GO:0008821
JSON
crossover junction DNA endonuclease activity
Molecular Function
Definition (GO:0008821 GONUTS page)
Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
Secondary IDs
GO:0008844
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
Holliday junction nuclease activity | related |
cruciform-cutting endonuclease activity | related |
endodeoxyribonuclease RUS activity | exact |
crossover junction endoribonuclease activity | exact |
endo X3 | related |
SpCCe1 holliday junction resolvase | narrow |
Hje endonuclease activity | related |
crossover junction endodeoxyribonuclease activity | exact |
endonuclease X3 activity | narrow |
endonuclease VII activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008821
Child Term | Relationship to GO:0008821 |
---|---|
Holliday junction resolvase complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A0G2K5G5 | 10116 | A0A0G2K5G5_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A4WYU7 | 349102 | AGO_CERS5 | GO:0004520 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24034694 | |
NOT-qualified manual | protein | A6J211 | 10116 | A6J211_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8DY77 | 7227 | A8DY77_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | B2GV68 | 10116 | B2GV68_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P0C5W1 | 10116 | MAP1S_RAT | GO:0004536 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.21.10 | |
InterPro | IPR016281 | Crossover junction endodeoxyribonuclease, RusA |
InterPro | IPR020563 | Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site |
InterPro | IPR033309 | Crossover junction endonuclease Mus81 |
InterPro | IPR037316 | Yen1, H3TH domain |
InterPro | IPR045290 | Holliday junction resolvase MOC1-like |
MetaCyc | 3.1.22.4-RXN |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008821 based on ALL annotations
The top 100 of 362 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
crossover junction DNA endonuclease activity
|
3,444.70 | 100.00 | 56,591 | 56,591 |
Holliday junction resolvase complex
|
1,204.71 | 31.26 | 42,247 | 120,799 |
mitotic intra-S DNA damage checkpoint signaling
|
1,074.58 | 10.18 | 7,431 | 23,821 |
DNA endonuclease activity
|
588.83 | 8.70 | 8,513 | 49,802 |
3'-flap endonuclease activity
|
3,444.70 | 8.25 | 4,668 | 4,668 |
resolution of meiotic recombination intermediates
|
604.15 | 8.13 | 7,443 | 42,438 |
meiotic DNA recombinase assembly
|
3,410.07 | 6.78 | 3,841 | 3,880 |
Rad51C-XRCC3 complex
|
2,174.87 | 6.69 | 3,941 | 6,242 |
Rad51B-Rad51C-Rad51D-XRCC2 complex
|
1,183.83 | 6.02 | 3,847 | 11,194 |
Slx1-Slx4 complex
|
1,703.54 | 5.51 | 3,306 | 6,685 |
Totals | 574341 | 122539136 |
No co-occurrence statistics for GO:0008821 based on MANUAL annotations
The top 100 of 137 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
crossover junction DNA endonuclease activity
|
3,158.43 | 100.00 | 409 | 409 |
Holliday junction resolvase complex
|
3,037.62 | 42.31 | 176 | 183 |
3'-flap endonuclease activity
|
3,158.43 | 30.81 | 126 | 126 |
Slx1-Slx4 complex
|
2,519.00 | 29.41 | 130 | 163 |
mitotic intra-S DNA damage checkpoint signaling
|
917.47 | 20.86 | 174 | 599 |
meiotic DNA recombinase assembly
|
2,898.33 | 18.75 | 78 | 85 |
Rad51C-XRCC3 complex
|
1,761.85 | 17.30 | 82 | 147 |
resolution of meiotic recombination intermediates
|
614.82 | 15.45 | 175 | 899 |
Rad51B-Rad51C-Rad51D-XRCC2 complex
|
1,273.04 | 15.02 | 79 | 196 |
5'-flap endonuclease activity
|
580.29 | 13.58 | 140 | 762 |
Totals | 2460 | 56018 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Added | XREF | EC:3.1.21.10 |
2022-12-18 | Deleted | SYNONYM | Endo X3 activity |
2022-12-18 | Deleted | SYNONYM | Holliday junction-resolving endoribonuclease activity |
2022-12-18 | Deleted | SYNONYM | RusA Holliday junction resolvase activity |
2022-12-18 | Deleted | SYNONYM | resolving enzyme CCE1 activity |
2022-12-18 | Deleted | SYNONYM | Holliday junction-cleaving endonuclease activity |
2022-12-18 | Added | SYNONYM | crossover junction endodeoxyribonuclease activity |
2022-12-18 | Updated | TERM | crossover junction DNA endonuclease activity |
2022-12-18 | Deleted | XREF | EC:3.1.22.4 |
2022-12-18 | Deleted | SYNONYM | RusA holliday junction resolvase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Updated | TERM | crossover junction DNA endonuclease activity |
