GO:0015666
JSON
restriction endodeoxyribonuclease activity
Molecular Function
Definition (GO:0015666 GONUTS page)
Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
restriction endonuclease activity | exact |
restriction enzyme activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0015666
Child Term | Relationship to GO:0015666 |
---|---|
type I site-specific deoxyribonuclease activity
|
is_a |
type IV site-specific deoxyribonuclease activity
|
is_a |
regulation of restriction endodeoxyribonuclease activity
|
regulates |
negative regulation of restriction endodeoxyribonuclease activity
|
negatively_regulates |
type II site-specific deoxyribonuclease activity
|
is_a |
type III site-specific deoxyribonuclease activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A0G2K5G5 | 10116 | A0A0G2K5G5_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A4WYU7 | 349102 | AGO_CERS5 | GO:0004520 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24034694 | |
NOT-qualified manual | protein | A6J211 | 10116 | A6J211_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8DY77 | 7227 | A8DY77_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | B2GV68 | 10116 | B2GV68_RAT | GO:0004519 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P0C5W1 | 10116 | MAP1S_RAT | GO:0004536 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0015666 based on ALL annotations
The top 79 of 79 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
restriction endodeoxyribonuclease activity
|
11,820.20 | 100.00 | 16,492 | 16,492 |
DNA restriction-modification system
|
651.62 | 5.51 | 16,474 | 298,835 |
endonuclease activity
|
88.37 | 0.75 | 16,480 | 2,204,272 |
bacterial nucleoid
|
70.92 | 0.55 | 1,041 | 173,514 |
DNA topoisomerase activity
|
40.22 | 0.32 | 1,049 | 308,259 |
DNA topological change
|
36.27 | 0.29 | 1,049 | 341,901 |
chromosome
|
14.96 | 0.12 | 1,049 | 828,779 |
DNA binding
|
12.60 | 0.11 | 16,473 | 15,456,294 |
membrane
|
1.28 | 0.01 | 5,554 | 51,131,591 |
N-methyltransferase activity
|
1.14 | 0.01 | 22 | 227,209 |
Totals | 76508 | 304741175 |
No co-occurrence statistics for GO:0015666 based on MANUAL annotations
The top 10 of 10 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
restriction endodeoxyribonuclease activity
|
49,684.58 | 100.00 | 26 | 26 |
type IV site-specific deoxyribonuclease activity
|
16,561.53 | 3.57 | 1 | 3 |
DNA restriction-modification system
|
3,105.29 | 3.57 | 2 | 32 |
response to hydrostatic pressure
|
4,140.38 | 2.70 | 1 | 12 |
bacterial nucleoid
|
1,072.33 | 1.85 | 3 | 139 |
GTP binding
|
5.92 | 0.01 | 1 | 8,396 |
GTPase activity
|
3.50 | 0.01 | 1 | 14,190 |
cellular_component
|
0.79 | 0.00 | 1 | 62,739 |
biological_process
|
0.75 | 0.00 | 1 | 66,439 |
molecular_function
|
0.71 | 0.00 | 1 | 69,561 |
Totals | 38 | 221537 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. |
2008-05-12 | Deleted | DEFINITION | Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. |
2008-04-01 | Updated | RELATION | is a GO:0004520 (DNA endonuclease activity) |
2007-08-09 | Deleted | SYNONYM | restriction enzyme activity |
2007-08-09 | Deleted | SYNONYM | restriction endonuclease activity |
2007-08-09 | Added | SYNONYM | restriction enzyme activity |
2007-08-09 | Added | SYNONYM | restriction endonuclease activity |
2006-06-08 | Added | SYNONYM | restriction endonuclease activity |
2006-06-08 | Added | SYNONYM | restriction enzyme activity |
2006-06-06 | Added | DEFINITION | Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | restriction endodeoxyribonuclease activity |
2002-02-06 | Updated | TERM | restriction endodeoxyribonuclease |
2001-04-03 | Updated | TERM | restriction endodeoxyribonuclease |
2001-03-30 | Added | TERM | restriction endodeoxyribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. |
2008-05-12 | Deleted | DEFINITION | Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. |
2007-08-09 | Deleted | SYNONYM | restriction enzyme activity |
2007-08-09 | Deleted | SYNONYM | restriction endonuclease activity |
2007-08-09 | Added | SYNONYM | restriction enzyme activity |
2007-08-09 | Added | SYNONYM | restriction endonuclease activity |
2006-06-08 | Added | SYNONYM | restriction endonuclease activity |
2006-06-08 | Added | SYNONYM | restriction enzyme activity |
2006-06-06 | Added | DEFINITION | Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004520 (DNA endonuclease activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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