This term is obsolete.

GO:0019371 JSON

cyclooxygenase pathway

Biological Process

Definition (GO:0019371 GONUTS page)

The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. PMID:19854273

3,299 annotations

Ancestor Chart

Ancestor chart for GO:0019371
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0019371 cyclooxygenase pathway Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein F1LN46 10116 CPT1C_RAT GO:0006631 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:24222496
NOT-qualified manual protein P95028 83331 P95028_MYCTO GO:0008610 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16952959
NOT-qualified manual protein Q8BGD5 10090 CPT1C_MOUSE GO:0006631 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q8TCG5 9606 CPT1C_HUMAN GO:0006631 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0019371 based on ALL annotations
The top 100 of 341 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cyclooxygenase pathway
59,925.85 100.00 3,253 3,253
prostaglandin-endoperoxide synthase activity
51,638.23 85.87 3,240 3,760
prostaglandin biosynthetic process
15,793.82 25.60 2,926 11,102
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
2,043.80 3.41 3,226 94,589
cellular response to non-ionic osmotic stress
59,925.85 2.49 81 81
positive regulation of fever generation
23,911.30 2.40 81 203
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
14,935.36 2.32 81 325
positive regulation of prostaglandin biosynthetic process
13,558.64 2.29 81 358
prostaglandin secretion
11,184.32 2.25 81 434
response to nematode
5,547.42 2.00 81 875
Totals 40628 10506882
No co-occurrence statistics for GO:0019371 based on MANUAL annotations
The top 100 of 286 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cyclooxygenase pathway
19,572.71 100.00 66 66
prostaglandin-endoperoxide synthase activity
19,572.71 80.30 53 53
regulation of neuroinflammatory response
7,527.97 12.20 10 26
prostaglandin biosynthetic process
2,060.29 8.22 18 171
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
1,130.12 5.64 47 814
negative regulation of cellular response to insulin stimulus
6,022.37 5.33 4 13
positive regulation of prostaglandin biosynthetic process
3,914.54 4.88 4 20
cellular response to non-ionic osmotic stress
19,572.71 4.55 3 3
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
4,516.78 3.95 3 13
positive regulation of fever generation
3,669.88 3.80 3 16
Totals 430 13042

Change Log

Timestamp Action Category Detail
2024-03-22 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2009-11-11 Added DEFINITION The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.
2008-04-01 Updated RELATION part of GO:0001516 (prostaglandin biosynthetic process)
2008-04-01 Updated RELATION is a GO:0019369 (arachidonate metabolic process)
2001-10-04 Added TERM cyclooxygenase pathway
Timestamp Action Category Detail
2001-10-04 Added TERM cyclooxygenase pathway
Timestamp Action Category Detail
2009-11-11 Added DEFINITION The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.
Timestamp Action Category Detail
2008-04-01 Updated RELATION part of GO:0001516 (prostaglandin biosynthetic process)
2008-04-01 Updated RELATION is a GO:0019369 (arachidonate metabolic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-22 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
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