This term is obsolete.

GO:0015385 JSON

sodium:proton antiporter activity

Molecular Function

Definition (GO:0015385 GONUTS page)

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

Secondary IDs

GO:0015502

142,386 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
pH-dependent sodium:hydrogen antiporter activity narrow
sodium:hydrogen antiporter activity exact
sodium/hydrogen antiporter activity exact
pH-dependent sodium:proton antiporter activity narrow
sodium:hydrogen exchange activity exact
sodium:hydrogen exchanger exact

Ancestor Chart

Ancestor chart for GO:0015385
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015385

Child Term Relationship to
GO:0015385
neutral amino acid, sodium:proton antiporter activity
is_a
positive regulation of sodium:proton antiporter activity
positively_regulates
sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
is_a
L-histidine, sodium:proton antiporter activity
is_a
L-asparagine, sodium:proton antiporter activity
is_a
negative regulation of sodium:proton antiporter activity
negatively_regulates
L-glutamine, sodium:proton antiporter activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2WLC1 39946 CDT3_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7MB71 9913 AT1B4_BOVIN GO:0098662 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein B4YDY0 10090 B4YDY0_MOUSE GO:0006811 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921
NOT-qualified manual protein B8B2D0 39946 CDT1_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4ABB2 10116 D4ABB2_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q5VRD7 39947 CDT3_ORYSJ GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867
NOT-qualified manual protein Q5VSB5 39947 CDT1_ORYSJ GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867
NOT-qualified manual protein Q7KTL6 7227 Q7KTL6_DROME GO:0015385 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:26324901
NOT-qualified manual protein Q8CHM1 10116 AQP11_RAT GO:0006811 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:16650285

Cross-references

Database ID Description
InterPro IPR001953 Sodium/hydrogen exchanger 2/4
InterPro IPR001970 Sodium/hydrogen exchanger 1-like
InterPro IPR002090 Sodium/hydrogen exchanger 6/7/9
InterPro IPR004671 Na+/H+ antiporter NhaB
InterPro IPR004705 Cation/H+ exchanger, CPA1 family, bacteria
InterPro IPR004709 Na+/H+ exchanger
InterPro IPR004712 Na+/H+ antiporter, fungi
InterPro IPR013928 Alkali metal cation/H+ antiporter Nha1, C-terminal
InterPro IPR018410 Na+/H+ exchanger, isoforms 3/5
InterPro IPR018422 Cation/H+ exchanger, CPA1 family

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29101 sodium(1+)
has_participant CHEBI CHEBI:15378 hydron
has_primary_input CHEBI CHEBI:29101 sodium(1+)
has_primary_input CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015385 based on ALL annotations
The top 100 of 614 co-occurring terms
Co-occurring Term PR S% #Together #Compared
sodium:proton antiporter activity
1,404.33 100.00 141,103 141,103
potassium:proton antiporter activity
1,256.34 41.83 62,084 69,397
sodium ion import across plasma membrane
1,376.59 35.55 50,528 51,546
regulation of intracellular pH
924.79 31.34 52,796 80,173
regulation of pH
1,129.57 30.13 45,884 57,045
sodium ion transmembrane transport
312.60 19.62 88,016 395,410
sodium ion transport
261.91 16.53 83,677 448,661
antiporter activity
217.63 14.26 90,520 584,097
potassium ion transmembrane transport
182.61 11.16 62,113 477,669
monoatomic ion transmembrane transporter activity
758.60 10.85 16,869 31,228
Totals 1198596 103827992
No co-occurrence statistics for GO:0015385 based on MANUAL annotations
The top 100 of 271 co-occurring terms
Co-occurring Term PR S% #Together #Compared
sodium:proton antiporter activity
1,461.21 100.00 966 966
potassium:proton antiporter activity
1,258.13 69.97 762 885
sodium ion import across plasma membrane
1,366.51 69.66 707 756
regulation of intracellular pH
666.55 40.15 744 1,631
potassium ion transmembrane transport
281.74 18.27 751 3,895
recycling endosome
84.13 3.77 95 1,650
regulation of stomatal closure
379.54 3.70 40 154
sodium ion transmembrane transport
53.85 2.63 81 2,198
brush border membrane
98.42 1.96 26 386
regulation of cellular pH
255.36 1.71 18 103
Totals 5567 203798

