GO:0009035
JSON
type I site-specific deoxyribonuclease activity
Molecular Function
Definition (GO:0009035 GONUTS page)
Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. PMID:15300241 PMID:15788748
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent) | related |
ATP-dependent DNase activity | related |
adenosine triphosphate-dependent deoxyribonuclease activity | related |
type I restriction enzyme activity | exact |
deoxyribonuclease (adenosine triphosphate-hydrolyzing) | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0009035
Child Term | Relationship to GO:0009035 |
---|---|
type I site-specific deoxyribonuclease complex
|
capable_of |
regulation of type I site-specific deoxyribonuclease activity
|
regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A0G2K5G5 | 10116 | A0A0G2K5G5_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K5U3 | 10116 | A0A0G2K5U3_RAT | GO:0016888 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GK02 | 10116 | A0A8I6GK02_RAT | GO:0016888 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A4WYU7 | 349102 | AGO_CERS5 | GO:0004520 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24034694 | |
NOT-qualified manual | protein | A6HL89 | 10116 | A6HL89_RAT | GO:0016888 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HL91 | 10116 | A6HL91_RAT | GO:0016888 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J211 | 10116 | A6J211_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8DY77 | 7227 | A8DY77_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | B2GV68 | 10116 | B2GV68_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.21.3 | |
InterPro | IPR004473 | Restriction endonuclease, type I, HsdR |
MetaCyc | 3.1.21.3-RXN |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0009035 based on ALL annotations
The top 100 of 199 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
type I site-specific deoxyribonuclease activity
|
6,426.41 | 100.00 | 30,334 | 30,334 |
DNA modification
|
1,146.96 | 12.81 | 9,471 | 53,066 |
DNA restriction-modification system
|
611.60 | 9.46 | 28,440 | 298,835 |
DNA conformation change
|
204.25 | 1.51 | 845 | 26,586 |
endonuclease activity
|
77.65 | 1.21 | 26,633 | 2,204,272 |
catalytic activity, acting on DNA
|
130.23 | 1.19 | 845 | 41,699 |
helicase activity
|
13.55 | 0.21 | 3,776 | 1,790,484 |
DNA binding
|
12.13 | 0.19 | 29,167 | 15,456,294 |
DNA metabolic process
|
9.97 | 0.15 | 895 | 576,758 |
ATP binding
|
9.41 | 0.15 | 27,600 | 18,856,705 |
Totals | 166234 | 93533261 |
No co-occurrence statistics for GO:0009035 based on MANUAL annotations
The top 6 of 6 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
type I site-specific deoxyribonuclease activity
|
1,291,799.00 | 100.00 | 1 | 1 |
DNA restriction-modification system
|
40,368.72 | 3.13 | 1 | 32 |
site-specific DNA-methyltransferase (adenine-specific) activity
|
18,721.73 | 1.45 | 1 | 69 |
S-adenosyl-L-methionine binding
|
6,395.04 | 0.50 | 1 | 202 |
ATP binding
|
198.46 | 0.02 | 1 | 6,509 |
sequence-specific DNA binding
|
127.21 | 0.01 | 1 | 10,155 |
Totals | 6 | 16968 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-09-14 | Deleted | SYNONYM | type I site-specific deoxyribonuclease activity |
2021-07-04 | Deleted | DEFINITION | Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. |
2021-07-04 | Added | DEFINITION | Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. |
2021-02-11 | Added | RELATION | is a GO:0015616 (DNA translocase activity) |
2020-10-08 | Added | SYNONYM | deoxyribonuclease (adenosine triphosphate-hydrolyzing) |
2020-10-08 | Added | SYNONYM | ATP-dependent DNase activity |
2020-10-08 | Added | SYNONYM | type I site-specific deoxyribonuclease activity |
2020-10-08 | Deleted | SYNONYM | deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent) |
2020-10-08 | Deleted | SYNONYM | deoxyribonuclease (adenosine triphosphate-hydrolyzing) |