2004-01-07 | Updated | TERM | crossover junction endodeoxyribonuclease activity |
2003-03-19 | Updated | TERM | crossover junction endoribonuclease activity |
2002-02-06 | Updated | TERM | crossover junction endoribonuclease |
2001-04-03 | Updated | TERM | crossover junction endoribonuclease |
2001-03-30 | Added | TERM | crossover junction endoribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Deleted | SYNONYM | Endo X3 activity |
2022-12-18 | Deleted | SYNONYM | Holliday junction-resolving endoribonuclease activity |
2022-12-18 | Deleted | SYNONYM | RusA Holliday junction resolvase activity |
2022-12-18 | Deleted | SYNONYM | resolving enzyme CCE1 activity |
2022-12-18 | Deleted | SYNONYM | Holliday junction-cleaving endonuclease activity |
2022-12-18 | Added | SYNONYM | crossover junction endodeoxyribonuclease activity |
2022-12-18 | Deleted | SYNONYM | RusA holliday junction resolvase |
2020-10-08 | Deleted | SYNONYM | cruciform-cutting endonuclease activity |
2020-10-08 | Deleted | SYNONYM | Hje endonuclease activity |
2020-10-08 | Added | SYNONYM | cruciform-cutting endonuclease activity |
2020-10-08 | Added | SYNONYM | Holliday junction nuclease activity |
2020-10-08 | Added | SYNONYM | Holliday junction-cleaving endonuclease activity |
2020-10-08 | Deleted | SYNONYM | Holliday junction-cleaving endonuclease activity |
2020-10-08 | Added | SYNONYM | Hje endonuclease activity |
2020-10-08 | Deleted | SYNONYM | Holliday junction nuclease activity |
2008-05-13 | Added | DEFINITION | Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). |
2007-11-08 | Added | SYNONYM | RusA holliday junction resolvase |
2007-11-08 | Added | SYNONYM | SpCCe1 holliday junction resolvase |
2007-11-08 | Added | SYNONYM | endo X3 |
2007-09-06 | Added | SYNONYM | resolving enzyme CCE1 activity |
2007-09-06 | Added | SYNONYM | endonuclease X3 activity |
2007-09-06 | Added | SYNONYM | cruciform-cutting endonuclease activity |
2007-09-06 | Added | SYNONYM | endonuclease RuvC activity |
2007-09-06 | Added | SYNONYM | endonuclease VII activity |
2007-09-06 | Deleted | SYNONYM | Holliday junction resolvase |
2007-09-06 | Added | SYNONYM | Endo X3 activity |
2007-09-06 | Added | SYNONYM | Hje endonuclease activity |
2007-09-06 | Added | SYNONYM | Holliday junction endonuclease CCE1 activity |
2007-09-06 | Added | SYNONYM | Holliday junction nuclease activity |
2007-09-06 | Added | SYNONYM | Holliday junction resolvase activity |
2007-09-06 | Added | SYNONYM | Holliday junction-cleaving endonuclease activity |
2007-09-06 | Added | SYNONYM | Holliday junction-resolving endoribonuclease activity |
2007-09-06 | Added | SYNONYM | RusA Holliday junction resolvase activity |
2007-09-06 | Added | SYNONYM | RusA endonuclease activity |
2007-09-06 | Added | SYNONYM | RuvC endonuclease activity |
2007-09-06 | Added | SYNONYM | SpCCe1 Holliday junction resolvase activity |
2007-08-09 | Added | SYNONYM | Holliday junction resolvase |
2007-08-09 | Added | SYNONYM | crossover junction endoribonuclease activity |
2007-08-09 | Deleted | SYNONYM | endodeoxyribonuclease RUS activity |
2007-08-09 | Deleted | SYNONYM | Holliday junction resolvase |
2007-08-09 | Added | SYNONYM | endodeoxyribonuclease RUS activity |
2007-08-09 | Deleted | SYNONYM | crossover junction endoribonuclease activity |
2004-07-22 | Added | SYNONYM | endodeoxyribonuclease RUS activity |
2004-07-22 | Added | SYNONYM | Holliday junction resolvase |
2004-04-19 | Added | SYNONYM | crossover junction endoribonuclease activity |
2004-04-16 | Deleted | SYNONYM | crossover junction endoribonuclease activity |
2004-01-07 | Added | SYNONYM | crossover junction endoribonuclease activity |
2002-11-27 | Added | DEFINITION | Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016889 (DNA endonuclease activity, producing 3'-phosphomonoesters) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Added | XREF | EC:3.1.21.10 |
2022-12-18 | Deleted | XREF | EC:3.1.22.4 |
2011-05-03 | Deleted | XREF | EC:3.1.22.- |
2004-07-22 | Added | XREF | EC:3.1.22.- |
2003-10-27 | Added | XREF | MetaCyc:3.1.22.4-RXN |
2001-03-30 | Added | XREF | EC:3.1.22.4 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-07-22 | Added | SECONDARY | GO:0008844 (endodeoxyribonuclease RUS activity) |
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