GO:0016521
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pituitary adenylate cyclase activating polypeptide activity
Molecular Function
Definition (GO:0016521 GONUTS page)
The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. PMID:19805477
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
pituitary adenylyl cyclase activating polypeptide activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O16262 | 6239 | NIPI4_CAEEL | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O95970 | 9606 | LGI1_HUMAN | GO:0005102 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223 | |
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | Q8K4Y5 | 10116 | LGI1_RAT | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016521 based on ALL annotations
The top 71 of 71 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pituitary adenylate cyclase activating polypeptide activity
|
152,893.17 | 100.00 | 1,275 | 1,275 |
peptide hormone receptor binding
|
47,701.74 | 30.87 | 1,233 | 3,952 |
regulation of protein localization
|
10,241.61 | 6.70 | 1,275 | 19,034 |
neuropeptide hormone activity
|
8,915.16 | 5.83 | 1,275 | 21,866 |
positive regulation of chemokine (C-C motif) ligand 5 production
|
30,184.92 | 5.58 | 92 | 466 |
positive regulation of ERK1 and ERK2 cascade
|
5,472.99 | 3.58 | 1,233 | 34,445 |
perikaryon
|
5,467.00 | 3.57 | 1,226 | 34,287 |
neuron projection development
|
3,064.28 | 2.00 | 1,233 | 61,521 |
neuropeptide signaling pathway
|
2,231.16 | 1.46 | 1,233 | 84,493 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
1,791.27 | 1.17 | 1,275 | 108,827 |
Totals | 14806 | 70975782 |
No co-occurrence statistics for GO:0016521 based on MANUAL annotations
The top 62 of 62 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pituitary adenylate cyclase activating polypeptide activity
|
47,844.41 | 100.00 | 27 | 27 |
type 2 vasoactive intestinal polypeptide receptor binding
|
43,059.97 | 32.14 | 9 | 10 |
peptide hormone receptor binding
|
10,311.30 | 21.19 | 25 | 116 |
type 1 vasoactive intestinal polypeptide receptor binding
|
14,848.27 | 19.15 | 9 | 29 |
positive regulation of growth hormone secretion
|
7,811.33 | 11.76 | 8 | 49 |
neuropeptide hormone activity
|
2,916.02 | 6.09 | 27 | 443 |
positive regulation of chemokine (C-C motif) ligand 5 production
|
6,834.92 | 5.13 | 2 | 14 |
positive regulation of protein kinase activity
|
2,518.13 | 4.44 | 6 | 114 |
perikaryon
|
2,049.20 | 4.25 | 23 | 537 |
negative regulation of acute inflammatory response to non-antigenic stimulus
|
47,844.41 | 3.70 | 1 | 1 |
Totals | 385 | 220101 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-29 | Added | DEFINITION | The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. |
2008-04-01 | Updated | RELATION | is a GO:0005179 (hormone activity) |
2007-08-09 | Added | SYNONYM | pituitary adenylyl cyclase activating polypeptide activity |
2007-08-09 | Deleted | SYNONYM | pituitary adenylyl cyclase activating polypeptide activity |
2004-09-03 | Added | SYNONYM | pituitary adenylyl cyclase activating polypeptide activity |
2003-03-19 | Updated | TERM | pituitary adenylate cyclase activating polypeptide activity |
2002-02-06 | Updated | TERM | pituitary adenylate cyclase activating polypeptide |
2001-04-03 | Updated | TERM | pituitary adenylate cyclase activating polypeptide |
2001-03-30 | Added | TERM | pituitary adenylate cyclase activating polypeptide |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | pituitary adenylate cyclase activating polypeptide activity |
2002-02-06 | Updated | TERM | pituitary adenylate cyclase activating polypeptide |
2001-04-03 | Updated | TERM | pituitary adenylate cyclase activating polypeptide |
2001-03-30 | Added | TERM | pituitary adenylate cyclase activating polypeptide |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-29 | Added | DEFINITION | The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. |
2007-08-09 | Added | SYNONYM | pituitary adenylyl cyclase activating polypeptide activity |
2007-08-09 | Deleted | SYNONYM | pituitary adenylyl cyclase activating polypeptide activity |
2004-09-03 | Added | SYNONYM | pituitary adenylyl cyclase activating polypeptide activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0005179 (hormone activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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