This term is obsolete.

GO:0015036 JSON

disulfide oxidoreductase activity

Molecular Function

Definition (GO:0015036 GONUTS page)

Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.

510,398 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
disulphide oxidoreductase activity exact

Ancestor Chart

Ancestor chart for GO:0015036
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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015036

Child Term Relationship to
GO:0015036
GO:0015035
protein-disulfide reductase activity
is_a
GO:0016972
thiol oxidase activity
is_a
GO:0015042
trypanothione-disulfide reductase (NADPH) activity
is_a
GO:0141049
protein-glutathione oxidoreductase (glutathione) activity
is_a
GO:0098622
selenodiglutathione-disulfide reductase (NADPH) activity
is_a
GO:0015038
glutathione disulfide oxidoreductase activity
is_a
GO:0050451
CoA-disulfide reductase (NADPH) activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
InterPro IPR001864 Trypanothione reductase
InterPro IPR004799 Periplasmic protein thiol:disulphide oxidoreductase DsbE
InterPro IPR014434 Monothiol glutaredoxin
InterPro IPR021170 DnaJ homologue subfamily C member 10
InterPro IPR023555 Thiol-disulphide oxidoreductase ResA
Reactome R-HSA-1222417
Reactome R-HSA-1222644
Reactome R-HSA-1222655
Reactome R-HSA-1222690

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0000008 obsolete thioredoxin consider GO:0015036
GO:0009487 obsolete glutaredoxin consider GO:0015036
GO:0030508 obsolete thiol-disulfide exchange intermediate activity consider GO:0015036

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015036 based on ALL annotations
The top 100 of 346 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0015036
disulfide oxidoreductase activity
1,952.80 100.00 101,472 101,472
GO:0015035
protein-disulfide reductase activity
327.82 12.86 35,993 214,408
GO:0045454
cell redox homeostasis
170.62 7.26 30,563 349,807
GO:0017004
cytochrome complex assembly
161.02 6.92 30,527 370,231
GO:0047134
protein-disulfide reductase [NAD(P)H] activity
257.56 4.35 6,184 46,886
GO:0016209
antioxidant activity
120.17 4.23 12,130 197,120
GO:0032843
hydroperoxide reductase activity
1,928.47 4.14 4,200 4,253
GO:0008785
alkyl hydroperoxide reductase activity
1,935.29 4.03 4,089 4,126
GO:0030313
cell envelope
51.13 2.33 17,812 680,335
GO:0051537
2 iron, 2 sulfur cluster binding
42.33 1.97 18,366 847,201
Totals 486029 191109152
No co-occurrence statistics for GO:0015036 based on MANUAL annotations
The top 100 of 143 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0015036
disulfide oxidoreductase activity
6,137.10 100.00 230 230
GO:0009657
plastid organization
4,659.65 16.87 41 54
GO:0044233
mitochondria-associated endoplasmic reticulum membrane contact site
1,210.53 10.62 43 218
GO:0030070
insulin processing
1,363.80 3.10 8 36
GO:0034975
protein folding in endoplasmic reticulum
315.88 2.87 14 272
GO:0016972
thiol oxidase activity
1,867.81 2.85 7 23
GO:0010868
negative regulation of triglyceride biosynthetic process
1,938.03 2.47 6 19
GO:0090331
negative regulation of platelet aggregation
722.01 2.18 6 51
GO:0001674
female germ cell nucleus
438.36 2.18 7 98
GO:0015035
protein-disulfide reductase activity
154.25 2.13 28 1,114
Totals 797 82025

Change Log

Timestamp Action Category Detail
2023-04-02 Deleted XREF Reactome:R-HSA-264997
2019-12-12 Added RELATION has part GO:2001310 (gliotoxin biosynthetic process)
2019-04-01 Deleted XREF reactome:R-HSA-1222417
2019-04-01 Deleted XREF reactome:R-HSA-1222655
2019-04-01 Deleted XREF reactome:R-HSA-1222644
2019-04-01 Added XREF Reactome:R-HSA-1222644
2019-04-01 Added XREF Reactome:R-HSA-264997
2019-04-01 Deleted XREF reactome:R-HSA-264997
2019-04-01 Deleted XREF reactome:R-HSA-1222690
2019-04-01 Added XREF Reactome:R-HSA-1222655
Timestamp Action Category Detail
2003-03-19 Updated TERM disulfide oxidoreductase activity
2002-02-06 Updated TERM disulfide oxidoreductase
2001-04-03 Updated TERM disulfide oxidoreductase
2001-03-30 Added TERM disulfide oxidoreductase
Timestamp Action Category Detail
2011-09-04 Added DEFINITION Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
2011-09-04 Deleted DEFINITION Catalysis of an oxidation-reduction (redox) reaction that interconverts reduced sulfide groups and oxidized disulfide bonds in a substrate.
2008-05-13 Added DEFINITION Catalysis of an oxidation-reduction (redox) reaction that interconverts reduced sulfide groups and oxidized disulfide bonds in a substrate.
2007-08-09 Added SYNONYM disulphide oxidoreductase activity
2007-08-09 Deleted SYNONYM disulphide oxidoreductase activity
2004-04-19 Added SYNONYM disulphide oxidoreductase activity
2004-04-16 Deleted SYNONYM disulphide oxidoreductase activity
2003-11-13 Added SYNONYM disulphide oxidoreductase activity
Timestamp Action Category Detail
2019-12-12 Added RELATION has part GO:2001310 (gliotoxin biosynthetic process)
2008-05-13 Deleted RELATION is a GO:0016491 (oxidoreductase activity)
2008-05-13 Added RELATION is a GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors)
2008-04-01 Updated RELATION is a GO:0016491 (oxidoreductase activity)
Timestamp Action Category Detail
2023-04-02 Deleted XREF Reactome:R-HSA-264997
2019-04-01 Deleted XREF reactome:R-HSA-1222417
2019-04-01 Deleted XREF reactome:R-HSA-1222655
2019-04-01 Deleted XREF reactome:R-HSA-1222644
2019-04-01 Added XREF Reactome:R-HSA-1222644
2019-04-01 Added XREF Reactome:R-HSA-264997
2019-04-01 Deleted XREF reactome:R-HSA-264997
2019-04-01 Deleted XREF reactome:R-HSA-1222690
2019-04-01 Added XREF Reactome:R-HSA-1222655
2019-04-01 Added XREF Reactome:R-HSA-1222417
2019-04-01 Added XREF Reactome:R-HSA-1222690
2018-12-11 Added XREF reactome:R-HSA-1222644
2018-12-11 Added XREF reactome:R-HSA-1222417
2018-12-11 Added XREF reactome:R-HSA-1222690
2018-12-11 Added XREF reactome:R-HSA-264997
2018-12-11 Added XREF reactome:R-HSA-1222655
Timestamp Action Category Detail
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