This term is obsolete.
Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.

GO:0012501 JSON

programmed cell death

Biological Process

Definition (GO:0012501 GONUTS page)

A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.

Comments

Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.

Secondary IDs

GO:0016244

426,234 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
PCD related
RCD related
regulated cell death broad
caspase-independent cell death narrow
caspase-independent apoptosis related
nonapoptotic programmed cell death narrow
non-apoptotic programmed cell death narrow

Ancestor Chart

Ancestor chart for GO:0012501
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0012501

Child Term Relationship to
GO:0012501
programmed necrotic cell death
is_a
autophagic cell death
is_a
positive regulation of programmed cell death
positively_regulates
symbiont-induced defense-related programmed cell death
is_a
negative regulation of programmed cell death
negatively_regulates
cuproptosis
is_a
granzyme-mediated programmed cell death signaling pathway
part_of
apoptotic process
is_a
regulation of programmed cell death
regulates
programmed cell death involved in cell development
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating cell death and apoptosis using the new guidelines Link

Cross-references

Database ID Description
InterPro IPR042377 Gasdermin-E
InterPro IPR044663 MACPF domain-containing protein CAD1/NSL1-like
UniProtKB-KW KW-1210 Necrosis
Wikipedia Programmed_cell_death

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0007559 obsolete histolysis consider GO:0012501
GO:0008220 obsolete necrosis consider GO:0012501
GO:0010702 obsolete regulation of histolysis consider GO:0012501
GO:0010703 obsolete negative regulation of histolysis consider GO:0012501
GO:0016265 obsolete death consider GO:0012501
GO:0016271 obsolete tissue death consider GO:0012501

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0012501 based on ALL annotations
The top 100 of 1,723 co-occurring terms
Co-occurring Term PR S% #Together #Compared
programmed cell death
12,166.19 100.00 16,023 16,023
regulation of salicylic acid mediated signaling pathway
8,016.31 21.77 3,931 5,966
plant-type hypersensitive response
4,360.01 15.91 3,564 9,945
positive regulation of apoptotic process
849.14 5.75 3,935 56,379
cytolysis
5,189.92 5.66 982 2,302
pyroptotic inflammatory response
4,541.92 5.66 1,002 2,684
mitochondrial respiratory chain complex assembly
1,650.90 4.83 1,118 8,239
NAD(P)H oxidase H2O2-forming activity
1,197.45 4.26 1,118 11,359
positive regulation of mitochondrial fission
1,101.14 3.60 904 9,988
canonical inflammasome complex
3,991.17 3.37 580 1,768
Totals 56563 1122749
No co-occurrence statistics for GO:0012501 based on MANUAL annotations
The top 100 of 1,276 co-occurring terms
Co-occurring Term PR S% #Together #Compared
programmed cell death
5,568.10 100.00 232 232
positive regulation of dendritic cell cytokine production
1,687.30 3.92 10 33
positive regulation of apoptotic process
228.89 3.88 95 2,311
ectopic germ cell programmed cell death
756.16 3.64 11 81
glandular epithelial cell development
2,004.52 3.63 9 25
positive regulation of mast cell cytokine production
2,004.52 3.63 9 25
negative regulation of cartilage development
1,392.02 3.47 9 36
stem cell factor receptor activity
5,568.10 3.45 8 8
growth plate cartilage development
1,138.93 3.37 9 44
melanocyte adhesion
2,969.65 3.35 8 15
Totals 1058 12100

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_agr 53
goslim_chembl 296
goslim_mouse 45
goslim_plant 97
goslim_drosophila 173
goslim_prokaryote 97
goslim_generic 141
goslim_plant_ribbon 62
goslim_euk_cellular_processes_ribbon 61

Change Log

Timestamp Action Category Detail
2024-03-22 Added SUBSET goslim_euk_cellular_processes_ribbon
2024-03-21 Added SUBSET goslim_plant_ribbon
2023-12-15 Added SUBSET goslim_prokaryote
2023-02-28 Added SUBSET goslim_agr
2023-02-28 Added SUBSET goslim_chembl
2023-02-28 Added SUBSET goslim_plant
2023-02-28 Added SUBSET goslim_mouse
2023-02-28 Added SUBSET goslim_drosophila
2021-11-15 Added SUBSET goslim_generic
2016-03-04 Added SYNONYM PCD
Timestamp Action Category Detail
2002-03-01 Added TERM programmed cell death
2002-02-27 Deleted TERM programmed cell death
2002-02-27 Added TERM programmed cell death
Timestamp Action Category Detail
2016-03-04 Added SYNONYM PCD
2016-03-04 Added SYNONYM regulated cell death
2016-03-04 Added SYNONYM RCD
2016-03-04 Deleted SYNONYM PCD
2016-03-04 Deleted SYNONYM regulated cell death
2013-11-28 Added SYNONYM caspase-independent apoptosis
2013-11-28 Added SYNONYM caspase-independent cell death
2013-03-10 Added SYNONYM regulated cell death
2011-11-26 Deleted DEFINITION Cell death resulting from activation of endogenous cellular processes.
2011-11-26 Added DEFINITION A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
2011-11-24 Added SYNONYM PCD
2009-03-13 Deleted SYNONYM type II programmed cell death
2009-02-05 Added SYNONYM type II programmed cell death
2009-02-05 Added SYNONYM nonapoptotic programmed cell death
2009-02-05 Added SYNONYM non-apoptotic programmed cell death
2009-02-05 Deleted SYNONYM necrosis
2009-02-01 Added SYNONYM necrosis
2009-02-01 Deleted SYNONYM type II programmed cell death
2009-02-01 Deleted SYNONYM nonapoptotic programmed cell death
2009-02-01 Deleted SYNONYM non-apoptotic programmed cell death
2009-01-31 Added SYNONYM nonapoptotic programmed cell death
2009-01-31 Deleted SYNONYM necrosis
2009-01-31 Added SYNONYM non-apoptotic programmed cell death
2009-01-31 Added SYNONYM type II programmed cell death
2008-05-13 Added DEFINITION Cell death resulting from activation of endogenous cellular processes.
2008-05-12 Deleted DEFINITION Cell death resulting from activation of endogenous cellular processes.
2007-08-09 Deleted SYNONYM necrosis
2007-08-09 Added SYNONYM necrosis
2005-08-10 Added SYNONYM necrosis
2002-11-27 Added DEFINITION Cell death resulting from activation of endogenous cellular processes.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008219 (cell death)
Timestamp Action Category Detail
2009-03-29 Added XREF Wikipedia:Programmed_cell_death
Timestamp Action Category Detail
2024-03-22 Added SUBSET goslim_euk_cellular_processes_ribbon
2024-03-21 Added SUBSET goslim_plant_ribbon
2023-12-15 Added SUBSET goslim_prokaryote
2023-02-28 Added SUBSET goslim_agr
2023-02-28 Added SUBSET goslim_chembl
2023-02-28 Added SUBSET goslim_plant
2023-02-28 Added SUBSET goslim_mouse
2023-02-28 Added SUBSET goslim_drosophila
2021-11-15 Added SUBSET goslim_generic
2009-02-05 Added SECONDARY GO:0016244 (non-apoptotic programmed cell death)
2009-02-01 Deleted SECONDARY GO:0016244 (non-apoptotic programmed cell death)
2009-01-31 Added SECONDARY GO:0016244 (non-apoptotic programmed cell death)
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