GO:0008794
JSON
arsenate reductase (glutaredoxin) activity
Molecular Function
Definition (GO:0008794 GONUTS page)
Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. PMID:10593884
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
glutharedoxin:arsenate oxidoreductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.20.4.1 | |
InterPro | IPR006659 | Arsenate reductase |
InterPro | IPR014062 | Arsenate reductase, glutathione/glutaredoxin type |
MetaCyc | RXN-982 | |
RHEA | 22016 | |
UM-BBD_reactionID | r0635 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:146199 | S-(S-glutathionyl)-L-cysteine(1-) residue |
has_participant | CHEBI | CHEBI:57925 | glutathionate(1-) |
has_participant | CHEBI | CHEBI:48597 | arsenate(2-) |
has_participant | CHEBI | CHEBI:29242 | arsenite(1-) |
has_participant | CHEBI | CHEBI:29950 | L-cysteine residue |
has_participant | CHEBI | CHEBI:15377 | water |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008794 based on ALL annotations
The top 100 of 145 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
arsenate reductase (glutaredoxin) activity
|
9,558.63 | 100.00 | 20,394 | 20,394 |
response to arsenic-containing substance
|
1,464.79 | 13.21 | 9,964 | 65,021 |
arsenate reductase (thioredoxin) activity
|
186.43 | 0.19 | 44 | 2,256 |
oxidoreductase activity
|
13.14 | 0.14 | 16,364 | 11,906,003 |
protein tyrosine phosphatase activity, metal-dependent
|
8.03 | 0.07 | 75 | 89,275 |
histone H2AXY142 phosphatase activity
|
8.02 | 0.07 | 75 | 89,358 |
non-membrane spanning protein tyrosine phosphatase activity
|
7.18 | 0.06 | 75 | 99,883 |
polyphosphate kinase complex
|
7.55 | 0.05 | 28 | 35,469 |
polyphosphate biosynthetic process
|
7.33 | 0.05 | 28 | 36,498 |
protein tyrosine phosphatase activity
|
5.02 | 0.05 | 98 | 186,783 |
Totals | 48147 | 101057382 |
No co-occurrence statistics for GO:0008794 based on MANUAL annotations
The top 24 of 24 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
arsenate reductase (glutaredoxin) activity
|
322,949.75 | 100.00 | 4 | 4 |
response to redox state
|
7,510.46 | 2.17 | 1 | 43 |
response to arsenic-containing substance
|
3,510.32 | 1.05 | 1 | 92 |
DNA protection
|
3,435.64 | 1.03 | 1 | 94 |
response to temperature stimulus
|
2,392.22 | 0.72 | 1 | 135 |
glutathione disulfide oxidoreductase activity
|
865.82 | 0.27 | 1 | 373 |
protein-disulfide reductase activity
|
325.23 | 0.10 | 1 | 993 |
protein disulfide isomerase activity
|
290.16 | 0.09 | 1 | 1,113 |
protein tyrosine phosphatase activity
|
284.29 | 0.09 | 2 | 2,272 |
apoptotic process
|
220.74 | 0.07 | 1 | 1,463 |
Totals | 32 | 536929 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | glutharedoxin:arsenate oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | glutharedoxin:arsenate oxidoreductase activity |
2020-06-22 | Added | XREF | RHEA:22016 |
2011-05-03 | Added | XREF | UM-BBD_reactionID:r0635 |
2011-05-03 | Deleted | XREF | UM-BBD_enzymeID:e0261 |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
2008-04-01 | Updated | RELATION | is a GO:0030614 (oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor) |
2008-04-01 | Updated | RELATION | is a GO:0030611 (arsenate reductase activity) |
2007-11-08 | Added | SYNONYM | glutharedoxin:arsenate oxidoreductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | arsenate reductase (glutaredoxin) activity |
2002-04-16 | Updated | TERM | arsenate reductase (glutaredoxin) |
2002-02-06 | Updated | TERM | arsenate reductase |
2001-04-03 | Updated | TERM | arsenate reductase |
2001-03-30 | Added | TERM | arsenate reductase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | glutharedoxin:arsenate oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | glutharedoxin:arsenate oxidoreductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
2007-11-08 | Added | SYNONYM | glutharedoxin:arsenate oxidoreductase activity |
2004-03-19 | Updated | DEFINITION | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
2003-04-24 | Updated | DEFINITION | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i. e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
2003-04-12 | Updated | DEFINITION | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is [ NADPH -> glutathione reductase (EC:1.6.4.2) -> ] glutathione -> glutaredoxin -> arsenate reductase, i. e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is [ NADPH -> glutathione reductase (EC 1.6.4.2) -> ] glutathione -> glutaredoxin -> arsenate reductase, i. e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0030614 (oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor) |
2008-04-01 | Updated | RELATION | is a GO:0030611 (arsenate reductase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:22016 |
2011-05-03 | Added | XREF | UM-BBD_reactionID:r0635 |
2011-05-03 | Deleted | XREF | UM-BBD_enzymeID:e0261 |
2003-10-27 | Added | XREF | MetaCyc:RXN-982 |
2003-10-27 | Added | XREF | UM-BBD_enzymeID:e0261 |
2002-04-16 | Added | XREF | EC:1.20.4.1 |
Timestamp | Action | Category | Detail |
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