This term is obsolete.

GO:0008781 JSON

N-acylneuraminate cytidylyltransferase activity

Molecular Function

Definition (GO:0008781 GONUTS page)

Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.

34,985 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cytidine monophosphosialate pyrophosphorylase activity related
CMP-NeuNAc synthetase activity related
CMP-sialate synthetase activity related
cytidine monophosphoacetylneuraminic synthetase activity related
CMP-N-acetylneuraminic acid synthetase activity related
cytidine monophosphosialic acid synthetase activity related
cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity related
CMP-sialate diphosphorylase activity related
acetylneuraminate cytidylyltransferase activity related
acylneuraminate cytidyltransferase activity related

Ancestor Chart

Ancestor chart for GO:0008781
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q4H4F3 1397 BTRD_NIACI GO:0016779 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17226887
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.7.7.43
MetaCyc RXN-9990
RHEA 11344
Reactome R-HSA-4084982

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:68671 CMP-N-acyl-beta-neuraminate(2-)
has_participant CHEBI CHEBI:60073 N-acylneuraminate
has_participant CHEBI CHEBI:37563 CTP(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008781 based on ALL annotations
The top 100 of 110 co-occurring terms
Co-occurring Term PR S% #Together #Compared
N-acylneuraminate cytidylyltransferase activity
5,581.00 100.00 34,929 34,929
3-deoxy-manno-octulosonate-8-phosphatase activity
5,529.57 28.25 9,892 9,984
N-acetylneuraminate metabolic process
4,196.33 7.21 2,579 3,430
hydrolase activity, acting on ester bonds
294.24 5.07 20,007 379,489
lipopolysaccharide biosynthetic process
255.07 4.39 18,382 402,199
nucleotidyltransferase activity
34.63 0.61 12,045 1,940,928
CMP-N-acetylneuraminate biosynthetic process
1,201.71 0.29 104 483
glycosylation
20.15 0.20 154 42,654
hydrolase activity
9.92 0.18 20,368 11,461,355
3-deoxy-manno-octulosonate cytidylyltransferase activity
14.09 0.11 67 26,540
Totals 137300 231910896
No co-occurrence statistics for GO:0008781 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term PR S% #Together #Compared
N-acylneuraminate cytidylyltransferase activity
23,922.20 100.00 54 54
CMP-N-acetylneuraminate biosynthetic process
6,379.25 6.15 4 15
N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity
23,922.21 5.56 3 3
keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity
23,922.21 5.56 3 3
glycosylation
63.54 0.25 2 753
protein glycosylation
17.36 0.07 1 1,378
chemical synaptic transmission
10.97 0.04 1 2,181
response to heat
9.06 0.04 1 2,640
trans-Golgi network
5.20 0.02 1 4,602
nucleoplasm
2.80 0.01 2 17,081
Totals 81 484266

