GO:0015385
JSON
sodium:proton antiporter activity
Molecular Function
Definition (GO:0015385 GONUTS page)
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
Secondary IDs
GO:0015502
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
pH-dependent sodium:hydrogen antiporter activity | narrow |
sodium:hydrogen antiporter activity | exact |
sodium/hydrogen antiporter activity | exact |
pH-dependent sodium:proton antiporter activity | narrow |
sodium:hydrogen exchange activity | exact |
sodium:hydrogen exchanger | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0015385
Child Term | Relationship to GO:0015385 |
---|---|
neutral amino acid, sodium:proton antiporter activity
|
is_a |
positive regulation of sodium:proton antiporter activity
|
positively_regulates |
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
|
is_a |
L-histidine, sodium:proton antiporter activity
|
is_a |
L-asparagine, sodium:proton antiporter activity
|
is_a |
negative regulation of sodium:proton antiporter activity
|
negatively_regulates |
L-glutamine, sodium:proton antiporter activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A2WLC1 | 39946 | CDT3_ORYSI | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7MB71 | 9913 | AT1B4_BOVIN | GO:0098662 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | B4YDY0 | 10090 | B4YDY0_MOUSE | GO:0006811 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921 | |
NOT-qualified manual | protein | B8B2D0 | 39946 | CDT1_ORYSI | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D4ABB2 | 10116 | D4ABB2_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q5VRD7 | 39947 | CDT3_ORYSJ | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867 | |
NOT-qualified manual | protein | Q5VSB5 | 39947 | CDT1_ORYSJ | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867 | |
NOT-qualified manual | protein | Q7KTL6 | 7227 | Q7KTL6_DROME | GO:0015385 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26324901 | |
NOT-qualified manual | protein | Q8CHM1 | 10116 | AQP11_RAT | GO:0006811 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:16650285 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001953 | Sodium/hydrogen exchanger 2/4 |
InterPro | IPR001970 | Sodium/hydrogen exchanger 1-like |
InterPro | IPR002090 | Sodium/hydrogen exchanger 6/7/9 |
InterPro | IPR004671 | Na+/H+ antiporter NhaB |
InterPro | IPR004705 | Cation/H+ exchanger, CPA1 family, bacteria |
InterPro | IPR004709 | Na+/H+ exchanger |
InterPro | IPR004712 | Na+/H+ antiporter, fungi |
InterPro | IPR013928 | Alkali metal cation/H+ antiporter Nha1, C-terminal |
InterPro | IPR018410 | Na+/H+ exchanger, isoforms 3/5 |
InterPro | IPR018422 | Cation/H+ exchanger, CPA1 family |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:29101 | sodium(1+) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_primary_input | CHEBI | CHEBI:29101 | sodium(1+) |
has_primary_input | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0015385 based on ALL annotations
The top 100 of 614 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
sodium:proton antiporter activity
|
1,404.33 | 100.00 | 141,103 | 141,103 |
potassium:proton antiporter activity
|
1,256.34 | 41.83 | 62,084 | 69,397 |
sodium ion import across plasma membrane
|
1,376.59 | 35.55 | 50,528 | 51,546 |
regulation of intracellular pH
|
924.79 | 31.34 | 52,796 | 80,173 |
regulation of pH
|
1,129.57 | 30.13 | 45,884 | 57,045 |
sodium ion transmembrane transport
|
312.60 | 19.62 | 88,016 | 395,410 |
sodium ion transport
|
261.91 | 16.53 | 83,677 | 448,661 |
antiporter activity
|
217.63 | 14.26 | 90,520 | 584,097 |
potassium ion transmembrane transport
|
182.61 | 11.16 | 62,113 | 477,669 |
monoatomic ion transmembrane transporter activity
|
758.60 | 10.85 | 16,869 | 31,228 |
Totals | 1198596 | 103827992 |
No co-occurrence statistics for GO:0015385 based on MANUAL annotations
The top 100 of 271 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
