GO:0019788
JSON
NEDD8 transferase activity
Molecular Function
Definition (GO:0019788 GONUTS page)
Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages.
Secondary IDs
GO:0016976, GO:0019945, GO:0042295
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
NEDD8 conjugating enzyme activity | related |
Hub1 conjugating enzyme activity | related |
RUB1 conjugating enzyme activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0019788
Child Term | Relationship to GO:0019788 |
---|---|
NEDD8 ligase activity
|
is_a |
NEDD8 conjugating enzyme activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | P53817 | 10116 | PLAT3_RAT | GO:0016746 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0019788 based on ALL annotations
The top 100 of 103 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NEDD8 transferase activity
|
566,682.50 | 100.00 | 344 | 344 |
NEDD8 conjugating enzyme activity
|
321,483.34 | 15.17 | 59 | 104 |
regulation of postsynapse assembly
|
11,050.75 | 1.75 | 50 | 2,564 |
protein neddylation
|
8,647.42 | 1.53 | 344 | 22,543 |
NEDD8 ligase activity
|
15,375.11 | 1.18 | 7 | 258 |
ubiquitin-like protein conjugating enzyme activity
|
22,442.87 | 0.91 | 4 | 101 |
protein localization to perinuclear region of cytoplasm
|
7,004.73 | 0.87 | 10 | 809 |
FHF complex
|
5,167.32 | 0.73 | 12 | 1,316 |
positive regulation of nematode male tail tip morphogenesis
|
7,762.77 | 0.41 | 2 | 146 |
positive regulation of protein binding
|
8,457.95 | 0.24 | 1 | 67 |
Totals | 2461 | 117761749 |
No co-occurrence statistics for GO:0019788 based on MANUAL annotations
The top 88 of 88 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
NEDD8 transferase activity
|
6,270.87 | 100.00 | 206 | 206 |
protein neddylation
|
1,489.60 | 23.73 | 205 | 863 |
NEDD8 conjugating enzyme activity
|
4,389.61 | 3.35 | 7 | 10 |
protein modification process
|
196.52 | 2.01 | 11 | 351 |
FHF complex
|
522.57 | 1.60 | 4 | 48 |
post-translational protein modification
|
145.16 | 1.20 | 5 | 216 |
regulation of postsynapse assembly
|
136.32 | 1.04 | 4 | 184 |
NEDD8 ligase activity
|
522.57 | 0.88 | 2 | 24 |
early endosome to late endosome transport
|
91.55 | 0.84 | 4 | 274 |
protein localization to perinuclear region of cytoplasm
|
266.85 | 0.80 | 2 | 47 |
Totals | 979 | 860765 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Added | DEFINITION | Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
2023-06-13 | Deleted | DEFINITION | Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
2023-04-02 | Added | XREF | Reactome:R-HSA-8952626 |
2023-04-02 | Added | XREF | Reactome:R-HSA-8952631 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8952638 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8951661 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8956025 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8951764 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8951648 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8952618 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-11-08 | Updated | TERM | NEDD8 transferase activity |
2003-03-19 | Updated | TERM | NEDD8 ligase activity |
2001-11-13 | Added | TERM | NEDD8 ligase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-06-13 | Added | DEFINITION | Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
2023-06-13 | Deleted | DEFINITION | Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
2014-11-16 | Added | DEFINITION | Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
2014-11-16 | Deleted | DEFINITION | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
2014-11-08 | Deleted | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue. |
2014-11-08 | Deleted | SYNONYM | Hub1 conjugating enzyme activity |
2014-11-08 | Added | SYNONYM | RUB1 conjugating enzyme activity |
2014-11-08 | Added | DEFINITION | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. |
2014-11-08 | Deleted | SYNONYM | NEDD8 conjugating enzyme activity |
2014-11-08 | Deleted | SYNONYM | RUB1 conjugating enzyme activity |
2014-11-08 | Added | SYNONYM | NEDD8 conjugating enzyme activity |
2014-11-08 | Added | SYNONYM | Hub1 conjugating enzyme activity |
2008-05-13 | Added | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue. |
2008-05-12 | Deleted | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue. |
2008-04-01 | Added | SYNONYM | RUB1 conjugating enzyme activity |
2008-04-01 | Added | SYNONYM | NEDD8 conjugating enzyme activity |
2008-04-01 | Added | SYNONYM | Hub1 conjugating enzyme activity |
2006-08-18 | Added | DEFINITION | Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0019787 (ubiquitin-like protein transferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-8952626 |
2023-04-02 | Added | XREF | Reactome:R-HSA-8952631 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8952638 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8951661 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8956025 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8951764 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8951648 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8952618 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8952044 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8951648 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8952618 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8952044 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8951764 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8956025 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8951661 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8952638 |
2018-12-11 | Added | XREF | reactome:R-HSA-8956025 |
2018-12-11 | Added | XREF | reactome:R-HSA-8952618 |
2018-12-11 | Added | XREF | reactome:R-HSA-8951648 |
2018-12-11 | Added | XREF | reactome:R-HSA-8952044 |
2018-12-11 | Added | XREF | reactome:R-HSA-8951764 |
2018-12-11 | Added | XREF | reactome:R-HSA-8952638 |
2018-12-11 | Added | XREF | reactome:R-HSA-8951661 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Added | SECONDARY | GO:0042295 (Hub1 conjugating enzyme activity) |
2008-04-01 | Added | SECONDARY | GO:0016976 (NEDD8 conjugating enzyme activity) |
2008-04-01 | Added | SECONDARY | GO:0019945 (RUB1 conjugating enzyme) |
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