Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.
GO:0012501
JSON
programmed cell death
Biological Process
Definition (GO:0012501 GONUTS page)
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
Comments
Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.
Secondary IDs
GO:0016244
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
PCD | related |
RCD | related |
regulated cell death | broad |
caspase-independent cell death | narrow |
caspase-independent apoptosis | related |
nonapoptotic programmed cell death | narrow |
non-apoptotic programmed cell death | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0012501
Child Term | Relationship to GO:0012501 |
---|---|
programmed necrotic cell death
|
is_a |
autophagic cell death
|
is_a |
positive regulation of programmed cell death
|
positively_regulates |
symbiont-induced defense-related programmed cell death
|
is_a |
negative regulation of programmed cell death
|
negatively_regulates |
cuproptosis
|
is_a |
granzyme-mediated programmed cell death signaling pathway
|
part_of |
apoptotic process
|
is_a |
regulation of programmed cell death
|
regulates |
programmed cell death involved in cell development
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating cell death and apoptosis using the new guidelines | Link |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR042377 | Gasdermin-E |
InterPro | IPR044663 | MACPF domain-containing protein CAD1/NSL1-like |
UniProtKB-KW | KW-1210 | Necrosis |
Wikipedia | Programmed_cell_death |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0007559 | obsolete histolysis | consider GO:0012501 |
GO:0008220 | obsolete necrosis | consider GO:0012501 |
GO:0010702 | obsolete regulation of histolysis | consider GO:0012501 |
GO:0010703 | obsolete negative regulation of histolysis | consider GO:0012501 |
GO:0016265 | obsolete death | consider GO:0012501 |
GO:0016271 | obsolete tissue death | consider GO:0012501 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0012501 based on ALL annotations
The top 100 of 1,723 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
programmed cell death
|
12,166.19 | 100.00 | 16,023 | 16,023 |
regulation of salicylic acid mediated signaling pathway
|
8,016.31 | 21.77 | 3,931 | 5,966 |
plant-type hypersensitive response
|
4,360.01 | 15.91 | 3,564 | 9,945 |
positive regulation of apoptotic process
|
849.14 | 5.75 | 3,935 | 56,379 |
cytolysis
|
5,189.92 | 5.66 | 982 | 2,302 |
pyroptotic inflammatory response
|
4,541.92 | 5.66 | 1,002 | 2,684 |
mitochondrial respiratory chain complex assembly
|
1,650.90 | 4.83 | 1,118 | 8,239 |
NAD(P)H oxidase H2O2-forming activity
|
1,197.45 | 4.26 | 1,118 | 11,359 |
positive regulation of mitochondrial fission
|
1,101.14 | 3.60 | 904 | 9,988 |
canonical inflammasome complex
|
3,991.17 | 3.37 | 580 | 1,768 |
Totals | 56563 | 1122749 |
No co-occurrence statistics for GO:0012501 based on MANUAL annotations
The top 100 of 1,276 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
programmed cell death
|
5,568.10 | 100.00 | 232 | 232 |
positive regulation of dendritic cell cytokine production
|
1,687.30 | 3.92 | 10 | 33 |
positive regulation of apoptotic process
|
228.89 | 3.88 | 95 | 2,311 |
ectopic germ cell programmed cell death
|
756.16 | 3.64 | 11 | 81 |
glandular epithelial cell development
|
2,004.52 | 3.63 | 9 | 25 |
positive regulation of mast cell cytokine production
|
2,004.52 | 3.63 | 9 | 25 |
negative regulation of cartilage development
|
1,392.02 | 3.47 | 9 | 36 |
stem cell factor receptor activity
|
5,568.10 | 3.45 | 8 | 8 |
growth plate cartilage development
|
1,138.93 | 3.37 | 9 | 44 |
melanocyte adhesion
|
2,969.65 | 3.35 | 8 | 15 |
Totals | 1058 | 12100 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_agr | 53 |
goslim_chembl | 296 |
goslim_mouse | 45 |
