GO:0017050
JSON
D-erythro-sphingosine kinase activity
Molecular Function
Definition (GO:0017050 GONUTS page)
Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
sphingosine kinase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0D1CPS5 | 5270 | A0A0D1CPS5_MYCMD | GO:0001727 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I3Q0M1 | 9615 | A0A8I3Q0M1_CANLF | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I6AKN3 | 10116 | A0A8I6AKN3_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ALM9 | 10116 | A0A8I6ALM9_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GLX5 | 10116 | A0A8I6GLX5_RAT | GO:0016301 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8J0TR01 | 8355 | A0A8J0TR01_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8J0TZJ2 | 8355 | A0A8J0TZJ2_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.1.91 | |
MetaCyc | RXN3DJ-11417 | |
RHEA | 35847 | |
Reactome | R-HSA-5218845 | |
Reactome | R-HSA-9625814 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:60119 | sphingosine 1-phosphate(1-) |
has_participant | CHEBI | CHEBI:57756 | sphingosine(1+) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0017050 based on ALL annotations
The top 100 of 355 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
D-erythro-sphingosine kinase activity
|
22,036.80 | 100.00 | 8,992 | 8,992 |
lipid kinase activity
|
7,615.09 | 24.58 | 4,135 | 11,966 |
sphingosine biosynthetic process
|
4,980.64 | 21.58 | 7,430 | 32,874 |
ceramide kinase activity
|
9,248.22 | 19.20 | 2,351 | 5,602 |
acylglycerol kinase activity
|
21,922.29 | 19.14 | 1,723 | 1,732 |
sphinganine-1-phosphate biosynthetic process
|
22,036.80 | 7.08 | 637 | 637 |
glycerolipid metabolic process
|
1,038.71 | 3.66 | 1,266 | 26,859 |
cellular response to growth factor stimulus
|
854.12 | 3.00 | 1,058 | 27,297 |
ceramide biosynthetic process
|
608.60 | 2.47 | 1,723 | 62,388 |
ATP-dependent diacylglycerol kinase activity
|
594.77 | 2.43 | 1,739 | 64,432 |
Totals | 63815 | 13749782 |
No co-occurrence statistics for GO:0017050 based on MANUAL annotations
The top 100 of 140 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
D-erythro-sphingosine kinase activity
|
11,665.56 | 100.00 | 121 | 121 |
acylglycerol kinase activity
|
11,017.48 | 27.64 | 34 | 36 |
sphingosine biosynthetic process
|
1,732.82 | 14.68 | 112 | 754 |
sphinganine-1-phosphate biosynthetic process
|
11,665.56 | 13.22 | 16 | 16 |
ceramide kinase activity
|
1,870.89 | 11.37 | 34 | 212 |
sphingosine kinase activity
|
11,665.56 | 7.44 | 9 | 9 |
ATP-dependent diacylglycerol kinase activity
|
598.67 | 4.56 | 35 | 682 |
lipid phosphorylation
|
1,458.20 | 3.68 | 6 | 48 |
sphingosine metabolic process
|
960.69 | 3.52 | 7 | 85 |
positive regulation of mast cell activation involved in immune response
|
11,665.56 | 3.31 | 4 | 4 |
Totals | 785 | 51994 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-02 | Deleted | RELATION | is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor) |
2024-09-02 | Added | SYNONYM | sphingosine kinase activity |
2024-09-02 | Deleted | SYNONYM | sphingosine kinase activity |
2024-09-02 | Deleted | RELATION | is a GO:0001727 (lipid kinase activity) |
2024-09-02 | Added | RELATION | is a GO:0008481 (sphingosine kinase activity) |
2023-12-26 | Deleted | XREF | Reactome:R-HSA-9695949 |
2023-12-26 | Deleted | XREF | Reactome:R-HSA-428273 |
2023-04-02 | Added | XREF | EC:2.7.1.91 |
2023-04-02 | Added | RELATION | is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor) |
2023-01-08 | Deleted | RELATION | is a GO:0016301 (kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | D-erythro-sphingosine kinase activity |
2001-05-16 | Added | TERM | D-erythro-sphingosine kinase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-02 | Added | SYNONYM | sphingosine kinase activity |
2024-09-02 | Deleted | SYNONYM | sphingosine kinase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. |
2007-08-09 | Added | SYNONYM | sphingosine kinase activity |
2007-08-09 | Deleted | SYNONYM | sphingosine kinase activity |
2005-04-01 | Added | SYNONYM | sphingosine kinase activity |
2003-08-07 | Added | DEFINITION | Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-02 | Deleted | RELATION | is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor) |
2024-09-02 | Deleted | RELATION | is a GO:0001727 (lipid kinase activity) |
2024-09-02 | Added | RELATION | is a GO:0008481 (sphingosine kinase activity) |
2023-04-02 | Added | RELATION | is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor) |
2023-01-08 | Deleted | RELATION | is a GO:0016301 (kinase activity) |
2023-01-08 | Added | RELATION | is a GO:0001727 (lipid kinase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016301 (kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-26 | Deleted | XREF | Reactome:R-HSA-9695949 |
2023-12-26 | Deleted | XREF | Reactome:R-HSA-428273 |
2023-04-02 | Added | XREF | EC:2.7.1.91 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9695949 |
2020-06-22 | Added | XREF | RHEA:35847 |
2019-05-04 | Added | XREF | Reactome:R-HSA-9625814 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-9625814 |
2019-04-29 | Added | XREF | Reactome:R-HSA-9625814 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-9625814 |
2019-04-27 | Added | XREF | Reactome:R-HSA-9625814 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-9625814 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5218845 |
2019-04-01 | Added | XREF | Reactome:R-HSA-9625814 |
2019-04-01 | Added | XREF | Reactome:R-HSA-428273 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5218845 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-428273 |
2018-12-11 | Added | XREF | reactome:R-HSA-5218845 |
2018-12-11 | Added | XREF | reactome:R-HSA-428273 |
2009-11-24 | Added | XREF | MetaCyc:RXN3DJ-11417 |
Timestamp | Action | Category | Detail |
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