GO:0015057
JSON
thrombin-activated receptor activity
Molecular Function
Definition (GO:0015057 GONUTS page)
A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. PMID:20423334
Secondary IDs
GO:0010655
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
thrombin receptor activity, G-protein coupled | exact |
thrombin receptor activity | exact |
Ancestor Chart
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A2ARI4 | 10090 | LGR4_MOUSE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646 | |
NOT-qualified manual | protein | B0BLW3 | 8364 | LGR4_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D4AC13 | 10116 | LGR5_RAT | GO:0004930 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | E5DHB5 | 8355 | LGR5A_XENLA | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | E7FE13 | 7955 | LGR4_DANRE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MLX5 | 9913 | LGR4_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MT22 | 9913 | LGR5_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F7D3V9 | 8364 | LGR5_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | G3QNC0 | 9595 | G3QNC0_GORGO | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290 | |
NOT-qualified manual | protein | O15529 | 9606 | GPR42_HUMAN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR002281 | Protease-activated receptor 2 |
InterPro | IPR003912 | Protease-activated receptor |
InterPro | IPR003943 | Protease-activated receptor 3 |
InterPro | IPR003944 | Protease-activated receptor 4 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0015057 based on ALL annotations
The top 100 of 176 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thrombin-activated receptor activity
|
48,807.91 | 100.00 | 3,994 | 3,994 |
thrombin-activated receptor signaling pathway
|
43,885.36 | 89.91 | 3,994 | 4,442 |
regulation of biological quality
|
12,289.85 | 24.94 | 3,846 | 15,274 |
positive regulation of blood coagulation
|
14,728.19 | 14.16 | 841 | 2,787 |
positive regulation of Rho protein signal transduction
|
6,013.97 | 12.25 | 3,801 | 30,848 |
blood coagulation
|
4,436.26 | 9.08 | 3,944 | 43,392 |
proteinase-activated receptor activity
|
48,807.91 | 5.81 | 232 | 232 |
phospholipase C-activating G protein-coupled receptor signaling pathway
|
2,734.18 | 5.58 | 3,786 | 67,584 |
regulation of blood coagulation
|
7,561.79 | 3.73 | 187 | 1,207 |
cell-cell junction maintenance
|
3,267.92 | 2.82 | 186 | 2,778 |
Totals | 41672 | 3205937 |
No co-occurrence statistics for GO:0015057 based on MANUAL annotations
The top 81 of 81 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thrombin-activated receptor activity
|
46,135.68 | 100.00 | 28 | 28 |
negative regulation of renin secretion into blood stream
|
32,954.06 | 31.25 | 10 | 14 |
positive regulation of blood coagulation
|
12,014.50 | 25.25 | 25 | 96 |
platelet dense tubular network
|
23,067.84 | 22.22 | 8 | 16 |
connective tissue replacement involved in inflammatory response wound healing
|
20,504.75 | 21.05 | 8 | 18 |
regulation of interleukin-1 beta production
|
13,980.51 | 19.61 | 10 | 33 |
negative regulation of glomerular filtration
|
13,840.70 | 18.37 | 9 | 30 |
thrombin-activated receptor signaling pathway
|
12,469.10 | 18.18 | 10 | 37 |
establishment of synaptic specificity at neuromuscular junction
|
5,695.76 | 10.10 | 10 | 81 |
positive regulation of calcium ion transport
|
3,548.90 | 6.76 | 10 | 130 |
Totals | 554 | 414066 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Added | RELATION | is a GO:0001648 (proteinase-activated receptor activity) |
2022-04-05 | Deleted | RELATION | is a GO:0008528 (G protein-coupled peptide receptor activity) |
2018-09-08 | Added | DEFINITION | A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. |
2018-09-08 | Deleted | DEFINITION | A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. |
2016-09-22 | Added | DEFINITION | A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. |
2016-09-22 | Deleted | DEFINITION | Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. |
2016-09-22 | Added | SYNONYM | thrombin receptor activity |
2016-09-22 | Updated | TERM | thrombin-activated receptor activity |
2010-06-15 | Added | RELATION | part of GO:0070493 (thrombin-activated receptor signaling pathway) |
2010-06-14 | Deleted | RELATION | part of GO:0070493 (thrombin-activated receptor signaling pathway) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-09-22 | Updated | TERM | thrombin-activated receptor activity |
2003-03-19 | Updated | TERM | thrombin receptor activity |
2002-02-06 | Updated | TERM | thrombin receptor |
2001-04-03 | Updated | TERM | thrombin receptor |
2001-03-30 | Added | TERM | thrombin receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-09-08 | Added | DEFINITION | A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. |
2018-09-08 | Deleted | DEFINITION | A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. |
2016-09-22 | Added | DEFINITION | A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. |
2016-09-22 | Deleted | DEFINITION | Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. |
2016-09-22 | Added | SYNONYM | thrombin receptor activity |
2009-10-27 | Added | DEFINITION | Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. |
2009-10-27 | Added | SYNONYM | thrombin receptor activity, G-protein coupled |
2009-10-27 | Deleted | DEFINITION | Combining with thrombin to initiate a change in cell activity. |
2008-05-13 | Added | DEFINITION | Combining with thrombin to initiate a change in cell activity. |
2008-05-12 | Deleted | DEFINITION | Combining with thrombin to initiate a change in cell activity. |
2004-01-03 | Updated | DEFINITION | Combining with thrombin to initiate a change in cell activity. |
2003-05-08 | Added | DEFINITION | The function of combining with thrombin to initiate a change in cell function. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Added | RELATION | is a GO:0001648 (proteinase-activated receptor activity) |
2022-04-05 | Deleted | RELATION | is a GO:0008528 (G protein-coupled peptide receptor activity) |
2010-06-15 | Added | RELATION | part of GO:0070493 (thrombin-activated receptor signaling pathway) |
2010-06-14 | Deleted | RELATION | part of GO:0070493 (thrombin-activated receptor signaling pathway) |
2010-06-08 | Added | RELATION | part of GO:0070493 (thrombin-activated receptor signaling pathway) |
2009-10-28 | Deleted | RELATION | is a GO:0001653 (peptide receptor activity) |
2009-10-27 | Added | RELATION | is a GO:0008528 (G protein-coupled peptide receptor activity) |
2008-08-11 | Added | RELATION | is a GO:0001653 (peptide receptor activity) |
2008-08-11 | Deleted | RELATION | is a GO:0008528 (G protein-coupled peptide receptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0008528 (G protein-coupled peptide receptor activity) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-10-27 | Added | SECONDARY | GO:0010655 (thrombin receptor activity, G-protein coupled) |
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