This term is obsolete.

GO:0015276 JSON

ligand-gated monoatomic ion channel activity

Molecular Function

Definition (GO:0015276 GONUTS page)

Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

424,668 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ligand-gated ion channel activity broad
ionotropic receptor activity narrow

Ancestor Chart

Ancestor chart for GO:0015276
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015276

Child Term Relationship to
GO:0015276
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
is_a
ligand-gated monoatomic cation channel activity
is_a
cyclic nucleotide-activated monoatomic ion channel activity
is_a
ligand-gated monoatomic anion channel activity
is_a
ionotropic olfactory receptor activity
is_a
pH-gated monoatomic ion channel activity
is_a
extracellular ligand-gated monoatomic ion channel activity
is_a
ionotropic taste receptor activity
is_a
intracellularly ligand-gated monoatomic ion channel activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZLE9 10116 A0A8I5ZLE9_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZST4 10116 A0A8I5ZST4_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AI08 10116 A0A8I6AI08_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0PK00 9606 T120B_HUMAN GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6HVQ8 10116 A6HVQ8_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J168 10116 A6J168_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J4P5 10116 A6J4P5_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6QPF8 9913 T120B_BOVIN GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
InterPro IPR001320 Ionotropic glutamate receptor, C-terminal
InterPro IPR008132 5-hydroxytryptamine 3 receptor
InterPro IPR008133 5-hydroxytryptamine 3 receptor, A subunit
InterPro IPR008134 5-hydroxytryptamine 3 receptor, B subunit
InterPro IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Reactome R-HSA-451310
Reactome R-HSA-451311
Reactome R-HSA-622325
Reactome R-HSA-622326
Reactome R-HSA-629595

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:24867 monoatomic ion
has_small_molecule_activator CHEBI CHEBI:24431 chemical entity

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015276 based on ALL annotations
The top 100 of 1,497 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ligand-gated monoatomic ion channel activity
1,894.41 100.00 102,902 102,902
postsynaptic membrane
367.38 13.92 33,995 175,298
signaling receptor activity
306.82 12.18 33,897 209,295
monoatomic ion transmembrane transport
228.74 12.07 102,877 852,025
ionotropic glutamate receptor signaling pathway
1,830.95 7.02 7,242 7,493
synapse
139.53 6.40 33,813 459,081
detection of stimulus involved in sensory perception
1,361.14 5.44 5,720 7,961
glutamate-gated receptor activity
1,893.48 3.94 4,052 4,054
monoatomic ion transport
71.96 3.52 33,047 869,970
NMDA selective glutamate receptor complex
1,837.78 3.09 3,180 3,278
Totals 594321 88218227
No co-occurrence statistics for GO:0015276 based on MANUAL annotations
The top 100 of 436 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ligand-gated monoatomic ion channel activity
1,153.39 100.00 1,120 1,120
signaling receptor activity
217.25 18.25 958 5,086
monoatomic ion transmembrane transport
245.86 4.96 68 319
detection of chemical stimulus
1,009.22 4.35 49 56
taste receptor activity
486.14 4.29 51 121
sensory perception of taste
576.70 3.86 45 90
NMDA selective glutamate receptor complex
309.24 3.03 37 138
ionotropic glutamate receptor signaling pathway
266.72 2.98 37 160
NMDA glutamate receptor activity
229.44 2.92 37 186
sweet taste receptor activity
543.74 2.85 33 70
Totals 4553 260894