Change Log

Timestamp Action Category Detail
2023-08-11 Added XREF MetaCyc:RXN-9990
2023-08-11 Deleted XREF MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN
2020-10-08 Added SYNONYM CMP-N-acetylneuraminate synthetase activity
2020-10-08 Added SYNONYM CMP-N-acetylneuraminic acid synthetase activity
2020-10-08 Deleted SYNONYM cytidine 5'-monophosphosialic acid synthetase activity
2020-10-08 Deleted SYNONYM cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity
2020-10-08 Deleted SYNONYM cytidine monophosphoacetylneuraminic synthetase activity
2020-10-08 Deleted SYNONYM acylneuraminate cytidyltransferase activity
2020-10-08 Deleted SYNONYM cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity
2020-10-08 Deleted SYNONYM CMP-sialate synthetase activity
Timestamp Action Category Detail
2003-09-09 Updated TERM N-acylneuraminate cytidylyltransferase activity
2003-03-19 Updated TERM acylneuraminate cytidylyltransferase activity
2002-02-06 Updated TERM acylneuraminate cytidylyltransferase
2001-04-03 Updated TERM acylneuraminate cytidylyltransferase
2001-03-30 Added TERM acylneuraminate cytidylyltransferase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM CMP-N-acetylneuraminate synthetase activity
2020-10-08 Added SYNONYM CMP-N-acetylneuraminic acid synthetase activity
2020-10-08 Deleted SYNONYM cytidine 5'-monophosphosialic acid synthetase activity
2020-10-08 Deleted SYNONYM cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity
2020-10-08 Deleted SYNONYM cytidine monophosphoacetylneuraminic synthetase activity
2020-10-08 Deleted SYNONYM acylneuraminate cytidyltransferase activity
2020-10-08 Deleted SYNONYM cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity
2020-10-08 Deleted SYNONYM CMP-sialate synthetase activity
2020-10-08 Deleted SYNONYM CMP-sialic synthetase activity
2020-10-08 Deleted SYNONYM acetylneuraminate cytidylyltransferase activity
2020-10-08 Deleted SYNONYM CMP-N-acetylneuraminic acid synthetase activity
2020-10-08 Deleted SYNONYM CMP-NeuNAc synthetase activity
2020-10-08 Deleted SYNONYM CMP-sialate diphosphorylase activity
2020-10-08 Deleted SYNONYM CMP-sialate pyrophosphorylase activity
2020-10-08 Deleted SYNONYM CMP-sialate synthase activity
2020-10-08 Deleted SYNONYM CMP-sialic acid synthetase activity
2020-10-08 Deleted SYNONYM CMP-N-acetylneuraminate synthase activity
2020-10-08 Deleted SYNONYM CMP-N-acetylneuraminate synthetase activity
2020-10-08 Deleted SYNONYM CMP-N-acetylneuraminic acid synthase activity
2020-10-08 Deleted SYNONYM CMP-NANA synthetase activity
2020-10-08 Deleted SYNONYM CMP-Neu5Ac synthetase activity
2020-10-08 Deleted SYNONYM CMP-NeuAc synthetase activity
2020-10-08 Added SYNONYM CMP-NANA synthetase activity
2020-10-08 Added SYNONYM cytidine 5'-monophosphosialic acid synthetase activity
2020-10-08 Added SYNONYM cytidine monophosphosialate pyrophosphorylase activity
2020-10-08 Deleted SYNONYM cytidine monophosphosialate pyrophosphorylase activity
2020-10-08 Deleted SYNONYM cytidine monophosphosialate synthetase activity
2020-10-08 Deleted SYNONYM cytidine monophosphosialic acid synthetase activity
2020-10-08 Added SYNONYM cytidine monophosphosialate synthetase activity
2020-10-08 Added SYNONYM CMP-sialate pyrophosphorylase activity
2020-10-08 Added SYNONYM CMP-sialate synthase activity
2020-10-08 Added SYNONYM CMP-Neu5Ac synthetase activity
2020-10-08 Added SYNONYM CMP-N-acetylneuraminic acid synthase activity
2020-10-08 Added SYNONYM cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity
2020-10-08 Added SYNONYM cytidine monophosphoacetylneuraminic synthetase activity
2020-10-08 Added SYNONYM cytidine monophosphosialic acid synthetase activity
2020-10-08 Added SYNONYM CMP-sialate synthetase activity
2020-10-08 Added SYNONYM CMP-NeuNAc synthetase activity
2020-10-08 Added SYNONYM CMP-N-acetylneuraminate synthase activity
2020-10-08 Added SYNONYM CMP-NeuAc synthetase activity
2020-10-08 Added SYNONYM CMP-sialate diphosphorylase activity
2020-10-08 Added SYNONYM CMP-sialic acid synthetase activity
2020-10-08 Added SYNONYM acylneuraminate cytidyltransferase activity
2020-10-08 Added SYNONYM CMP-sialic synthetase activity
2020-10-08 Added SYNONYM acetylneuraminate cytidylyltransferase activity
2020-10-08 Added SYNONYM cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.
2007-11-08 Added SYNONYM CMP-NANA synthetase activity
2007-11-08 Added SYNONYM CMP-Neu5Ac synthetase activity
2007-11-08 Added SYNONYM CMP-NeuAc synthetase activity
2007-11-08 Added SYNONYM CMP-sialate synthetase activity
2007-11-08 Added SYNONYM CMP-sialic synthetase activity
2007-11-08 Added SYNONYM CMP-N-acetylneuraminic acid synthase activity
2007-11-08 Added SYNONYM CMP-N-acetylneuraminate synthetase activity
2007-11-08 Added SYNONYM CMP-N-acetylneuraminate synthase activity
2007-11-08 Added SYNONYM cytidine monophosphosialate synthetase activity
2007-11-08 Added SYNONYM cytidine monophosphosialic acid synthetase activity
2007-11-08 Added SYNONYM cytidine monophosphosialate pyrophosphorylase activity
2007-11-08 Added SYNONYM acylneuraminate cytidyltransferase activity
2007-11-08 Added SYNONYM cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity
2007-11-08 Added SYNONYM cytidine 5'-monophosphosialic acid synthetase activity
2007-11-08 Added SYNONYM acetylneuraminate cytidylyltransferase activity
2007-11-08 Added SYNONYM cytidine monophosphoacetylneuraminic synthetase activity
2007-11-08 Added SYNONYM cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity
2007-09-06 Added SYNONYM CMP-N-acetylneuraminic acid synthetase activity
2007-09-06 Added SYNONYM CMP-NeuNAc synthetase activity
2007-09-06 Added SYNONYM CMP-sialate diphosphorylase activity
2007-09-06 Added SYNONYM CMP-sialate pyrophosphorylase activity
2007-09-06 Added SYNONYM CMP-sialic acid synthetase activity
2007-09-06 Added SYNONYM CMP-sialate synthase activity
2007-08-09 Added SYNONYM CTP:N-acylneuraminate cytidylyltransferase activity
2007-08-09 Deleted SYNONYM CTP:N-acylneuraminate cytidylyltransferase activity
2005-10-24 Added SYNONYM CTP:N-acylneuraminate cytidylyltransferase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.
Timestamp Action Category Detail
2009-04-29 Deleted RELATION is a GO:0016779 (nucleotidyltransferase activity)
2009-04-29 Added RELATION is a GO:0070567 (cytidylyltransferase activity)
2008-04-01 Updated RELATION is a GO:0016779 (nucleotidyltransferase activity)
Timestamp Action Category Detail
2023-08-11 Added XREF MetaCyc:RXN-9990
2023-08-11 Deleted XREF MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN
2019-04-01 Deleted XREF reactome:R-HSA-4084982
2019-04-01 Added XREF Reactome:R-HSA-4084982
2018-12-11 Added XREF reactome:R-HSA-4084982
2018-07-13 Added XREF RHEA:11344
2018-07-13 Deleted XREF RHEA:11347
2011-09-16 Added XREF RHEA:11347
2003-10-27 Added XREF MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN
2001-03-30 Added XREF EC:2.7.7.43
Timestamp Action Category Detail
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