GO:0008995
JSON
ribonuclease E activity
Molecular Function
Definition (GO:0008995 GONUTS page)
Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. PMID:10722715 PMID:16854990
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A8I6A3V5 | 10116 | A0A8I6A3V5_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ACW3 | 10116 | A0A8I6ACW3_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JWR1 | 10116 | A6JWR1_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8DY77 | 7227 | A8DY77_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | D3Z898 | 10116 | D3Z898_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A2W9 | 10116 | D4A2W9_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR028878 | Ribonuclease E |
MetaCyc | 3.1.26.12-RXN |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008995 based on ALL annotations
The top 59 of 59 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ribonuclease E activity
|
15,871.91 | 100.00 | 12,282 | 12,282 |
cytoplasmic side of plasma membrane
|
937.30 | 5.89 | 11,664 | 197,514 |
mRNA catabolic process
|
841.85 | 5.29 | 11,664 | 219,909 |
RNA nuclease activity
|
756.41 | 4.77 | 12,279 | 257,653 |
RNA endonuclease activity
|
594.42 | 3.74 | 11,664 | 311,444 |
RNA processing
|
185.28 | 1.17 | 12,281 | 1,052,040 |
rRNA processing
|
176.12 | 1.11 | 12,281 | 1,106,747 |
tRNA binding
|
143.28 | 0.90 | 11,663 | 1,291,960 |
tRNA processing
|
110.41 | 0.70 | 12,161 | 1,748,269 |
rRNA binding
|
95.72 | 0.60 | 12,281 | 2,036,482 |
Totals | 204937 | 213398853 |
No co-occurrence statistics for GO:0008995 based on MANUAL annotations
The top 29 of 29 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ribonuclease E activity
|
645,899.50 | 100.00 | 2 | 2 |
regulation of RNA helicase activity
|
645,899.50 | 50.00 | 1 | 1 |
bacterial degradosome
|
161,474.88 | 20.00 | 1 | 4 |
endoribonuclease complex
|
43,059.97 | 6.25 | 1 | 15 |
DEAD/H-box RNA helicase binding
|
10,764.99 | 1.64 | 1 | 60 |
rRNA 5'-end processing
|
5,338.01 | 0.82 | 1 | 121 |
molecular function inhibitor activity
|
4,968.46 | 0.76 | 1 | 130 |
protein serine/threonine phosphatase inhibitor activity
|
2,282.33 | 0.35 | 1 | 283 |
7S RNA binding
|
1,626.95 | 0.25 | 1 | 397 |
RNA nuclease activity
|
1,516.20 | 0.23 | 1 | 426 |
Totals | 33 | 571578 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2009-05-21 | Added | XREF | MetaCyc:3.1.26.12-RXN |
2008-05-13 | Added | DEFINITION | Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. |
2008-04-01 | Updated | RELATION | is a GO:0004540 (RNA nuclease activity) |
2006-09-29 | Added | DEFINITION | Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. |
2003-03-19 | Updated | TERM | ribonuclease E activity |
2002-02-06 | Updated | TERM | ribonuclease E |
2001-04-03 | Updated | TERM | ribonuclease E |
2001-03-30 | Added | TERM | ribonuclease E |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | ribonuclease E activity |
2002-02-06 | Updated | TERM | ribonuclease E |
2001-04-03 | Updated | TERM | ribonuclease E |
2001-03-30 | Added | TERM | ribonuclease E |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. |
2006-09-29 | Added | DEFINITION | Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004540 (RNA nuclease activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-05-21 | Added | XREF | MetaCyc:3.1.26.12-RXN |
Timestamp | Action | Category | Detail |
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