098662 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9R193 | 10116 | AT1B4_RAT | GO:0098662 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 7.1.1.1 | |
InterPro | IPR012136 | NADP transhydrogenase, beta subunit |
RHEA | 47992 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0008746 | obsolete NAD(P)+ transhydrogenase activity | consider GO:0008750 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008750 based on ALL annotations
The top 100 of 122 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
proton-translocating NAD(P)+ transhydrogenase activity
|
4,771.83 | 100.00 | 41,526 | 41,526 |
NADPH regeneration
|
1,609.08 | 24.67 | 19,888 | 58,979 |
NADP binding
|
213.94 | 4.47 | 39,640 | 884,170 |
proton transmembrane transport
|
79.28 | 1.66 | 41,524 | 2,499,177 |
nucleotide binding
|
21.60 | 0.45 | 8,717 | 1,925,949 |
plasma membrane
|
8.08 | 0.17 | 38,704 | 22,848,296 |
alanine dehydrogenase activity
|
17.04 | 0.16 | 115 | 32,203 |
L-alanine catabolic process
|
15.35 | 0.14 | 107 | 33,267 |
reactive oxygen species metabolic process
|
49.16 | 0.13 | 64 | 6,212 |
alanine catabolic process
|
12.71 | 0.12 | 97 | 36,423 |
Totals | 228733 | 177598437 |
No co-occurrence statistics for GO:0008750 based on MANUAL annotations
The top 13 of 13 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
proton-translocating NAD(P)+ transhydrogenase activity
|
235,255.50 | 100.00 | 6 | 6 |
proton export across plasma membrane
|
117,627.75 | 33.33 | 3 | 6 |
NAD(P)+ transhydrogenase (Si-specific) activity
|
78,418.50 | 12.50 | 1 | 3 |
NADPH regeneration
|
6,358.26 | 2.70 | 6 | 222 |
NADH binding
|
4,568.07 | 1.87 | 2 | 103 |
protein dimerization activity
|
2,276.67 | 0.96 | 3 | 310 |
NADP binding
|
953.74 | 0.40 | 3 | 740 |
NAD binding
|
953.74 | 0.40 | 3 | 740 |
NADH oxidation
|
649.88 | 0.27 | 1 | 362 |
NAD+ binding
|
466.31 | 0.20 | 2 | 1,009 |
Totals | 38 | 193117 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-09 | Added | RELATION | is a GO:0022853 (active monoatomic ion transmembrane transporter activity) |
2024-05-09 | Updated | TERM | proton-translocating NAD(P)+ transhydrogenase activity |
2024-05-09 | Added | RELATION | is a GO:0015078 (proton transmembrane transporter activity) |
2024-05-09 | Added | RELATION | is a GO:0015453 (oxidoreduction-driven active transmembrane transporter activity) |
2024-05-09 | Deleted | RELATION | is a GO:0008746 (obsolete NAD(P)+ transhydrogenase activity) |
2024-05-09 | Added | DEFINITION | Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+. |
2024-05-09 | Deleted | DEFINITION | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. |
2024-05-09 | Added | SYNONYM | NAD(P)+ transhydrogenase (AB-specific) activity |
2024-05-09 | Deleted | SYNONYM | pyridine nucleotide transhydrogenase activity |
2024-05-09 | Deleted | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-09 | Updated | TERM | proton-translocating NAD(P)+ transhydrogenase activity |
2004-01-07 | Updated | TERM | NAD(P)+ transhydrogenase (AB-specific) activity |
2003-09-06 | Updated | TERM | NAD(P) transhydrogenase (AB-specific) activity |
2003-03-19 | Updated | TERM | NAD(P)+ transhydrogenase (AB-specific) activity |
2002-05-15 | Updated | TERM | NAD(P)+ transhydrogenase (AB-specific) |
2002-02-06 | Updated | TERM | NAD(P)(+) transhydrogenase (AB-specific) |
2001-04-03 | Updated | TERM | NAD(P)(+) transhydrogenase (AB-specific) |
2001-03-30 | Added | TERM | NAD(P)(+) transhydrogenase (AB-specific) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-09 | Added | DEFINITION | Catalysis of the reaction: H+(in) + NAD+ + NADPH = H+(out) + NADH + NADP+. |
2024-05-09 | Deleted | DEFINITION | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. |
2024-05-09 | Added | SYNONYM | NAD(P)+ transhydrogenase (AB-specific) activity |
2024-05-09 | Deleted | SYNONYM | pyridine nucleotide transhydrogenase activity |
2024-05-09 | Deleted | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
2024-05-09 | Deleted | SYNONYM | NADPH:NAD+ oxidoreductase (AB-specific) |
2024-05-09 | Deleted | SYNONYM | transhydrogenase activity |
2020-10-08 | Deleted | SYNONYM | NADPH:NAD+ oxidoreductase (AB-specific) |
2020-10-08 | Deleted | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
2020-10-08 | Added | SYNONYM | NADPH:NAD+ oxidoreductase (AB-specific) |
2020-10-08 | Added | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. |
2007-12-06 | Added | SYNONYM | NADPH:NAD+ oxidoreductase (AB-specific) |
2007-09-06 | Added | SYNONYM | transhydrogenase activity |
2007-09-06 | Added | SYNONYM | pyridine nucleotide transhydrogenase activity |
2007-08-09 | Added | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
2007-08-09 | Deleted | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
2007-05-27 | Updated | DEFINITION | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. |
2004-04-19 | Added | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
2004-04-16 | Deleted | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
2004-01-07 | Added | SYNONYM | NAD(P) transhydrogenase (AB-specific) activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-09 | Added | RELATION | is a GO:0022853 (active monoatomic ion transmembrane transporter activity) |
2024-05-09 | Added | RELATION | is a GO:0015078 (proton transmembrane transporter activity) |
2024-05-09 | Added | RELATION | is a GO:0015453 (oxidoreduction-driven active transmembrane transporter activity) |
2024-05-09 | Deleted | RELATION | is a GO:0008746 (obsolete NAD(P)+ transhydrogenase activity) |
2008-04-01 | Updated | RELATION | is a GO:0008746 (obsolete NAD(P)+ transhydrogenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-09 | Added | XREF | EC:7.1.1.1 |
2024-05-09 | Deleted | XREF | MetaCyc:PYRNUTRANSHYDROGEN-RXN |
2024-05-09 | Deleted | XREF | EC:1.6.1.2 |
2024-05-09 | Added | XREF | RHEA:47992 |
2023-08-11 | Added | XREF | MetaCyc:PYRNUTRANSHYDROGEN-RXN |
2023-08-11 | Deleted | XREF | MetaCyc:1.6.1.2-RXN |
2013-10-02 | Deleted | XREF | RHEA:11695 |
2011-09-16 | Added | XREF | RHEA:11695 |
2010-10-08 | Deleted | XREF | KEGG:R00112 |
2010-09-03 | Added | XREF | KEGG:R00112 |
2003-10-27 | Added | XREF | MetaCyc:1.6.1.2-RXN |
2001-03-30 | Added | XREF | EC:1.6.1.2 |
Timestamp | Action | Category | Detail |
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