GO:0019787
JSON
ubiquitin-like protein transferase activity
Molecular Function
Definition (GO:0019787 GONUTS page)
Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. PMID:10806345 PMID:10884686
Secondary IDs
GO:0008639, GO:0008640
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ubiquitin-like-protein ligase activity | narrow |
E2 | broad |
small conjugating protein ligase activity | narrow |
ubiquitin-like conjugating enzyme activity | narrow |
small conjugating protein transferase activity | exact |
small protein conjugating enzyme activity | narrow |
E3 | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0019787
Child Term | Relationship to GO:0019787 |
---|---|
URM1 transferase activity
|
is_a |
ubiquitin-protein transferase activity
|
is_a |
ubiquitin-like protein ligase activity
|
is_a |
ISG15 transferase activity
|
is_a |
FAT10 transferase activity
|
is_a |
ubiquitin-like protein conjugating enzyme activity
|
is_a |
Atg12 transferase activity
|
is_a |
NEDD8 transferase activity
|
is_a |
UFM1 transferase activity
|
is_a |
SUMO transferase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR007135 | Ubiquitin-like-conjugating enzyme Atg3/Atg10 |
Reactome | R-HSA-5678490 | |
Reactome | R-HSA-688137 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0019787 based on ALL annotations
The top 100 of 658 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ubiquitin-like protein transferase activity
|
10,673.39 | 100.00 | 18,264 | 18,264 |
nucleophagy
|
8,334.74 | 22.59 | 4,405 | 5,641 |
Atg8-family ligase activity
|
3,787.65 | 16.37 | 4,257 | 11,996 |
Atg12 conjugating enzyme activity
|
10,579.03 | 15.94 | 2,915 | 2,941 |
glycophagy
|
2,855.85 | 14.51 | 4,398 | 16,437 |
protein modification by small protein conjugation
|
2,678.64 | 13.81 | 4,293 | 17,106 |
protein pupylation
|
2,604.95 | 12.96 | 3,955 | 16,205 |
autophagy of mitochondrion
|
1,275.24 | 10.10 | 7,216 | 60,396 |
modification-dependent protein catabolic process
|
1,502.73 | 9.40 | 4,023 | 28,574 |
proteasomal protein catabolic process
|
868.84 | 6.29 | 3,955 | 48,586 |
Totals | 114018 | 19448110 |
No co-occurrence statistics for GO:0019787 based on MANUAL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
ubiquitin-like protein transferase activity
|
17,456.74 | 100.00 | 74 | 74 |
protein-RNA covalent cross-linking repair
|
9,241.81 | 10.98 | 9 | 17 |
nucleophagy
|
1,542.12 | 8.47 | 50 | 566 |
glycophagy
|
1,099.29 | 6.11 | 50 | 794 |
regulation of androgen receptor signaling pathway
|
1,785.35 | 5.88 | 9 | 88 |
Atg12 transferase activity
|
4,655.13 | 4.71 | 4 | 15 |
protein K6-linked ubiquitination
|
1,193.62 | 4.37 | 8 | 117 |
nuclear androgen receptor binding
|
969.82 | 3.96 | 9 | 162 |
regulation of protein processing
|
1,119.02 | 3.40 | 5 | 78 |
Derlin-1 retrotranslocation complex
|
1,039.09 | 3.27 | 5 | 84 |
Totals | 524 | 56963 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_pir | 439 |
goslim_drosophila | 173 |
Change Log
- All changes
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2023-06-13 | Deleted | DEFINITION | Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. |
2023-06-13 | Added | SYNONYM | E2 |
2023-06-13 | Deleted | SYNONYM | E2 |
2023-06-13 | Added | DEFINITION | Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. |
2023-02-10 | Added | RELATION | is a GO:0016755 (aminoacyltransferase activity) |
2023-02-10 | Deleted | RELATION | is a GO:0016740 (transferase activity) |
2023-02-10 | Deleted | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2019-04-01 | Added | XREF | Reactome:R-HSA-688137 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-01-24 | Updated | TERM | ubiquitin-like protein transferase activity |
2014-11-08 | Updated | TERM | small conjugating protein transferase activity |
2006-08-20 | Updated | TERM | small conjugating protein ligase activity |
2003-03-19 | Updated | TERM | ubiquitin-like-protein ligase activity |
2001-11-13 | Added | TERM | ubiquitin-like-protein ligase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Deleted | DEFINITION | Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. |
2023-06-13 | Added | SYNONYM | E2 |
2023-06-13 | Deleted | SYNONYM | E2 |
2023-06-13 | Added | DEFINITION | Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. |
2015-01-24 | Deleted | DEFINITION | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-SCP + Y --> Y-SCP + X, where both X-SCP and Y-SCP are covalent linkages. SCP represents a small conjugating protein. |
2015-01-24 | Added | DEFINITION | Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. |
2015-01-24 | Added | SYNONYM | small conjugating protein transferase activity |
2014-11-08 | Added | SYNONYM | small conjugating protein ligase activity |
2014-11-08 | Added | SYNONYM | small protein conjugating enzyme activity |
2014-11-08 | Added | SYNONYM | E3 |
2014-11-08 | Added | SYNONYM | E2 |
2014-11-08 | Deleted | SYNONYM | E2 |
2014-11-08 | Deleted | SYNONYM | small protein conjugating enzyme activity |
2014-11-08 | Added | DEFINITION | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-SCP + Y --> Y-SCP + X, where both X-SCP and Y-SCP are covalent linkages. SCP represents a small conjugating protein. |
2014-11-08 | Deleted | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. |
2008-05-13 | Added | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. |
2008-05-12 | Deleted | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. |
2008-04-27 | Updated | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. |
2008-04-01 | Added | SYNONYM | ubiquitin-like conjugating enzyme activity |
2008-04-01 | Added | SYNONYM | small protein conjugating enzyme activity |
2008-04-01 | Added | SYNONYM | E2 |
2007-08-09 | Deleted | SYNONYM | ubiquitin-like-protein ligase activity |
2007-08-09 | Added | SYNONYM | ubiquitin-like-protein ligase activity |
2006-08-25 | Updated | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. |
2006-08-22 | Updated | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugahting protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. |
2006-08-20 | Added | SYNONYM | ubiquitin-like-protein ligase activity |
2006-08-18 | Added | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugahting protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2023-02-10 | Added | RELATION | is a GO:0016755 (aminoacyltransferase activity) |
2023-02-10 | Deleted | RELATION | is a GO:0016740 (transferase activity) |
2023-02-10 | Deleted | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2017-09-19 | Added | RELATION | is a GO:0140096 (catalytic activity, acting on a protein) |
2014-11-08 | Deleted | RELATION | is a GO:0016881 (acid-amino acid ligase activity) |
2014-11-08 | Added | RELATION | is a GO:0016740 (transferase activity) |
2008-04-17 | Deleted | RELATION | is a GO:0003824 (catalytic activity) |
2008-04-05 | Added | RELATION | is a GO:0003824 (catalytic activity) |
2008-04-01 | Updated | RELATION | is a GO:0016881 (acid-amino acid ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-688137 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5678490 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5678490 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-688137 |
2018-12-11 | Added | XREF | reactome:R-HSA-688137 |
2018-12-11 | Added | XREF | reactome:R-HSA-5678490 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-11-09 | Added | SUBSET | goslim_drosophila |
2018-07-13 | Added | SUBSET | goslim_pir |
2008-04-01 | Added | SECONDARY | GO:0008639 (small protein conjugating enzyme activity) |
2008-04-01 | Added | SECONDARY | GO:0008640 (ubiquitin-like conjugating enzyme activity) |
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