goslim_plant | 97 |
goslim_drosophila | 173 |
goslim_prokaryote | 97 |
goslim_generic | 141 |
goslim_plant_ribbon | 62 |
goslim_euk_cellular_processes_ribbon | 61 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | SUBSET | goslim_euk_cellular_processes_ribbon |
2024-03-21 | Added | SUBSET | goslim_plant_ribbon |
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2023-02-28 | Added | SUBSET | goslim_agr |
2023-02-28 | Added | SUBSET | goslim_chembl |
2023-02-28 | Added | SUBSET | goslim_plant |
2023-02-28 | Added | SUBSET | goslim_mouse |
2023-02-28 | Added | SUBSET | goslim_drosophila |
2021-11-15 | Added | SUBSET | goslim_generic |
2016-03-04 | Added | SYNONYM | PCD |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-03-01 | Added | TERM | programmed cell death |
2002-02-27 | Deleted | TERM | programmed cell death |
2002-02-27 | Added | TERM | programmed cell death |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-03-04 | Added | SYNONYM | PCD |
2016-03-04 | Added | SYNONYM | regulated cell death |
2016-03-04 | Added | SYNONYM | RCD |
2016-03-04 | Deleted | SYNONYM | PCD |
2016-03-04 | Deleted | SYNONYM | regulated cell death |
2013-11-28 | Added | SYNONYM | caspase-independent apoptosis |
2013-11-28 | Added | SYNONYM | caspase-independent cell death |
2013-03-10 | Added | SYNONYM | regulated cell death |
2011-11-26 | Deleted | DEFINITION | Cell death resulting from activation of endogenous cellular processes. |
2011-11-26 | Added | DEFINITION | A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. |
2011-11-24 | Added | SYNONYM | PCD |
2009-03-13 | Deleted | SYNONYM | type II programmed cell death |
2009-02-05 | Added | SYNONYM | type II programmed cell death |
2009-02-05 | Added | SYNONYM | nonapoptotic programmed cell death |
2009-02-05 | Added | SYNONYM | non-apoptotic programmed cell death |
2009-02-05 | Deleted | SYNONYM | necrosis |
2009-02-01 | Added | SYNONYM | necrosis |
2009-02-01 | Deleted | SYNONYM | type II programmed cell death |
2009-02-01 | Deleted | SYNONYM | nonapoptotic programmed cell death |
2009-02-01 | Deleted | SYNONYM | non-apoptotic programmed cell death |
2009-01-31 | Added | SYNONYM | nonapoptotic programmed cell death |
2009-01-31 | Deleted | SYNONYM | necrosis |
2009-01-31 | Added | SYNONYM | non-apoptotic programmed cell death |
2009-01-31 | Added | SYNONYM | type II programmed cell death |
2008-05-13 | Added | DEFINITION | Cell death resulting from activation of endogenous cellular processes. |
2008-05-12 | Deleted | DEFINITION | Cell death resulting from activation of endogenous cellular processes. |
2007-08-09 | Deleted | SYNONYM | necrosis |
2007-08-09 | Added | SYNONYM | necrosis |
2005-08-10 | Added | SYNONYM | necrosis |
2002-11-27 | Added | DEFINITION | Cell death resulting from activation of endogenous cellular processes. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008219 (cell death) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-03-29 | Added | XREF | Wikipedia:Programmed_cell_death |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | SUBSET | goslim_euk_cellular_processes_ribbon |
2024-03-21 | Added | SUBSET | goslim_plant_ribbon |
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2023-02-28 | Added | SUBSET | goslim_agr |
2023-02-28 | Added | SUBSET | goslim_chembl |
2023-02-28 | Added | SUBSET | goslim_plant |
2023-02-28 | Added | SUBSET | goslim_mouse |
2023-02-28 | Added | SUBSET | goslim_drosophila |
2021-11-15 | Added | SUBSET | goslim_generic |
2009-02-05 | Added | SECONDARY | GO:0016244 (non-apoptotic programmed cell death) |
2009-02-01 | Deleted | SECONDARY | GO:0016244 (non-apoptotic programmed cell death) |
2009-01-31 | Added | SECONDARY | GO:0016244 (non-apoptotic programmed cell death) |
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