This term is obsolete.

GO:0019787 JSON

ubiquitin-like protein transferase activity

Molecular Function

Definition (GO:0019787 GONUTS page)

Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. PMID:10806345 PMID:10884686

Secondary IDs

GO:0008639, GO:0008640

969,723 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ubiquitin-like-protein ligase activity narrow
E2 broad
small conjugating protein ligase activity narrow
ubiquitin-like conjugating enzyme activity narrow
small conjugating protein transferase activity exact
small protein conjugating enzyme activity narrow
E3 related

Ancestor Chart

Ancestor chart for GO:0019787
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019787

Child Term Relationship to
GO:0019787
URM1 transferase activity
is_a
ubiquitin-protein transferase activity
is_a
ubiquitin-like protein ligase activity
is_a
ISG15 transferase activity
is_a
FAT10 transferase activity
is_a
ubiquitin-like protein conjugating enzyme activity
is_a
Atg12 transferase activity
is_a
NEDD8 transferase activity
is_a
UFM1 transferase activity
is_a
SUMO transferase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
InterPro IPR007135 Ubiquitin-like-conjugating enzyme Atg3/Atg10
Reactome R-HSA-5678490
Reactome R-HSA-688137

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0019787 based on ALL annotations
The top 100 of 658 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ubiquitin-like protein transferase activity
10,673.39 100.00 18,264 18,264
nucleophagy
8,334.74 22.59 4,405 5,641
Atg8-family ligase activity
3,787.65 16.37 4,257 11,996
Atg12 conjugating enzyme activity
10,579.03 15.94 2,915 2,941
glycophagy
2,855.85 14.51 4,398 16,437
protein modification by small protein conjugation
2,678.64 13.81 4,293 17,106
protein pupylation
2,604.95 12.96 3,955 16,205
autophagy of mitochondrion
1,275.24 10.10 7,216 60,396
modification-dependent protein catabolic process
1,502.73 9.40 4,023 28,574
proteasomal protein catabolic process
868.84 6.29 3,955 48,586
Totals 114018 19448110
No co-occurrence statistics for GO:0019787 based on MANUAL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term PR S% #Together #Compared
ubiquitin-like protein transferase activity
17,456.74 100.00 74 74
protein-RNA covalent cross-linking repair
9,241.81 10.98 9 17
nucleophagy
1,542.12 8.47 50 566
glycophagy
1,099.29 6.11 50 794
regulation of androgen receptor signaling pathway
1,785.35 5.88 9 88
Atg12 transferase activity
4,655.13 4.71 4 15
protein K6-linked ubiquitination
1,193.62 4.37 8 117
nuclear androgen receptor binding
969.82 3.96 9 162
regulation of protein processing
1,119.02 3.40 5 78
Derlin-1 retrotranslocation complex
1,039.09 3.27 5 84
Totals 524 56963

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_pir 439
goslim_drosophila 173

Change Log

Timestamp Action Category Detail
2023-06-13 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2023-06-13 Deleted DEFINITION Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
2023-06-13 Added SYNONYM E2
2023-06-13 Deleted SYNONYM E2
2023-06-13 Added DEFINITION Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
2023-02-10 Added RELATION is a GO:0016755 (aminoacyltransferase activity)
2023-02-10 Deleted RELATION is a GO:0016740 (transferase activity)
2023-02-10 Deleted RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2019-11-09 Added SUBSET goslim_drosophila
2019-04-01 Added XREF Reactome:R-HSA-688137
Timestamp Action Category Detail
2015-01-24 Updated TERM ubiquitin-like protein transferase activity
2014-11-08 Updated TERM small conjugating protein transferase activity
2006-08-20 Updated TERM small conjugating protein ligase activity
2003-03-19 Updated TERM ubiquitin-like-protein ligase activity
2001-11-13 Added TERM ubiquitin-like-protein ligase
Timestamp Action Category Detail
2023-06-13 Deleted DEFINITION Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
2023-06-13 Added SYNONYM E2
2023-06-13 Deleted SYNONYM E2
2023-06-13 Added DEFINITION Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
2015-01-24 Deleted DEFINITION Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-SCP + Y --> Y-SCP + X, where both X-SCP and Y-SCP are covalent linkages. SCP represents a small conjugating protein.
2015-01-24 Added DEFINITION Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.
2015-01-24 Added SYNONYM small conjugating protein transferase activity
2014-11-08 Added SYNONYM small conjugating protein ligase activity
2014-11-08 Added SYNONYM small protein conjugating enzyme activity
2014-11-08 Added SYNONYM E3
2014-11-08 Added SYNONYM E2
2014-11-08 Deleted SYNONYM E2
2014-11-08 Deleted SYNONYM small protein conjugating enzyme activity
2014-11-08 Added DEFINITION Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-SCP + Y --> Y-SCP + X, where both X-SCP and Y-SCP are covalent linkages. SCP represents a small conjugating protein.
2014-11-08 Deleted DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
2008-05-13 Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
2008-05-12 Deleted DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
2008-04-27 Updated DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.
2008-04-01 Added SYNONYM ubiquitin-like conjugating enzyme activity
2008-04-01 Added SYNONYM small protein conjugating enzyme activity
2008-04-01 Added SYNONYM E2
2007-08-09 Deleted SYNONYM ubiquitin-like-protein ligase activity
2007-08-09 Added SYNONYM ubiquitin-like-protein ligase activity
2006-08-25 Updated DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue.
2006-08-22 Updated DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugahting protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue.
2006-08-20 Added SYNONYM ubiquitin-like-protein ligase activity
2006-08-18 Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugahting protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue.
Timestamp Action Category Detail
2023-06-13 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2023-02-10 Added RELATION is a GO:0016755 (aminoacyltransferase activity)
2023-02-10 Deleted RELATION is a GO:0016740 (transferase activity)
2023-02-10 Deleted RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2017-09-19 Added RELATION is a GO:0140096 (catalytic activity, acting on a protein)
2014-11-08 Deleted RELATION is a GO:0016881 (acid-amino acid ligase activity)
2014-11-08 Added RELATION is a GO:0016740 (transferase activity)
2008-04-17 Deleted RELATION is a GO:0003824 (catalytic activity)
2008-04-05 Added RELATION is a GO:0003824 (catalytic activity)
2008-04-01 Updated RELATION is a GO:0016881 (acid-amino acid ligase activity)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-688137
2019-04-01 Added XREF Reactome:R-HSA-5678490
2019-04-01 Deleted XREF reactome:R-HSA-5678490
2019-04-01 Deleted XREF reactome:R-HSA-688137
2018-12-11 Added XREF reactome:R-HSA-688137
2018-12-11 Added XREF reactome:R-HSA-5678490
Timestamp Action Category Detail
2019-11-09 Added SUBSET goslim_drosophila
2018-07-13 Added SUBSET goslim_pir
2008-04-01 Added SECONDARY GO:0008639 (small protein conjugating enzyme activity)
2008-04-01 Added SECONDARY GO:0008640 (ubiquitin-like conjugating enzyme activity)
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