This term is obsolete.

GO:0015297 JSON

antiporter activity

Molecular Function

Definition (GO:0015297 GONUTS page)

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). PMID:10839820

Secondary IDs

GO:0015300, GO:0099516

989,350 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
porter broad
exchanger broad
antiport related
ion antiporter activity narrow
solute:solute exchange related
solute:solute antiporter activity exact
exchange transporter activity exact
countertransporter activity exact

Ancestor Chart

Ancestor chart for GO:0015297
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015297

Child Term Relationship to
GO:0015297
L-lysine:L-arginine antiporter activity
is_a
tetracycline:proton antiporter activity
is_a
monoatomic ion antiporter activity involved in regulation of presynaptic membrane potential
is_a
polyspecific organic cation:proton antiporter activity
is_a
succinate:fumarate antiporter activity
is_a
carnitine:O-acyl-L-carnitine antiporter activity
is_a
broad specificity neutral L-amino acid:basic L-amino acid antiporter activity
is_a
S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity
is_a
solute:inorganic anion antiporter activity
is_a
lysine:cadaverine antiporter activity
is_a

Cross-references

Database ID Description
InterPro IPR002528 Multi antimicrobial extrusion protein
InterPro IPR004672 Na(+)/H(+) antiporter NhaD
InterPro IPR004706 Arsenical-resistance protein Acr3
InterPro IPR004770 Na+/H+ antiporter NhaC
InterPro IPR004847 Na(+)/H(+) antiporter subunit E1
InterPro IPR005133 Na+/H+ antiporter subunit G
InterPro IPR005663 Monovalent cation proton antiporter subunit A
InterPro IPR006153 Cation/H+ exchanger, transmembrane domain
InterPro IPR045016 Na(+)/H(+) antiporter NhaD-like
InterPro IPR048123 Na(+),Li(+),K(+)/H(+) antiporter subunit UmpB

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0015363 obsolete dicarboxylate (succinate/fumarate/malate) antiporter activity consider GO:0015297
GO:0030180 obsolete solute:solute exchange consider GO:0015297
GO:0015982 obsolete antiport replaced_by GO:0015297

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015297 based on ALL annotations
The top 100 of 2,547 co-occurring terms
Co-occurring Term PR S% #Together #Compared
antiporter activity
339.25 100.00 584,097 584,097
xenobiotic transmembrane transporter activity
131.46 20.14 172,569 445,332
xenobiotic transport
122.69 17.14 143,522 396,862
sodium:proton antiporter activity
217.63 14.26 90,520 141,103
sodium ion transport
77.53 11.02 102,530 448,661
monoatomic ion transport
50.64 9.99 135,380 906,918
sodium ion transmembrane transport
67.95 8.80 79,204 395,410
regulation of pH
289.06 8.20 48,606 57,045
potassium ion transport
51.83 7.75 79,395 519,696
potassium:proton antiporter activity
227.53 7.67 46,544 69,397
Totals 3930125 112116216
No co-occurrence statistics for GO:0015297 based on MANUAL annotations
The top 100 of 450 co-occurring terms
Co-occurring Term PR S% #Together #Compared
antiporter activity
615.32 100.00 2,294 2,294
nucleotide-sugar transmembrane transporter activity
599.88 13.51 311 319
nucleotide-sugar transmembrane transport
605.03 12.79 294 299
UDP-galactose transmembrane transporter activity
325.50 11.75 301 569
UDP-xylose transmembrane transporter activity
501.59 10.51 247 303
transmembrane transport
61.45 9.51 1,531 15,330
Golgi apparatus
52.49 8.48 2,140 25,086
triose-phosphate transmembrane transporter activity
597.22 7.18 165 170
phosphoglycerate transmembrane transporter activity
593.34 7.04 162 168
GDP-mannose transmembrane transporter activity
606.65 6.10 140 142
Totals 9341 94850

