This term is obsolete.

GO:0008821 JSON

crossover junction DNA endonuclease activity

Molecular Function

Definition (GO:0008821 GONUTS page)

Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

Secondary IDs

GO:0008844

56,769 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
Holliday junction nuclease activity related
cruciform-cutting endonuclease activity related
endodeoxyribonuclease RUS activity exact
crossover junction endoribonuclease activity exact
endo X3 related
SpCCe1 holliday junction resolvase narrow
Hje endonuclease activity related
crossover junction endodeoxyribonuclease activity exact
endonuclease X3 activity narrow
endonuclease VII activity narrow

Ancestor Chart

Ancestor chart for GO:0008821
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008821

Child Term Relationship to
GO:0008821
Holliday junction resolvase complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A4WYU7 349102 AGO_CERS5 GO:0004520 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24034694
NOT-qualified manual protein A6J211 10116 A6J211_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8DY77 7227 A8DY77_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein B2GV68 10116 B2GV68_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P0C5W1 10116 MAP1S_RAT GO:0004536 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 3.1.21.10
InterPro IPR016281 Crossover junction endodeoxyribonuclease, RusA
InterPro IPR020563 Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site
InterPro IPR033309 Crossover junction endonuclease Mus81
InterPro IPR037316 Yen1, H3TH domain
InterPro IPR045290 Holliday junction resolvase MOC1-like
MetaCyc 3.1.22.4-RXN

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008821 based on ALL annotations
The top 100 of 362 co-occurring terms
Co-occurring Term PR S% #Together #Compared
crossover junction DNA endonuclease activity
3,444.70 100.00 56,591 56,591
Holliday junction resolvase complex
1,204.71 31.26 42,247 120,799
mitotic intra-S DNA damage checkpoint signaling
1,074.58 10.18 7,431 23,821
DNA endonuclease activity
588.83 8.70 8,513 49,802
3'-flap endonuclease activity
3,444.70 8.25 4,668 4,668
resolution of meiotic recombination intermediates
604.15 8.13 7,443 42,438
meiotic DNA recombinase assembly
3,410.07 6.78 3,841 3,880
Rad51C-XRCC3 complex
2,174.87 6.69 3,941 6,242
Rad51B-Rad51C-Rad51D-XRCC2 complex
1,183.83 6.02 3,847 11,194
Slx1-Slx4 complex
1,703.54 5.51 3,306 6,685
Totals 574341 122539136
No co-occurrence statistics for GO:0008821 based on MANUAL annotations
The top 100 of 137 co-occurring terms
Co-occurring Term PR S% #Together #Compared
crossover junction DNA endonuclease activity
3,158.43 100.00 409 409
Holliday junction resolvase complex
3,037.62 42.31 176 183
3'-flap endonuclease activity
3,158.43 30.81 126 126
Slx1-Slx4 complex
2,519.00 29.41 130 163
mitotic intra-S DNA damage checkpoint signaling
917.47 20.86 174 599
meiotic DNA recombinase assembly
2,898.33 18.75 78 85
Rad51C-XRCC3 complex
1,761.85 17.30 82 147
resolution of meiotic recombination intermediates
614.82 15.45 175 899
Rad51B-Rad51C-Rad51D-XRCC2 complex
1,273.04 15.02 79 196
5'-flap endonuclease activity
580.29 13.58 140 762
Totals 2460 56018

