GO:0015276
JSON
ligand-gated monoatomic ion channel activity
Molecular Function
Definition (GO:0015276 GONUTS page)
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ligand-gated ion channel activity | broad |
ionotropic receptor activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0015276
Child Term | Relationship to GO:0015276 |
---|---|
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
|
is_a |
ligand-gated monoatomic cation channel activity
|
is_a |
cyclic nucleotide-activated monoatomic ion channel activity
|
is_a |
ligand-gated monoatomic anion channel activity
|
is_a |
ionotropic olfactory receptor activity
|
is_a |
pH-gated monoatomic ion channel activity
|
is_a |
extracellular ligand-gated monoatomic ion channel activity
|
is_a |
ionotropic taste receptor activity
|
is_a |
intracellularly ligand-gated monoatomic ion channel activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5ZLE9 | 10116 | A0A8I5ZLE9_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZST4 | 10116 | A0A8I5ZST4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0PK00 | 9606 | T120B_HUMAN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HVQ8 | 10116 | A6HVQ8_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J168 | 10116 | A6J168_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J4P5 | 10116 | A6J4P5_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6QPF8 | 9913 | T120B_BOVIN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001320 | Ionotropic glutamate receptor, C-terminal |
InterPro | IPR008132 | 5-hydroxytryptamine 3 receptor |
InterPro | IPR008133 | 5-hydroxytryptamine 3 receptor, A subunit |
InterPro | IPR008134 | 5-hydroxytryptamine 3 receptor, B subunit |
InterPro | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
Reactome | R-HSA-451310 | |
Reactome | R-HSA-451311 | |
Reactome | R-HSA-622325 | |
Reactome | R-HSA-622326 | |
Reactome | R-HSA-629595 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CHEBI | CHEBI:24867 | monoatomic ion |
has_small_molecule_activator | CHEBI | CHEBI:24431 | chemical entity |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0015276 based on ALL annotations
The top 100 of 1,497 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ligand-gated monoatomic ion channel activity
|
1,894.41 | 100.00 | 102,902 | 102,902 |
postsynaptic membrane
|
367.38 | 13.92 | 33,995 | 175,298 |
signaling receptor activity
|
306.82 | 12.18 | 33,897 | 209,295 |
monoatomic ion transmembrane transport
|
228.74 | 12.07 | 102,877 | 852,025 |
ionotropic glutamate receptor signaling pathway
|
1,830.95 | 7.02 | 7,242 | 7,493 |
synapse
|
139.53 | 6.40 | 33,813 | 459,081 |
detection of stimulus involved in sensory perception
|
1,361.14 | 5.44 | 5,720 | 7,961 |
glutamate-gated receptor activity
|
1,893.48 | 3.94 | 4,052 | 4,054 |
monoatomic ion transport
|
71.96 | 3.52 | 33,047 | 869,970 |
NMDA selective glutamate receptor complex
|
1,837.78 | 3.09 | 3,180 | 3,278 |
Totals | 594321 | 88218227 |
No co-occurrence statistics for GO:0015276 based on MANUAL annotations
The top 100 of 436 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ligand-gated monoatomic ion channel activity
|
1,153.39 | 100.00 | 1,120 | 1,120 |
signaling receptor activity
|
217.25 | 18.25 | 958 | 5,086 |
monoatomic ion transmembrane transport
|
245.86 | 4.96 | 68 | 319 |
detection of chemical stimulus
|
1,009.22 | 4.35 | 49 | 56 |
taste receptor activity
|
486.14 | 4.29 | 51 | 121 |
sensory perception of taste
|
576.70 | 3.86 | 45 | 90 |
NMDA selective glutamate receptor complex
|
309.24 | 3.03 | 37 | 138 |
ionotropic glutamate receptor signaling pathway
|
266.72 | 2.98 | 37 | 160 |
NMDA glutamate receptor activity
|
229.44 | 2.92 | 37 | 186 |
sweet taste receptor activity
|
543.74 | 2.85 | 33 | 70 |
Totals | 4553 | 260894 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-10-10 | Added | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
2023-10-10 | Deleted | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2022-12-02 | Added | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2022-12-02 | Added | SYNONYM | ligand-gated ion channel activity |
2022-12-02 | Updated | TERM | ligand-gated monoatomic ion channel activity |
2022-12-02 | Deleted | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
