GO:0008781
JSON
N-acylneuraminate cytidylyltransferase activity
Molecular Function
Definition (GO:0008781 GONUTS page)
Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cytidine monophosphosialate pyrophosphorylase activity | related |
CMP-NeuNAc synthetase activity | related |
CMP-sialate synthetase activity | related |
cytidine monophosphoacetylneuraminic synthetase activity | related |
CMP-N-acetylneuraminic acid synthetase activity | related |
cytidine monophosphosialic acid synthetase activity | related |
cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity | related |
CMP-sialate diphosphorylase activity | related |
acetylneuraminate cytidylyltransferase activity | related |
acylneuraminate cytidyltransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q4H4F3 | 1397 | BTRD_NIACI | GO:0016779 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17226887 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.7.43 | |
MetaCyc | RXN-9990 | |
RHEA | 11344 | |
Reactome | R-HSA-4084982 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:68671 | CMP-N-acyl-beta-neuraminate(2-) |
has_participant | CHEBI | CHEBI:60073 | N-acylneuraminate |
has_participant | CHEBI | CHEBI:37563 | CTP(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008781 based on ALL annotations
The top 100 of 110 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
N-acylneuraminate cytidylyltransferase activity
|
5,581.00 | 100.00 | 34,929 | 34,929 |
3-deoxy-manno-octulosonate-8-phosphatase activity
|
5,529.57 | 28.25 | 9,892 | 9,984 |
N-acetylneuraminate metabolic process
|
4,196.33 | 7.21 | 2,579 | 3,430 |
hydrolase activity, acting on ester bonds
|
294.24 | 5.07 | 20,007 | 379,489 |
lipopolysaccharide biosynthetic process
|
255.07 | 4.39 | 18,382 | 402,199 |
nucleotidyltransferase activity
|
34.63 | 0.61 | 12,045 | 1,940,928 |
CMP-N-acetylneuraminate biosynthetic process
|
1,201.71 | 0.29 | 104 | 483 |
glycosylation
|
20.15 | 0.20 | 154 | 42,654 |
hydrolase activity
|
9.92 | 0.18 | 20,368 | 11,461,355 |
3-deoxy-manno-octulosonate cytidylyltransferase activity
|
14.09 | 0.11 | 67 | 26,540 |
Totals | 137300 | 231910896 |
No co-occurrence statistics for GO:0008781 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
N-acylneuraminate cytidylyltransferase activity
|
23,922.20 | 100.00 | 54 | 54 |
CMP-N-acetylneuraminate biosynthetic process
|
6,379.25 | 6.15 | 4 | 15 |
N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity
|
23,922.21 | 5.56 | 3 | 3 |
keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity
|
23,922.21 | 5.56 | 3 | 3 |
glycosylation
|
63.54 | 0.25 | 2 | 753 |
protein glycosylation
|
17.36 | 0.07 | 1 | 1,378 |
chemical synaptic transmission
|
10.97 | 0.04 | 1 | 2,181 |
response to heat
|
9.06 | 0.04 | 1 | 2,640 |
trans-Golgi network
|
5.20 | 0.02 | 1 | 4,602 |
nucleoplasm
|
2.80 | 0.01 | 2 | 17,081 |
Totals | 81 | 484266 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Added | XREF | MetaCyc:RXN-9990 |
2023-08-11 | Deleted | XREF | MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN |
2020-10-08 | Added | SYNONYM | CMP-N-acetylneuraminate synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-N-acetylneuraminic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | cytidine 5'-monophosphosialic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | cytidine monophosphoacetylneuraminic synthetase activity |
2020-10-08 | Deleted | SYNONYM | acylneuraminate cytidyltransferase activity |
2020-10-08 | Deleted | SYNONYM | cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-sialate synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-09 | Updated | TERM | N-acylneuraminate cytidylyltransferase activity |
2003-03-19 | Updated | TERM | acylneuraminate cytidylyltransferase activity |
2002-02-06 | Updated | TERM | acylneuraminate cytidylyltransferase |
2001-04-03 | Updated | TERM | acylneuraminate cytidylyltransferase |
2001-03-30 | Added | TERM | acylneuraminate cytidylyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | CMP-N-acetylneuraminate synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-N-acetylneuraminic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | cytidine 5'-monophosphosialic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | cytidine monophosphoacetylneuraminic synthetase activity |
2020-10-08 | Deleted | SYNONYM | acylneuraminate cytidyltransferase activity |
2020-10-08 | Deleted | SYNONYM | cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-sialate synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-sialic synthetase activity |
2020-10-08 | Deleted | SYNONYM | acetylneuraminate cytidylyltransferase activity |
2020-10-08 | Deleted | SYNONYM | CMP-N-acetylneuraminic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-NeuNAc synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-sialate diphosphorylase activity |
2020-10-08 | Deleted | SYNONYM | CMP-sialate pyrophosphorylase activity |
2020-10-08 | Deleted | SYNONYM | CMP-sialate synthase activity |
2020-10-08 | Deleted | SYNONYM | CMP-sialic acid synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-N-acetylneuraminate synthase activity |
