GO:0016639
JSON
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Molecular Function
Definition (GO:0016639 GONUTS page)
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
Ancestor Chart
Ancestor chart for GO:0016639
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0016639
Child Term | Relationship to GO:0016639 |
---|---|
glycine dehydrogenase activity
|
is_a |
phenylalanine dehydrogenase activity
|
is_a |
valine dehydrogenase (NADP+) activity
|
is_a |
tryptophan dehydrogenase activity
|
is_a |
N-methylalanine dehydrogenase activity
|
is_a |
2,4-diaminopentanoate dehydrogenase activity
|
is_a |
L-amino-acid dehydrogenase activity
|
is_a |
dehydroquinate synthase activity
|
is_a |
lysine dehydrogenase activity
|
is_a |
L-leucine dehydrogenase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.4.1.- | |
InterPro | IPR006005 | Glutamate synthase, NADH/NADPH, small subunit 1 |
InterPro | IPR014362 | Glutamate dehydrogenase |
InterPro | IPR016211 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, bacterial/archaeal |
InterPro | IPR023866 | 2,3-diaminopropionate biosynthesis protein SbnB |
InterPro | IPR033922 | NAD(P) binding domain of glutamate dehydrogenase |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016639 based on ALL annotations
The top 100 of 352 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
|
2,091.43 | 100.00 | 94,746 | 94,746 |
glutamate dehydrogenase [NAD(P)+] activity
|
2,000.49 | 39.18 | 37,791 | 39,509 |
glutamate dehydrogenase (NAD+) activity
|
1,223.19 | 26.86 | 31,446 | 53,767 |
glutamate biosynthetic process
|
699.01 | 24.31 | 44,649 | 133,589 |
glutamate catabolic process
|
965.37 | 22.34 | 28,627 | 62,019 |
glutamate dehydrogenase (NADP+) activity
|
1,770.86 | 22.01 | 21,715 | 25,646 |
amino acid metabolic process
|
225.70 | 10.24 | 63,291 | 586,483 |
aspartate dehydrogenase activity
|
1,564.69 | 5.11 | 4,931 | 6,591 |
glutamate synthase (NADPH) activity
|
412.15 | 4.04 | 4,584 | 23,261 |
glutamate synthase (NADH) activity
|
1,308.21 | 3.17 | 3,065 | 4,900 |
Totals | 581046 | 105854781 |
No co-occurrence statistics for GO:0016639 based on MANUAL annotations
The top 8 of 8 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
|
470,511.00 | 100.00 | 3 | 3 |
glycolate catabolic process
|
20,457.00 | 4.00 | 1 | 23 |
arginine metabolic process
|
5,808.78 | 1.20 | 1 | 81 |
siderophore biosynthetic process
|
5,668.81 | 1.18 | 1 | 83 |
NADH binding
|
4,568.07 | 0.95 | 1 | 103 |
arginine catabolic process
|
4,438.78 | 0.93 | 1 | 106 |
glyoxylate catabolic process
|
3,290.29 | 0.69 | 1 | 143 |
cytoplasm
|
4.76 | 0.00 | 2 | 197,513 |
Totals | 11 | 198055 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-04 | Deleted | XREF | EC:1.4.1 |
2021-01-04 | Added | XREF | EC:1.4.1.- |
2008-05-13 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2008-05-12 | Deleted | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2008-04-01 | Updated | RELATION | is a GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors) |
2006-02-09 | Deleted | XREF | EC:1.4.1.- |
2006-02-09 | Added | XREF | EC:1.4.1 |
2003-10-31 | Updated | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2003-09-25 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD or NADP. |
2003-03-25 | Updated | TERM | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-25 | Updated | TERM | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
2003-03-19 | Updated | TERM | oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor activity |
2002-02-06 | Updated | TERM | oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
2001-04-03 | Updated | TERM | oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
2001-03-30 | Added | TERM | oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2008-05-12 | Deleted | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2003-10-31 | Updated | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2003-09-25 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD or NADP. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-04 | Deleted | XREF | EC:1.4.1 |
2021-01-04 | Added | XREF | EC:1.4.1.- |
2006-02-09 | Deleted | XREF | EC:1.4.1.- |
2006-02-09 | Added | XREF | EC:1.4.1 |
2001-03-30 | Added | XREF | EC:1.4.1.- |
Timestamp | Action | Category | Detail |
---|
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