Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'.
GO:0010998
JSON
regulation of translational initiation by eIF2 alpha phosphorylation
Biological Process
Definition (GO:0010998 GONUTS page)
Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
Restrictions
This term should not be used for direct annotation.
See comment below for further information.
Comments
Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'.
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
regulation of translational initiation by eIF2 alpha phosphorylation in response to stress | exact |
eIF2 alpha phosphorylation in response to stress | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0010998
Child Term | Relationship to GO:0010998 |
---|---|
eukaryotic translation initiation factor 2alpha kinase activity
|
part_of |
regulation of eIF2 alpha phosphorylation by dsRNA
|
regulates |
regulation of eIF2 alpha phosphorylation by heme
|
regulates |
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y7T8 | 10116 | A0A8I5Y7T8_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5YBE4 | 10116 | A0A8I5YBE4_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A3QJU3 | 7955 | COQ8B_DANRE | GO:0006468 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HXN4 | 10116 | A6HXN4_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HXN5 | 10116 | A6HXN5_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HXN7 | 10116 | A6HXN7_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JXC6 | 10116 | A6JXC6_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZJ50 | 10116 | D3ZJ50_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A417 | 10116 | D4A417_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P27697 | 559292 | COQ8_YEAST | GO:0006468 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27499294 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR016255 | eIF-2-alpha kinase Gcn2 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0010998 based on ALL annotations
The top 100 of 146 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
regulation of translational initiation by eIF2 alpha phosphorylation
|
16,244,899.00 | 100.00 | 12 | 12 |
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
|
12,995,919.00 | 30.77 | 4 | 5 |
regulation of eIF2 alpha phosphorylation by heme
|
16,244,899.00 | 16.67 | 2 | 2 |
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
|
10,829,933.00 | 15.38 | 2 | 3 |
negative regulation of CREB transcription factor activity
|
3,481,049.80 | 13.04 | 3 | 14 |
dormancy maintenance of symbiont in host
|
16,244,899.00 | 8.33 | 1 | 1 |
response to manganese-induced endoplasmic reticulum stress
|
1,624,489.90 | 4.76 | 1 | 10 |
viral translation
|
560,168.94 | 3.13 | 3 | 87 |
peptidyl-serine phosphorylation
|
507,653.10 | 3.03 | 6 | 192 |
regulation of translational initiation in response to stress
|
177,539.89 | 1.04 | 2 | 183 |
Totals | 306 | 4116752 |
No co-occurrence statistics for GO:0010998 based on MANUAL annotations
The top 100 of 105 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
regulation of translational initiation by eIF2 alpha phosphorylation
|
107,649.92 | 100.00 | 12 | 12 |
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
|
86,119.94 | 30.77 | 4 | 5 |
positive regulation of translational initiation in response to starvation
|
46,135.68 | 18.75 | 3 | 7 |
regulation of eIF2 alpha phosphorylation by heme
|
107,649.91 | 16.67 | 2 | 2 |
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
|
71,766.62 | 15.38 | 2 | 3 |
viral translation
|
26,912.48 | 14.29 | 3 | 12 |
negative regulation of CREB transcription factor activity
|
23,067.84 | 13.04 | 3 | 14 |
regulation of translational initiation in response to stress
|
21,529.98 | 10.00 | 2 | 10 |
dormancy maintenance of symbiont in host
|
107,649.91 | 8.33 | 1 | 1 |
negative regulation of hemoglobin biosynthetic process
|
26,912.48 | 6.67 | 1 | 4 |
Totals | 254 | 186978 |
Change Log
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-26 | Added | SUBSET | gocheck_obsoletion_candidate |
2024-07-26 | Deleted | SUBSET | gocheck_do_not_annotate |
2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
2016-06-22 | Deleted | RELATION | is a GO:0044763 (single-organism cellular process) |
2016-06-22 | Deleted | RELATION | is a GO:0044710 (single-organism metabolic process) |
2015-02-18 | Added | DEFINITION | Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha. |
2015-02-18 | Added | SYNONYM | regulation of translational initiation by eIF2 alpha phosphorylation in response to stress |
2015-02-18 | Added | SYNONYM | eIF2 alpha phosphorylation in response to stress |
2015-02-18 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha. |
2014-02-17 | Added | RELATION | is a GO:0044763 (single-organism cellular process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-06-16 | Added | TERM | regulation of translational initiation by eIF2 alpha phosphorylation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-02-18 | Added | DEFINITION | Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha. |
2015-02-18 | Added | SYNONYM | regulation of translational initiation by eIF2 alpha phosphorylation in response to stress |
2015-02-18 | Added | SYNONYM | eIF2 alpha phosphorylation in response to stress |
2015-02-18 | Deleted | DEFINITION | Any process that activates or increases the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha. |
2009-06-16 | Added | DEFINITION | Any process that activates or increases the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-06-22 | Deleted | RELATION | is a GO:0044763 (single-organism cellular process) |
2016-06-22 | Deleted | RELATION | is a GO:0044710 (single-organism metabolic process) |
2014-02-17 | Added | RELATION | is a GO:0044763 (single-organism cellular process) |
2013-11-28 | Added | RELATION | is a GO:0044710 (single-organism metabolic process) |
2009-06-16 | Added | RELATION | is a GO:0006468 (protein phosphorylation) |
2009-06-16 | Added | RELATION | is a GO:0043558 (regulation of translational initiation in response to stress) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-26 | Added | SUBSET | gocheck_obsoletion_candidate |
2024-07-26 | Deleted | SUBSET | gocheck_do_not_annotate |
2023-06-13 | Added | SUBSET | gocheck_do_not_annotate |
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