This term is obsolete.

GO:0017171 JSON

serine hydrolase activity

Molecular Function

Definition (GO:0017171 GONUTS page)

Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

2,740,386 annotations

Ancestor Chart

Ancestor chart for GO:0017171
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0017171

Child Term Relationship to
GO:0017171
serine-type peptidase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0017171 based on ALL annotations
The top 100 of 488 co-occurring terms
Co-occurring Term PR S% #Together #Compared
serine hydrolase activity
15,796.03 100.00 12,341 12,341
lipase activity
1,749.40 10.03 6,358 57,409
phosphatidylserine 1-acylhydrolase activity
961.65 2.27 432 7,096
lipid catabolic process
244.49 1.53 6,557 423,639
phospholipase A1 activity
316.95 1.29 433 21,580
ether lipid metabolic process
3,760.96 0.75 95 399
acetylcholine binding
2,414.01 0.72 92 602
osteoblast development
1,138.90 0.68 92 1,276
alpha-amino-acid esterase activity
10,484.09 0.61 75 113
phosphatidylcholine catabolic process
493.29 0.60 91 2,914
Totals 52347 20483179
No co-occurrence statistics for GO:0017171 based on MANUAL annotations
The top 100 of 314 co-occurring terms
Co-occurring Term PR S% #Together #Compared
serine hydrolase activity
6,945.16 100.00 186 186
carboxylesterase activity
1,513.69 6.88 17 78
positive regulation of triglyceride catabolic process
1,556.67 5.63 13 58
triacylglycerol lipase activity
356.99 4.15 33 642
ether lipid metabolic process
1,225.62 2.80 6 34
lipid catabolic process
188.49 1.99 13 479
juvenile hormone epoxide hydrolase activity
5,208.87 1.60 3 4
juvenile hormone catabolic process
3,472.58 1.59 3 6
insulin catabolic process
1,389.03 1.52 3 15
keratohyalin granule
1,041.77 1.48 3 20
Totals 647 34502

Change Log

Timestamp Action Category Detail
2020-08-06 Deleted RELATION is a GO:0016825 (hydrolase activity, acting on acid phosphorus-nitrogen bonds)
2020-08-06 Added RELATION is a GO:0016787 (hydrolase activity)
2019-05-16 Added RELATION is a GO:0016825 (hydrolase activity, acting on acid phosphorus-nitrogen bonds)
2019-05-16 Deleted RELATION is a GO:0016787 (hydrolase activity)
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-04-01 Updated RELATION is a GO:0016787 (hydrolase activity)
2007-06-27 Added DEFINITION Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2003-03-19 Updated TERM serine hydrolase activity
2001-10-01 Added TERM serine hydrolase
Timestamp Action Category Detail
2003-03-19 Updated TERM serine hydrolase activity
2001-10-01 Added TERM serine hydrolase
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2007-06-27 Added DEFINITION Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Timestamp Action Category Detail
2020-08-06 Deleted RELATION is a GO:0016825 (hydrolase activity, acting on acid phosphorus-nitrogen bonds)
2020-08-06 Added RELATION is a GO:0016787 (hydrolase activity)
2019-05-16 Added RELATION is a GO:0016825 (hydrolase activity, acting on acid phosphorus-nitrogen bonds)
2019-05-16 Deleted RELATION is a GO:0016787 (hydrolase activity)
2008-04-01 Updated RELATION is a GO:0016787 (hydrolase activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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