This term is obsolete.
Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity.

GO:0015091 JSON

ferric iron transmembrane transporter activity

Molecular Function

Definition (GO:0015091 GONUTS page)

Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.

Comments

Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity.

30,842 annotations

Ancestor Chart

Ancestor chart for GO:0015091
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015091

Child Term Relationship to
GO:0015091
ABC-type ferric iron transporter activity
is_a
high-affinity ferric iron transmembrane transporter activity
is_a
low-affinity ferric iron ion transmembrane transporter activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2WLC1 39946 CDT3_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7MB71 9913 AT1B4_BOVIN GO:0098662 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein B4YDY0 10090 B4YDY0_MOUSE GO:0006811 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921
NOT-qualified manual protein B8B2D0 39946 CDT1_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4ABB2 10116 D4ABB2_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q5VRD7 39947 CDT3_ORYSJ GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867
NOT-qualified manual protein Q5VSB5 39947 CDT1_ORYSJ GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867
NOT-qualified manual protein Q6R3K9 3702 YSL2_ARATH GO:0006826 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15753101
NOT-qualified manual protein Q6ZG85 39947 NRAT1_ORYSJ GO:0005381 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20937890

Cross-references

Database ID Description
InterPro IPR010948 TonB-dependent lactoferrin/transferrin receptor

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:29034 iron(3+)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015091 based on ALL annotations
The top 28 of 28 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ferric iron transmembrane transporter activity
469,561.25 100.00 422 422
high-affinity ferric iron transmembrane transporter activity
195,650.53 1.17 5 12
ABC-type ferric hydroxamate transporter activity
313,040.84 0.47 2 3
ferrichrome transmembrane transporter activity
156,520.42 0.24 1 3
ferric-hydroxamate import into cell
93,912.26 0.23 1 5
ferrichrome import into cell
93,912.26 0.23 1 5
ferric-enterobactin transmembrane transporter activity
58,695.16 0.23 1 8
ferric-enterobactin import into cell
52,173.48 0.23 1 9
iron ion import across plasma membrane
2,006.67 0.15 1 234
siderophore uptake transmembrane transporter activity
693.24 0.15 416 281,773
Totals 3382 116228069
No co-occurrence statistics for GO:0015091 based on MANUAL annotations
The top 16 of 16 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ferric iron transmembrane transporter activity
201,647.58 100.00 7 7
high-affinity ferric iron transmembrane transporter activity
84,019.82 35.71 5 12
ABC-type ferric hydroxamate transporter activity
201,647.58 28.57 2 2
ferrichrome transmembrane transporter activity
67,215.86 11.11 1 3
ferric-hydroxamate import into cell
40,329.52 9.09 1 5
ferric-enterobactin transmembrane transporter activity
28,806.80 7.69 1 7
siderophore-iron transmembrane transporter activity
12,871.12 5.88 3 47
iron ion import across plasma membrane
8,767.29 3.45 1 23
ferric iron binding
1,448.96 0.72 6 835
intracellular iron ion homeostasis
914.50 0.45 6 1,323
Totals 44 221044

Change Log

Timestamp Action Category Detail
2023-12-15 Deleted RELATION is a GO:1901682 (sulfur compound transmembrane transporter activity)
2023-12-15 Deleted RELATION is a GO:1901702 (salt transmembrane transporter activity)
2022-12-24 Added RELATION is a GO:1901702 (salt transmembrane transporter activity)
2022-12-24 Added RELATION is a GO:1901682 (sulfur compound transmembrane transporter activity)
2020-12-17 Deleted RELATION is a GO:0072510 (trivalent inorganic cation transmembrane transporter activity)
2018-10-18 Deleted RELATION part of GO:0015682 (ferric iron transport)
2015-05-11 Added DEFINITION Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
2015-05-11 Deleted DEFINITION Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
2010-12-19 Added RELATION is a GO:0072510 (trivalent inorganic cation transmembrane transporter activity)
2010-06-15 Added RELATION part of GO:0015682 (ferric iron transport)
Timestamp Action Category Detail
2010-06-09 Updated TERM ferric iron transmembrane transporter activity
2010-06-08 Updated TERM ferric iron transmembrane transporter activity
2007-07-14 Updated TERM ferric iron transmembrane transporter activity
2003-03-19 Updated TERM ferric iron transporter activity
2002-02-06 Updated TERM ferric iron transporter
2001-04-03 Updated TERM ferric iron transporter
2001-03-30 Added TERM ferric iron transporter
Timestamp Action Category Detail
2015-05-11 Added DEFINITION Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
2015-05-11 Deleted DEFINITION Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
2008-05-13 Added DEFINITION Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
2007-07-27 Updated DEFINITION Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other.
2003-03-26 Added DEFINITION Enables the directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of, within or between cells.
Timestamp Action Category Detail
2023-12-15 Deleted RELATION is a GO:1901682 (sulfur compound transmembrane transporter activity)
2023-12-15 Deleted RELATION is a GO:1901702 (salt transmembrane transporter activity)
2022-12-24 Added RELATION is a GO:1901702 (salt transmembrane transporter activity)
2022-12-24 Added RELATION is a GO:1901682 (sulfur compound transmembrane transporter activity)
2020-12-17 Deleted RELATION is a GO:0072510 (trivalent inorganic cation transmembrane transporter activity)
2018-10-18 Deleted RELATION part of GO:0015682 (ferric iron transport)
2010-12-19 Added RELATION is a GO:0072510 (trivalent inorganic cation transmembrane transporter activity)
2010-06-15 Added RELATION part of GO:0015682 (ferric iron transport)
2010-06-14 Deleted RELATION part of GO:0015682 (ferric iron transport)
2010-06-08 Added RELATION part of GO:0015682 (ferric iron transport)
2008-04-01 Updated RELATION is a GO:0005381 (iron ion transmembrane transporter activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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