This term is obsolete.

GO:0015056 JSON

corticotrophin-releasing factor receptor activity

Molecular Function

Definition (GO:0015056 GONUTS page)

Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. PMID:12032352

2,999 annotations

Ancestor Chart

Ancestor chart for GO:0015056
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0015056 corticotrophin-releasing factor receptor activity Never in Taxon 4751 Fungi

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2ARI4 10090 LGR4_MOUSE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646
NOT-qualified manual protein B0BLW3 8364 LGR4_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4AC13 10116 LGR5_RAT GO:0004930 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein E5DHB5 8355 LGR5A_XENLA GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein E7FE13 7955 LGR4_DANRE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MLX5 9913 LGR4_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MT22 9913 LGR5_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F7D3V9 8364 LGR5_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein G3QNC0 9595 G3QNC0_GORGO GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290
NOT-qualified manual protein O15529 9606 GPR42_HUMAN GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015056 based on ALL annotations
The top 100 of 107 co-occurring terms
Co-occurring Term PR S% #Together #Compared
corticotrophin-releasing factor receptor activity
65,481.63 100.00 2,977 2,977
corticotropin-releasing hormone receptor activity
65,437.52 99.63 2,968 2,970
corticotropin-releasing hormone binding
35,296.62 36.85 1,602 2,972
cellular response to corticotropin-releasing hormone stimulus
15,332.61 23.42 2,977 12,714
long-term synaptic potentiation
11,144.05 14.11 1,346 7,909
hormone-mediated signaling pathway
4,996.00 7.63 2,968 38,901
axon terminus
4,584.26 6.45 1,345 19,212
G protein-coupled peptide receptor activity
4,123.86 6.30 2,968 47,128
peptide hormone binding
3,685.99 5.28 1,366 24,267
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
2,068.86 3.05 1,367 43,267
Totals 42013 82277346
No co-occurrence statistics for GO:0015056 based on MANUAL annotations
The top 90 of 90 co-occurring terms
Co-occurring Term PR S% #Together #Compared
corticotrophin-releasing factor receptor activity
36,908.54 100.00 35 35
corticotropin-releasing hormone receptor activity
34,671.66 83.78 31 33
corticotropin-releasing hormone binding
15,141.97 27.59 16 39
corticotropin secretion
28,706.65 18.92 7 9
regulation of corticosterone secretion
10,334.39 13.21 7 25
cellular response to corticotropin-releasing hormone stimulus
2,808.26 5.83 7 92
general adaptation syndrome, behavioral process
4,921.14 4.17 2 15
long-term synaptic potentiation
1,412.77 3.66 16 418
fear response
2,733.97 3.33 2 27
gastric motility
36,908.54 2.86 1 1
Totals 382 343550

Change Log

Timestamp Action Category Detail
2024-03-22 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2012-01-12 Added RELATION part of GO:0071376 (cellular response to corticotropin-releasing hormone stimulus)
2010-06-09 Updated TERM corticotrophin-releasing factor receptor activity
2010-06-08 Updated TERM corticotrophin-releasing factor receptor activity
2008-10-10 Deleted RELATION is a GO:0001636 (obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity)
2008-10-10 Added RELATION is a GO:0004930 (G protein-coupled receptor activity)
2008-05-13 Added DEFINITION Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.
2008-04-01 Updated RELATION is a GO:0001636 (obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity)
2004-01-03 Updated DEFINITION Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.
Timestamp Action Category Detail
2010-06-09 Updated TERM corticotrophin-releasing factor receptor activity
2010-06-08 Updated TERM corticotrophin-releasing factor receptor activity
2003-03-19 Updated TERM corticotrophin-releasing factor receptor activity
2002-02-06 Updated TERM corticotrophin-releasing factor receptor
2002-01-09 Updated TERM corticotrophin-releasing factor receptor
2001-04-03 Updated TERM corticotropin releasing factor receptor
2001-03-30 Added TERM corticotropin releasing factor receptor
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.
2004-01-03 Updated DEFINITION Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity.
2003-05-14 Updated DEFINITION The function of combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell function.
2002-11-27 Added DEFINITION A GPCR that binds the corticotrophin-releasing factor family of ligands, including the urocortins.
Timestamp Action Category Detail
2012-01-12 Added RELATION part of GO:0071376 (cellular response to corticotropin-releasing hormone stimulus)
2008-10-10 Deleted RELATION is a GO:0001636 (obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity)
2008-10-10 Added RELATION is a GO:0004930 (G protein-coupled receptor activity)
2008-04-01 Updated RELATION is a GO:0001636 (obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-22 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
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