2022-01-12 | Added | RELATION | has part GO:1990806 (ligand-gated ion channel signaling pathway) |
2019-09-12 | Deleted | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2019-04-01 | Added | XREF | Reactome:R-HSA-451310 |
2019-04-01 | Added | XREF | Reactome:R-HSA-622326 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-02 | Updated | TERM | ligand-gated monoatomic ion channel activity |
2003-03-19 | Updated | TERM | ligand-gated ion channel activity |
2002-02-06 | Updated | TERM | ligand-gated ion channel |
2001-04-03 | Updated | TERM | ligand-gated ion channel |
2001-03-30 | Added | TERM | ligand-gated ion channel |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-02 | Added | SYNONYM | ligand-gated ion channel activity |
2015-05-11 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
2015-05-11 | Added | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
2011-12-21 | Added | SYNONYM | ionotropic receptor activity |
2011-12-21 | Deleted | SYNONYM | ionotropic neurotransmitter receptor |
2008-05-13 | Added | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
2007-08-09 | Deleted | SYNONYM | ionotropic neurotransmitter receptor |
2007-08-09 | Added | SYNONYM | ionotropic neurotransmitter receptor |
2007-07-27 | Added | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
2001-03-30 | Added | SYNONYM | ionotropic neurotransmitter receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-10-10 | Added | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
2023-10-10 | Deleted | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2022-12-02 | Added | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2022-12-02 | Deleted | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
2022-01-12 | Added | RELATION | has part GO:1990806 (ligand-gated ion channel signaling pathway) |
2019-09-12 | Deleted | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2018-02-09 | Deleted | RELATION | is a GO:0015318 (inorganic molecular entity transmembrane transporter activity) |
2018-02-09 | Added | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
2018-02-09 | Deleted | RELATION | is a GO:0008381 (mechanosensitive monoatomic ion channel activity) |
2017-11-19 | Added | RELATION | is a GO:0008381 (mechanosensitive monoatomic ion channel activity) |
2017-11-17 | Deleted | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
2017-11-17 | Added | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2017-11-08 | Added | RELATION | is a GO:0015318 (inorganic molecular entity transmembrane transporter activity) |
2016-03-02 | Deleted | RELATION | is a GO:0004888 (transmembrane signaling receptor activity) |
2016-01-20 | Added | RELATION | is a GO:0004888 (transmembrane signaling receptor activity) |
2014-01-16 | Added | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
2014-01-16 | Deleted | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2013-08-29 | Deleted | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
2012-11-02 | Added | RELATION | is a GO:0022839 (monoatomic ion-gated channel activity) |
2008-04-01 | Updated | RELATION | is a GO:0022834 (ligand-gated channel activity) |
2008-04-01 | Updated | RELATION | is a GO:0005216 (monoatomic ion channel activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-451310 |
2019-04-01 | Added | XREF | Reactome:R-HSA-622326 |
2019-04-01 | Added | XREF | Reactome:R-HSA-622325 |
2019-04-01 | Added | XREF | Reactome:R-HSA-451311 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-622326 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-622325 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-451310 |
2019-04-01 | Added | XREF | Reactome:R-HSA-629595 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-451311 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-629595 |
2018-12-11 | Added | XREF | reactome:R-HSA-451311 |
2018-12-11 | Added | XREF | reactome:R-HSA-451310 |
2018-12-11 | Added | XREF | reactome:R-HSA-622326 |
2018-12-11 | Added | XREF | reactome:R-HSA-629595 |
2018-12-11 | Added | XREF | reactome:R-HSA-622325 |
2007-07-11 | Deleted | XREF | TC:1.A.9.-.- |
2001-03-30 | Added | XREF | TC:1.A.9.-.- |
Timestamp | Action | Category | Detail |
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