This term is obsolete.

GO:0009035 JSON

type I site-specific deoxyribonuclease activity

Molecular Function

Definition (GO:0009035 GONUTS page)

Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. PMID:15300241 PMID:15788748

30,245 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent) related
ATP-dependent DNase activity related
adenosine triphosphate-dependent deoxyribonuclease activity related
type I restriction enzyme activity exact
deoxyribonuclease (adenosine triphosphate-hydrolyzing) related

Ancestor Chart

Ancestor chart for GO:0009035
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0009035

Child Term Relationship to
GO:0009035
type I site-specific deoxyribonuclease complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K5U3 10116 A0A0G2K5U3_RAT GO:0016888 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GK02 10116 A0A8I6GK02_RAT GO:0016888 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A4WYU7 349102 AGO_CERS5 GO:0004520 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24034694
NOT-qualified manual protein A6HL89 10116 A6HL89_RAT GO:0016888 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HL91 10116 A6HL91_RAT GO:0016888 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J211 10116 A6J211_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8DY77 7227 A8DY77_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein B2GV68 10116 B2GV68_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 3.1.21.3
InterPro IPR004473 Restriction endonuclease, type I, HsdR
MetaCyc 3.1.21.3-RXN

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0009035 based on ALL annotations
The top 100 of 199 co-occurring terms
Co-occurring Term PR S% #Together #Compared
type I site-specific deoxyribonuclease activity
6,551.66 100.00 30,245 30,245
DNA modification
1,135.60 12.47 9,308 53,701
DNA restriction-modification system
618.81 9.39 28,399 300,675
DNA conformation change
207.34 1.51 848 26,796
endonuclease activity
77.30 1.18 26,601 2,254,459
catalytic activity, acting on DNA
118.92 1.11 848 46,719
helicase activity
13.66 0.21 3,727 1,787,686
DNA binding
12.22 0.19 29,105 15,603,631
DNA metabolic process
10.76 0.16 860 523,465
ATP binding
9.50 0.14 27,574 19,024,482
Totals 165648 94507426
No co-occurrence statistics for GO:0009035 based on MANUAL annotations
The top 6 of 6 co-occurring terms
Co-occurring Term PR S% #Together #Compared
type I site-specific deoxyribonuclease activity
1,411,533.00 100.00 1 1
DNA restriction-modification system
42,773.73 3.03 1 33
site-specific DNA-methyltransferase (adenine-specific) activity
17,867.51 1.27 1 79
S-adenosyl-L-methionine binding
6,786.22 0.48 1 208
ATP binding
206.09 0.01 1 6,849
sequence-specific DNA binding
126.91 0.01 1 11,122
Totals 6 18292

Change Log

Timestamp Action Category Detail
2021-09-14 Deleted SYNONYM type I site-specific deoxyribonuclease activity
2021-07-04 Deleted DEFINITION Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
2021-07-04 Added DEFINITION Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
2021-02-11 Added RELATION is a GO:0015616 (DNA translocase activity)
2020-10-08 Deleted SYNONYM ATP-dependent DNase activity
2020-10-08 Deleted SYNONYM deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)
2020-10-08 Deleted SYNONYM adenosine triphosphate-dependent deoxyribonuclease activity
2020-10-08 Deleted SYNONYM type I site-specific deoxyribonuclease activity
2020-10-08 Added SYNONYM type I site-specific deoxyribonuclease activity
2020-10-08 Added SYNONYM ATP-dependent DNase activity
Timestamp Action Category Detail
2018-05-31 Updated TERM type I site-specific deoxyribonuclease activity
2006-06-08 Updated TERM Type I site-specific deoxyribonuclease activity
2004-04-16 Updated TERM type I site-specific deoxyribonuclease activity
2004-01-07 Updated TERM type 1 site-specific deoxyribonuclease activity
2003-03-19 Updated TERM type I site-specific deoxyribonuclease activity
2002-02-06 Updated TERM type I site-specific deoxyribonuclease
2001-04-03 Updated TERM type I site-specific deoxyribonuclease
2001-03-30 Added TERM type I site-specific deoxyribonuclease
Timestamp Action Category Detail
2021-09-14 Deleted SYNONYM type I site-specific deoxyribonuclease activity
2021-07-04 Deleted DEFINITION Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
2021-07-04 Added DEFINITION Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
2020-10-08 Deleted SYNONYM ATP-dependent DNase activity
2020-10-08 Deleted SYNONYM deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)
2020-10-08 Deleted SYNONYM adenosine triphosphate-dependent deoxyribonuclease activity
2020-10-08 Deleted SYNONYM type I site-specific deoxyribonuclease activity
2020-10-08 Added SYNONYM type I site-specific deoxyribonuclease activity
2020-10-08 Added SYNONYM ATP-dependent DNase activity
2020-10-08 Added SYNONYM deoxyribonuclease (adenosine triphosphate-hydrolyzing)
2020-10-08 Added SYNONYM adenosine triphosphate-dependent deoxyribonuclease activity
2020-10-08 Added SYNONYM deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)
2020-10-08 Deleted SYNONYM deoxyribonuclease (adenosine triphosphate-hydrolyzing)
2018-05-31 Added SYNONYM type I restriction enzyme activity
2018-05-31 Deleted SYNONYM Type I restriction enzyme activity
2008-05-13 Added DEFINITION Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
2008-05-12 Deleted DEFINITION Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
2007-11-08 Added SYNONYM ATP-dependent DNase activity
2007-11-08 Added SYNONYM type I site-specific deoxyribonuclease activity
2007-11-08 Added SYNONYM deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)
2007-11-08 Added SYNONYM deoxyribonuclease (adenosine triphosphate-hydrolyzing)
2007-11-08 Added SYNONYM adenosine triphosphate-dependent deoxyribonuclease activity
2007-08-09 Added SYNONYM Type I restriction enzyme activity
2007-08-09 Deleted SYNONYM Type I restriction enzyme activity
2006-06-08 Deleted SYNONYM type 1 site-specific deoxyribonuclease activity
2006-06-08 Added SYNONYM Type I restriction enzyme activity
2006-06-06 Updated DEFINITION Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.
2004-04-19 Added SYNONYM type 1 site-specific deoxyribonuclease activity
2004-04-16 Deleted SYNONYM type I site-specific deoxyribonuclease activity
2004-01-07 Added SYNONYM type I site-specific deoxyribonuclease activity
2002-11-27 Added DEFINITION Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphate; ATP is simultaneously hydrolyzed.
Timestamp Action Category Detail
2021-02-11 Added RELATION is a GO:0015616 (DNA translocase activity)
2008-04-01 Updated RELATION is a GO:0016888 (endodeoxyribonuclease activity, producing 5'-phosphomonoesters)
2008-04-01 Updated RELATION is a GO:0015666 (restriction endodeoxyribonuclease activity)
Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.1.21.3-RXN
2001-03-30 Added XREF EC:3.1.21.3
Timestamp Action Category Detail
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