Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.
GO:0016068
JSON
type I hypersensitivity
Biological Process
Definition (GO:0016068 GONUTS page)
An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
Comments
Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
immediate hypersensitivity response | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0016068
Child Term | Relationship to GO:0016068 |
---|---|
regulation of type I hypersensitivity
|
regulates |
negative regulation of type I hypersensitivity
|
negatively_regulates |
positive regulation of type I hypersensitivity
|
positively_regulates |
type I hypersensitivity mediated by mast cells
|
is_a |
type I hypersensitivity mediated by basophils
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0016068 | type I hypersensitivity | Only in Taxon | 7742 | Vertebrata |
More information on taxon constraints in GO is available here
Cross-references
Database | ID | Description |
---|---|---|
Wikipedia | Type_I_hypersensitivity |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016068 based on ALL annotations
The top 29 of 29 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
type I hypersensitivity
|
3,609,977.50 | 100.00 | 54 | 54 |
high-affinity IgE receptor activity
|
1,597,858.90 | 44.26 | 54 | 122 |
eosinophil degranulation
|
878,102.60 | 24.32 | 54 | 222 |
type 2 immune response
|
727,383.50 | 20.15 | 54 | 268 |
positive regulation of type I hypersensitivity
|
1,110,762.20 | 11.11 | 8 | 26 |
Fc-epsilon receptor signaling pathway
|
239,482.53 | 6.63 | 54 | 814 |
positive regulation of interleukin-3 production
|
300,831.47 | 5.63 | 8 | 96 |
serotonin secretion
|
257,855.53 | 5.06 | 8 | 112 |
positive regulation of mast cell cytokine production
|
142,265.12 | 3.21 | 8 | 203 |
mast cell degranulation
|
109,701.06 | 3.04 | 54 | 1,777 |
Totals | 793 | 79554631 |
No co-occurrence statistics for GO:0016068 based on MANUAL annotations
The top 26 of 26 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
type I hypersensitivity
|
645,899.50 | 100.00 | 2 | 2 |
high-affinity IgE receptor activity
|
143,533.22 | 22.22 | 2 | 9 |
positive regulation of interleukin-3 production
|
129,179.90 | 16.67 | 1 | 5 |
serotonin secretion
|
49,684.58 | 7.14 | 1 | 13 |
eosinophil degranulation
|
43,059.97 | 6.67 | 2 | 30 |
positive regulation of type I hypersensitivity
|
43,059.97 | 6.25 | 1 | 15 |
type 2 immune response
|
36,908.54 | 5.71 | 2 | 35 |
IgE receptor activity
|
37,994.09 | 5.56 | 1 | 17 |
positive regulation of mast cell cytokine production
|
25,835.98 | 3.85 | 1 | 25 |
positive regulation of granulocyte macrophage colony-stimulating factor production
|
17,941.65 | 2.70 | 1 | 36 |
Totals | 37 | 221222 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
2009-03-29 | Added | XREF | Wikipedia:Type_I_hypersensitivity |
2008-05-13 | Added | DEFINITION | An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. |
2008-05-12 | Deleted | DEFINITION | An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. |
2008-04-01 | Updated | RELATION | is a GO:0016064 (immunoglobulin mediated immune response) |
2008-04-01 | Updated | RELATION | is a GO:0002524 (hypersensitivity) |
2007-08-09 | Deleted | SYNONYM | immediate hypersensitivity response |
2007-08-09 | Added | SYNONYM | immediate hypersensitivity response |
2006-09-19 | Updated | DEFINITION | An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. |
2004-04-19 | Added | SYNONYM | immediate hypersensitivity response |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-02-05 | Updated | TERM | type I hypersensitivity |
2002-02-06 | Updated | TERM | immediate hypersensitivity response |
2001-04-03 | Updated | TERM | immediate hypersensitivity response |
2001-03-30 | Added | TERM | immediate hypersensitivity response |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. |
2008-05-12 | Deleted | DEFINITION | An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. |
2007-08-09 | Deleted | SYNONYM | immediate hypersensitivity response |
2007-08-09 | Added | SYNONYM | immediate hypersensitivity response |
2006-09-19 | Updated | DEFINITION | An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. |
2004-04-19 | Added | SYNONYM | immediate hypersensitivity response |
2004-04-16 | Deleted | SYNONYM | immediate hypersensitivity response |
2004-02-05 | Added | SYNONYM | immediate hypersensitivity response |
2004-02-05 | Updated | DEFINITION | An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. |
2001-08-06 | Added | DEFINITION | An exaggerated immune response mediated by antibodies occurring within minutes after exposing a sensitized individual to the approximate antigen. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016064 (immunoglobulin mediated immune response) |
2008-04-01 | Updated | RELATION | is a GO:0002524 (hypersensitivity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-03-29 | Added | XREF | Wikipedia:Type_I_hypersensitivity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
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