Change Log

Timestamp Action Category Detail
2024-02-24 Added XREF MetaCyc:TRANS-RXN-129
2023-04-02 Added XREF Reactome:R-HSA-2889070
2022-04-05 Deleted RELATION is a GO:0005451 (obsolete monoatomic cation:proton antiporter activity)
2019-05-04 Added XREF Reactome:R-HSA-5661086
2019-05-04 Added XREF Reactome:R-HSA-5661039
2019-04-30 Deleted XREF Reactome:R-HSA-5661086
2019-04-30 Deleted XREF Reactome:R-HSA-5661039
2019-04-29 Added XREF Reactome:R-HSA-5661039
2019-04-29 Added XREF Reactome:R-HSA-5661086
2019-04-28 Deleted XREF Reactome:R-HSA-5661086
Timestamp Action Category Detail
2014-05-16 Updated TERM sodium:proton antiporter activity
2010-06-09 Updated TERM sodium:hydrogen antiporter activity
2010-06-08 Updated TERM sodium:hydrogen antiporter activity
2003-03-19 Updated TERM sodium:hydrogen antiporter activity
2002-02-06 Updated TERM sodium:hydrogen antiporter
2001-04-03 Updated TERM sodium:hydrogen antiporter
2001-03-30 Added TERM sodium:hydrogen antiporter
Timestamp Action Category Detail
2017-10-13 Added DEFINITION Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2017-10-13 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2014-05-16 Deleted SYNONYM sodium:proton antiporter activity
2014-05-16 Added SYNONYM sodium:hydrogen antiporter activity
2009-07-30 Deleted SYNONYM sodium:proton antiporter
2009-07-30 Added SYNONYM sodium:proton antiporter activity
2009-07-30 Added SYNONYM sodium/hydrogen antiporter activity
2009-07-30 Deleted SYNONYM sodium/hydrogen antiporter
2009-07-30 Added SYNONYM pH-dependent sodium:proton antiporter activity
2009-07-30 Deleted SYNONYM pH-dependent sodium:proton antiporter
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2007-12-21 Added SYNONYM sodium:hydrogen exchange activity
2007-12-21 Added SYNONYM sodium:hydrogen exchanger
2007-08-09 Added SYNONYM sodium:proton antiporter
2007-08-09 Added SYNONYM sodium/hydrogen antiporter
2007-08-09 Added SYNONYM pH-dependent sodium:proton antiporter
2007-08-09 Deleted SYNONYM sodium:proton antiporter
2007-08-09 Added SYNONYM pH-dependent sodium:hydrogen antiporter activity
2007-08-09 Deleted SYNONYM pH-dependent sodium:hydrogen antiporter activity
2007-08-09 Deleted SYNONYM pH-dependent sodium:proton antiporter
2007-08-09 Deleted SYNONYM sodium/hydrogen antiporter
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2004-04-19 Added SYNONYM sodium/hydrogen antiporter
2004-04-19 Added SYNONYM pH-dependent sodium:hydrogen antiporter activity
2004-04-19 Added SYNONYM pH-dependent sodium:proton antiporter
2004-04-19 Added SYNONYM sodium:proton antiporter
2004-04-16 Deleted SYNONYM sodium:proton antiporter
2004-04-16 Deleted SYNONYM sodium/hydrogen antiporter
2004-04-16 Deleted SYNONYM pH-dependent sodium:hydrogen antiporter activity
2004-04-16 Deleted SYNONYM pH-dependent sodium:proton antiporter
2004-02-26 Deleted SYNONYM pH dependent sodium:proton antiporter
2004-02-26 Added SYNONYM pH-dependent sodium:hydrogen antiporter activity
2004-02-26 Added SYNONYM pH-dependent sodium:proton antiporter
