GO:0016639
JSON
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Molecular Function
Definition (GO:0016639 GONUTS page)
Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
Ancestor Chart
Ancestor chart for GO:0016639
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0016639
Child Term | Relationship to GO:0016639 |
---|---|
glutamate dehydrogenase [NAD(P)+] activity
|
is_a |
glycine dehydrogenase activity
|
is_a |
phenylalanine dehydrogenase activity
|
is_a |
valine dehydrogenase (NAD+) activity
|
is_a |
lysine 6-dehydrogenase activity
|
is_a |
valine dehydrogenase (NADP+) activity
|
is_a |
N-methylalanine dehydrogenase activity
|
is_a |
tryptophan dehydrogenase activity
|
is_a |
2,4-diaminopentanoate dehydrogenase activity
|
is_a |
L-amino-acid dehydrogenase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.4.1.- | |
InterPro | IPR006005 | Glutamate synthase, NADH/NADPH, small subunit 1 |
InterPro | IPR014362 | Glutamate dehydrogenase |
InterPro | IPR016211 | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, bacterial/archaeal |
InterPro | IPR023866 | 2,3-diaminopropionate biosynthesis protein SbnB |
InterPro | IPR033922 | NAD(P) binding domain of glutamate dehydrogenase |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016639 based on ALL annotations
The top 100 of 342 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
|
2,101.90 | 100.00 | 92,744 | 92,744 |
glutamate dehydrogenase [NAD(P)+] activity
|
2,011.63 | 39.51 | 37,305 | 38,979 |
glutamate dehydrogenase (NAD+) activity
|
1,229.13 | 26.95 | 30,904 | 52,848 |
glutamate biosynthetic process
|
703.22 | 24.35 | 43,779 | 130,854 |
glutamate catabolic process
|
974.92 | 22.40 | 28,032 | 60,436 |
glutamate dehydrogenase (NADP+) activity
|
1,780.69 | 22.18 | 21,432 | 25,298 |
amino acid metabolic process
|
241.82 | 10.89 | 62,110 | 539,854 |
aspartate dehydrogenase activity
|
1,580.51 | 5.13 | 4,838 | 6,434 |
glutamate synthase (NADPH) activity
|
414.60 | 4.15 | 4,636 | 23,503 |
glutamate synthase (NADH) activity
|
1,294.59 | 3.13 | 2,965 | 4,814 |
Totals | 570933 | 106297750 |
No co-occurrence statistics for GO:0016639 based on MANUAL annotations
The top 7 of 7 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
|
430,599.70 | 100.00 | 3 | 3 |
glycolate catabolic process
|
35,883.31 | 7.14 | 1 | 12 |
siderophore biosynthetic process
|
7,298.30 | 1.64 | 1 | 59 |
arginine metabolic process
|
5,818.91 | 1.32 | 1 | 74 |
NADH binding
|
4,580.85 | 1.04 | 1 | 94 |
arginine catabolic process
|
4,439.17 | 1.01 | 1 | 97 |
glyoxylate catabolic process
|
3,337.98 | 0.76 | 1 | 129 |
Totals | 9 | 468 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-04 | Deleted | XREF | EC:1.4.1 |
2021-01-04 | Added | XREF | EC:1.4.1.- |
2008-05-13 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2008-05-12 | Deleted | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2008-04-01 | Updated | RELATION | is a GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors) |
2006-02-09 | Added | XREF | EC:1.4.1 |
2006-02-09 | Deleted | XREF | EC:1.4.1.- |
2003-10-31 | Updated | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2003-09-25 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD or NADP. |
2003-03-25 | Updated | TERM | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-25 | Updated | TERM | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
2003-03-19 | Updated | TERM | oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor activity |
2002-02-06 | Updated | TERM | oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
2001-04-03 | Updated | TERM | oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
2001-03-30 | Added | TERM | oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2008-05-12 | Deleted | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2003-10-31 | Updated | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. |
2003-09-25 | Added | DEFINITION | Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD or NADP. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-04 | Deleted | XREF | EC:1.4.1 |
2021-01-04 | Added | XREF | EC:1.4.1.- |
2006-02-09 | Added | XREF | EC:1.4.1 |
2006-02-09 | Deleted | XREF | EC:1.4.1.- |
2001-03-30 | Added | XREF | EC:1.4.1.- |
Timestamp | Action | Category | Detail |
---|
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