2020-10-08 | Deleted | SYNONYM | CMP-N-acetylneuraminate synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-N-acetylneuraminic acid synthase activity |
2020-10-08 | Deleted | SYNONYM | CMP-NANA synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-Neu5Ac synthetase activity |
2020-10-08 | Deleted | SYNONYM | CMP-NeuAc synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-NANA synthetase activity |
2020-10-08 | Added | SYNONYM | cytidine 5'-monophosphosialic acid synthetase activity |
2020-10-08 | Added | SYNONYM | cytidine monophosphosialate pyrophosphorylase activity |
2020-10-08 | Deleted | SYNONYM | cytidine monophosphosialate pyrophosphorylase activity |
2020-10-08 | Deleted | SYNONYM | cytidine monophosphosialate synthetase activity |
2020-10-08 | Deleted | SYNONYM | cytidine monophosphosialic acid synthetase activity |
2020-10-08 | Added | SYNONYM | cytidine monophosphosialate synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-sialate pyrophosphorylase activity |
2020-10-08 | Added | SYNONYM | CMP-sialate synthase activity |
2020-10-08 | Added | SYNONYM | CMP-Neu5Ac synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-N-acetylneuraminic acid synthase activity |
2020-10-08 | Added | SYNONYM | cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity |
2020-10-08 | Added | SYNONYM | cytidine monophosphoacetylneuraminic synthetase activity |
2020-10-08 | Added | SYNONYM | cytidine monophosphosialic acid synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-sialate synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-NeuNAc synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-N-acetylneuraminate synthase activity |
2020-10-08 | Added | SYNONYM | CMP-NeuAc synthetase activity |
2020-10-08 | Added | SYNONYM | CMP-sialate diphosphorylase activity |
2020-10-08 | Added | SYNONYM | CMP-sialic acid synthetase activity |
2020-10-08 | Added | SYNONYM | acylneuraminate cytidyltransferase activity |
2020-10-08 | Added | SYNONYM | CMP-sialic synthetase activity |
2020-10-08 | Added | SYNONYM | acetylneuraminate cytidylyltransferase activity |
2020-10-08 | Added | SYNONYM | cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. |
2007-11-08 | Added | SYNONYM | CMP-NANA synthetase activity |
2007-11-08 | Added | SYNONYM | CMP-Neu5Ac synthetase activity |
2007-11-08 | Added | SYNONYM | CMP-NeuAc synthetase activity |
2007-11-08 | Added | SYNONYM | CMP-sialate synthetase activity |
2007-11-08 | Added | SYNONYM | CMP-sialic synthetase activity |
2007-11-08 | Added | SYNONYM | CMP-N-acetylneuraminic acid synthase activity |
2007-11-08 | Added | SYNONYM | CMP-N-acetylneuraminate synthetase activity |
2007-11-08 | Added | SYNONYM | CMP-N-acetylneuraminate synthase activity |
2007-11-08 | Added | SYNONYM | cytidine monophosphosialate synthetase activity |
2007-11-08 | Added | SYNONYM | cytidine monophosphosialic acid synthetase activity |
2007-11-08 | Added | SYNONYM | cytidine monophosphosialate pyrophosphorylase activity |
2007-11-08 | Added | SYNONYM | acylneuraminate cytidyltransferase activity |
2007-11-08 | Added | SYNONYM | cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity |
2007-11-08 | Added | SYNONYM | cytidine 5'-monophosphosialic acid synthetase activity |
2007-11-08 | Added | SYNONYM | acetylneuraminate cytidylyltransferase activity |
2007-11-08 | Added | SYNONYM | cytidine monophosphoacetylneuraminic synthetase activity |
2007-11-08 | Added | SYNONYM | cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity |
2007-09-06 | Added | SYNONYM | CMP-N-acetylneuraminic acid synthetase activity |
2007-09-06 | Added | SYNONYM | CMP-NeuNAc synthetase activity |
2007-09-06 | Added | SYNONYM | CMP-sialate diphosphorylase activity |
2007-09-06 | Added | SYNONYM | CMP-sialate pyrophosphorylase activity |
2007-09-06 | Added | SYNONYM | CMP-sialic acid synthetase activity |
2007-09-06 | Added | SYNONYM | CMP-sialate synthase activity |
2007-08-09 | Added | SYNONYM | CTP:N-acylneuraminate cytidylyltransferase activity |
2007-08-09 | Deleted | SYNONYM | CTP:N-acylneuraminate cytidylyltransferase activity |
2005-10-24 | Added | SYNONYM | CTP:N-acylneuraminate cytidylyltransferase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-04-29 | Deleted | RELATION | is a GO:0016779 (nucleotidyltransferase activity) |
2009-04-29 | Added | RELATION | is a GO:0070567 (cytidylyltransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016779 (nucleotidyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-11 | Added | XREF | MetaCyc:RXN-9990 |
2023-08-11 | Deleted | XREF | MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN |
2019-04-01 | Deleted | XREF | reactome:R-HSA-4084982 |
2019-04-01 | Added | XREF | Reactome:R-HSA-4084982 |
2018-12-11 | Added | XREF | reactome:R-HSA-4084982 |
2018-07-13 | Added | XREF | RHEA:11344 |
2018-07-13 | Deleted | XREF | RHEA:11347 |
2011-09-16 | Added | XREF | RHEA:11347 |
2003-10-27 | Added | XREF | MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN |
2001-03-30 | Added | XREF | EC:2.7.7.43 |
Timestamp | Action | Category | Detail |
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