This term is obsolete.

GO:0019788 JSON

NEDD8 transferase activity

Molecular Function

Definition (GO:0019788 GONUTS page)

Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.

Secondary IDs

GO:0016976, GO:0019945, GO:0042295

750 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
NEDD8 conjugating enzyme activity related
Hub1 conjugating enzyme activity related
RUB1 conjugating enzyme activity related

Ancestor Chart

Ancestor chart for GO:0019788
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019788

Child Term Relationship to
GO:0019788
NEDD8 ligase activity
is_a
NEDD8 conjugating enzyme activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein P53817 10116 PLAT3_RAT GO:0016746 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
Reactome R-HSA-8951648
Reactome R-HSA-8951661
Reactome R-HSA-8951764
Reactome R-HSA-8952044
Reactome R-HSA-8952618
Reactome R-HSA-8952626
Reactome R-HSA-8952631
Reactome R-HSA-8952638
Reactome R-HSA-8956025

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0019788 based on ALL annotations
The top 100 of 103 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NEDD8 transferase activity
566,682.50 100.00 344 344
NEDD8 conjugating enzyme activity
321,483.34 15.17 59 104
regulation of postsynapse assembly
11,050.75 1.75 50 2,564
protein neddylation
8,647.42 1.53 344 22,543
NEDD8 ligase activity
15,375.11 1.18 7 258
ubiquitin-like protein conjugating enzyme activity
22,442.87 0.91 4 101
protein localization to perinuclear region of cytoplasm
7,004.73 0.87 10 809
FHF complex
5,167.32 0.73 12 1,316
positive regulation of nematode male tail tip morphogenesis
7,762.77 0.41 2 146
positive regulation of protein binding
8,457.95 0.24 1 67
Totals 2461 117761749
No co-occurrence statistics for GO:0019788 based on MANUAL annotations
The top 88 of 88 co-occurring terms
Co-occurring Term PR S% #Together #Compared
NEDD8 transferase activity
6,270.87 100.00 206 206
protein neddylation
1,489.60 23.73 205 863
NEDD8 conjugating enzyme activity
4,389.61 3.35 7 10
protein modification process
196.52 2.01 11 351
FHF complex
522.57 1.60 4 48
post-translational protein modification
145.16 1.20 5 216
regulation of postsynapse assembly
136.32 1.04 4 184
NEDD8 ligase activity
522.57 0.88 2 24
early endosome to late endosome transport
91.55 0.84 4 274
protein localization to perinuclear region of cytoplasm
266.85 0.80 2 47
Totals 979 860765

Change Log

Timestamp Action Category Detail
2023-06-13 Added DEFINITION Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
2023-06-13 Deleted DEFINITION Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
2023-04-02 Added XREF Reactome:R-HSA-8952626
2023-04-02 Added XREF Reactome:R-HSA-8952631
2019-04-01 Deleted XREF reactome:R-HSA-8952638
2019-04-01 Deleted XREF reactome:R-HSA-8951661
2019-04-01 Deleted XREF reactome:R-HSA-8956025
2019-04-01 Deleted XREF reactome:R-HSA-8951764
2019-04-01 Deleted XREF reactome:R-HSA-8951648
2019-04-01 Deleted XREF reactome:R-HSA-8952618
Timestamp Action Category Detail
2014-11-08 Updated TERM NEDD8 transferase activity
2003-03-19 Updated TERM NEDD8 ligase activity
2001-11-13 Added TERM NEDD8 ligase
Timestamp Action Category Detail
2023-06-13 Added DEFINITION Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
2023-06-13 Deleted DEFINITION Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
2014-11-16 Added DEFINITION Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
2014-11-16 Deleted DEFINITION Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
2014-11-08 Deleted DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue.
2014-11-08 Deleted SYNONYM Hub1 conjugating enzyme activity
2014-11-08 Added SYNONYM RUB1 conjugating enzyme activity
2014-11-08 Added DEFINITION Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
2014-11-08 Deleted SYNONYM NEDD8 conjugating enzyme activity
2014-11-08 Deleted SYNONYM RUB1 conjugating enzyme activity
2014-11-08 Added SYNONYM NEDD8 conjugating enzyme activity
2014-11-08 Added SYNONYM Hub1 conjugating enzyme activity
2008-05-13 Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue.
2008-05-12 Deleted DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue.
2008-04-01 Added SYNONYM RUB1 conjugating enzyme activity
2008-04-01 Added SYNONYM NEDD8 conjugating enzyme activity
2008-04-01 Added SYNONYM Hub1 conjugating enzyme activity
2006-08-18 Added DEFINITION Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0019787 (ubiquitin-like protein transferase activity)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-8952626
2023-04-02 Added XREF Reactome:R-HSA-8952631
2019-04-01 Deleted XREF reactome:R-HSA-8952638
2019-04-01 Deleted XREF reactome:R-HSA-8951661
2019-04-01 Deleted XREF reactome:R-HSA-8956025
2019-04-01 Deleted XREF reactome:R-HSA-8951764
2019-04-01 Deleted XREF reactome:R-HSA-8951648
2019-04-01 Deleted XREF reactome:R-HSA-8952618
2019-04-01 Deleted XREF reactome:R-HSA-8952044
2019-04-01 Added XREF Reactome:R-HSA-8951648
2019-04-01 Added XREF Reactome:R-HSA-8952618
2019-04-01 Added XREF Reactome:R-HSA-8952044
2019-04-01 Added XREF Reactome:R-HSA-8951764
2019-04-01 Added XREF Reactome:R-HSA-8956025
2019-04-01 Added XREF Reactome:R-HSA-8951661
2019-04-01 Added XREF Reactome:R-HSA-8952638
2018-12-11 Added XREF reactome:R-HSA-8956025
2018-12-11 Added XREF reactome:R-HSA-8952618
2018-12-11 Added XREF reactome:R-HSA-8951648
2018-12-11 Added XREF reactome:R-HSA-8952044
2018-12-11 Added XREF reactome:R-HSA-8951764
2018-12-11 Added XREF reactome:R-HSA-8952638
2018-12-11 Added XREF reactome:R-HSA-8951661
Timestamp Action Category Detail
2008-04-01 Added SECONDARY GO:0042295 (Hub1 conjugating enzyme activity)
2008-04-01 Added SECONDARY GO:0016976 (NEDD8 conjugating enzyme activity)
2008-04-01 Added SECONDARY GO:0019945 (RUB1 conjugating enzyme)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.