This term is obsolete.

GO:0016768 JSON

spermine synthase activity

Molecular Function

Definition (GO:0016768 GONUTS page)

Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.

1,784 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity related
spermine synthetase activity related
spermidine aminopropyltransferase activity related

Ancestor Chart

Ancestor chart for GO:0016768
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.5.1.22
InterPro IPR015576 Spermine synthase, animal
MetaCyc SPERMINE-SYNTHASE-RXN
RHEA 19973
Reactome R-HSA-351210

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57834 spermidine(3+)
has_participant CHEBI CHEBI:45725 spermine(4+)
has_participant CHEBI CHEBI:57443 S-adenosylmethioninaminium
has_participant CHEBI CHEBI:17509 5'-S-methyl-5'-thioadenosine

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016768 based on ALL annotations
The top 61 of 61 co-occurring terms
Co-occurring Term PR S% #Together #Compared
spermine synthase activity
115,072.51 100.00 1,722 1,722
spermine biosynthetic process
24,337.81 21.04 1,681 7,948
spermine metabolic process
107,991.13 3.53 61 65
xylem vessel member cell differentiation
41,729.59 1.85 33 91
polyamine biosynthetic process
2,006.97 1.74 1,668 95,637
polyamine metabolic process
1,383.96 0.75 34 2,827
phloem or xylem histogenesis
1,026.32 0.61 33 3,700
auxin polar transport
544.74 0.38 33 6,971
spermidine synthase activity
329.09 0.27 82 28,673
thermospermine synthase activity
335.71 0.26 36 12,340
Totals 7467 273670220
No co-occurrence statistics for GO:0016768 based on MANUAL annotations
The top 19 of 19 co-occurring terms
Co-occurring Term PR S% #Together #Compared
spermine synthase activity
25,664.24 100.00 55 55
spermine biosynthetic process
4,263.96 16.51 53 319
spermine metabolic process
21,386.86 8.93 5 6
xylem vessel member cell differentiation
2,333.11 1.54 1 11
polyamine metabolic process
1,166.56 1.32 1 22
thermospermine synthase activity
251.61 0.64 1 102
spermidine synthase activity
194.43 0.63 2 264
polyamine biosynthetic process
154.60 0.45 1 166
methionine metabolic process
105.18 0.34 1 244
pantothenate biosynthetic process
97.21 0.31 1 264
Totals 136 400085

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM spermine synthetase activity
2020-10-08 Added SYNONYM S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity
2020-10-08 Added SYNONYM spermidine aminopropyltransferase activity
2020-10-08 Deleted SYNONYM spermidine aminopropyltransferase activity
2020-10-08 Deleted SYNONYM spermine synthetase activity
2020-10-08 Deleted SYNONYM S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity
2019-04-01 Added XREF Reactome:R-HSA-351210
2019-04-01 Deleted XREF reactome:R-HSA-351210
2018-12-11 Added XREF reactome:R-HSA-351210
2018-07-13 Added XREF RHEA:19973
Timestamp Action Category Detail
2003-03-19 Updated TERM spermine synthase activity
2002-02-06 Updated TERM spermine synthase
2001-04-03 Updated TERM spermine synthase
2001-03-30 Added TERM spermine synthase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM spermine synthetase activity
2020-10-08 Added SYNONYM S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity
2020-10-08 Added SYNONYM spermidine aminopropyltransferase activity
2020-10-08 Deleted SYNONYM spermidine aminopropyltransferase activity
2020-10-08 Deleted SYNONYM spermine synthetase activity
2020-10-08 Deleted SYNONYM S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.
2007-11-08 Added SYNONYM spermine synthetase activity
2007-11-08 Added SYNONYM S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity
2007-09-06 Added SYNONYM spermidine aminopropyltransferase activity
2003-03-19 Deleted SYNONYM spermine synthase
2002-11-27 Added DEFINITION Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.
2001-03-30 Added SYNONYM spermine synthase
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-351210
2019-04-01 Deleted XREF reactome:R-HSA-351210
2018-12-11 Added XREF reactome:R-HSA-351210
2018-07-13 Added XREF RHEA:19973
2018-07-13 Deleted XREF RHEA:19976
2011-09-16 Added XREF RHEA:19976
2003-10-27 Added XREF MetaCyc:SPERMINE-SYNTHASE-RXN
2001-03-30 Added XREF EC:2.5.1.22
Timestamp Action Category Detail
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