sodium:proton antiporter activity
|
1,461.21 | 100.00 | 966 | 966 |
potassium:proton antiporter activity
|
1,258.13 | 69.97 | 762 | 885 |
sodium ion import across plasma membrane
|
1,366.51 | 69.66 | 707 | 756 |
regulation of intracellular pH
|
666.55 | 40.15 | 744 | 1,631 |
potassium ion transmembrane transport
|
281.74 | 18.27 | 751 | 3,895 |
recycling endosome
|
84.13 | 3.77 | 95 | 1,650 |
regulation of stomatal closure
|
379.54 | 3.70 | 40 | 154 |
sodium ion transmembrane transport
|
53.85 | 2.63 | 81 | 2,198 |
brush border membrane
|
98.42 | 1.96 | 26 | 386 |
regulation of cellular pH
|
255.36 | 1.71 | 18 | 103 |
Totals | 5567 | 203798 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | XREF | MetaCyc:TRANS-RXN-129 |
2023-04-02 | Added | XREF | Reactome:R-HSA-2889070 |
2022-04-05 | Deleted | RELATION | is a GO:0005451 (obsolete monoatomic cation:proton antiporter activity) |
2019-05-04 | Added | XREF | Reactome:R-HSA-5661086 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5661039 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5661086 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5661039 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5661039 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5661086 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5661086 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-05-16 | Updated | TERM | sodium:proton antiporter activity |
2010-06-09 | Updated | TERM | sodium:hydrogen antiporter activity |
2010-06-08 | Updated | TERM | sodium:hydrogen antiporter activity |
2003-03-19 | Updated | TERM | sodium:hydrogen antiporter activity |
2002-02-06 | Updated | TERM | sodium:hydrogen antiporter |
2001-04-03 | Updated | TERM | sodium:hydrogen antiporter |
2001-03-30 | Added | TERM | sodium:hydrogen antiporter |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-10-13 | Added | DEFINITION | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
2017-10-13 | Deleted | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
2014-05-16 | Deleted | SYNONYM | sodium:proton antiporter activity |
2014-05-16 | Added | SYNONYM | sodium:hydrogen antiporter activity |
2009-07-30 | Deleted | SYNONYM | sodium:proton antiporter |
2009-07-30 | Added | SYNONYM | sodium:proton antiporter activity |
2009-07-30 | Added | SYNONYM | sodium/hydrogen antiporter activity |
2009-07-30 | Deleted | SYNONYM | sodium/hydrogen antiporter |
2009-07-30 | Added | SYNONYM | pH-dependent sodium:proton antiporter activity |
2009-07-30 | Deleted | SYNONYM | pH-dependent sodium:proton antiporter |
2008-05-13 | Added | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
2007-12-21 | Added | SYNONYM | sodium:hydrogen exchange activity |
2007-12-21 | Added | SYNONYM | sodium:hydrogen exchanger |
2007-08-09 | Added | SYNONYM | sodium:proton antiporter |
2007-08-09 | Added | SYNONYM | sodium/hydrogen antiporter |
2007-08-09 | Added | SYNONYM | pH-dependent sodium:proton antiporter |
2007-08-09 | Deleted | SYNONYM | sodium:proton antiporter |
2007-08-09 | Added | SYNONYM | pH-dependent sodium:hydrogen antiporter activity |
2007-08-09 | Deleted | SYNONYM | pH-dependent sodium:hydrogen antiporter activity |
2007-08-09 | Deleted | SYNONYM | pH-dependent sodium:proton antiporter |
2007-08-09 | Deleted | SYNONYM | sodium/hydrogen antiporter |
2007-07-27 | Updated | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
2004-04-19 | Added | SYNONYM | sodium/hydrogen antiporter |
2004-04-19 | Added | SYNONYM | pH-dependent sodium:hydrogen antiporter activity |
2004-04-19 | Added | SYNONYM | pH-dependent sodium:proton antiporter |
2004-04-19 | Added | SYNONYM | sodium:proton antiporter |
2004-04-16 | Deleted | SYNONYM | sodium:proton antiporter |
2004-04-16 | Deleted | SYNONYM | sodium/hydrogen antiporter |
2004-04-16 | Deleted | SYNONYM | pH-dependent sodium:hydrogen antiporter activity |
2004-04-16 | Deleted | SYNONYM | pH-dependent sodium:proton antiporter |