Change Log

Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:20.03.07
2019-05-04 Added XREF MIPS_funcat:20.03.07
2019-04-18 Added SECONDARY GO:0099516 (ion antiporter activity)
2019-04-18 Added SYNONYM ion antiporter activity
2019-04-01 Deleted XREF reactome:R-HSA-2730959
2019-04-01 Deleted XREF reactome:R-HSA-2730692
2019-04-01 Added XREF Reactome:R-HSA-2730959
2019-04-01 Added XREF Reactome:R-HSA-2731002
2019-04-01 Deleted XREF reactome:R-HSA-2731002
2019-04-01 Added XREF Reactome:R-HSA-2730692
Timestamp Action Category Detail
2003-03-19 Updated TERM antiporter activity
2002-02-06 Updated TERM antiporter
2001-04-03 Updated TERM antiporter
2001-03-30 Added TERM antiporter
Timestamp Action Category Detail
2019-04-18 Added SYNONYM ion antiporter activity
2012-08-11 Deleted DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2012-08-11 Added SYNONYM solute:solute exchange
2012-08-11 Added SYNONYM solute:solute antiporter activity
2012-08-11 Deleted SYNONYM dicarboxylate (succinate/fumarate/malate) antiporter activity
2012-08-11 Added DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
2009-07-30 Added SYNONYM exchange transporter activity
2009-07-30 Added SYNONYM countertransporter activity
2009-07-30 Deleted SYNONYM exchange transporter
2009-07-30 Deleted SYNONYM countertransporter
2008-05-13 Added DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2008-05-12 Deleted DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2007-09-10 Deleted SYNONYM antiporter activity
2007-08-09 Deleted SYNONYM exchanger
2007-08-09 Deleted SYNONYM exchange transporter
2007-08-09 Deleted SYNONYM dicarboxylate (succinate/fumarate/malate) antiporter activity
2007-08-09 Deleted SYNONYM countertransporter
2007-08-09 Deleted SYNONYM antiport
2007-08-09 Added SYNONYM porter
2007-08-09 Deleted SYNONYM antiporter activity
2007-08-09 Added SYNONYM exchanger
2007-08-09 Added SYNONYM exchange transporter
2007-08-09 Added SYNONYM dicarboxylate (succinate/fumarate/malate) antiporter activity
2007-08-09 Added SYNONYM countertransporter
2007-08-09 Added SYNONYM antiporter activity
2007-08-09 Added SYNONYM antiport
2007-08-09 Deleted SYNONYM porter
2007-07-27 Updated DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2007-07-11 Added SYNONYM antiporter activity
2007-07-11 Added SYNONYM porter
2005-08-10 Added SYNONYM antiport
2005-08-10 Added SYNONYM dicarboxylate (succinate/fumarate/malate) antiporter activity
2004-04-19 Added SYNONYM countertransporter
2004-04-19 Added SYNONYM exchanger
2004-04-19 Added SYNONYM exchange transporter
2004-04-16 Deleted SYNONYM exchanger
2004-04-16 Deleted SYNONYM exchange transporter
2004-04-16 Deleted SYNONYM countertransporter
2002-11-27 Updated DEFINITION Catalysis of the exchange of one or more molecular species for another across a membrane.
2001-08-06 Added DEFINITION Catalyze the exchange of one or more molecular species for another across a membrane.
2001-03-30 Added SYNONYM countertransporter
2001-03-30 Added SYNONYM exchange transporter
2001-03-30 Added SYNONYM exchanger
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0015291 (secondary active transmembrane transporter activity)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:20.03.07
2019-05-04 Added XREF MIPS_funcat:20.03.07
2019-04-01 Deleted XREF reactome:R-HSA-2730959
2019-04-01 Deleted XREF reactome:R-HSA-2730692
2019-04-01 Added XREF Reactome:R-HSA-2730959
2019-04-01 Added XREF Reactome:R-HSA-2731002
2019-04-01 Deleted XREF reactome:R-HSA-2731002
2019-04-01 Added XREF Reactome:R-HSA-2730692
2018-12-11 Added XREF reactome:R-HSA-2730959
2018-12-11 Added XREF reactome:R-HSA-2730692
2018-12-11 Added XREF reactome:R-HSA-2731002
Timestamp Action Category Detail
2019-04-18 Added SECONDARY GO:0099516 (ion antiporter activity)
2012-08-11 Added SECONDARY GO:0015300 (solute:solute antiporter activity)
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