GO:0016934
JSON
extracellularly glycine-gated chloride channel activity
Molecular Function
Definition (GO:0016934 GONUTS page)
Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Secondary IDs
GO:0004891
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
glycine receptor | broad |
glycine-inhibited chloride channel activity | related |
extracellular-glycine-gated chloride channel activity | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0016934 | extracellularly glycine-gated chloride channel activity | Only in Taxon | 33208 | Metazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2K0W3 | 10116 | A0A0G2K0W3_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZKP5 | 10116 | A0A8I5ZKP5_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZLE9 | 10116 | A0A8I5ZLE9_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZST4 | 10116 | A0A8I5ZST4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0PK00 | 9606 | T120B_HUMAN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HVQ8 | 10116 | A6HVQ8_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J168 | 10116 | A6J168_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J4P5 | 10116 | A6J4P5_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K1R8 | 10116 | A6K1R8_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR008060 | Glycine receptor beta |
InterPro | IPR008128 | Glycine receptor alpha1 |
InterPro | IPR008129 | Glycine receptor alpha2 |
InterPro | IPR008130 | Glycine receptor alpha3 |
Reactome | R-HSA-975389 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0016934 based on ALL annotations
The top 100 of 105 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extracellularly glycine-gated chloride channel activity
|
65,196.92 | 100.00 | 2,990 | 2,990 |
transmitter-gated monoatomic ion channel activity
|
30,324.53 | 36.34 | 1,867 | 4,014 |
glycinergic synapse
|
45,883.87 | 11.85 | 373 | 530 |
excitatory postsynaptic potential
|
4,971.66 | 7.63 | 2,990 | 39,210 |
glycine-gated chloride channel complex
|
65,196.92 | 7.22 | 216 | 216 |
glycine-gated chloride ion channel activity
|
64,269.94 | 6.95 | 208 | 211 |
synaptic transmission, glycinergic
|
37,874.51 | 6.41 | 201 | 346 |
cellular response to ethanol
|
16,887.35 | 5.64 | 201 | 776 |
righting reflex
|
19,111.16 | 5.56 | 192 | 655 |
startle response
|
8,361.13 | 5.36 | 252 | 1,965 |
Totals | 45252 | 112615274 |
No co-occurrence statistics for GO:0016934 based on MANUAL annotations
The top 77 of 77 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extracellularly glycine-gated chloride channel activity
|
46,135.68 | 100.00 | 28 | 28 |
glycinergic synapse
|
18,742.62 | 27.66 | 13 | 32 |
glycine-gated chloride channel complex
|
41,009.49 | 27.59 | 8 | 9 |
extracellularly glycine-gated ion channel activity
|
25,951.32 | 25.71 | 9 | 16 |
synaptic transmission, glycinergic
|
7,583.95 | 13.48 | 12 | 73 |
negative regulation of transmission of nerve impulse
|
23,067.84 | 12.50 | 4 | 8 |
taurine binding
|
23,067.84 | 12.50 | 4 | 8 |
glycine-gated chloride ion channel activity
|
23,067.84 | 12.50 | 4 | 8 |
startle response
|
4,092.68 | 7.80 | 11 | 124 |
cellular response to ethanol
|
4,342.18 | 7.62 | 8 | 85 |
Totals | 477 | 347206 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2019-04-01 | Added | XREF | Reactome:R-HSA-975389 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-975389 |
2018-12-11 | Added | XREF | reactome:R-HSA-975389 |
2017-11-01 | Updated | TERM | extracellularly glycine-gated chloride channel activity |
2017-11-01 | Added | SYNONYM | extracellular-glycine-gated chloride channel activity |
2017-11-01 | Added | DEFINITION | Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
2017-11-01 | Deleted | DEFINITION | Enables the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
2016-11-28 | Added | RELATION | is a GO:0005254 (chloride channel activity) |
2016-11-28 | Deleted | RELATION | is a GO:0061797 (pH-gated chloride channel activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-11-01 | Updated | TERM | extracellularly glycine-gated chloride channel activity |
2010-06-09 | Updated | TERM | extracellular-glycine-gated chloride channel activity |
2010-06-08 | Updated | TERM | extracellular-glycine-gated chloride channel activity |
2007-07-11 | Updated | TERM | extracellular-glycine-gated chloride channel activity |
2003-03-19 | Updated | TERM | glycine-gated chloride channel activity |
2002-02-06 | Updated | TERM | glycine-gated chloride channel |
2001-04-03 | Updated | TERM | glycine-gated chloride channel |
2001-03-30 | Added | TERM | glycine-gated chloride channel |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-11-01 | Added | SYNONYM | extracellular-glycine-gated chloride channel activity |
2017-11-01 | Added | DEFINITION | Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
2017-11-01 | Deleted | DEFINITION | Enables the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
2015-05-11 | Added | DEFINITION | Enables the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
2015-05-11 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
2009-10-30 | Added | SYNONYM | glycine-inhibited chloride channel activity |
2008-05-13 | Added | DEFINITION | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
2008-03-11 | Updated | DEFINITION | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts. |
2007-08-09 | Added | SYNONYM | glycine receptor |
2007-08-09 | Deleted | SYNONYM | glycine receptor |
2007-07-27 | Added | DEFINITION | Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts. |
2004-04-19 | Added | SYNONYM | glycine receptor |
2004-04-16 | Deleted | SYNONYM | glycine receptor |
2001-03-30 | Added | SYNONYM | glycine receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-11-28 | Added | RELATION | is a GO:0005254 (chloride channel activity) |
2016-11-28 | Deleted | RELATION | is a GO:0061797 (pH-gated chloride channel activity) |
2016-11-28 | Added | RELATION | is a GO:0099095 (ligand-gated monoatomic anion channel activity) |
2016-10-08 | Added | RELATION | is a GO:0061797 (pH-gated chloride channel activity) |
2016-10-08 | Deleted | RELATION | is a GO:0005254 (chloride channel activity) |
2009-10-30 | Added | RELATION | is a GO:0005237 (inhibitory extracellular ligand-gated monoatomic ion channel activity) |
2008-04-01 | Updated | RELATION | is a GO:0005254 (chloride channel activity) |
2008-04-01 | Updated | RELATION | is a GO:0016933 (extracellularly glycine-gated ion channel activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-975389 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-975389 |
2018-12-11 | Added | XREF | reactome:R-HSA-975389 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2009-10-30 | Added | SECONDARY | GO:0004891 (glycine-inhibited chloride channel activity) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link