2020-10-08 | Added | SYNONYM | adenosine triphosphate-dependent deoxyribonuclease activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-05-31 | Updated | TERM | type I site-specific deoxyribonuclease activity |
2006-06-08 | Updated | TERM | Type I site-specific deoxyribonuclease activity |
2004-04-16 | Updated | TERM | type I site-specific deoxyribonuclease activity |
2004-01-07 | Updated | TERM | type 1 site-specific deoxyribonuclease activity |
2003-03-19 | Updated | TERM | type I site-specific deoxyribonuclease activity |
2002-02-06 | Updated | TERM | type I site-specific deoxyribonuclease |
2001-04-03 | Updated | TERM | type I site-specific deoxyribonuclease |
2001-03-30 | Added | TERM | type I site-specific deoxyribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-09-14 | Deleted | SYNONYM | type I site-specific deoxyribonuclease activity |
2021-07-04 | Deleted | DEFINITION | Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. |
2021-07-04 | Added | DEFINITION | Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. |
2020-10-08 | Added | SYNONYM | deoxyribonuclease (adenosine triphosphate-hydrolyzing) |
2020-10-08 | Added | SYNONYM | ATP-dependent DNase activity |
2020-10-08 | Added | SYNONYM | type I site-specific deoxyribonuclease activity |
2020-10-08 | Deleted | SYNONYM | deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent) |
2020-10-08 | Deleted | SYNONYM | deoxyribonuclease (adenosine triphosphate-hydrolyzing) |
2020-10-08 | Added | SYNONYM | adenosine triphosphate-dependent deoxyribonuclease activity |
2020-10-08 | Added | SYNONYM | deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent) |
2020-10-08 | Deleted | SYNONYM | type I site-specific deoxyribonuclease activity |
2020-10-08 | Deleted | SYNONYM | ATP-dependent DNase activity |
2020-10-08 | Deleted | SYNONYM | adenosine triphosphate-dependent deoxyribonuclease activity |
2018-05-31 | Deleted | SYNONYM | Type I restriction enzyme activity |
2018-05-31 | Added | SYNONYM | type I restriction enzyme activity |
2008-05-13 | Added | DEFINITION | Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. |
2007-11-08 | Added | SYNONYM | deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent) |
2007-11-08 | Added | SYNONYM | adenosine triphosphate-dependent deoxyribonuclease activity |
2007-11-08 | Added | SYNONYM | type I site-specific deoxyribonuclease activity |
2007-11-08 | Added | SYNONYM | deoxyribonuclease (adenosine triphosphate-hydrolyzing) |
2007-11-08 | Added | SYNONYM | ATP-dependent DNase activity |
2007-08-09 | Deleted | SYNONYM | Type I restriction enzyme activity |
2007-08-09 | Added | SYNONYM | Type I restriction enzyme activity |
2006-06-08 | Deleted | SYNONYM | type 1 site-specific deoxyribonuclease activity |
2006-06-08 | Added | SYNONYM | Type I restriction enzyme activity |
2006-06-06 | Updated | DEFINITION | Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. |
2004-04-19 | Added | SYNONYM | type 1 site-specific deoxyribonuclease activity |
2004-04-16 | Deleted | SYNONYM | type I site-specific deoxyribonuclease activity |
2004-01-07 | Added | SYNONYM | type I site-specific deoxyribonuclease activity |
2002-11-27 | Added | DEFINITION | Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphate; ATP is simultaneously hydrolyzed. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-11 | Added | RELATION | is a GO:0015616 (DNA translocase activity) |
2008-04-01 | Updated | RELATION | is a GO:0015666 (restriction endodeoxyribonuclease activity) |
2008-04-01 | Updated | RELATION | is a GO:0016888 (endodeoxyribonuclease activity, producing 5'-phosphomonoesters) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-10-27 | Added | XREF | MetaCyc:3.1.21.3-RXN |
2001-03-30 | Added | XREF | EC:3.1.21.3 |
Timestamp | Action | Category | Detail |
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