This term is obsolete.
Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.

GO:0016068 JSON

type I hypersensitivity

Biological Process

Definition (GO:0016068 GONUTS page)

An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.

Comments

Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.

54 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
immediate hypersensitivity response exact

Ancestor Chart

Ancestor chart for GO:0016068
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016068

Child Term Relationship to
GO:0016068
negative regulation of type I hypersensitivity
negatively_regulates
type I hypersensitivity mediated by basophils
is_a
type I hypersensitivity mediated by mast cells
is_a
regulation of type I hypersensitivity
regulates
positive regulation of type I hypersensitivity
positively_regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0016068 type I hypersensitivity Only in Taxon 7742 Vertebrata

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
Wikipedia Type_I_hypersensitivity

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016068 based on ALL annotations
The top 28 of 28 co-occurring terms
Co-occurring Term PR S% #Together #Compared
type I hypersensitivity
3,669,534.80 100.00 54 54
high-affinity IgE receptor activity
1,585,239.00 43.20 54 125
eosinophil degranulation
892,589.50 24.32 54 222
type 2 immune response
717,952.44 19.57 54 276
positive regulation of type I hypersensitivity
1,129,087.50 11.11 8 26
Fc-epsilon receptor signaling pathway
237,595.75 6.47 54 834
positive regulation of interleukin-3 production
305,794.53 5.63 8 96
serotonin secretion
257,511.20 5.00 8 114
positive regulation of mast cell cytokine production
144,612.19 3.21 8 203
mast cell degranulation
111,260.45 3.03 54 1,781
Totals 791 81399598
No co-occurrence statistics for GO:0016068 based on MANUAL annotations
The top 25 of 25 co-occurring terms
Co-occurring Term PR S% #Together #Compared
type I hypersensitivity
705,766.50 100.00 2 2
high-affinity IgE receptor activity
128,321.19 18.18 2 11
positive regulation of interleukin-3 production
141,153.30 16.67 1 5
serotonin secretion
54,289.73 7.14 1 13
eosinophil degranulation
47,051.10 6.67 2 30
positive regulation of type I hypersensitivity
47,051.10 6.25 1 15
IgE receptor activity
41,515.68 5.56 1 17
type 2 immune response
32,826.35 4.65 2 43
positive regulation of mast cell cytokine production
28,230.66 3.85 1 25
positive regulation of granulocyte macrophage colony-stimulating factor production
19,604.63 2.70 1 36
Totals 36 238086

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2009-03-29 Added XREF Wikipedia:Type_I_hypersensitivity
2008-05-13 Added DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2008-05-12 Deleted DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2008-04-01 Updated RELATION is a GO:0002524 (hypersensitivity)
2008-04-01 Updated RELATION is a GO:0016064 (immunoglobulin mediated immune response)
2007-08-09 Added SYNONYM immediate hypersensitivity response
2007-08-09 Deleted SYNONYM immediate hypersensitivity response
2006-09-19 Updated DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2004-04-19 Added SYNONYM immediate hypersensitivity response
Timestamp Action Category Detail
2004-02-05 Updated TERM type I hypersensitivity
2002-02-06 Updated TERM immediate hypersensitivity response
2001-04-03 Updated TERM immediate hypersensitivity response
2001-03-30 Added TERM immediate hypersensitivity response
Timestamp Action Category Detail
2008-05-13 Added DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2008-05-12 Deleted DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2007-08-09 Added SYNONYM immediate hypersensitivity response
2007-08-09 Deleted SYNONYM immediate hypersensitivity response
2006-09-19 Updated DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2004-04-19 Added SYNONYM immediate hypersensitivity response
2004-04-16 Deleted SYNONYM immediate hypersensitivity response
2004-02-05 Updated DEFINITION An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
2004-02-05 Added SYNONYM immediate hypersensitivity response
2001-08-06 Added DEFINITION An exaggerated immune response mediated by antibodies occurring within minutes after exposing a sensitized individual to the approximate antigen.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0002524 (hypersensitivity)
2008-04-01 Updated RELATION is a GO:0016064 (immunoglobulin mediated immune response)
Timestamp Action Category Detail
2009-03-29 Added XREF Wikipedia:Type_I_hypersensitivity
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
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