This term is obsolete.

GO:0016925 JSON

protein sumoylation

Biological Process

Definition (GO:0016925 GONUTS page)

The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. PMID:11265250

Secondary IDs

GO:0006485, GO:0016927, GO:0019947, GO:0019951

42,464 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
Smt3-protein conjugation related
Smt3p-protein conjugation related
sumoylation exact
small ubiquitin-related protein 1 conjugation exact
protein sumolation exact
SUMO-protein conjugation exact

Ancestor Chart

Ancestor chart for GO:0016925
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016925

Child Term Relationship to
GO:0016925
protein autosumoylation
is_a
SUMO ligase complex
capable_of_part_of
positive regulation of protein sumoylation
positively_regulates
negative regulation of protein sumoylation
negatively_regulates
regulation of protein sumoylation
regulates

Cross-references

Database ID Description
InterPro IPR030661 SUMO-activating enzyme subunit Uba2
InterPro IPR033950 Sumo domain
Reactome R-HSA-2990846
Wikipedia SUMO_protein

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0019940 obsolete SUMO-dependent protein catabolic process consider GO:0016925

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0016925 based on ALL annotations
The top 100 of 1,238 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein sumoylation
4,780.46 100.00 41,451 41,451
SUMO ligase activity
4,769.31 53.60 22,247 22,299
SUMO activating enzyme activity
4,779.77 33.59 13,922 13,924
SUMO activating enzyme complex
4,780.46 33.49 13,883 13,883
SUMO transferase activity
4,579.72 21.64 9,057 9,454
regulation of macromolecule metabolic process
811.92 9.86 7,891 46,461
ubiquitin-like modifier activating enzyme activity
430.69 7.15 10,670 118,431
protein modification by small protein conjugation
979.27 6.36 3,498 17,076
Smc5-Smc6 complex
740.80 6.20 3,880 25,038
transcription coregulator activity
251.99 4.52 10,005 189,800
Totals 239323 17014710
No co-occurrence statistics for GO:0016925 based on MANUAL annotations
The top 100 of 776 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein sumoylation
838.20 100.00 1,684 1,684
SUMO ligase activity
831.61 37.36 631 636
ubiquitin-like protein ligase binding
572.79 22.50 423 619
SUMO activating enzyme activity
831.55 14.83 250 252
SUMO activating enzyme complex
838.20 14.79 249 249
protein tag activity
174.42 12.90 427 2,052
SUMO conjugating enzyme activity
838.20 11.88 200 200
Smc5-Smc6 complex
156.76 5.48 121 647
PML body
114.90 4.48 105 766
transcription factor binding
364.44 4.47 80 184
Totals 7275 376188

