GO:0019371
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cyclooxygenase pathway
Biological Process
Definition (GO:0019371 GONUTS page)
The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. PMID:19854273
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0019371 | cyclooxygenase pathway | Only in Taxon | 6072 | Eumetazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | F1LN46 | 10116 | CPT1C_RAT | GO:0006631 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:24222496 | |
NOT-qualified manual | protein | P95028 | 83331 | P95028_MYCTO | GO:0008610 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16952959 | |
NOT-qualified manual | protein | Q8BGD5 | 10090 | CPT1C_MOUSE | GO:0006631 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q8TCG5 | 9606 | CPT1C_HUMAN | GO:0006631 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0019371 based on ALL annotations
The top 100 of 341 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cyclooxygenase pathway
|
59,925.85 | 100.00 | 3,253 | 3,253 |
prostaglandin-endoperoxide synthase activity
|
51,638.23 | 85.87 | 3,240 | 3,760 |
prostaglandin biosynthetic process
|
15,793.82 | 25.60 | 2,926 | 11,102 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
2,043.80 | 3.41 | 3,226 | 94,589 |
cellular response to non-ionic osmotic stress
|
59,925.85 | 2.49 | 81 | 81 |
positive regulation of fever generation
|
23,911.30 | 2.40 | 81 | 203 |
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
|
14,935.36 | 2.32 | 81 | 325 |
positive regulation of prostaglandin biosynthetic process
|
13,558.64 | 2.29 | 81 | 358 |
prostaglandin secretion
|
11,184.32 | 2.25 | 81 | 434 |
response to nematode
|
5,547.42 | 2.00 | 81 | 875 |
Totals | 40628 | 10506882 |
No co-occurrence statistics for GO:0019371 based on MANUAL annotations
The top 100 of 286 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cyclooxygenase pathway
|
19,572.71 | 100.00 | 66 | 66 |
prostaglandin-endoperoxide synthase activity
|
19,572.71 | 80.30 | 53 | 53 |
regulation of neuroinflammatory response
|
7,527.97 | 12.20 | 10 | 26 |
prostaglandin biosynthetic process
|
2,060.29 | 8.22 | 18 | 171 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
1,130.12 | 5.64 | 47 | 814 |
negative regulation of cellular response to insulin stimulus
|
6,022.37 | 5.33 | 4 | 13 |
positive regulation of prostaglandin biosynthetic process
|
3,914.54 | 4.88 | 4 | 20 |
cellular response to non-ionic osmotic stress
|
19,572.71 | 4.55 | 3 | 3 |
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
|
4,516.78 | 3.95 | 3 | 13 |
positive regulation of fever generation
|
3,669.88 | 3.80 | 3 | 16 |
Totals | 430 | 13042 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
2009-11-11 | Added | DEFINITION | The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. |
2008-04-01 | Updated | RELATION | part of GO:0001516 (prostaglandin biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0019369 (arachidonate metabolic process) |
2001-10-04 | Added | TERM | cyclooxygenase pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2001-10-04 | Added | TERM | cyclooxygenase pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-11-11 | Added | DEFINITION | The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | part of GO:0001516 (prostaglandin biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0019369 (arachidonate metabolic process) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
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