2004-02-26 | Deleted | SYNONYM | pH dependent sodium:proton antiporter |
2004-02-26 | Added | SYNONYM | pH-dependent sodium:hydrogen antiporter activity |
2004-02-26 | Added | SYNONYM | pH-dependent sodium:proton antiporter |
2004-02-26 | Deleted | SYNONYM | pH dependent sodium:hydrogen antiporter activity |
2003-03-26 | Added | DEFINITION | Catalysis of the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). |
2003-03-19 | Added | SYNONYM | pH dependent sodium:proton antiporter |
2003-03-19 | Added | SYNONYM | pH dependent sodium:hydrogen antiporter activity |
2001-10-01 | Added | SYNONYM | sodium:proton antiporter |
2001-03-30 | Added | SYNONYM | sodium/hydrogen antiporter |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Deleted | RELATION | is a GO:0005451 (obsolete monoatomic cation:proton antiporter activity) |
2019-04-18 | Added | RELATION | is a GO:0051139 (metal cation:proton antiporter activity) |
2011-01-10 | Added | RELATION | is a GO:0015081 (sodium ion transmembrane transporter activity) |
2008-04-05 | Deleted | RELATION | is a GO:0015299 (obsolete solute:proton antiporter activity) |
2008-04-01 | Updated | RELATION | is a GO:0005451 (obsolete monoatomic cation:proton antiporter activity) |
2008-04-01 | Added | RELATION | is a GO:0015299 (obsolete solute:proton antiporter activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Added | XREF | MetaCyc:TRANS-RXN-129 |
2023-04-02 | Added | XREF | Reactome:R-HSA-2889070 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5661086 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5661039 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5661086 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5661039 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5661039 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5661086 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5661086 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5661039 |
2019-04-27 | Added | XREF | Reactome:R-HSA-5661086 |
2019-04-27 | Added | XREF | Reactome:R-HSA-5661039 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-5661039 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-5661086 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2872444 |
2019-04-01 | Added | XREF | Reactome:R-HSA-425965 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2872463 |
2019-04-01 | Added | XREF | Reactome:R-HSA-426015 |
2019-04-01 | Added | XREF | Reactome:R-HSA-425983 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-425983 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2872444 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-425994 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5661039 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5661086 |
2019-04-01 | Added | XREF | Reactome:R-HSA-425994 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2872463 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-425965 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-426015 |
2018-12-11 | Added | XREF | reactome:R-HSA-425965 |
2018-12-11 | Added | XREF | reactome:R-HSA-2872463 |
2018-12-11 | Added | XREF | reactome:R-HSA-426015 |
2018-12-11 | Added | XREF | reactome:R-HSA-425994 |
2018-12-11 | Added | XREF | reactome:R-HSA-2872444 |
2018-12-11 | Added | XREF | reactome:R-HSA-425983 |
2018-07-13 | Deleted | XREF | RHEA:29254 |
2018-07-13 | Added | XREF | RHEA:29251 |
2012-09-14 | Added | XREF | RHEA:29254 |
2007-07-11 | Deleted | XREF | TC:2.A.34.1.1 |
2007-07-11 | Deleted | XREF | TC:2.A.35.1.1 |
2007-07-11 | Deleted | XREF | TC:2.A.36.-.- |
2003-03-19 | Added | XREF | TC:2.A.34.1.1 |
2001-03-30 | Added | XREF | TC:2.A.36.-.- |
2001-03-30 | Added | XREF | TC:2.A.35.1.1 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Added | SECONDARY | GO:0015502 (pH dependent sodium:hydrogen antiporter) |
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