This term is obsolete.
Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'.

GO:0010998 JSON

regulation of translational initiation by eIF2 alpha phosphorylation

Biological Process

Definition (GO:0010998 GONUTS page)

Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.

Restrictions

This term should not be used for direct annotation.
See comment below for further information.

Comments

Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'.

Acknowledgement

This term was created by the GO Consortium with support from: BHF image

173,719 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
regulation of translational initiation by eIF2 alpha phosphorylation in response to stress exact
eIF2 alpha phosphorylation in response to stress exact

Ancestor Chart

Ancestor chart for GO:0010998
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0010998

Child Term Relationship to
GO:0010998
eukaryotic translation initiation factor 2alpha kinase activity
part_of
regulation of eIF2 alpha phosphorylation by dsRNA
regulates
regulation of eIF2 alpha phosphorylation by heme
regulates
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y7T8 10116 A0A8I5Y7T8_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5YBE4 10116 A0A8I5YBE4_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A3QJU3 7955 COQ8B_DANRE GO:0006468 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6HXN4 10116 A6HXN4_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN5 10116 A6HXN5_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN7 10116 A6HXN7_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JXC6 10116 A6JXC6_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZJ50 10116 D3ZJ50_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A417 10116 D4A417_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P27697 559292 COQ8_YEAST GO:0006468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27499294

Cross-references

Database ID Description
InterPro IPR016255 eIF-2-alpha kinase Gcn2

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0010998 based on ALL annotations
The top 100 of 146 co-occurring terms
Co-occurring Term PR S% #Together #Compared
regulation of translational initiation by eIF2 alpha phosphorylation
16,244,899.00 100.00 12 12
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
12,995,919.00 30.77 4 5
regulation of eIF2 alpha phosphorylation by heme
16,244,899.00 16.67 2 2
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
10,829,933.00 15.38 2 3
negative regulation of CREB transcription factor activity
3,481,049.80 13.04 3 14
dormancy maintenance of symbiont in host
16,244,899.00 8.33 1 1
response to manganese-induced endoplasmic reticulum stress
1,624,489.90 4.76 1 10
viral translation
560,168.94 3.13 3 87
peptidyl-serine phosphorylation
507,653.10 3.03 6 192
regulation of translational initiation in response to stress
177,539.89 1.04 2 183
Totals 306 4116752
No co-occurrence statistics for GO:0010998 based on MANUAL annotations
The top 100 of 105 co-occurring terms
Co-occurring Term PR S% #Together #Compared
regulation of translational initiation by eIF2 alpha phosphorylation
107,649.92 100.00 12 12
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
86,119.94 30.77 4 5
positive regulation of translational initiation in response to starvation
46,135.68 18.75 3 7
regulation of eIF2 alpha phosphorylation by heme
107,649.91 16.67 2 2
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
71,766.62 15.38 2 3
viral translation
26,912.48 14.29 3 12
negative regulation of CREB transcription factor activity
23,067.84 13.04 3 14
regulation of translational initiation in response to stress
21,529.98 10.00 2 10
dormancy maintenance of symbiont in host
107,649.91 8.33 1 1
negative regulation of hemoglobin biosynthetic process
26,912.48 6.67 1 4
Totals 254 186978

Change Log

Timestamp Action Category Detail
2024-07-26 Added SUBSET gocheck_obsoletion_candidate
2024-07-26 Deleted SUBSET gocheck_do_not_annotate
2023-06-13 Added SUBSET gocheck_do_not_annotate
2016-06-22 Deleted RELATION is a GO:0044763 (single-organism cellular process)
2016-06-22 Deleted RELATION is a GO:0044710 (single-organism metabolic process)
2015-02-18 Added DEFINITION Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
2015-02-18 Added SYNONYM regulation of translational initiation by eIF2 alpha phosphorylation in response to stress
2015-02-18 Added SYNONYM eIF2 alpha phosphorylation in response to stress
2015-02-18 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
2014-02-17 Added RELATION is a GO:0044763 (single-organism cellular process)
Timestamp Action Category Detail
2009-06-16 Added TERM regulation of translational initiation by eIF2 alpha phosphorylation
Timestamp Action Category Detail
2015-02-18 Added DEFINITION Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
2015-02-18 Added SYNONYM regulation of translational initiation by eIF2 alpha phosphorylation in response to stress
2015-02-18 Added SYNONYM eIF2 alpha phosphorylation in response to stress
2015-02-18 Deleted DEFINITION Any process that activates or increases the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
2009-06-16 Added DEFINITION Any process that activates or increases the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha.
Timestamp Action Category Detail
2016-06-22 Deleted RELATION is a GO:0044763 (single-organism cellular process)
2016-06-22 Deleted RELATION is a GO:0044710 (single-organism metabolic process)
2014-02-17 Added RELATION is a GO:0044763 (single-organism cellular process)
2013-11-28 Added RELATION is a GO:0044710 (single-organism metabolic process)
2009-06-16 Added RELATION is a GO:0006468 (protein phosphorylation)
2009-06-16 Added RELATION is a GO:0043558 (regulation of translational initiation in response to stress)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-07-26 Added SUBSET gocheck_obsoletion_candidate
2024-07-26 Deleted SUBSET gocheck_do_not_annotate
2023-06-13 Added SUBSET gocheck_do_not_annotate
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