This term is obsolete.
Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.

GO:0016068 JSON

type I hypersensitivity

Biological Process

Definition (GO:0016068 GONUTS page)

An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.

Comments

Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.

54 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
immediate hypersensitivity response exact

Ancestor Chart

Ancestor chart for GO:0016068
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016068

Child Term Relationship to
GO:0016068
regulation of type I hypersensitivity
regulates
negative regulation of type I hypersensitivity
negatively_regulates
positive regulation of type I hypersensitivity
positively_regulates
type I hypersensitivity mediated by mast cells
is_a
type I hypersensitivity mediated by basophils
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0016068 type I hypersensitivity Only in Taxon 7742 Vertebrata

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
Wikipedia Type_I_hypersensitivity

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016068 based on ALL annotations
The top 29 of 29 co-occurring terms
Co-occurring Term PR S% #Together #Compared
type I hypersensitivity
3,609,977.50 100.00 54 54
high-affinity IgE receptor activity
1,597,858.90 44.26 54 122
eosinophil degranulation
878,102.60 24.32 54 222
type 2 immune response
727,383.50 20.15 54 268
positive regulation of type I hypersensitivity
1,110,762.20 11.11 8 26
Fc-epsilon receptor signaling pathway
239,482.53 6.63 54 814
positive regulation of interleukin-3 production
300,831.47 5.63 8 96
serotonin secretion
257,855.53 5.06 8 112
positive regulation of mast cell cytokine production
142,265.12 3.21 8 203
mast cell degranulation
109,701.06 3.04 54 1,777
Totals 793 79554631
No co-occurrence statistics for GO:0016068 based on MANUAL annotations
The top 26 of 26 co-occurring terms
Co-occurring Term PR S% #Together #Compared
type I hypersensitivity
645,899.50 100.00 2 2
high-affinity IgE receptor activity
143,533.22 22.22 2 9
positive regulation of interleukin-3 production
129,179.90 16.67 1 5
serotonin secretion
49,684.58 7.14 1 13
eosinophil degranulation
43,059.97 6.67 2 30
positive regulation of type I hypersensitivity
43,059.97 6.25 1 15
type 2 immune response
36,908.54 5.71 2 35
IgE receptor activity
37,994.09 5.56 1 17
positive regulation of mast cell cytokine production
25,835.98 3.85 1 25
positive regulation of granulocyte macrophage colony-stimulating factor production
17,941.65 2.70 1 36
Totals 37 221222

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2009-03-29 Added XREF Wikipedia:Type_I_hypersensitivity
2008-05-13 Added DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2008-05-12 Deleted DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2008-04-01 Updated RELATION is a GO:0016064 (immunoglobulin mediated immune response)
2008-04-01 Updated RELATION is a GO:0002524 (hypersensitivity)
2007-08-09 Deleted SYNONYM immediate hypersensitivity response
2007-08-09 Added SYNONYM immediate hypersensitivity response
2006-09-19 Updated DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2004-04-19 Added SYNONYM immediate hypersensitivity response
Timestamp Action Category Detail
2004-02-05 Updated TERM type I hypersensitivity
2002-02-06 Updated TERM immediate hypersensitivity response
2001-04-03 Updated TERM immediate hypersensitivity response
2001-03-30 Added TERM immediate hypersensitivity response
Timestamp Action Category Detail
2008-05-13 Added DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2008-05-12 Deleted DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2007-08-09 Deleted SYNONYM immediate hypersensitivity response
2007-08-09 Added SYNONYM immediate hypersensitivity response
2006-09-19 Updated DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2004-04-19 Added SYNONYM immediate hypersensitivity response
2004-04-16 Deleted SYNONYM immediate hypersensitivity response
2004-02-05 Added SYNONYM immediate hypersensitivity response
2004-02-05 Updated DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2001-08-06 Added DEFINITION An exaggerated immune response mediated by antibodies occurring within minutes after exposing a sensitized individual to the approximate antigen.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016064 (immunoglobulin mediated immune response)
2008-04-01 Updated RELATION is a GO:0002524 (hypersensitivity)
Timestamp Action Category Detail
2009-03-29 Added XREF Wikipedia:Type_I_hypersensitivity
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
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