GO:0017171
JSON
serine hydrolase activity
Molecular Function
Definition (GO:0017171 GONUTS page)
Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0017171
Child Term | Relationship to GO:0017171 |
---|---|
serine-type peptidase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0017171 based on ALL annotations
The top 100 of 487 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
serine hydrolase activity
|
15,322.83 | 100.00 | 12,932 | 12,932 |
lipase activity
|
1,717.14 | 10.18 | 6,793 | 60,617 |
lipid catabolic process
|
240.02 | 1.55 | 6,978 | 445,475 |
phospholipase A1 activity
|
296.17 | 1.24 | 433 | 22,402 |
ether lipid metabolic process
|
3,666.67 | 0.72 | 95 | 397 |
acetylcholine binding
|
2,323.96 | 0.68 | 91 | 600 |
osteoblast development
|
1,093.63 | 0.64 | 91 | 1,275 |
alpha-amino-acid esterase activity
|
10,170.02 | 0.58 | 75 | 113 |
phosphatidylcholine catabolic process
|
468.27 | 0.57 | 90 | 2,945 |
extracellular space
|
87.52 | 0.57 | 7,067 | 1,237,256 |
Totals | 52918 | 21004154 |
No co-occurrence statistics for GO:0017171 based on MANUAL annotations
The top 100 of 314 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
serine hydrolase activity
|
7,588.89 | 100.00 | 186 | 186 |
carboxylesterase activity
|
1,433.46 | 6.56 | 17 | 90 |
positive regulation of triglyceride catabolic process
|
1,346.42 | 4.64 | 11 | 62 |
triacylglycerol lipase activity
|
358.08 | 3.82 | 31 | 657 |
ether lipid metabolic process
|
1,379.80 | 2.82 | 6 | 33 |
lipid catabolic process
|
180.69 | 1.81 | 13 | 546 |
juvenile hormone epoxide hydrolase activity
|
5,691.67 | 1.60 | 3 | 4 |
juvenile hormone catabolic process
|
3,794.44 | 1.59 | 3 | 6 |
insulin catabolic process
|
1,517.78 | 1.52 | 3 | 15 |
cholinesterase activity
|
1,084.13 | 1.47 | 3 | 21 |
Totals | 630 | 35172 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-08-06 | Deleted | RELATION | is a GO:0016825 (hydrolase activity, acting on acid phosphorus-nitrogen bonds) |
2020-08-06 | Added | RELATION | is a GO:0016787 (hydrolase activity) |
2019-05-16 | Added | RELATION | is a GO:0016825 (hydrolase activity, acting on acid phosphorus-nitrogen bonds) |
2019-05-16 | Deleted | RELATION | is a GO:0016787 (hydrolase activity) |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
2008-04-01 | Updated | RELATION | is a GO:0016787 (hydrolase activity) |
2007-06-27 | Added | DEFINITION | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
2003-03-19 | Updated | TERM | serine hydrolase activity |
2001-10-01 | Added | TERM | serine hydrolase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | serine hydrolase activity |
2001-10-01 | Added | TERM | serine hydrolase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
2007-06-27 | Added | DEFINITION | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-08-06 | Deleted | RELATION | is a GO:0016825 (hydrolase activity, acting on acid phosphorus-nitrogen bonds) |
2020-08-06 | Added | RELATION | is a GO:0016787 (hydrolase activity) |
2019-05-16 | Added | RELATION | is a GO:0016825 (hydrolase activity, acting on acid phosphorus-nitrogen bonds) |
2019-05-16 | Deleted | RELATION | is a GO:0016787 (hydrolase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016787 (hydrolase activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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