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-2990846
2021-08-30 Added SECONDARY GO:0019951 (Smt3-protein conjugation)
2021-08-30 Added SYNONYM Smt3p-protein conjugation
2021-08-30 Added SYNONYM Smt3-protein conjugation
2020-02-28 Deleted XREF MIPS_funcat:14.07.07
2019-05-04 Added XREF MIPS_funcat:14.07.07
2018-12-18 Deleted DEFINITION The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2018-12-18 Added DEFINITION The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2015-01-30 Added RELATION is a GO:0018205 (peptidyl-lysine modification)
2010-12-01 Deleted DEFINITION The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
Timestamp Action Category Detail
2002-02-06 Updated TERM protein sumoylation
2001-04-03 Updated TERM protein sumoylation
2001-03-30 Added TERM protein sumoylation
Timestamp Action Category Detail
2021-08-30 Added SYNONYM Smt3p-protein conjugation
2021-08-30 Added SYNONYM Smt3-protein conjugation
2018-12-18 Deleted DEFINITION The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2018-12-18 Added DEFINITION The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2010-12-01 Deleted DEFINITION The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2010-12-01 Added DEFINITION The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2008-05-13 Added DEFINITION The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2008-05-12 Deleted DEFINITION The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2007-09-10 Deleted SYNONYM SUMO-dependent protein catabolic process
2007-09-10 Deleted SYNONYM SUMO-dependent protein catabolism
2007-08-09 Added SYNONYM sumoylation
2007-08-09 Deleted SYNONYM SUMO-dependent protein catabolic process
2007-08-09 Added SYNONYM SUMO-dependent protein catabolic process
2007-08-09 Deleted SYNONYM sumoylation
2007-08-09 Deleted SYNONYM small ubiquitin-related protein 1 conjugation
2007-08-09 Added SYNONYM small ubiquitin-related protein 1 conjugation
2007-08-09 Added SYNONYM SUMO-dependent protein catabolism
2007-08-09 Added SYNONYM SUMO-protein conjugation
2007-08-09 Added SYNONYM protein sumolation
2007-08-09 Deleted SYNONYM SUMO-dependent protein catabolism
2007-08-09 Deleted SYNONYM protein sumolation
2007-08-09 Deleted SYNONYM SUMO-protein conjugation
2007-01-15 Added SYNONYM SUMO-dependent protein catabolic process
2005-08-10 Added SYNONYM SUMO-dependent protein catabolism
2004-04-19 Added SYNONYM protein sumolation
2004-04-19 Added SYNONYM sumoylation
2004-04-19 Added SYNONYM small ubiquitin-related protein 1 conjugation
2004-04-19 Added SYNONYM SUMO-protein conjugation
2004-04-16 Deleted SYNONYM SUMO-protein conjugation
2004-04-16 Deleted SYNONYM protein sumolation
2004-04-16 Deleted SYNONYM small ubiquitin-related protein 1 conjugation
2004-04-16 Deleted SYNONYM sumoylation
2003-08-18 Added SYNONYM protein sumolation
2003-05-08 Added SYNONYM sumoylation
2003-05-08 Added SYNONYM SUMO-protein conjugation
2003-05-08 Updated DEFINITION The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2003-04-24 Updated DEFINITION The posttranslational modification of a protein by a member of the SUMO protein family; SUMO proteins (small ubiquitin-related modifiers, otherwise known as sentrin) are present in all eukaryotic kingdoms and are highly conserved from yeast to humans. They seem to play a role in the nuclear import of protein and eventually serve as address tags for transport to PML bodies.
2002-11-27 Updated DEFINITION Post-translational modification of a protein by a member of the SUMO protein family; SUMO proteins (small ubuquitin-related modifiers, otherwise known as sentrin) are present in all eukaryotic kingdoms and are highly conserved from yeast to humans. They seem to play a role in the nuclear import of protein and eventually serve as address tags for transport to PML bodies.
2001-08-06 Added DEFINITION Post-translational modification of a protein by a member of the SUMO protein family; SUMO proteins (small ubuquitin-related modifiers, aka sentrin) are present in all eukaryotic kingdoms and are highly conserved from yeast to humans. They seem to play a role in the nuclear import of protein and eventually serve as address tags for transport to PML bodies.
2001-03-30 Added SYNONYM small ubiquitin-related protein 1 conjugation
Timestamp Action Category Detail
2015-01-30 Added RELATION is a GO:0018205 (peptidyl-lysine modification)
2010-10-17 Deleted RELATION is a GO:0006464 (cellular protein modification process)
2010-10-15 Added RELATION is a GO:0006464 (cellular protein modification process)
2010-10-15 Deleted RELATION is a GO:0043687 (post-translational protein modification)
2008-08-04 Added RELATION is a GO:0043687 (post-translational protein modification)
2008-04-01 Updated RELATION is a GO:0032446 (protein modification by small protein conjugation)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-2990846
2020-02-28 Deleted XREF MIPS_funcat:14.07.07
2019-05-04 Added XREF MIPS_funcat:14.07.07
2009-03-29 Added XREF Wikipedia:SUMO_protein
Timestamp Action Category Detail
2021-08-30 Added SECONDARY GO:0019951 (Smt3-protein conjugation)
2003-05-08 Added SECONDARY GO:0016927 (sumoylation)
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