GO:0019674
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NAD metabolic process
Biological Process
Definition (GO:0019674 GONUTS page)
The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme involved in many redox and catabolic reactions; metabolism may be of either the oxidized form, NAD+, or the reduced form, NADH. PMID:28648096
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
oxidized NAD metabolic process | exact |
nicotinamide adenine dinucleotide metabolism | exact |
oxidized NAD metabolism | exact |
oxidized nicotinamide adenine dinucleotide metabolic process | exact |
nicotinamide adenine dinucleotide metabolic process | exact |
oxidized nicotinamide adenine dinucleotide metabolism | exact |
NAD phosphorylation and dephosphorylation | narrow |
NAD metabolism | exact |
NAD (oxidized) metabolism | exact |
NAD (oxidized) metabolic process | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0019674
Child Term | Relationship to GO:0019674 |
---|---|
NAD biosynthetic process
|
is_a |
positive regulation of NAD metabolic process
|
positively_regulates |
NAD catabolic process
|
is_a |
NADH regeneration
|
is_a |
regulation of NAD metabolic process
|
regulates |
negative regulation of NAD metabolic process
|
negatively_regulates |
NADH oxidation
|
is_a |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR017437 | ATP-NAD kinase, PpnK-type, C-terminal |
Reactome | R-HSA-196807 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input_or_output | CHEBI | CHEBI:57540 | NAD(1-) |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0019675 | obsolete NAD phosphorylation and dephosphorylation | consider GO:0019674 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0019674 based on ALL annotations
The top 100 of 471 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD metabolic process
|
3,315.68 | 100.00 | 59,763 | 59,763 |
NAD+ kinase activity
|
2,968.88 | 89.21 | 59,514 | 66,466 |
NADP biosynthetic process
|
2,957.53 | 84.29 | 56,104 | 62,898 |
phosphotransferase activity, alcohol group as acceptor
|
236.36 | 5.40 | 10,884 | 152,679 |
NAD binding
|
112.38 | 3.33 | 40,127 | 1,183,877 |
kinase activity
|
35.26 | 1.06 | 56,885 | 5,349,025 |
protein homodimerization activity
|
15.03 | 0.35 | 939 | 207,186 |
NADH kinase activity
|
3,315.68 | 0.23 | 138 | 138 |
ATP binding
|
7.55 | 0.23 | 43,339 | 19,024,482 |
kynurenine 3-monooxygenase activity
|
53.42 | 0.21 | 141 | 8,751 |
Totals | 416905 | 92197995 |
No co-occurrence statistics for GO:0019674 based on MANUAL annotations
The top 98 of 98 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NAD metabolic process
|
19,336.07 | 100.00 | 73 | 73 |
NAD+ kinase activity
|
2,266.32 | 11.01 | 47 | 401 |
kynurenine 3-monooxygenase activity
|
3,184.76 | 9.72 | 14 | 85 |
kynurenine metabolic process
|
2,417.01 | 7.64 | 12 | 96 |
lactate dehydrogenase activity
|
7,734.43 | 2.63 | 2 | 5 |
regulation of ventricular cardiac muscle cell membrane depolarization
|
2,148.45 | 2.25 | 2 | 18 |
L-tryptophan catabolic process
|
1,611.34 | 2.11 | 2 | 24 |
oxidoreductase complex
|
577.20 | 1.45 | 2 | 67 |
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
|
552.46 | 1.42 | 2 | 70 |
ribosylnicotinate kinase activity
|
522.60 | 1.38 | 2 | 74 |
Totals | 378 | 1110463 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2025-02-07 | Deleted | DEFINITION | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
2025-02-07 | Added | DEFINITION | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme involved in many redox and catabolic reactions; metabolism may be of either the oxidized form, NAD+, or the reduced form, NADH. |
2024-12-05 | Added | XREF | Reactome:R-HSA-196807 |
2022-10-31 | Added | RELATION | is a GO:0006163 (purine nucleotide metabolic process) |
2022-06-20 | Added | RELATION | is a GO:0046496 (nicotinamide nucleotide metabolic process) |
2022-06-20 | Deleted | RELATION | is a GO:0008152 (metabolic process) |
2019-03-05 | Added | RELATION | is a GO:0008152 (metabolic process) |
2019-03-05 | Deleted | RELATION | is a GO:0046496 (nicotinamide nucleotide metabolic process) |
2010-05-02 | Deleted | RELATION | is a GO:0006769 (nicotinamide metabolic process) |
