GO:0008984
JSON
protein-glutamate methylesterase activity
Molecular Function
Definition (GO:0008984 GONUTS page)
Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
methylesterase CheB activity | narrow |
methyl-accepting chemotaxis protein methyl-esterase activity | narrow |
chemotaxis-specific methylesterase activity | narrow |
CheB methylesterase activity | narrow |
protein-L-glutamate-5-O-methyl-ester acylhydrolase activity | related |
protein-L-glutamate-O5-methyl-ester acylhydrolase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q6DFZ6 | 7955 | NOT1B_DANRE | GO:0052689 | To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 21st April 2015. | IPR004963 |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P33438 | 7227 | GLT_DROME | GO:0052689 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:2108864 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.1.61 | |
InterPro | IPR000673 | Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase |
InterPro | IPR008248 | Protein-glutamate methylesterase/protein-glutamine glutaminase, CheB type |
MetaCyc | MCPMETEST-RXN | |
RESID | AA0072 | |
RHEA | 23236 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:17790 | methanol |
has_participant | CHEBI | CHEBI:29973 | L-glutamate residue |
has_participant | CHEBI | CHEBI:82795 | gamma-methyl L-glutamate residue |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008984 based on ALL annotations
The top 100 of 126 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein-glutamate methylesterase activity
|
4,296.93 | 100.00 | 45,367 | 45,367 |
protein-glutamine glutaminase activity
|
2,761.59 | 40.07 | 23,392 | 36,397 |
chemotaxis
|
333.21 | 7.74 | 44,429 | 572,937 |
phosphorelay response regulator activity
|
283.29 | 6.58 | 44,555 | 675,816 |
protein-glutamate O-methyltransferase activity
|
497.75 | 3.56 | 2,219 | 19,156 |
phosphorelay signal transduction system
|
61.46 | 1.43 | 45,207 | 3,160,480 |
protein histidine kinase activity
|
113.31 | 1.19 | 968 | 36,708 |
S-adenosylmethionine-dependent methyltransferase activity
|
51.13 | 1.12 | 7,195 | 604,634 |
hydrolase activity
|
16.43 | 0.38 | 43,813 | 11,461,355 |
phosphorelay sensor kinase activity
|
9.44 | 0.21 | 3,238 | 1,473,219 |
Totals | 326801 | 230014512 |
No co-occurrence statistics for GO:0008984 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein-glutamate methylesterase activity
|
1,291,799.00 | 100.00 | 1 | 1 |
deaminase binding
|
645,899.50 | 50.00 | 1 | 2 |
protein deamination
|
143,533.22 | 11.11 | 1 | 9 |
protein-glutamine glutaminase activity
|
117,436.27 | 9.09 | 1 | 11 |
protein demethylation
|
99,369.16 | 7.69 | 1 | 13 |
phosphorelay response regulator activity
|
2,050.47 | 0.16 | 1 | 630 |
chemotaxis
|
1,877.61 | 0.15 | 1 | 688 |
signal transduction
|
59.50 | 0.00 | 1 | 21,712 |
protein binding
|
30.89 | 0.00 | 1 | 41,817 |
cytosol
|
15.34 | 0.00 | 1 | 84,217 |
Totals | 11 | 281028 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | protein-L-glutamate-5-O-methyl-ester acylhydrolase activity |
2020-10-08 | Deleted | SYNONYM | protein-L-glutamate-5-O-methyl-ester acylhydrolase activity |
2020-10-08 | Added | SYNONYM | protein-L-glutamate-O5-methyl-ester acylhydrolase activity |
2020-10-08 | Deleted | SYNONYM | protein-L-glutamate-O5-methyl-ester acylhydrolase activity |
2020-06-22 | Added | XREF | RHEA:23236 |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. |
2008-04-01 | Updated | RELATION | is a GO:0051723 (protein methylesterase activity) |
2007-11-08 | Added | SYNONYM | protein-L-glutamate-O5-methyl-ester acylhydrolase activity |
2007-11-08 | Added | SYNONYM | protein-L-glutamate-5-O-methyl-ester acylhydrolase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | protein-glutamate methylesterase activity |
2002-02-06 | Updated | TERM | protein-glutamate methylesterase |
2001-04-03 | Updated | TERM | protein-glutamate methylesterase |
2001-03-30 | Added | TERM | protein-glutamate methylesterase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | protein-L-glutamate-5-O-methyl-ester acylhydrolase activity |
2020-10-08 | Deleted | SYNONYM | protein-L-glutamate-5-O-methyl-ester acylhydrolase activity |
2020-10-08 | Added | SYNONYM | protein-L-glutamate-O5-methyl-ester acylhydrolase activity |
2020-10-08 | Deleted | SYNONYM | protein-L-glutamate-O5-methyl-ester acylhydrolase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. |
2007-11-08 | Added | SYNONYM | protein-L-glutamate-O5-methyl-ester acylhydrolase activity |
2007-11-08 | Added | SYNONYM | protein-L-glutamate-5-O-methyl-ester acylhydrolase activity |
2007-09-06 | Added | SYNONYM | methylesterase CheB activity |
2007-09-06 | Added | SYNONYM | chemotaxis-specific methylesterase activity |
2007-09-06 | Added | SYNONYM | CheB methylesterase activity |
2007-09-06 | Added | SYNONYM | methyl-accepting chemotaxis protein methyl-esterase activity |
2003-09-19 | Updated | DEFINITION | Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. |
2003-08-05 | Updated | DEFINITION | Catalysis of the hydrolyis of peptidyl-L-glutamate 5-methyl ester to peptidyl-L-glutamate. |
2002-11-27 | Added | DEFINITION | The hydrolyis of peptidyl-L-glutamate 5-methyl ester to peptidyl-L-glutamate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0051723 (protein methylesterase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:23236 |
2005-02-24 | Added | XREF | RESID:AA0072 |
2003-10-27 | Added | XREF | MetaCyc:MCPMETEST-RXN |
2001-03-30 | Added | XREF | EC:3.1.1.61 |
Timestamp | Action | Category | Detail |
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