2004-02-26 Deleted SYNONYM pH dependent sodium:hydrogen antiporter activity
2003-03-26 Added DEFINITION Catalysis of the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2003-03-19 Added SYNONYM pH dependent sodium:proton antiporter
2003-03-19 Added SYNONYM pH dependent sodium:hydrogen antiporter activity
2001-10-01 Added SYNONYM sodium:proton antiporter
2001-03-30 Added SYNONYM sodium/hydrogen antiporter
Timestamp Action Category Detail
2022-04-05 Deleted RELATION is a GO:0005451 (obsolete monoatomic cation:proton antiporter activity)
2019-04-18 Added RELATION is a GO:0051139 (metal cation:proton antiporter activity)
2011-01-10 Added RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2008-04-05 Deleted RELATION is a GO:0015299 (obsolete solute:proton antiporter activity)
2008-04-01 Updated RELATION is a GO:0005451 (obsolete monoatomic cation:proton antiporter activity)
2008-04-01 Added RELATION is a GO:0015299 (obsolete solute:proton antiporter activity)
Timestamp Action Category Detail
2024-02-24 Added XREF MetaCyc:TRANS-RXN-129
2023-04-02 Added XREF Reactome:R-HSA-2889070
2019-05-04 Added XREF Reactome:R-HSA-5661086
2019-05-04 Added XREF Reactome:R-HSA-5661039
2019-04-30 Deleted XREF Reactome:R-HSA-5661086
2019-04-30 Deleted XREF Reactome:R-HSA-5661039
2019-04-29 Added XREF Reactome:R-HSA-5661039
2019-04-29 Added XREF Reactome:R-HSA-5661086
2019-04-28 Deleted XREF Reactome:R-HSA-5661086
2019-04-28 Deleted XREF Reactome:R-HSA-5661039
2019-04-27 Added XREF Reactome:R-HSA-5661086
2019-04-27 Added XREF Reactome:R-HSA-5661039
2019-04-23 Deleted XREF Reactome:R-HSA-5661039
2019-04-23 Deleted XREF Reactome:R-HSA-5661086
2019-04-01 Added XREF Reactome:R-HSA-2872444
2019-04-01 Added XREF Reactome:R-HSA-425965
2019-04-01 Added XREF Reactome:R-HSA-2872463
2019-04-01 Added XREF Reactome:R-HSA-426015
2019-04-01 Added XREF Reactome:R-HSA-425983
2019-04-01 Deleted XREF reactome:R-HSA-425983
2019-04-01 Deleted XREF reactome:R-HSA-2872444
2019-04-01 Deleted XREF reactome:R-HSA-425994
2019-04-01 Added XREF Reactome:R-HSA-5661039
2019-04-01 Added XREF Reactome:R-HSA-5661086
2019-04-01 Added XREF Reactome:R-HSA-425994
2019-04-01 Deleted XREF reactome:R-HSA-2872463
2019-04-01 Deleted XREF reactome:R-HSA-425965
2019-04-01 Deleted XREF reactome:R-HSA-426015
2018-12-11 Added XREF reactome:R-HSA-425965
2018-12-11 Added XREF reactome:R-HSA-2872463
2018-12-11 Added XREF reactome:R-HSA-426015
2018-12-11 Added XREF reactome:R-HSA-425994
2018-12-11 Added XREF reactome:R-HSA-2872444
2018-12-11 Added XREF reactome:R-HSA-425983
2018-07-13 Deleted XREF RHEA:29254
2018-07-13 Added XREF RHEA:29251
2012-09-14 Added XREF RHEA:29254
2007-07-11 Deleted XREF TC:2.A.34.1.1
2007-07-11 Deleted XREF TC:2.A.35.1.1
2007-07-11 Deleted XREF TC:2.A.36.-.-
2003-03-19 Added XREF TC:2.A.34.1.1
2001-03-30 Added XREF TC:2.A.36.-.-
2001-03-30 Added XREF TC:2.A.35.1.1
Timestamp Action Category Detail
2003-03-19 Added SECONDARY GO:0015502 (pH dependent sodium:hydrogen antiporter)
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