This term is obsolete.

GO:0015666 JSON

restriction endodeoxyribonuclease activity

Molecular Function

Definition (GO:0015666 GONUTS page)

Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.

66,359 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
restriction endonuclease activity exact
restriction enzyme activity exact

Ancestor Chart

Ancestor chart for GO:0015666
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015666

Child Term Relationship to
GO:0015666
type I site-specific deoxyribonuclease activity
is_a
type IV site-specific deoxyribonuclease activity
is_a
regulation of restriction endodeoxyribonuclease activity
regulates
negative regulation of restriction endodeoxyribonuclease activity
negatively_regulates
type II site-specific deoxyribonuclease activity
is_a
type III site-specific deoxyribonuclease activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A4WYU7 349102 AGO_CERS5 GO:0004520 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24034694
NOT-qualified manual protein A6J211 10116 A6J211_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8DY77 7227 A8DY77_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein B2GV68 10116 B2GV68_RAT GO:0004519 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P0C5W1 10116 MAP1S_RAT GO:0004536 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0015666 based on ALL annotations
The top 79 of 79 co-occurring terms
Co-occurring Term PR S% #Together #Compared
restriction endodeoxyribonuclease activity
11,820.20 100.00 16,492 16,492
DNA restriction-modification system
651.62 5.51 16,474 298,835
endonuclease activity
88.37 0.75 16,480 2,204,272
bacterial nucleoid
70.92 0.55 1,041 173,514
DNA topoisomerase activity
40.22 0.32 1,049 308,259
DNA topological change
36.27 0.29 1,049 341,901
chromosome
14.96 0.12 1,049 828,779
DNA binding
12.60 0.11 16,473 15,456,294
membrane
1.28 0.01 5,554 51,131,591
N-methyltransferase activity
1.14 0.01 22 227,209
Totals 76508 304741175
No co-occurrence statistics for GO:0015666 based on MANUAL annotations
The top 10 of 10 co-occurring terms
Co-occurring Term PR S% #Together #Compared
restriction endodeoxyribonuclease activity
49,684.58 100.00 26 26
type IV site-specific deoxyribonuclease activity
16,561.53 3.57 1 3
DNA restriction-modification system
3,105.29 3.57 2 32
response to hydrostatic pressure
4,140.38 2.70 1 12
bacterial nucleoid
1,072.33 1.85 3 139
GTP binding
5.92 0.01 1 8,396
GTPase activity
3.50 0.01 1 14,190
cellular_component
0.79 0.00 1 62,739
biological_process
0.75 0.00 1 66,439
molecular_function
0.71 0.00 1 69,561
Totals 38 221537

Change Log

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
2008-05-12 Deleted DEFINITION Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
2008-04-01 Updated RELATION is a GO:0004520 (DNA endonuclease activity)
2007-08-09 Deleted SYNONYM restriction enzyme activity
2007-08-09 Deleted SYNONYM restriction endonuclease activity
2007-08-09 Added SYNONYM restriction enzyme activity
2007-08-09 Added SYNONYM restriction endonuclease activity
2006-06-08 Added SYNONYM restriction endonuclease activity
2006-06-08 Added SYNONYM restriction enzyme activity
2006-06-06 Added DEFINITION Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
Timestamp Action Category Detail
2003-03-19 Updated TERM restriction endodeoxyribonuclease activity
2002-02-06 Updated TERM restriction endodeoxyribonuclease
2001-04-03 Updated TERM restriction endodeoxyribonuclease
2001-03-30 Added TERM restriction endodeoxyribonuclease
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
2008-05-12 Deleted DEFINITION Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
2007-08-09 Deleted SYNONYM restriction enzyme activity
2007-08-09 Deleted SYNONYM restriction endonuclease activity
2007-08-09 Added SYNONYM restriction enzyme activity
2007-08-09 Added SYNONYM restriction endonuclease activity
2006-06-08 Added SYNONYM restriction endonuclease activity
2006-06-08 Added SYNONYM restriction enzyme activity
2006-06-06 Added DEFINITION Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004520 (DNA endonuclease activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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