Change Log

Timestamp Action Category Detail
2022-12-18 Added XREF EC:3.1.21.10
2022-12-18 Deleted SYNONYM Endo X3 activity
2022-12-18 Deleted SYNONYM Holliday junction-resolving endoribonuclease activity
2022-12-18 Deleted SYNONYM RusA Holliday junction resolvase activity
2022-12-18 Deleted SYNONYM resolving enzyme CCE1 activity
2022-12-18 Deleted SYNONYM Holliday junction-cleaving endonuclease activity
2022-12-18 Added SYNONYM crossover junction endodeoxyribonuclease activity
2022-12-18 Updated TERM crossover junction DNA endonuclease activity
2022-12-18 Deleted XREF EC:3.1.22.4
2022-12-18 Deleted SYNONYM RusA holliday junction resolvase
Timestamp Action Category Detail
2022-12-18 Updated TERM crossover junction DNA endonuclease activity
2004-01-07 Updated TERM crossover junction endodeoxyribonuclease activity
2003-03-19 Updated TERM crossover junction endoribonuclease activity
2002-02-06 Updated TERM crossover junction endoribonuclease
2001-04-03 Updated TERM crossover junction endoribonuclease
2001-03-30 Added TERM crossover junction endoribonuclease
Timestamp Action Category Detail
2022-12-18 Deleted SYNONYM Endo X3 activity
2022-12-18 Deleted SYNONYM Holliday junction-resolving endoribonuclease activity
2022-12-18 Deleted SYNONYM RusA Holliday junction resolvase activity
2022-12-18 Deleted SYNONYM resolving enzyme CCE1 activity
2022-12-18 Deleted SYNONYM Holliday junction-cleaving endonuclease activity
2022-12-18 Added SYNONYM crossover junction endodeoxyribonuclease activity
2022-12-18 Deleted SYNONYM RusA holliday junction resolvase
2020-10-08 Deleted SYNONYM cruciform-cutting endonuclease activity
2020-10-08 Deleted SYNONYM Hje endonuclease activity
2020-10-08 Added SYNONYM cruciform-cutting endonuclease activity
2020-10-08 Added SYNONYM Holliday junction nuclease activity
2020-10-08 Added SYNONYM Holliday junction-cleaving endonuclease activity
2020-10-08 Deleted SYNONYM Holliday junction-cleaving endonuclease activity
2020-10-08 Added SYNONYM Hje endonuclease activity
2020-10-08 Deleted SYNONYM Holliday junction nuclease activity
2008-05-13 Added DEFINITION Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
2008-05-12 Deleted DEFINITION Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
2007-11-08 Added SYNONYM RusA holliday junction resolvase
2007-11-08 Added SYNONYM SpCCe1 holliday junction resolvase
2007-11-08 Added SYNONYM endo X3
2007-09-06 Added SYNONYM resolving enzyme CCE1 activity
2007-09-06 Added SYNONYM endonuclease X3 activity
2007-09-06 Added SYNONYM cruciform-cutting endonuclease activity
2007-09-06 Added SYNONYM endonuclease RuvC activity
2007-09-06 Added SYNONYM endonuclease VII activity
2007-09-06 Deleted SYNONYM Holliday junction resolvase
2007-09-06 Added SYNONYM Endo X3 activity
2007-09-06 Added SYNONYM Hje endonuclease activity
2007-09-06 Added SYNONYM Holliday junction endonuclease CCE1 activity
2007-09-06 Added SYNONYM Holliday junction nuclease activity
2007-09-06 Added SYNONYM Holliday junction resolvase activity
2007-09-06 Added SYNONYM Holliday junction-cleaving endonuclease activity
2007-09-06 Added SYNONYM Holliday junction-resolving endoribonuclease activity
2007-09-06 Added SYNONYM RusA Holliday junction resolvase activity
2007-09-06 Added SYNONYM RusA endonuclease activity
2007-09-06 Added SYNONYM RuvC endonuclease activity
2007-09-06 Added SYNONYM SpCCe1 Holliday junction resolvase activity
2007-08-09 Added SYNONYM Holliday junction resolvase
2007-08-09 Added SYNONYM crossover junction endoribonuclease activity
2007-08-09 Deleted SYNONYM endodeoxyribonuclease RUS activity
2007-08-09 Deleted SYNONYM Holliday junction resolvase
2007-08-09 Added SYNONYM endodeoxyribonuclease RUS activity
2007-08-09 Deleted SYNONYM crossover junction endoribonuclease activity
2004-07-22 Added SYNONYM endodeoxyribonuclease RUS activity
2004-07-22 Added SYNONYM Holliday junction resolvase
2004-04-19 Added SYNONYM crossover junction endoribonuclease activity
2004-04-16 Deleted SYNONYM crossover junction endoribonuclease activity
2004-01-07 Added SYNONYM crossover junction endoribonuclease activity
2002-11-27 Added DEFINITION Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016889 (DNA endonuclease activity, producing 3'-phosphomonoesters)
Timestamp Action Category Detail
2022-12-18 Added XREF EC:3.1.21.10
2022-12-18 Deleted XREF EC:3.1.22.4
2011-05-03 Deleted XREF EC:3.1.22.-
2004-07-22 Added XREF EC:3.1.22.-
2003-10-27 Added XREF MetaCyc:3.1.22.4-RXN
2001-03-30 Added XREF EC:3.1.22.4
Timestamp Action Category Detail
2004-07-22 Added SECONDARY GO:0008844 (endodeoxyribonuclease RUS activity)
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