This term is obsolete.

GO:0015297 JSON

antiporter activity

Molecular Function

Definition (GO:0015297 GONUTS page)

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). PMID:10839820

Secondary IDs

GO:0015300, GO:0099516

943,363 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
porter broad
exchanger broad
antiport related
countertransporter activity exact
ion antiporter activity narrow
solute:solute exchange related
solute:solute antiporter activity exact
exchange transporter activity exact

Ancestor Chart

Ancestor chart for GO:0015297
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015297

Child Term Relationship to
GO:0015297
acridine:proton antiporter activity
is_a
amino acid:monoatomic cation antiporter activity
is_a
(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
is_a
oxoglutarate:malate antiporter activity
is_a
metal cation:monoatomic cation antiporter activity
is_a
arginine:agmatine antiporter activity
is_a
bicarbonate:monoatomic anion antiporter activity
is_a
agmatine:putrescine antiporter activity
is_a
solute:inorganic anion antiporter activity
is_a
acetyl-CoA:CoA antiporter activity
is_a

Cross-references

Database ID Description
InterPro IPR002528 Multi antimicrobial extrusion protein
InterPro IPR004672 Na(+)/H(+) antiporter NhaD
InterPro IPR004706 Arsenical-resistance protein Acr3
InterPro IPR004770 Na+/H+ antiporter NhaC
InterPro IPR004847 Na(+)/H(+) antiporter subunit E1
InterPro IPR005133 Na+/H+ antiporter subunit G
InterPro IPR005663 Monovalent cation proton antiporter subunit A
InterPro IPR006153 Cation/H+ exchanger
InterPro IPR045016 Na(+)/H(+) antiporter NhaD-like
InterPro IPR048123 Na(+),Li(+),K(+)/H(+) antiporter subunit UmpB

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0015363 obsolete dicarboxylate (succinate/fumarate/malate) antiporter activity consider GO:0015297
GO:0030180 obsolete solute:solute exchange consider GO:0015297
GO:0015982 obsolete antiport replaced_by GO:0015297

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015297 based on ALL annotations
The top 100 of 2,546 co-occurring terms
Co-occurring Term PR S% #Together #Compared
antiporter activity
338.14 100.00 576,507 576,507
xenobiotic transmembrane transporter activity
130.00 19.88 168,104 437,255
xenobiotic transport
126.84 17.41 141,370 376,886
sodium:proton antiporter activity
217.36 14.15 88,566 137,779
sodium ion transport
75.40 10.90 101,286 454,207
monoatomic ion transport
50.79 9.93 130,663 869,970
sodium ion transmembrane transport
67.90 8.77 77,625 386,573
regulation of pH
288.21 7.99 46,718 54,811
potassium ion transport
50.69 7.58 76,704 511,671
potassium:proton antiporter activity
225.97 7.47 44,731 66,935
Totals 3866203 109668466
No co-occurrence statistics for GO:0015297 based on MANUAL annotations
The top 100 of 475 co-occurring terms
Co-occurring Term PR S% #Together #Compared
antiporter activity
561.65 100.00 2,300 2,300
nucleotide-sugar transmembrane transporter activity
548.19 12.35 285 292
nucleotide-sugar transmembrane transport
549.40 11.67 269 275
UDP-galactose transmembrane transporter activity
294.41 10.64 271 517
UDP-xylose transmembrane transporter activity
456.22 9.57 225 277
transmembrane transport
55.69 9.33 1,405 14,169
malate transmembrane transporter activity
537.92 8.83 204 213
thiosulfate transmembrane transporter activity
556.12 8.73 201 203
thiosulfate transport
540.15 8.71 201 209
oxaloacetate transport
508.04 8.57 199 220
Totals 10928 79620

