GO:0008795
JSON
NAD+ synthase activity
Molecular Function
Definition (GO:0008795 GONUTS page)
Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.
Secondary IDs
GO:0008749, GO:0016965
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
diphosphopyridine nucleotide synthetase activity | related |
nicotinamide adenine dinucleotide synthetase activity | related |
deamido-NAD+:ammonia ligase (AMP-forming) | related |
NAD(+) synthetase activity | related |
NAD+ synthetase activity | related |
NAD synthetase activity | related |
NAD synthase activity | exact |
NAD synthase (AMP-forming) | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.3.1.5 | |
InterPro | IPR022926 | NH(3)-dependent NAD(+) synthetase |
MetaCyc | NAD-SYNTH-NH3-RXN | |
RHEA | 21188 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:28938 | ammonium |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:456215 | adenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:58437 | deamido-NAD(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008795 based on ALL annotations
The top 100 of 114 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD+ synthase activity
|
4,488.32 | 100.00 | 44,149 | 44,149 |
NAD+ synthase (glutamine-hydrolyzing) activity
|
3,532.23 | 78.49 | 44,001 | 55,911 |
glutaminase activity
|
1,036.78 | 23.08 | 43,988 | 190,428 |
NAD biosynthetic process
|
664.59 | 14.80 | 44,019 | 297,281 |
nitrilase activity
|
1,438.60 | 9.57 | 5,303 | 16,545 |
ligase activity
|
64.50 | 1.44 | 44,105 | 3,069,286 |
ATP binding
|
10.38 | 0.23 | 43,983 | 19,024,482 |
cytoplasm
|
7.74 | 0.17 | 43,983 | 25,503,657 |
metal ion binding
|
3.04 | 0.07 | 14,730 | 21,769,638 |
GMP synthase activity
|
1.40 | 0.02 | 17 | 54,515 |
Totals | 329038 | 238423338 |
No co-occurrence statistics for GO:0008795 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD+ synthase activity
|
470,511.00 | 100.00 | 3 | 3 |
'de novo' NAD biosynthetic process
|
94,102.20 | 14.29 | 1 | 5 |
NAD+ synthase (glutamine-hydrolyzing) activity
|
7,528.18 | 1.59 | 2 | 125 |
'de novo' NAD biosynthetic process from aspartate
|
4,056.13 | 0.85 | 1 | 116 |
NAD salvage
|
2,851.58 | 0.60 | 1 | 165 |
NAD biosynthetic process
|
1,680.40 | 0.36 | 2 | 560 |
glutaminase activity
|
1,387.94 | 0.29 | 1 | 339 |
determination of adult lifespan
|
556.16 | 0.12 | 1 | 846 |
magnesium ion binding
|
154.72 | 0.03 | 1 | 3,041 |
DNA damage response
|
116.49 | 0.02 | 1 | 4,039 |
Totals | 18 | 343420 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | NAD(+) synthetase activity |
2020-10-08 | Deleted | SYNONYM | NAD synthetase activity |
2020-10-08 | Deleted | SYNONYM | NAD+ synthetase activity |
2020-10-08 | Added | SYNONYM | NAD+ synthetase activity |
2020-10-08 | Deleted | SYNONYM | diphosphopyridine nucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | diphosphopyridine nucleotide synthetase activity |
2020-10-08 | Deleted | SYNONYM | deamido-NAD+:ammonia ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | NAD(+) synthetase activity |
2020-10-08 | Added | SYNONYM | NAD synthetase activity |
2020-10-08 | Added | SYNONYM | nicotinamide adenine dinucleotide synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-11-14 | Updated | TERM | NAD+ synthase activity |
2003-09-06 | Updated | TERM | NAD synthase (AMP-forming) activity |
2003-03-19 | Updated | TERM | NAD+ synthase (AMP-forming) activity |
2002-11-05 | Updated | TERM | NAD+ synthase (AMP-forming) |
2002-05-15 | Updated | TERM | NAD+ synthase |
2002-02-06 | Updated | TERM | NAD(+) synthase |
2001-04-03 | Updated | TERM | NAD(+) synthase |
2001-03-30 | Added | TERM | NAD(+) synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | NAD(+) synthetase activity |
2020-10-08 | Deleted | SYNONYM | NAD synthetase activity |
2020-10-08 | Deleted | SYNONYM | NAD+ synthetase activity |
2020-10-08 | Added | SYNONYM | NAD+ synthetase activity |
2020-10-08 | Deleted | SYNONYM | diphosphopyridine nucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | diphosphopyridine nucleotide synthetase activity |
2020-10-08 | Deleted | SYNONYM | deamido-NAD+:ammonia ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | NAD(+) synthetase activity |
2020-10-08 | Added | SYNONYM | NAD synthetase activity |
2020-10-08 | Added | SYNONYM | nicotinamide adenine dinucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | deamido-NAD+:ammonia ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | nicotinamide adenine dinucleotide synthetase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. |
2007-11-08 | Added | SYNONYM | deamido-NAD+:ammonia ligase (AMP-forming) |
2007-11-08 | Added | SYNONYM | NAD+ synthetase activity |
2007-11-08 | Added | SYNONYM | diphosphopyridine nucleotide synthetase activity |
2007-11-08 | Added | SYNONYM | nicotinamide adenine dinucleotide synthetase activity |
2007-11-08 | Added | SYNONYM | NAD synthetase activity |
2007-09-06 | Added | SYNONYM | NAD(+) synthetase activity |
2007-08-09 | Added | SYNONYM | NAD synthase activity |
2007-08-09 | Deleted | SYNONYM | NAD synthase activity |
2007-08-09 | Deleted | SYNONYM | NAD synthase (AMP-forming) |
2007-08-09 | Added | SYNONYM | NAD synthase (AMP-forming) |
2004-04-19 | Added | SYNONYM | NAD synthase (AMP-forming) |
2004-04-19 | Added | SYNONYM | NAD synthase activity |
2004-04-16 | Deleted | SYNONYM | NAD synthase activity |
2004-04-16 | Deleted | SYNONYM | NAD synthase (AMP-forming) |
2003-11-14 | Added | SYNONYM | NAD synthase activity |
2003-10-30 | Updated | DEFINITION | Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. |
2003-10-27 | Added | SYNONYM | NAD synthase (AMP-forming) |
2003-09-19 | Deleted | SYNONYM | NAD synthase (AMP-forming) |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + deamido-NAD+ + ammonia = AMP + diphosphate + NAD+. |
2002-11-05 | Added | SYNONYM | NAD synthase (AMP-forming) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016880 (acid-ammonia (or amide) ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-13 | Deleted | XREF | RHEA:21191 |
2018-07-13 | Added | XREF | RHEA:21188 |
2011-09-16 | Added | XREF | RHEA:21191 |
2003-10-27 | Added | XREF | MetaCyc:NAD-SYNTH-NH3-RXN |
2001-03-30 | Added | XREF | EC:6.3.1.5 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-11-14 | Added | SECONDARY | GO:0016965 (NAD synthase activity) |
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