This term is obsolete.

GO:0008984 JSON

protein-glutamate methylesterase activity

Molecular Function

Definition (GO:0008984 GONUTS page)

Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.

45,369 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
methylesterase CheB activity narrow
methyl-accepting chemotaxis protein methyl-esterase activity narrow
chemotaxis-specific methylesterase activity narrow
CheB methylesterase activity narrow
protein-L-glutamate-5-O-methyl-ester acylhydrolase activity related
protein-L-glutamate-O5-methyl-ester acylhydrolase activity related

Ancestor Chart

Ancestor chart for GO:0008984
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q6DFZ6 7955 NOT1B_DANRE GO:0052689 To remove over-annotation from InterPro entries; Eukaryotic TrEmbl proteins are false positives probably due to low quality sequences. Reported by InterPro on 21st April 2015. IPR004963
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P33438 7227 GLT_DROME GO:0052689 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:2108864
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 3.1.1.61
InterPro IPR000673 Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase
InterPro IPR008248 Protein-glutamate methylesterase/protein-glutamine glutaminase, CheB type
MetaCyc MCPMETEST-RXN
RESID AA0072
RHEA 23236

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:17790 methanol
has_participant CHEBI CHEBI:29973 L-glutamate residue
has_participant CHEBI CHEBI:82795 gamma-methyl L-glutamate residue
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008984 based on ALL annotations
The top 100 of 126 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-glutamate methylesterase activity
4,296.93 100.00 45,367 45,367
protein-glutamine glutaminase activity
2,761.59 40.07 23,392 36,397
chemotaxis
333.21 7.74 44,429 572,937
phosphorelay response regulator activity
283.29 6.58 44,555 675,816
protein-glutamate O-methyltransferase activity
497.75 3.56 2,219 19,156
phosphorelay signal transduction system
61.46 1.43 45,207 3,160,480
protein histidine kinase activity
113.31 1.19 968 36,708
S-adenosylmethionine-dependent methyltransferase activity
51.13 1.12 7,195 604,634
hydrolase activity
16.43 0.38 43,813 11,461,355
phosphorelay sensor kinase activity
9.44 0.21 3,238 1,473,219
Totals 326801 230014512
No co-occurrence statistics for GO:0008984 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein-glutamate methylesterase activity
1,291,799.00 100.00 1 1
deaminase binding
645,899.50 50.00 1 2
protein deamination
143,533.22 11.11 1 9
protein-glutamine glutaminase activity
117,436.27 9.09 1 11
protein demethylation
99,369.16 7.69 1 13
phosphorelay response regulator activity
2,050.47 0.16 1 630
chemotaxis
1,877.61 0.15 1 688
signal transduction
59.50 0.00 1 21,712
protein binding
30.89 0.00 1 41,817
cytosol
15.34 0.00 1 84,217
Totals 11 281028

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM protein-L-glutamate-5-O-methyl-ester acylhydrolase activity
2020-10-08 Deleted SYNONYM protein-L-glutamate-5-O-methyl-ester acylhydrolase activity
2020-10-08 Added SYNONYM protein-L-glutamate-O5-methyl-ester acylhydrolase activity
2020-10-08 Deleted SYNONYM protein-L-glutamate-O5-methyl-ester acylhydrolase activity
2020-06-22 Added XREF RHEA:23236
2008-05-13 Added DEFINITION Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.
2008-04-01 Updated RELATION is a GO:0051723 (protein methylesterase activity)
2007-11-08 Added SYNONYM protein-L-glutamate-O5-methyl-ester acylhydrolase activity
2007-11-08 Added SYNONYM protein-L-glutamate-5-O-methyl-ester acylhydrolase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM protein-glutamate methylesterase activity
2002-02-06 Updated TERM protein-glutamate methylesterase
2001-04-03 Updated TERM protein-glutamate methylesterase
2001-03-30 Added TERM protein-glutamate methylesterase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM protein-L-glutamate-5-O-methyl-ester acylhydrolase activity
2020-10-08 Deleted SYNONYM protein-L-glutamate-5-O-methyl-ester acylhydrolase activity
2020-10-08 Added SYNONYM protein-L-glutamate-O5-methyl-ester acylhydrolase activity
2020-10-08 Deleted SYNONYM protein-L-glutamate-O5-methyl-ester acylhydrolase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.
2007-11-08 Added SYNONYM protein-L-glutamate-O5-methyl-ester acylhydrolase activity
2007-11-08 Added SYNONYM protein-L-glutamate-5-O-methyl-ester acylhydrolase activity
2007-09-06 Added SYNONYM methylesterase CheB activity
2007-09-06 Added SYNONYM chemotaxis-specific methylesterase activity
2007-09-06 Added SYNONYM CheB methylesterase activity
2007-09-06 Added SYNONYM methyl-accepting chemotaxis protein methyl-esterase activity
2003-09-19 Updated DEFINITION Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.
2003-08-05 Updated DEFINITION Catalysis of the hydrolyis of peptidyl-L-glutamate 5-methyl ester to peptidyl-L-glutamate.
2002-11-27 Added DEFINITION The hydrolyis of peptidyl-L-glutamate 5-methyl ester to peptidyl-L-glutamate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0051723 (protein methylesterase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:23236
2005-02-24 Added XREF RESID:AA0072
2003-10-27 Added XREF MetaCyc:MCPMETEST-RXN
2001-03-30 Added XREF EC:3.1.1.61
Timestamp Action Category Detail
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