Change Log

Timestamp Action Category Detail
2023-10-10 Added RELATION is a GO:0005216 (monoatomic ion channel activity)
2023-10-10 Deleted RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2022-12-02 Added RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2022-12-02 Added SYNONYM ligand-gated ion channel activity
2022-12-02 Updated TERM ligand-gated monoatomic ion channel activity
2022-12-02 Deleted RELATION is a GO:0005216 (monoatomic ion channel activity)
2022-01-12 Added RELATION has part GO:1990806 (ligand-gated ion channel signaling pathway)
2019-09-12 Deleted RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2019-04-01 Added XREF Reactome:R-HSA-451310
2019-04-01 Added XREF Reactome:R-HSA-622326
Timestamp Action Category Detail
2022-12-02 Updated TERM ligand-gated monoatomic ion channel activity
2003-03-19 Updated TERM ligand-gated ion channel activity
2002-02-06 Updated TERM ligand-gated ion channel
2001-04-03 Updated TERM ligand-gated ion channel
2001-03-30 Added TERM ligand-gated ion channel
Timestamp Action Category Detail
2022-12-02 Added SYNONYM ligand-gated ion channel activity
2015-05-11 Deleted DEFINITION Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2015-05-11 Added DEFINITION Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2011-12-21 Added SYNONYM ionotropic receptor activity
2011-12-21 Deleted SYNONYM ionotropic neurotransmitter receptor
2008-05-13 Added DEFINITION Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2008-05-12 Deleted DEFINITION Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2007-08-09 Deleted SYNONYM ionotropic neurotransmitter receptor
2007-08-09 Added SYNONYM ionotropic neurotransmitter receptor
2007-07-27 Added DEFINITION Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2001-03-30 Added SYNONYM ionotropic neurotransmitter receptor
Timestamp Action Category Detail
2023-10-10 Added RELATION is a GO:0005216 (monoatomic ion channel activity)
2023-10-10 Deleted RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2022-12-02 Added RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2022-12-02 Deleted RELATION is a GO:0005216 (monoatomic ion channel activity)
2022-01-12 Added RELATION has part GO:1990806 (ligand-gated ion channel signaling pathway)
2019-09-12 Deleted RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2018-02-09 Deleted RELATION is a GO:0015318 (inorganic molecular entity transmembrane transporter activity)
2018-02-09 Added RELATION is a GO:0005216 (monoatomic ion channel activity)
2018-02-09 Deleted RELATION is a GO:0008381 (mechanosensitive monoatomic ion channel activity)
2017-11-19 Added RELATION is a GO:0008381 (mechanosensitive monoatomic ion channel activity)
2017-11-17 Deleted RELATION is a GO:0005216 (monoatomic ion channel activity)
2017-11-17 Added RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2017-11-08 Added RELATION is a GO:0015318 (inorganic molecular entity transmembrane transporter activity)
2016-03-02 Deleted RELATION is a GO:0004888 (transmembrane signaling receptor activity)
2016-01-20 Added RELATION is a GO:0004888 (transmembrane signaling receptor activity)
2014-01-16 Added RELATION is a GO:0005216 (monoatomic ion channel activity)
2014-01-16 Deleted RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2013-08-29 Deleted RELATION is a GO:0005216 (monoatomic ion channel activity)
2012-11-02 Added RELATION is a GO:0022839 (monoatomic ion-gated channel activity)
2008-04-01 Updated RELATION is a GO:0022834 (ligand-gated channel activity)
2008-04-01 Updated RELATION is a GO:0005216 (monoatomic ion channel activity)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-451310
2019-04-01 Added XREF Reactome:R-HSA-622326
2019-04-01 Added XREF Reactome:R-HSA-622325
2019-04-01 Added XREF Reactome:R-HSA-451311
2019-04-01 Deleted XREF reactome:R-HSA-622326
2019-04-01 Deleted XREF reactome:R-HSA-622325
2019-04-01 Deleted XREF reactome:R-HSA-451310
2019-04-01 Added XREF Reactome:R-HSA-629595
2019-04-01 Deleted XREF reactome:R-HSA-451311
2019-04-01 Deleted XREF reactome:R-HSA-629595
2018-12-11 Added XREF reactome:R-HSA-451311
2018-12-11 Added XREF reactome:R-HSA-451310
2018-12-11 Added XREF reactome:R-HSA-622326
2018-12-11 Added XREF reactome:R-HSA-629595
2018-12-11 Added XREF reactome:R-HSA-622325
2007-07-11 Deleted XREF TC:1.A.9.-.-
2001-03-30 Added XREF TC:1.A.9.-.-
Timestamp Action Category Detail
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