This term is obsolete.

GO:0017050 JSON

D-erythro-sphingosine kinase activity

Molecular Function

Definition (GO:0017050 GONUTS page)

Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.

9,089 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
sphingosine kinase activity broad

Ancestor Chart

Ancestor chart for GO:0017050
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0D1CPS5 5270 A0A0D1CPS5_MYCMD GO:0001727 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8J0TZJ2 8355 A0A8J0TZJ2_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.1.91
MetaCyc RXN3DJ-11417
RHEA 35847
Reactome R-HSA-5218845
Reactome R-HSA-9625814

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:60119 sphingosine 1-phosphate(1-)
has_participant CHEBI CHEBI:57756 sphingosine(1+)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0017050 based on ALL annotations
The top 100 of 355 co-occurring terms
Co-occurring Term PR S% #Together #Compared
D-erythro-sphingosine kinase activity
22,036.80 100.00 8,992 8,992
lipid kinase activity
7,615.09 24.58 4,135 11,966
sphingosine biosynthetic process
4,980.64 21.58 7,430 32,874
ceramide kinase activity
9,248.22 19.20 2,351 5,602
acylglycerol kinase activity
21,922.29 19.14 1,723 1,732
sphinganine-1-phosphate biosynthetic process
22,036.80 7.08 637 637
glycerolipid metabolic process
1,038.71 3.66 1,266 26,859
cellular response to growth factor stimulus
854.12 3.00 1,058 27,297
ceramide biosynthetic process
608.60 2.47 1,723 62,388
ATP-dependent diacylglycerol kinase activity
594.77 2.43 1,739 64,432
Totals 63815 13749782
No co-occurrence statistics for GO:0017050 based on MANUAL annotations
The top 100 of 140 co-occurring terms
Co-occurring Term PR S% #Together #Compared
D-erythro-sphingosine kinase activity
11,665.56 100.00 121 121
acylglycerol kinase activity
11,017.48 27.64 34 36
sphingosine biosynthetic process
1,732.82 14.68 112 754
sphinganine-1-phosphate biosynthetic process
11,665.56 13.22 16 16
ceramide kinase activity
1,870.89 11.37 34 212
sphingosine kinase activity
11,665.56 7.44 9 9
ATP-dependent diacylglycerol kinase activity
598.67 4.56 35 682
lipid phosphorylation
1,458.20 3.68 6 48
sphingosine metabolic process
960.69 3.52 7 85
positive regulation of mast cell activation involved in immune response
11,665.56 3.31 4 4
Totals 785 51994

Change Log

Timestamp Action Category Detail
2024-09-02 Deleted RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2024-09-02 Added SYNONYM sphingosine kinase activity
2024-09-02 Deleted SYNONYM sphingosine kinase activity
2024-09-02 Deleted RELATION is a GO:0001727 (lipid kinase activity)
2024-09-02 Added RELATION is a GO:0008481 (sphingosine kinase activity)
2023-12-26 Deleted XREF Reactome:R-HSA-9695949
2023-12-26 Deleted XREF Reactome:R-HSA-428273
2023-04-02 Added XREF EC:2.7.1.91
2023-04-02 Added RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2023-01-08 Deleted RELATION is a GO:0016301 (kinase activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM D-erythro-sphingosine kinase activity
2001-05-16 Added TERM D-erythro-sphingosine kinase
Timestamp Action Category Detail
2024-09-02 Added SYNONYM sphingosine kinase activity
2024-09-02 Deleted SYNONYM sphingosine kinase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.
2007-08-09 Added SYNONYM sphingosine kinase activity
2007-08-09 Deleted SYNONYM sphingosine kinase activity
2005-04-01 Added SYNONYM sphingosine kinase activity
2003-08-07 Added DEFINITION Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.
Timestamp Action Category Detail
2024-09-02 Deleted RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2024-09-02 Deleted RELATION is a GO:0001727 (lipid kinase activity)
2024-09-02 Added RELATION is a GO:0008481 (sphingosine kinase activity)
2023-04-02 Added RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2023-01-08 Deleted RELATION is a GO:0016301 (kinase activity)
2023-01-08 Added RELATION is a GO:0001727 (lipid kinase activity)
2008-04-01 Updated RELATION is a GO:0016301 (kinase activity)
Timestamp Action Category Detail
2023-12-26 Deleted XREF Reactome:R-HSA-9695949
2023-12-26 Deleted XREF Reactome:R-HSA-428273
2023-04-02 Added XREF EC:2.7.1.91
2020-12-17 Added XREF Reactome:R-HSA-9695949
2020-06-22 Added XREF RHEA:35847
2019-05-04 Added XREF Reactome:R-HSA-9625814
2019-04-30 Deleted XREF Reactome:R-HSA-9625814
2019-04-29 Added XREF Reactome:R-HSA-9625814
2019-04-28 Deleted XREF Reactome:R-HSA-9625814
2019-04-27 Added XREF Reactome:R-HSA-9625814
2019-04-23 Deleted XREF Reactome:R-HSA-9625814
2019-04-01 Added XREF Reactome:R-HSA-5218845
2019-04-01 Added XREF Reactome:R-HSA-9625814
2019-04-01 Added XREF Reactome:R-HSA-428273
2019-04-01 Deleted XREF reactome:R-HSA-5218845
2019-04-01 Deleted XREF reactome:R-HSA-428273
2018-12-11 Added XREF reactome:R-HSA-5218845
2018-12-11 Added XREF reactome:R-HSA-428273
2009-11-24 Added XREF MetaCyc:RXN3DJ-11417
Timestamp Action Category Detail
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