GO:0016768
JSON
spermine synthase activity
Molecular Function
Definition (GO:0016768 GONUTS page)
Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
spermine synthetase activity | related |
spermidine aminopropyltransferase activity | related |
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.5.1.22 | |
InterPro | IPR015576 | Spermine synthase, animal |
MetaCyc | SPERMINE-SYNTHASE-RXN | |
RHEA | 19973 | |
Reactome | R-HSA-351210 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57443 | S-adenosylmethioninaminium |
has_participant | CHEBI | CHEBI:17509 | 5'-S-methyl-5'-thioadenosine |
has_participant | CHEBI | CHEBI:45725 | spermine(4+) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57834 | spermidine(3+) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016768 based on ALL annotations
The top 62 of 62 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
spermine synthase activity
|
117,221.16 | 100.00 | 1,663 | 1,663 |
spermine biosynthetic process
|
25,103.34 | 21.30 | 1,622 | 7,574 |
spermine metabolic process
|
110,007.55 | 3.66 | 61 | 65 |
xylem vessel member cell differentiation
|
42,508.77 | 1.92 | 33 | 91 |
polyamine biosynthetic process
|
2,004.74 | 1.71 | 1,614 | 94,374 |
polyamine metabolic process
|
1,472.30 | 0.78 | 34 | 2,707 |
phloem or xylem histogenesis
|
1,147.18 | 0.66 | 33 | 3,372 |
thermospermine synthase activity
|
943.43 | 0.59 | 36 | 4,473 |
auxin polar transport
|
611.30 | 0.41 | 33 | 6,328 |
spermidine synthase activity
|
350.04 | 0.28 | 84 | 28,130 |
Totals | 7246 | 274147409 |
No co-occurrence statistics for GO:0016768 based on MANUAL annotations
The top 19 of 19 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
spermine synthase activity
|
28,082.59 | 100.00 | 46 | 46 |
spermine biosynthetic process
|
4,275.55 | 15.12 | 44 | 289 |
spermine metabolic process
|
23,402.16 | 10.64 | 5 | 6 |
xylem vessel member cell differentiation
|
2,552.96 | 1.79 | 1 | 11 |
polyamine metabolic process
|
1,276.48 | 1.49 | 1 | 22 |
thermospermine synthase activity
|
289.51 | 0.70 | 1 | 97 |
spermidine synthase activity
|
232.09 | 0.70 | 2 | 242 |
polyamine biosynthetic process
|
174.43 | 0.49 | 1 | 161 |
methionine metabolic process
|
123.71 | 0.37 | 1 | 227 |
phloem or xylem histogenesis
|
114.16 | 0.34 | 1 | 246 |
Totals | 118 | 376487 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity |
2020-10-08 | Added | SYNONYM | spermidine aminopropyltransferase activity |
2020-10-08 | Deleted | SYNONYM | spermidine aminopropyltransferase activity |
2020-10-08 | Deleted | SYNONYM | spermine synthetase activity |
2020-10-08 | Deleted | SYNONYM | S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity |
2020-10-08 | Added | SYNONYM | spermine synthetase activity |
2019-04-01 | Deleted | XREF | reactome:R-HSA-351210 |
2019-04-01 | Added | XREF | Reactome:R-HSA-351210 |
2018-12-11 | Added | XREF | reactome:R-HSA-351210 |
2018-07-13 | Added | XREF | RHEA:19973 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | spermine synthase activity |
2002-02-06 | Updated | TERM | spermine synthase |
2001-04-03 | Updated | TERM | spermine synthase |
2001-03-30 | Added | TERM | spermine synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity |
2020-10-08 | Added | SYNONYM | spermidine aminopropyltransferase activity |
2020-10-08 | Deleted | SYNONYM | spermidine aminopropyltransferase activity |
2020-10-08 | Deleted | SYNONYM | spermine synthetase activity |
2020-10-08 | Deleted | SYNONYM | S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity |
2020-10-08 | Added | SYNONYM | spermine synthetase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. |
2007-11-08 | Added | SYNONYM | spermine synthetase activity |
2007-11-08 | Added | SYNONYM | S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity |
2007-09-06 | Added | SYNONYM | spermidine aminopropyltransferase activity |
2003-03-19 | Deleted | SYNONYM | spermine synthase |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. |
2001-03-30 | Added | SYNONYM | spermine synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-351210 |
2019-04-01 | Added | XREF | Reactome:R-HSA-351210 |
2018-12-11 | Added | XREF | reactome:R-HSA-351210 |
2018-07-13 | Added | XREF | RHEA:19973 |
2018-07-13 | Deleted | XREF | RHEA:19976 |
2011-09-16 | Added | XREF | RHEA:19976 |
2003-10-27 | Added | XREF | MetaCyc:SPERMINE-SYNTHASE-RXN |
2001-03-30 | Added | XREF | EC:2.5.1.22 |
Timestamp | Action | Category | Detail |
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