2009-07-03 | Added | RELATION | is a GO:0046496 (nicotinamide nucleotide metabolic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-01-15 | Updated | TERM | NAD metabolic process |
2004-02-05 | Updated | TERM | NAD metabolism |
2001-10-22 | Added | TERM | nicotinamide adenine dinucleotide metabolism |
Timestamp | Action | Category | Detail |
---|---|---|---|
2025-02-07 | Deleted | DEFINITION | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
2025-02-07 | Added | DEFINITION | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme involved in many redox and catabolic reactions; metabolism may be of either the oxidized form, NAD+, or the reduced form, NADH. |
2008-05-13 | Added | DEFINITION | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
2007-08-09 | Deleted | SYNONYM | NAD (oxidized) metabolism |
2007-08-09 | Deleted | SYNONYM | NAD phosphorylation and dephosphorylation |
2007-08-09 | Deleted | SYNONYM | nicotinamide adenine dinucleotide metabolism |
2007-08-09 | Deleted | SYNONYM | oxidized NAD metabolism |
2007-08-09 | Deleted | SYNONYM | oxidized nicotinamide adenine dinucleotide metabolism |
2007-08-09 | Added | SYNONYM | NAD (oxidized) metabolic process |
2007-08-09 | Added | SYNONYM | NAD (oxidized) metabolism |
2007-08-09 | Added | SYNONYM | NAD metabolism |
2007-08-09 | Added | SYNONYM | NAD phosphorylation and dephosphorylation |
2007-08-09 | Added | SYNONYM | nicotinamide adenine dinucleotide metabolic process |
2007-08-09 | Added | SYNONYM | nicotinamide adenine dinucleotide metabolism |
2007-08-09 | Added | SYNONYM | oxidized NAD metabolic process |
2007-08-09 | Added | SYNONYM | oxidized NAD metabolism |
2007-08-09 | Added | SYNONYM | oxidized nicotinamide adenine dinucleotide metabolic process |
2007-08-09 | Added | SYNONYM | oxidized nicotinamide adenine dinucleotide metabolism |
2007-08-09 | Deleted | SYNONYM | NAD (oxidized) metabolic process |
2007-08-09 | Deleted | SYNONYM | nicotinamide adenine dinucleotide metabolic process |
2007-08-09 | Deleted | SYNONYM | oxidized NAD metabolic process |
2007-08-09 | Deleted | SYNONYM | oxidized nicotinamide adenine dinucleotide metabolic process |
2007-08-09 | Deleted | SYNONYM | NAD metabolism |
2007-01-29 | Added | SYNONYM | NAD metabolism |
2007-01-15 | Added | SYNONYM | oxidized nicotinamide adenine dinucleotide metabolic process |
2007-01-15 | Added | SYNONYM | oxidized NAD metabolic process |
2007-01-15 | Added | SYNONYM | nicotinamide adenine dinucleotide metabolic process |
2007-01-15 | Added | SYNONYM | NAD (oxidized) metabolic process |
2006-05-04 | Updated | DEFINITION | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
2005-08-10 | Added | SYNONYM | NAD phosphorylation and dephosphorylation |
2005-02-24 | Added | SYNONYM | NAD (oxidized) metabolism |
2005-02-24 | Added | SYNONYM | oxidized NAD metabolism |
2005-02-24 | Added | SYNONYM | oxidized nicotinamide adenine dinucleotide metabolism |
2005-01-21 | Updated | DEFINITION | The chemical reactions involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
2004-04-19 | Added | SYNONYM | nicotinamide adenine dinucleotide metabolism |
2004-04-16 | Deleted | SYNONYM | nicotinamide adenine dinucleotide metabolism |
2004-02-05 | Added | SYNONYM | nicotinamide adenine dinucleotide metabolism |
2004-02-05 | Added | DEFINITION | The chemical reactions and physical changes involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-10-31 | Added | RELATION | is a GO:0006163 (purine nucleotide metabolic process) |
2022-06-20 | Added | RELATION | is a GO:0046496 (nicotinamide nucleotide metabolic process) |
2022-06-20 | Deleted | RELATION | is a GO:0008152 (metabolic process) |
2019-03-05 | Added | RELATION | is a GO:0008152 (metabolic process) |
2019-03-05 | Deleted | RELATION | is a GO:0046496 (nicotinamide nucleotide metabolic process) |
2010-05-02 | Deleted | RELATION | is a GO:0006769 (nicotinamide metabolic process) |
2009-07-03 | Added | RELATION | is a GO:0046496 (nicotinamide nucleotide metabolic process) |
2008-04-01 | Updated | RELATION | is a GO:0006769 (nicotinamide metabolic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-196807 |
Timestamp | Action | Category | Detail |
---|
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