This term is obsolete.

GO:0016152 JSON

mercury (II) reductase (NADP+) activity

Molecular Function

Definition (GO:0016152 GONUTS page)

Catalysis of the reaction: H+ + Hg + NADP+ = Hg2+ + NADPH.

Secondary IDs

GO:0018692

6,085 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
mer A related
mercuric reductase activity related
mercurate(II) reductase activity related
reduced NADP:mercuric ion oxidoreductase activity related
Hg:NADP+ oxidoreductase activity related
mercury reductase activity related
mercuric ion reductase activity related
mercury(II) reductase activity related

Ancestor Chart

Ancestor chart for GO:0016152
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A6K252 10116 A6K252_RAT GO:0016723 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.16.1.1
InterPro IPR021179 Mercury(II) reductase
KEGG_REACTION R02807
MetaCyc MERCURY-II-REDUCTASE-RXN
RHEA 23856
UM-BBD_reactionID r0406

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:16793 mercury(2+)
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:16170 mercury(0)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016152 based on ALL annotations
The top 40 of 40 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mercury (II) reductase (NADP+) activity
32,564.48 100.00 6,085 6,085
detoxification of mercury ion
31,907.66 74.68 4,615 4,710
mercury ion binding
14,570.98 39.16 4,615 10,314
response to mercury ion
8,883.70 25.00 4,558 16,708
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
3,684.23 11.17 5,456 48,225
NAD(P)H dehydrogenase (quinone) activity
1,617.94 4.96 5,914 119,032
alkylmercury lyase activity
891.69 0.86 75 2,739
NADP binding
169.97 0.52 4,615 884,170
flavin adenine dinucleotide binding
115.12 0.35 5,999 1,696,922
nucleotide binding
83.39 0.26 4,932 1,925,949
Totals 58081 184731995
No co-occurrence statistics for GO:0016152 based on MANUAL annotations
The top 0 of 0 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Totals 0 0

Change Log

Timestamp Action Category Detail
2024-06-13 Updated TERM mercury (II) reductase (NADP+) activity
2022-09-01 Added DEFINITION Catalysis of the reaction: H+ + Hg + NADP+ = Hg2+ + NADPH.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH.
2020-10-08 Added SYNONYM mercuric reductase activity
2020-10-08 Added SYNONYM reduced NADP:mercuric ion oxidoreductase activity
2020-10-08 Deleted SYNONYM reduced NADP:mercuric ion oxidoreductase activity
2020-10-08 Deleted SYNONYM mercury(II) reductase activity
2020-10-08 Deleted SYNONYM mercury reductase activity
2020-10-08 Deleted SYNONYM mercuric ion reductase activity
2020-10-08 Deleted SYNONYM mercurate(II) reductase activity
Timestamp Action Category Detail
2024-06-13 Updated TERM mercury (II) reductase (NADP+) activity
2003-03-19 Updated TERM mercury (II) reductase activity
2002-02-06 Updated TERM mercury (II) reductase
2001-04-03 Updated TERM mercury (II) reductase
2001-03-30 Added TERM mercury (II) reductase
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: H+ + Hg + NADP+ = Hg2+ + NADPH.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH.
2020-10-08 Added SYNONYM mercuric reductase activity
2020-10-08 Added SYNONYM reduced NADP:mercuric ion oxidoreductase activity
2020-10-08 Deleted SYNONYM reduced NADP:mercuric ion oxidoreductase activity
2020-10-08 Deleted SYNONYM mercury(II) reductase activity
2020-10-08 Deleted SYNONYM mercury reductase activity
2020-10-08 Deleted SYNONYM mercuric ion reductase activity
2020-10-08 Deleted SYNONYM mercurate(II) reductase activity
2020-10-08 Deleted SYNONYM Hg:NADP+ oxidoreductase activity
2020-10-08 Added SYNONYM mercury(II) reductase activity
2020-10-08 Deleted SYNONYM mercuric reductase activity
2020-10-08 Added SYNONYM mercury reductase activity
2020-10-08 Added SYNONYM mercuric ion reductase activity
2020-10-08 Added SYNONYM Hg:NADP+ oxidoreductase activity
2020-10-08 Added SYNONYM mercurate(II) reductase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: Hg + NADP+ + H+ = Hg2+ + NADPH + H+.
2010-10-11 Added DEFINITION Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH.
2008-05-13 Added DEFINITION Catalysis of the reaction: Hg + NADP+ + H+ = Hg2+ + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: Hg + NADP+ + H+ = Hg2+ + NADPH + H+.
2007-11-08 Added SYNONYM mercuric ion reductase activity
2007-11-08 Added SYNONYM mercury reductase activity
2007-11-08 Added SYNONYM mercury(II) reductase activity
2007-11-08 Added SYNONYM reduced NADP:mercuric ion oxidoreductase activity
2007-11-08 Added SYNONYM Hg:NADP+ oxidoreductase activity
2007-11-08 Added SYNONYM mercurate(II) reductase activity
2007-11-08 Added SYNONYM mer A
2007-09-06 Deleted SYNONYM mercuric reductase
2007-09-06 Added SYNONYM mercuric reductase activity
2007-08-09 Deleted SYNONYM mercuric reductase
2007-08-09 Added SYNONYM mercuric reductase
2004-04-19 Added SYNONYM mercuric reductase
2004-04-16 Deleted SYNONYM mercuric reductase
2003-10-27 Added SYNONYM mercuric reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: Hg + NADP+ + H+ = Hg2+ + NADPH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016723 (oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R02807
2019-06-20 Added XREF KEGG_REACTION:R02807
2018-07-13 Deleted XREF RHEA:23859
2018-07-13 Added XREF RHEA:23856
2011-05-03 Added XREF UM-BBD_reactionID:r0406
2011-05-03 Deleted XREF UM-BBD_enzymeID:e0056
2010-10-11 Added XREF RHEA:23859
2010-10-11 Added XREF KEGG:R02807
2009-05-21 Added XREF MetaCyc:MERCURY-II-REDUCTASE-RXN
2009-05-21 Deleted XREF MetaCyc:MERCURY-(II)-REDUCTASE-RXN
2003-10-27 Added XREF UM-BBD_enzymeID:e0056
2003-10-27 Added XREF MetaCyc:MERCURY-(II)-REDUCTASE-RXN
2001-03-30 Added XREF EC:1.16.1.1
Timestamp Action Category Detail
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