This term is obsolete.

GO:0008794 JSON

arsenate reductase (glutaredoxin) activity

Molecular Function

Definition (GO:0008794 GONUTS page)

Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. PMID:10593884

20,778 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
glutharedoxin:arsenate oxidoreductase activity related

Ancestor Chart

Ancestor chart for GO:0008794
Chart options
Apply Download Chart
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.20.4.1
InterPro IPR006659 Arsenate reductase
InterPro IPR014062 Arsenate reductase, glutathione/glutaredoxin type
MetaCyc RXN-982
RHEA 22016
UM-BBD_reactionID r0635

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29950 L-cysteine residue
has_participant CHEBI CHEBI:146199 S-(S-glutathionyl)-L-cysteine(1-) residue
has_participant CHEBI CHEBI:29242 arsenite(1-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:48597 arsenate(2-)
has_participant CHEBI CHEBI:57925 glutathionate(1-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008794 based on ALL annotations
The top 100 of 143 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0008794
arsenate reductase (glutaredoxin) activity
9,538.60 100.00 20,774 20,774
GO:0046685
response to arsenic-containing substance
1,581.46 14.09 10,061 60,683
GO:0030612
arsenate reductase (thioredoxin) activity
182.64 0.19 44 2,298
GO:0016491
oxidoreductase activity
15.68 0.16 20,283 12,339,325
GO:0030946
protein tyrosine phosphatase activity, metal-dependent
7.86 0.07 73 88,583
GO:0140793
histone H2AXY142 phosphatase activity
7.85 0.07 73 88,666
GO:0004726
non-membrane spanning protein tyrosine phosphatase activity
6.99 0.06 73 99,605
GO:0009358
polyphosphate kinase complex
7.44 0.05 28 35,879
GO:0004725
protein tyrosine phosphatase activity
4.99 0.05 100 191,166
GO:0006799
polyphosphate biosynthetic process
5.49 0.04 28 48,652
Totals 52549 103871228
No co-occurrence statistics for GO:0008794 based on MANUAL annotations
The top 24 of 24 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0008794
arsenate reductase (glutaredoxin) activity
352,883.25 100.00 4 4
GO:0051775
response to redox state
8,206.59 2.17 1 43
GO:0046685
response to arsenic-containing substance
3,794.44 1.04 1 93
GO:0042262
DNA protection
3,600.85 0.99 1 98
GO:0009266
response to temperature stimulus
2,594.73 0.72 1 136
GO:0015038
glutathione disulfide oxidoreductase activity
877.82 0.25 1 402
GO:0015035
protein-disulfide reductase activity
316.77 0.09 1 1,114
GO:0004725
protein tyrosine phosphatase activity
311.60 0.09 2 2,265
GO:0003756
protein disulfide isomerase activity
278.30 0.08 1 1,268
GO:0016791
phosphatase activity
213.74 0.06 2 3,302
Totals 32 582135

Change Log

Timestamp Action Category Detail
2025-02-19 Deleted RELATION is a GO:0030611 (arsenate reductase activity)
2025-02-19 Added RELATION is a GO:0030614 (oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor)
2025-02-12 Deleted RELATION is a GO:0030614 (oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor)
2020-10-08 Deleted SYNONYM glutharedoxin:arsenate oxidoreductase activity
2020-10-08 Added SYNONYM glutharedoxin:arsenate oxidoreductase activity
2020-06-22 Added XREF RHEA:22016
2011-05-03 Added XREF UM-BBD_reactionID:r0635
2011-05-03 Deleted XREF UM-BBD_enzymeID:e0261
2008-05-13 Added DEFINITION Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
Timestamp Action Category Detail
2003-03-19 Updated TERM arsenate reductase (glutaredoxin) activity
2002-04-16 Updated TERM arsenate reductase (glutaredoxin)
2002-02-06 Updated TERM arsenate reductase
2001-04-03 Updated TERM arsenate reductase
2001-03-30 Added TERM arsenate reductase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM glutharedoxin:arsenate oxidoreductase activity
2020-10-08 Added SYNONYM glutharedoxin:arsenate oxidoreductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
2007-11-08 Added SYNONYM glutharedoxin:arsenate oxidoreductase activity
2004-03-19 Updated DEFINITION Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
2003-04-24 Updated DEFINITION Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i. e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
2003-04-12 Updated DEFINITION Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is [ NADPH -> glutathione reductase (EC:1.6.4.2) -> ] glutathione -> glutaredoxin -> arsenate reductase, i. e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
2002-11-27 Added DEFINITION Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is [ NADPH -> glutathione reductase (EC 1.6.4.2) -> ] glutathione -> glutaredoxin -> arsenate reductase, i. e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
Timestamp Action Category Detail
2025-02-19 Deleted RELATION is a GO:0030611 (arsenate reductase activity)
2025-02-19 Added RELATION is a GO:0030614 (oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor)
2025-02-12 Deleted RELATION is a GO:0030614 (oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor)
2008-04-01 Updated RELATION is a GO:0030614 (oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor)
2008-04-01 Updated RELATION is a GO:0030611 (arsenate reductase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:22016
2011-05-03 Added XREF UM-BBD_reactionID:r0635
2011-05-03 Deleted XREF UM-BBD_enzymeID:e0261
2003-10-27 Added XREF UM-BBD_enzymeID:e0261
2003-10-27 Added XREF MetaCyc:RXN-982
2002-04-16 Added XREF EC:1.20.4.1
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.
I agree, dismiss this banner