GO:0019797
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procollagen-proline 3-dioxygenase activity
Molecular Function
Definition (GO:0019797 GONUTS page)
Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
procollagen-proline,2-oxoglutarate 3-dioxygenase activity | related |
prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity | related |
protocollagen proline 3-hydroxylase activity | related |
prolyl 3-hydroxylase activity | broad |
proline,2-oxoglutarate 3-dioxygenase activity | related |
procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A0G2K2I9 | 10116 | A0A0G2K2I9_RAT | GO:0016706 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0016705 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0A8A1U9H3 | 10116 | A0A8A1U9H3_RAT | GO:0016706 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.14.11.7 | |
KEGG_REACTION | R03218 | |
MetaCyc | PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN | |
RHEA | 22872 | |
Reactome | R-HSA-1980233 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:85428 | trans-3-hydroxy-L-proline residue |
has_participant | CHEBI | CHEBI:30031 | succinate(2-) |
has_participant | CHEBI | CHEBI:16810 | 2-oxoglutarate(2-) |
has_participant | CHEBI | CHEBI:15379 | dioxygen |
has_participant | CHEBI | CHEBI:50342 | L-proline residue |
has_participant | CHEBI | CHEBI:16526 | carbon dioxide |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0019797 based on ALL annotations
The top 53 of 53 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
procollagen-proline 3-dioxygenase activity
|
62,489.71 | 100.00 | 3,171 | 3,171 |
collagen metabolic process
|
41,105.15 | 65.66 | 3,162 | 4,807 |
L-ascorbic acid binding
|
2,515.48 | 4.03 | 3,166 | 78,650 |
negative regulation of post-translational protein modification
|
15,665.47 | 2.64 | 91 | 363 |
collagen biosynthetic process
|
5,144.85 | 2.14 | 89 | 1,081 |
regulation of protein secretion
|
1,214.30 | 1.17 | 91 | 4,683 |
catalytic complex
|
720.88 | 0.82 | 89 | 7,715 |
bone development
|
572.09 | 0.70 | 91 | 9,940 |
dioxygenase activity
|
280.83 | 0.45 | 3,098 | 689,371 |
negative regulation of cell population proliferation
|
254.92 | 0.38 | 185 | 45,350 |
Totals | 26066 | 183814308 |
No co-occurrence statistics for GO:0019797 based on MANUAL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
procollagen-proline 3-dioxygenase activity
|
22,766.66 | 100.00 | 62 | 62 |
collagen metabolic process
|
12,274.20 | 53.91 | 62 | 115 |
peptidyl-proline hydroxylation
|
19,514.28 | 9.52 | 6 | 7 |
collagen biosynthetic process
|
1,393.88 | 2.78 | 3 | 49 |
negative regulation of post-translational protein modification
|
3,794.44 | 2.78 | 2 | 12 |
catalytic complex
|
683.00 | 1.89 | 3 | 100 |
regulation of ossification
|
722.75 | 1.63 | 2 | 63 |
protein hydroxylation
|
1,517.78 | 1.32 | 1 | 15 |
negative regulation of collagen fibril organization
|
1,422.92 | 1.30 | 1 | 16 |
peptidyl-lysine hydroxylation
|
1,264.81 | 1.27 | 1 | 18 |
Totals | 265 | 929692 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | protocollagen proline 3-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | proline,2-oxoglutarate 3-dioxygenase activity |
2020-10-08 | Deleted | SYNONYM | procollagen-proline,2-oxoglutarate 3-dioxygenase activity |
2020-10-08 | Deleted | SYNONYM | prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity |
2020-10-08 | Deleted | SYNONYM | procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity |
2020-10-08 | Added | SYNONYM | prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity |
2020-10-08 | Added | SYNONYM | proline,2-oxoglutarate 3-dioxygenase activity |
2020-10-08 | Added | SYNONYM | procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity |
2020-10-08 | Added | SYNONYM | procollagen-proline,2-oxoglutarate 3-dioxygenase activity |
2020-10-08 | Added | SYNONYM | protocollagen proline 3-hydroxylase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | procollagen-proline 3-dioxygenase activity |
2001-11-15 | Added | TERM | procollagen-proline 3-dioxygenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | protocollagen proline 3-hydroxylase activity |
2020-10-08 | Deleted | SYNONYM | proline,2-oxoglutarate 3-dioxygenase activity |
2020-10-08 | Deleted | SYNONYM | procollagen-proline,2-oxoglutarate 3-dioxygenase activity |
2020-10-08 | Deleted | SYNONYM | prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity |
2020-10-08 | Deleted | SYNONYM | procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity |
2020-10-08 | Added | SYNONYM | prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity |
2020-10-08 | Added | SYNONYM | proline,2-oxoglutarate 3-dioxygenase activity |
2020-10-08 | Added | SYNONYM | procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity |
2020-10-08 | Added | SYNONYM | procollagen-proline,2-oxoglutarate 3-dioxygenase activity |
2020-10-08 | Added | SYNONYM | protocollagen proline 3-hydroxylase activity |
2011-12-08 | Added | SYNONYM | prolyl 3-hydroxylase activity |
2011-12-08 | Deleted | SYNONYM | prolyl 3-hydroxylase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. |
2007-12-14 | Added | SYNONYM | protocollagen proline 3-hydroxylase activity |
2007-12-14 | Added | SYNONYM | prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity |
2007-12-14 | Added | SYNONYM | procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity |
2007-09-06 | Added | SYNONYM | proline,2-oxoglutarate 3-dioxygenase activity |
2007-09-06 | Added | SYNONYM | prolyl 3-hydroxylase activity |
2007-09-06 | Added | SYNONYM | procollagen-proline,2-oxoglutarate 3-dioxygenase activity |
2003-10-23 | Updated | DEFINITION | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + carbon dioxide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0031544 (peptidyl-proline 3-dioxygenase activity) |
2008-04-01 | Updated | RELATION | is a GO:0019798 (procollagen-proline dioxygenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:22872 |
2019-06-20 | Added | XREF | KEGG_REACTION:R03218 |
2019-06-20 | Deleted | XREF | KEGG:R03218 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1980233 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1980233 |
2018-12-11 | Added | XREF | reactome:R-HSA-1980233 |
2010-09-03 | Added | XREF | KEGG:R03218 |
2003-10-27 | Added | XREF | MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN |
2001-11-15 | Added | XREF | EC:1.14.11.7 |
Timestamp | Action | Category | Detail |
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