This term is obsolete.

GO:0016521 JSON

pituitary adenylate cyclase activating polypeptide activity

Molecular Function

Definition (GO:0016521 GONUTS page)

The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. PMID:19805477

1,302 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
pituitary adenylyl cyclase activating polypeptide activity exact

Ancestor Chart

Ancestor chart for GO:0016521
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O95970 9606 LGI1_HUMAN GO:0005102 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein Q8K4Y5 10116 LGI1_RAT GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016521 based on ALL annotations
The top 71 of 71 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pituitary adenylate cyclase activating polypeptide activity
152,893.17 100.00 1,275 1,275
peptide hormone receptor binding
47,701.74 30.87 1,233 3,952
regulation of protein localization
10,241.61 6.70 1,275 19,034
neuropeptide hormone activity
8,915.16 5.83 1,275 21,866
positive regulation of chemokine (C-C motif) ligand 5 production
30,184.92 5.58 92 466
positive regulation of ERK1 and ERK2 cascade
5,472.99 3.58 1,233 34,445
perikaryon
5,467.00 3.57 1,226 34,287
neuron projection development
3,064.28 2.00 1,233 61,521
neuropeptide signaling pathway
2,231.16 1.46 1,233 84,493
adenylate cyclase-activating G protein-coupled receptor signaling pathway
1,791.27 1.17 1,275 108,827
Totals 14806 70975782
No co-occurrence statistics for GO:0016521 based on MANUAL annotations
The top 62 of 62 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pituitary adenylate cyclase activating polypeptide activity
47,844.41 100.00 27 27
type 2 vasoactive intestinal polypeptide receptor binding
43,059.97 32.14 9 10
peptide hormone receptor binding
10,311.30 21.19 25 116
type 1 vasoactive intestinal polypeptide receptor binding
14,848.27 19.15 9 29
positive regulation of growth hormone secretion
7,811.33 11.76 8 49
neuropeptide hormone activity
2,916.02 6.09 27 443
positive regulation of chemokine (C-C motif) ligand 5 production
6,834.92 5.13 2 14
positive regulation of protein kinase activity
2,518.13 4.44 6 114
perikaryon
2,049.20 4.25 23 537
negative regulation of acute inflammatory response to non-antigenic stimulus
47,844.41 3.70 1 1
Totals 385 220101

Change Log

Timestamp Action Category Detail
2010-10-29 Added DEFINITION The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.
2008-04-01 Updated RELATION is a GO:0005179 (hormone activity)
2007-08-09 Added SYNONYM pituitary adenylyl cyclase activating polypeptide activity
2007-08-09 Deleted SYNONYM pituitary adenylyl cyclase activating polypeptide activity
2004-09-03 Added SYNONYM pituitary adenylyl cyclase activating polypeptide activity
2003-03-19 Updated TERM pituitary adenylate cyclase activating polypeptide activity
2002-02-06 Updated TERM pituitary adenylate cyclase activating polypeptide
2001-04-03 Updated TERM pituitary adenylate cyclase activating polypeptide
2001-03-30 Added TERM pituitary adenylate cyclase activating polypeptide
Timestamp Action Category Detail
2003-03-19 Updated TERM pituitary adenylate cyclase activating polypeptide activity
2002-02-06 Updated TERM pituitary adenylate cyclase activating polypeptide
2001-04-03 Updated TERM pituitary adenylate cyclase activating polypeptide
2001-03-30 Added TERM pituitary adenylate cyclase activating polypeptide
Timestamp Action Category Detail
2010-10-29 Added DEFINITION The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation.
2007-08-09 Added SYNONYM pituitary adenylyl cyclase activating polypeptide activity
2007-08-09 Deleted SYNONYM pituitary adenylyl cyclase activating polypeptide activity
2004-09-03 Added SYNONYM pituitary adenylyl cyclase activating polypeptide activity
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0005179 (hormone activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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