This term is obsolete.

GO:0016656 JSON

monodehydroascorbate reductase (NADH) activity

Molecular Function

Definition (GO:0016656 GONUTS page)

Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate.

223 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
SDA reductase activity related
NADH:monodehydroascorbate oxidoreductase activity related
semidehydroascorbate reductase activity related
NADH-semidehydroascorbate oxidoreductase activity related
MDHA related
AFR related
NADH:ascorbate radical oxidoreductase activity related
AFR-reductase activity related
NADH:AFR oxidoreductase activity related
ascorbic free radical reductase activity related

Ancestor Chart

Ancestor chart for GO:0016656
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.6.5.4
MetaCyc 1.6.5.4-RXN
RHEA 14581

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:59513 monodehydro-L-ascorbate(1-)
has_participant CHEBI CHEBI:38290 L-ascorbate

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016656 based on ALL annotations
The top 64 of 64 co-occurring terms
Co-occurring Term PR S% #Together #Compared
monodehydroascorbate reductase (NADH) activity
930,304.50 100.00 213 213
response to oxygen radical
398,701.94 1.38 3 7
regulation of biological process involved in symbiotic interaction
232,576.14 0.46 1 4
stromule
3,389.09 0.26 2 549
peroxisomal matrix
1,116.77 0.12 34 28,323
oxidoreductase activity, acting on NAD(P)H
458.33 0.05 142 288,228
cellular response to carbon dioxide
411.64 0.04 2 4,520
response to jasmonic acid
407.49 0.04 1 2,283
positive regulation of phagocytosis
376.95 0.04 2 4,936
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
363.77 0.04 5 12,787
Totals 1023 221040222
No co-occurrence statistics for GO:0016656 based on MANUAL annotations
The top 33 of 33 co-occurring terms
Co-occurring Term PR S% #Together #Compared
monodehydroascorbate reductase (NADH) activity
176,441.62 100.00 8 8
response to oxygen radical
75,617.84 25.00 3 7
L-ascorbic acid binding
44,110.41 14.29 2 8
regulation of biological process involved in symbiotic interaction
88,220.81 11.11 1 2
cellular oxidant detoxification
12,309.88 6.25 3 43
carbon utilization
7,057.67 3.57 2 50
cellular response to carbon dioxide
5,784.97 2.99 2 61
antioxidant activity
4,103.29 2.17 2 86
response to symbiotic fungus
2,714.49 1.39 1 65
carbonate dehydratase activity
989.39 0.56 3 535
Totals 57 515111

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM AFR-reductase activity
2020-10-08 Deleted SYNONYM ascorbate free radical reductase activity
2020-10-08 Added SYNONYM NADH-semidehydroascorbate oxidoreductase activity
2020-10-08 Added SYNONYM ascorbate free radical reductase activity
2020-10-08 Added SYNONYM NADH:ascorbate radical oxidoreductase activity
2020-10-08 Added SYNONYM MDAsA reductase (NADPH)
2020-10-08 Added SYNONYM semidehydroascorbate reductase activity
2020-10-08 Added SYNONYM NADH:semidehydroascorbic acid oxidoreductase activity
2020-10-08 Added SYNONYM NADH:monodehydroascorbate oxidoreductase activity
2020-10-08 Added SYNONYM NADH:AFR oxidoreductase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM monodehydroascorbate reductase (NADH) activity
2002-05-21 Updated TERM monodehydroascorbate reductase (NADH)
2002-03-31 Updated TERM monodehydroascorbate reductase (NADH2)
2002-02-06 Updated TERM monodehydroascorbate reductase (NADH)
2001-04-03 Updated TERM monodehydroascorbate reductase (NADH)
2001-03-30 Added TERM monodehydroascorbate reductase (NADH)
Timestamp Action Category Detail
2020-10-08 Added SYNONYM AFR-reductase activity
2020-10-08 Deleted SYNONYM ascorbate free radical reductase activity
2020-10-08 Added SYNONYM NADH-semidehydroascorbate oxidoreductase activity
2020-10-08 Added SYNONYM ascorbate free radical reductase activity
2020-10-08 Added SYNONYM NADH:ascorbate radical oxidoreductase activity
2020-10-08 Added SYNONYM MDAsA reductase (NADPH)
2020-10-08 Added SYNONYM semidehydroascorbate reductase activity
2020-10-08 Added SYNONYM NADH:semidehydroascorbic acid oxidoreductase activity
2020-10-08 Added SYNONYM NADH:monodehydroascorbate oxidoreductase activity
2020-10-08 Added SYNONYM NADH:AFR oxidoreductase activity
2020-10-08 Deleted SYNONYM semidehydroascorbate reductase activity
2020-10-08 Deleted SYNONYM ascorbic free radical reductase activity
2020-10-08 Deleted SYNONYM ascorbate free-radical reductase activity
2020-10-08 Added SYNONYM ascorbate free-radical reductase activity
2020-10-08 Added SYNONYM ascorbic free radical reductase activity
2020-10-08 Deleted SYNONYM AFR-reductase activity
2020-10-08 Deleted SYNONYM MDAsA reductase (NADPH)
2020-10-08 Deleted SYNONYM NADH-semidehydroascorbate oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH:AFR oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH:ascorbate radical oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH:monodehydroascorbate oxidoreductase activity
2020-10-08 Deleted SYNONYM NADH:semidehydroascorbic acid oxidoreductase activity
2020-10-08 Deleted SYNONYM SDA reductase activity
2020-10-08 Added SYNONYM SDA reductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate.
2007-11-08 Added SYNONYM semidehydroascorbate reductase activity
2007-11-08 Added SYNONYM NADH:AFR oxidoreductase activity
2007-11-08 Added SYNONYM NADH-semidehydroascorbate oxidoreductase activity
2007-11-08 Added SYNONYM MDHA
2007-11-08 Added SYNONYM MDAsA reductase (NADPH)
2007-11-08 Added SYNONYM AFR-reductase activity
2007-11-08 Added SYNONYM AFR
2007-11-08 Deleted SYNONYM monodehydroascorbate reductase
2007-11-08 Added SYNONYM monodehydroascorbate reductase activity
2007-11-08 Added SYNONYM ascorbic free radical reductase activity
2007-11-08 Added SYNONYM ascorbate free-radical reductase activity
2007-11-08 Added SYNONYM ascorbate free radical reductase activity
2007-11-08 Added SYNONYM SDA reductase activity
2007-11-08 Added SYNONYM NADH:semidehydroascorbic acid oxidoreductase activity
2007-11-08 Added SYNONYM NADH:monodehydroascorbate oxidoreductase activity
2007-11-08 Added SYNONYM NADH:ascorbate radical oxidoreductase activity
2007-08-09 Deleted SYNONYM monodehydroascorbate reductase
2007-08-09 Added SYNONYM monodehydroascorbate reductase
2004-04-19 Added SYNONYM monodehydroascorbate reductase
2004-04-16 Deleted SYNONYM monodehydroascorbate reductase
2003-10-27 Added SYNONYM monodehydroascorbate reductase
2003-08-18 Deleted SYNONYM monodehydroascorbate reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate.
2001-03-30 Added SYNONYM monodehydroascorbate reductase
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
Timestamp Action Category Detail
2018-07-13 Added XREF RHEA:14581
2018-07-13 Deleted XREF RHEA:14584
2011-09-16 Added XREF RHEA:14584
2003-10-27 Added XREF MetaCyc:1.6.5.4-RXN
2001-03-30 Added XREF EC:1.6.5.4
Timestamp Action Category Detail
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