This term is obsolete.

GO:0008795 JSON

NAD+ synthase activity

Molecular Function

Definition (GO:0008795 GONUTS page)

Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.

Secondary IDs

GO:0008749, GO:0016965

44,150 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
diphosphopyridine nucleotide synthetase activity related
nicotinamide adenine dinucleotide synthetase activity related
deamido-NAD+:ammonia ligase (AMP-forming) related
NAD(+) synthetase activity related
NAD+ synthetase activity related
NAD synthetase activity related
NAD synthase activity exact
NAD synthase (AMP-forming) exact

Ancestor Chart

Ancestor chart for GO:0008795
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.3.1.5
InterPro IPR022926 NH(3)-dependent NAD(+) synthetase
MetaCyc NAD-SYNTH-NH3-RXN
RHEA 21188

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:33019 diphosphate(3-)
has_participant CHEBI CHEBI:28938 ammonium
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:456215 adenosine 5'-monophosphate(2-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:58437 deamido-NAD(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008795 based on ALL annotations
The top 100 of 114 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD+ synthase activity
4,488.32 100.00 44,149 44,149
NAD+ synthase (glutamine-hydrolyzing) activity
3,532.23 78.49 44,001 55,911
glutaminase activity
1,036.78 23.08 43,988 190,428
NAD biosynthetic process
664.59 14.80 44,019 297,281
nitrilase activity
1,438.60 9.57 5,303 16,545
ligase activity
64.50 1.44 44,105 3,069,286
ATP binding
10.38 0.23 43,983 19,024,482
cytoplasm
7.74 0.17 43,983 25,503,657
metal ion binding
3.04 0.07 14,730 21,769,638
GMP synthase activity
1.40 0.02 17 54,515
Totals 329038 238423338
No co-occurrence statistics for GO:0008795 based on MANUAL annotations
The top 14 of 14 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NAD+ synthase activity
470,511.00 100.00 3 3
'de novo' NAD biosynthetic process
94,102.20 14.29 1 5
NAD+ synthase (glutamine-hydrolyzing) activity
7,528.18 1.59 2 125
'de novo' NAD biosynthetic process from aspartate
4,056.13 0.85 1 116
NAD salvage
2,851.58 0.60 1 165
NAD biosynthetic process
1,680.40 0.36 2 560
glutaminase activity
1,387.94 0.29 1 339
determination of adult lifespan
556.16 0.12 1 846
magnesium ion binding
154.72 0.03 1 3,041
DNA damage response
116.49 0.02 1 4,039
Totals 18 343420

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM NAD(+) synthetase activity
2020-10-08 Deleted SYNONYM NAD synthetase activity
2020-10-08 Deleted SYNONYM NAD+ synthetase activity
2020-10-08 Added SYNONYM NAD+ synthetase activity
2020-10-08 Deleted SYNONYM diphosphopyridine nucleotide synthetase activity
2020-10-08 Added SYNONYM diphosphopyridine nucleotide synthetase activity
2020-10-08 Deleted SYNONYM deamido-NAD+:ammonia ligase (AMP-forming)
2020-10-08 Added SYNONYM NAD(+) synthetase activity
2020-10-08 Added SYNONYM NAD synthetase activity
2020-10-08 Added SYNONYM nicotinamide adenine dinucleotide synthetase activity
Timestamp Action Category Detail
2003-11-14 Updated TERM NAD+ synthase activity
2003-09-06 Updated TERM NAD synthase (AMP-forming) activity
2003-03-19 Updated TERM NAD+ synthase (AMP-forming) activity
2002-11-05 Updated TERM NAD+ synthase (AMP-forming)
2002-05-15 Updated TERM NAD+ synthase
2002-02-06 Updated TERM NAD(+) synthase
2001-04-03 Updated TERM NAD(+) synthase
2001-03-30 Added TERM NAD(+) synthase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM NAD(+) synthetase activity
2020-10-08 Deleted SYNONYM NAD synthetase activity
2020-10-08 Deleted SYNONYM NAD+ synthetase activity
2020-10-08 Added SYNONYM NAD+ synthetase activity
2020-10-08 Deleted SYNONYM diphosphopyridine nucleotide synthetase activity
2020-10-08 Added SYNONYM diphosphopyridine nucleotide synthetase activity
2020-10-08 Deleted SYNONYM deamido-NAD+:ammonia ligase (AMP-forming)
2020-10-08 Added SYNONYM NAD(+) synthetase activity
2020-10-08 Added SYNONYM NAD synthetase activity
2020-10-08 Added SYNONYM nicotinamide adenine dinucleotide synthetase activity
2020-10-08 Added SYNONYM deamido-NAD+:ammonia ligase (AMP-forming)
2020-10-08 Deleted SYNONYM nicotinamide adenine dinucleotide synthetase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.
2007-11-08 Added SYNONYM deamido-NAD+:ammonia ligase (AMP-forming)
2007-11-08 Added SYNONYM NAD+ synthetase activity
2007-11-08 Added SYNONYM diphosphopyridine nucleotide synthetase activity
2007-11-08 Added SYNONYM nicotinamide adenine dinucleotide synthetase activity
2007-11-08 Added SYNONYM NAD synthetase activity
2007-09-06 Added SYNONYM NAD(+) synthetase activity
2007-08-09 Added SYNONYM NAD synthase activity
2007-08-09 Deleted SYNONYM NAD synthase activity
2007-08-09 Deleted SYNONYM NAD synthase (AMP-forming)
2007-08-09 Added SYNONYM NAD synthase (AMP-forming)
2004-04-19 Added SYNONYM NAD synthase (AMP-forming)
2004-04-19 Added SYNONYM NAD synthase activity
2004-04-16 Deleted SYNONYM NAD synthase activity
2004-04-16 Deleted SYNONYM NAD synthase (AMP-forming)
2003-11-14 Added SYNONYM NAD synthase activity
2003-10-30 Updated DEFINITION Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.
2003-10-27 Added SYNONYM NAD synthase (AMP-forming)
2003-09-19 Deleted SYNONYM NAD synthase (AMP-forming)
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + deamido-NAD+ + ammonia = AMP + diphosphate + NAD+.
2002-11-05 Added SYNONYM NAD synthase (AMP-forming)
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016880 (acid-ammonia (or amide) ligase activity)
Timestamp Action Category Detail
2018-07-13 Deleted XREF RHEA:21191
2018-07-13 Added XREF RHEA:21188
2011-09-16 Added XREF RHEA:21191
2003-10-27 Added XREF MetaCyc:NAD-SYNTH-NH3-RXN
2001-03-30 Added XREF EC:6.3.1.5
Timestamp Action Category Detail
2003-11-14 Added SECONDARY GO:0016965 (NAD synthase activity)
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