This term is obsolete.

GO:0015057 JSON

thrombin-activated receptor activity

Molecular Function

Definition (GO:0015057 GONUTS page)

A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. PMID:20423334

Secondary IDs

GO:0010655

4,032 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
thrombin receptor activity, G-protein coupled exact
thrombin receptor activity exact

Ancestor Chart

Ancestor chart for GO:0015057
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Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2ARI4 10090 LGR4_MOUSE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646
NOT-qualified manual protein B0BLW3 8364 LGR4_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4AC13 10116 LGR5_RAT GO:0004930 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein E5DHB5 8355 LGR5A_XENLA GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein E7FE13 7955 LGR4_DANRE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MLX5 9913 LGR4_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MT22 9913 LGR5_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F7D3V9 8364 LGR5_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein G3QNC0 9595 G3QNC0_GORGO GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290
NOT-qualified manual protein O15529 9606 GPR42_HUMAN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283

Cross-references

Database ID Description
InterPro IPR002281 Protease-activated receptor 2
InterPro IPR003912 Protease-activated receptor
InterPro IPR003943 Protease-activated receptor 3
InterPro IPR003944 Protease-activated receptor 4

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015057 based on ALL annotations
The top 100 of 176 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thrombin-activated receptor activity
48,807.91 100.00 3,994 3,994
thrombin-activated receptor signaling pathway
43,885.36 89.91 3,994 4,442
regulation of biological quality
12,289.85 24.94 3,846 15,274
positive regulation of blood coagulation
14,728.19 14.16 841 2,787
positive regulation of Rho protein signal transduction
6,013.97 12.25 3,801 30,848
blood coagulation
4,436.26 9.08 3,944 43,392
proteinase-activated receptor activity
48,807.91 5.81 232 232
phospholipase C-activating G protein-coupled receptor signaling pathway
2,734.18 5.58 3,786 67,584
regulation of blood coagulation
7,561.79 3.73 187 1,207
cell-cell junction maintenance
3,267.92 2.82 186 2,778
Totals 41672 3205937
No co-occurrence statistics for GO:0015057 based on MANUAL annotations
The top 81 of 81 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thrombin-activated receptor activity
46,135.68 100.00 28 28
negative regulation of renin secretion into blood stream
32,954.06 31.25 10 14
positive regulation of blood coagulation
12,014.50 25.25 25 96
platelet dense tubular network
23,067.84 22.22 8 16
connective tissue replacement involved in inflammatory response wound healing
20,504.75 21.05 8 18
regulation of interleukin-1 beta production
13,980.51 19.61 10 33
negative regulation of glomerular filtration
13,840.70 18.37 9 30
thrombin-activated receptor signaling pathway
12,469.10 18.18 10 37
establishment of synaptic specificity at neuromuscular junction
5,695.76 10.10 10 81
positive regulation of calcium ion transport
3,548.90 6.76 10 130
Totals 554 414066

Change Log

Timestamp Action Category Detail
2022-04-05 Added RELATION is a GO:0001648 (proteinase-activated receptor activity)
2022-04-05 Deleted RELATION is a GO:0008528 (G protein-coupled peptide receptor activity)
2018-09-08 Added DEFINITION A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2018-09-08 Deleted DEFINITION A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2016-09-22 Added DEFINITION A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2016-09-22 Deleted DEFINITION Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
2016-09-22 Added SYNONYM thrombin receptor activity
2016-09-22 Updated TERM thrombin-activated receptor activity
2010-06-15 Added RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
Timestamp Action Category Detail
2016-09-22 Updated TERM thrombin-activated receptor activity
2003-03-19 Updated TERM thrombin receptor activity
2002-02-06 Updated TERM thrombin receptor
2001-04-03 Updated TERM thrombin receptor
2001-03-30 Added TERM thrombin receptor
Timestamp Action Category Detail
2018-09-08 Added DEFINITION A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2018-09-08 Deleted DEFINITION A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2016-09-22 Added DEFINITION A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2016-09-22 Deleted DEFINITION Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
2016-09-22 Added SYNONYM thrombin receptor activity
2009-10-27 Added DEFINITION Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
2009-10-27 Added SYNONYM thrombin receptor activity, G-protein coupled
2009-10-27 Deleted DEFINITION Combining with thrombin to initiate a change in cell activity.
2008-05-13 Added DEFINITION Combining with thrombin to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with thrombin to initiate a change in cell activity.
2004-01-03 Updated DEFINITION Combining with thrombin to initiate a change in cell activity.
2003-05-08 Added DEFINITION The function of combining with thrombin to initiate a change in cell function.
Timestamp Action Category Detail
2022-04-05 Added RELATION is a GO:0001648 (proteinase-activated receptor activity)
2022-04-05 Deleted RELATION is a GO:0008528 (G protein-coupled peptide receptor activity)
2010-06-15 Added RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2010-06-08 Added RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2009-10-28 Deleted RELATION is a GO:0001653 (peptide receptor activity)
2009-10-27 Added RELATION is a GO:0008528 (G protein-coupled peptide receptor activity)
2008-08-11 Added RELATION is a GO:0001653 (peptide receptor activity)
2008-08-11 Deleted RELATION is a GO:0008528 (G protein-coupled peptide receptor activity)
2008-04-01 Updated RELATION is a GO:0008528 (G protein-coupled peptide receptor activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
2009-10-27 Added SECONDARY GO:0010655 (thrombin receptor activity, G-protein coupled)
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