This term is obsolete.

GO:0016639 JSON

oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Molecular Function

Definition (GO:0016639 GONUTS page)

Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

216,822 annotations

Ancestor Chart

Ancestor chart for GO:0016639
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016639

Child Term Relationship to
GO:0016639
glutamate dehydrogenase [NAD(P)+] activity
is_a
glycine dehydrogenase activity
is_a
phenylalanine dehydrogenase activity
is_a
valine dehydrogenase (NAD+) activity
is_a
lysine 6-dehydrogenase activity
is_a
valine dehydrogenase (NADP+) activity
is_a
N-methylalanine dehydrogenase activity
is_a
tryptophan dehydrogenase activity
is_a
2,4-diaminopentanoate dehydrogenase activity
is_a
L-amino-acid dehydrogenase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.4.1.-
InterPro IPR006005 Glutamate synthase, NADH/NADPH, small subunit 1
InterPro IPR014362 Glutamate dehydrogenase
InterPro IPR016211 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, bacterial/archaeal
InterPro IPR023866 2,3-diaminopropionate biosynthesis protein SbnB
InterPro IPR033922 NAD(P) binding domain of glutamate dehydrogenase

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016639 based on ALL annotations
The top 100 of 342 co-occurring terms
Co-occurring Term PR S% #Together #Compared
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
2,101.90 100.00 92,744 92,744
glutamate dehydrogenase [NAD(P)+] activity
2,011.63 39.51 37,305 38,979
glutamate dehydrogenase (NAD+) activity
1,229.13 26.95 30,904 52,848
glutamate biosynthetic process
703.22 24.35 43,779 130,854
glutamate catabolic process
974.92 22.40 28,032 60,436
glutamate dehydrogenase (NADP+) activity
1,780.69 22.18 21,432 25,298
amino acid metabolic process
241.82 10.89 62,110 539,854
aspartate dehydrogenase activity
1,580.51 5.13 4,838 6,434
glutamate synthase (NADPH) activity
414.60 4.15 4,636 23,503
glutamate synthase (NADH) activity
1,294.59 3.13 2,965 4,814
Totals 570933 106297750
No co-occurrence statistics for GO:0016639 based on MANUAL annotations
The top 7 of 7 co-occurring terms
Co-occurring Term PR S% #Together #Compared
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
430,599.70 100.00 3 3
glycolate catabolic process
35,883.31 7.14 1 12
siderophore biosynthetic process
7,298.30 1.64 1 59
arginine metabolic process
5,818.91 1.32 1 74
NADH binding
4,580.85 1.04 1 94
arginine catabolic process
4,439.17 1.01 1 97
glyoxylate catabolic process
3,337.98 0.76 1 129
Totals 9 468

Change Log

Timestamp Action Category Detail
2021-01-04 Deleted XREF EC:1.4.1
2021-01-04 Added XREF EC:1.4.1.-
2008-05-13 Added DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
2008-05-12 Deleted DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
2008-04-01 Updated RELATION is a GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors)
2006-02-09 Added XREF EC:1.4.1
2006-02-09 Deleted XREF EC:1.4.1.-
2003-10-31 Updated DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
2003-09-25 Added DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD or NADP.
2003-03-25 Updated TERM oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Timestamp Action Category Detail
2003-03-25 Updated TERM oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
2003-03-19 Updated TERM oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor activity
2002-02-06 Updated TERM oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
2001-04-03 Updated TERM oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
2001-03-30 Added TERM oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
2008-05-12 Deleted DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
2003-10-31 Updated DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
2003-09-25 Added DEFINITION Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD or NADP.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors)
Timestamp Action Category Detail
2021-01-04 Deleted XREF EC:1.4.1
2021-01-04 Added XREF EC:1.4.1.-
2006-02-09 Added XREF EC:1.4.1
2006-02-09 Deleted XREF EC:1.4.1.-
2001-03-30 Added XREF EC:1.4.1.-
Timestamp Action Category Detail
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