Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity.
GO:0015091
JSON
ferric iron transmembrane transporter activity
Molecular Function
Definition (GO:0015091 GONUTS page)
Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
Comments
Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity.
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0015091
Child Term | Relationship to GO:0015091 |
---|---|
ABC-type ferric iron transporter activity
|
is_a |
high-affinity ferric iron transmembrane transporter activity
|
is_a |
low-affinity ferric iron ion transmembrane transporter activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A2WLC1 | 39946 | CDT3_ORYSI | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7MB71 | 9913 | AT1B4_BOVIN | GO:0098662 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | B4YDY0 | 10090 | B4YDY0_MOUSE | GO:0006811 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921 | |
NOT-qualified manual | protein | B8B2D0 | 39946 | CDT1_ORYSI | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D4ABB2 | 10116 | D4ABB2_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q5VRD7 | 39947 | CDT3_ORYSJ | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867 | |
NOT-qualified manual | protein | Q5VSB5 | 39947 | CDT1_ORYSJ | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867 | |
NOT-qualified manual | protein | Q6R3K9 | 3702 | YSL2_ARATH | GO:0006826 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15753101 | |
NOT-qualified manual | protein | Q6ZG85 | 39947 | NRAT1_ORYSJ | GO:0005381 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20937890 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR010948 | TonB-dependent lactoferrin/transferrin receptor |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CHEBI | CHEBI:29034 | iron(3+) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0015091 based on ALL annotations
The top 28 of 28 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ferric iron transmembrane transporter activity
|
469,561.25 | 100.00 | 422 | 422 |
high-affinity ferric iron transmembrane transporter activity
|
195,650.53 | 1.17 | 5 | 12 |
ABC-type ferric hydroxamate transporter activity
|
313,040.84 | 0.47 | 2 | 3 |
ferrichrome transmembrane transporter activity
|
156,520.42 | 0.24 | 1 | 3 |
ferric-hydroxamate import into cell
|
93,912.26 | 0.23 | 1 | 5 |
ferrichrome import into cell
|
93,912.26 | 0.23 | 1 | 5 |
ferric-enterobactin transmembrane transporter activity
|
58,695.16 | 0.23 | 1 | 8 |
ferric-enterobactin import into cell
|
52,173.48 | 0.23 | 1 | 9 |
iron ion import across plasma membrane
|
2,006.67 | 0.15 | 1 | 234 |
siderophore uptake transmembrane transporter activity
|
693.24 | 0.15 | 416 | 281,773 |
Totals | 3382 | 116228069 |
No co-occurrence statistics for GO:0015091 based on MANUAL annotations
The top 16 of 16 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ferric iron transmembrane transporter activity
|
201,647.58 | 100.00 | 7 | 7 |
high-affinity ferric iron transmembrane transporter activity
|
84,019.82 | 35.71 | 5 | 12 |
ABC-type ferric hydroxamate transporter activity
|
201,647.58 | 28.57 | 2 | 2 |
ferrichrome transmembrane transporter activity
|
67,215.86 | 11.11 | 1 | 3 |
ferric-hydroxamate import into cell
|
40,329.52 | 9.09 | 1 | 5 |
ferric-enterobactin transmembrane transporter activity
|
28,806.80 | 7.69 | 1 | 7 |
siderophore-iron transmembrane transporter activity
|
12,871.12 | 5.88 | 3 | 47 |
iron ion import across plasma membrane
|
8,767.29 | 3.45 | 1 | 23 |
ferric iron binding
|
1,448.96 | 0.72 | 6 | 835 |
intracellular iron ion homeostasis
|
914.50 | 0.45 | 6 | 1,323 |
Totals | 44 | 221044 |
Change Log
- All changes
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | RELATION | is a GO:1901682 (sulfur compound transmembrane transporter activity) |
2023-12-15 | Deleted | RELATION | is a GO:1901702 (salt transmembrane transporter activity) |
2022-12-24 | Added | RELATION | is a GO:1901702 (salt transmembrane transporter activity) |
2022-12-24 | Added | RELATION | is a GO:1901682 (sulfur compound transmembrane transporter activity) |
2020-12-17 | Deleted | RELATION | is a GO:0072510 (trivalent inorganic cation transmembrane transporter activity) |
2018-10-18 | Deleted | RELATION | part of GO:0015682 (ferric iron transport) |
2015-05-11 | Added | DEFINITION | Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. |
2015-05-11 | Deleted | DEFINITION | Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. |
2010-12-19 | Added | RELATION | is a GO:0072510 (trivalent inorganic cation transmembrane transporter activity) |
2010-06-15 | Added | RELATION | part of GO:0015682 (ferric iron transport) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-09 | Updated | TERM | ferric iron transmembrane transporter activity |
2010-06-08 | Updated | TERM | ferric iron transmembrane transporter activity |
2007-07-14 | Updated | TERM | ferric iron transmembrane transporter activity |
2003-03-19 | Updated | TERM | ferric iron transporter activity |
2002-02-06 | Updated | TERM | ferric iron transporter |
2001-04-03 | Updated | TERM | ferric iron transporter |
2001-03-30 | Added | TERM | ferric iron transporter |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-11 | Added | DEFINITION | Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. |
2015-05-11 | Deleted | DEFINITION | Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. |
2008-05-13 | Added | DEFINITION | Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. |
2007-07-27 | Updated | DEFINITION | Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. |
2003-03-26 | Added | DEFINITION | Enables the directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of, within or between cells. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Deleted | RELATION | is a GO:1901682 (sulfur compound transmembrane transporter activity) |
2023-12-15 | Deleted | RELATION | is a GO:1901702 (salt transmembrane transporter activity) |
2022-12-24 | Added | RELATION | is a GO:1901702 (salt transmembrane transporter activity) |
2022-12-24 | Added | RELATION | is a GO:1901682 (sulfur compound transmembrane transporter activity) |
2020-12-17 | Deleted | RELATION | is a GO:0072510 (trivalent inorganic cation transmembrane transporter activity) |
2018-10-18 | Deleted | RELATION | part of GO:0015682 (ferric iron transport) |
2010-12-19 | Added | RELATION | is a GO:0072510 (trivalent inorganic cation transmembrane transporter activity) |
2010-06-15 | Added | RELATION | part of GO:0015682 (ferric iron transport) |
2010-06-14 | Deleted | RELATION | part of GO:0015682 (ferric iron transport) |
2010-06-08 | Added | RELATION | part of GO:0015682 (ferric iron transport) |
2008-04-01 | Updated | RELATION | is a GO:0005381 (iron ion transmembrane transporter activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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