Change Log

Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:20.03.07
2019-05-04 Added XREF MIPS_funcat:20.03.07
2019-04-18 Added SECONDARY GO:0099516 (ion antiporter activity)
2019-04-18 Added SYNONYM ion antiporter activity
2019-04-01 Added XREF Reactome:R-HSA-2730692
2019-04-01 Added XREF Reactome:R-HSA-2731002
2019-04-01 Deleted XREF reactome:R-HSA-2730692
2019-04-01 Deleted XREF reactome:R-HSA-2731002
2019-04-01 Added XREF Reactome:R-HSA-2730959
2019-04-01 Deleted XREF reactome:R-HSA-2730959
Timestamp Action Category Detail
2003-03-19 Updated TERM antiporter activity
2002-02-06 Updated TERM antiporter
2001-04-03 Updated TERM antiporter
2001-03-30 Added TERM antiporter
Timestamp Action Category Detail
2019-04-18 Added SYNONYM ion antiporter activity
2012-08-11 Added SYNONYM solute:solute exchange
2012-08-11 Added SYNONYM solute:solute antiporter activity
2012-08-11 Deleted SYNONYM dicarboxylate (succinate/fumarate/malate) antiporter activity
2012-08-11 Added DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
2012-08-11 Deleted DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2009-07-30 Added SYNONYM countertransporter activity
2009-07-30 Added SYNONYM exchange transporter activity
2009-07-30 Deleted SYNONYM countertransporter
2009-07-30 Deleted SYNONYM exchange transporter
2008-05-13 Added DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2008-05-12 Deleted DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2007-09-10 Deleted SYNONYM antiporter activity
2007-08-09 Deleted SYNONYM exchanger
2007-08-09 Deleted SYNONYM porter
2007-08-09 Deleted SYNONYM antiporter activity
2007-08-09 Added SYNONYM exchanger
2007-08-09 Added SYNONYM exchange transporter
2007-08-09 Added SYNONYM dicarboxylate (succinate/fumarate/malate) antiporter activity
2007-08-09 Added SYNONYM countertransporter
2007-08-09 Added SYNONYM antiporter activity
2007-08-09 Added SYNONYM antiport
2007-08-09 Deleted SYNONYM exchange transporter
2007-08-09 Deleted SYNONYM dicarboxylate (succinate/fumarate/malate) antiporter activity
2007-08-09 Deleted SYNONYM countertransporter
2007-08-09 Deleted SYNONYM antiport
2007-08-09 Added SYNONYM porter
2007-07-27 Updated DEFINITION Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2007-07-11 Added SYNONYM antiporter activity
2007-07-11 Added SYNONYM porter
2005-08-10 Added SYNONYM dicarboxylate (succinate/fumarate/malate) antiporter activity
2005-08-10 Added SYNONYM antiport
2004-04-19 Added SYNONYM exchanger
2004-04-19 Added SYNONYM countertransporter
2004-04-19 Added SYNONYM exchange transporter
2004-04-16 Deleted SYNONYM countertransporter
2004-04-16 Deleted SYNONYM exchanger
2004-04-16 Deleted SYNONYM exchange transporter
2002-11-27 Updated DEFINITION Catalysis of the exchange of one or more molecular species for another across a membrane.
2001-08-06 Added DEFINITION Catalyze the exchange of one or more molecular species for another across a membrane.
2001-03-30 Added SYNONYM countertransporter
2001-03-30 Added SYNONYM exchange transporter
2001-03-30 Added SYNONYM exchanger
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0015291 (secondary active transmembrane transporter activity)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:20.03.07
2019-05-04 Added XREF MIPS_funcat:20.03.07
2019-04-01 Added XREF Reactome:R-HSA-2730692
2019-04-01 Added XREF Reactome:R-HSA-2731002
2019-04-01 Deleted XREF reactome:R-HSA-2730692
2019-04-01 Deleted XREF reactome:R-HSA-2731002
2019-04-01 Added XREF Reactome:R-HSA-2730959
2019-04-01 Deleted XREF reactome:R-HSA-2730959
2018-12-11 Added XREF reactome:R-HSA-2730959
2018-12-11 Added XREF reactome:R-HSA-2730692
2018-12-11 Added XREF reactome:R-HSA-2731002
Timestamp Action Category Detail
2019-04-18 Added SECONDARY GO:0099516 (ion antiporter activity)
2012-08-11 Added SECONDARY GO:0015300 (solute:solute antiporter activity)
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