This term is obsolete.

GO:0019797 JSON

procollagen-proline 3-dioxygenase activity

Molecular Function

Definition (GO:0019797 GONUTS page)

Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.

3,167 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
procollagen-proline,2-oxoglutarate 3-dioxygenase activity related
prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity related
protocollagen proline 3-hydroxylase activity related
prolyl 3-hydroxylase activity broad
proline,2-oxoglutarate 3-dioxygenase activity related
procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity related

Ancestor Chart

Ancestor chart for GO:0019797
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A0G2K2I9 10116 A0A0G2K2I9_RAT GO:0016706 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A8A1U9H3 10116 A0A8A1U9H3_RAT GO:0016706 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 1.14.11.7
KEGG_REACTION R03218
MetaCyc PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN
RHEA 22872
Reactome R-HSA-1980233

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:50342 L-proline residue
has_participant CHEBI CHEBI:15379 dioxygen
has_participant CHEBI CHEBI:16810 2-oxoglutarate(2-)
has_participant CHEBI CHEBI:85428 trans-3-hydroxy-L-proline residue
has_participant CHEBI CHEBI:30031 succinate(2-)
has_participant CHEBI CHEBI:16526 carbon dioxide

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0019797 based on ALL annotations
The top 53 of 53 co-occurring terms
Co-occurring Term PR S% #Together #Compared
procollagen-proline 3-dioxygenase activity
62,741.81 100.00 3,107 3,107
collagen metabolic process
41,604.05 66.18 3,098 4,672
L-ascorbic acid binding
2,732.04 4.35 3,101 71,215
negative regulation of post-translational protein modification
15,340.72 2.63 89 364
collagen biosynthetic process
5,049.53 2.12 87 1,081
regulation of protein secretion
1,220.28 1.17 89 4,576
catalytic complex
745.80 0.84 87 7,319
bone development
565.59 0.69 89 9,873
dioxygenase activity
276.50 0.44 3,040 689,815
negative regulation of cell population proliferation
256.41 0.38 183 44,779
Totals 25565 182619696
No co-occurrence statistics for GO:0019797 based on MANUAL annotations
The top 36 of 36 co-occurring terms
Co-occurring Term PR S% #Together #Compared
procollagen-proline 3-dioxygenase activity
24,373.57 100.00 53 53
collagen metabolic process
12,302.85 50.48 53 105
peptidyl-proline hydroxylation
20,891.63 11.11 6 7
negative regulation of post-translational protein modification
4,062.26 3.17 2 12
collagen biosynthetic process
1,492.26 3.03 3 49
catalytic complex
731.21 2.00 3 100
regulation of ossification
773.76 1.75 2 63
protein hydroxylation
1,624.90 1.49 1 15
negative regulation of collagen fibril organization
1,523.35 1.47 1 16
peptidyl-lysine hydroxylation
1,354.09 1.43 1 18
Totals 238 864072

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM proline,2-oxoglutarate 3-dioxygenase activity
2020-10-08 Deleted SYNONYM prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity
2020-10-08 Deleted SYNONYM procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
2020-10-08 Deleted SYNONYM protocollagen proline 3-hydroxylase activity
2020-10-08 Added SYNONYM prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity
2020-10-08 Deleted SYNONYM procollagen-proline,2-oxoglutarate 3-dioxygenase activity
2020-10-08 Added SYNONYM protocollagen proline 3-hydroxylase activity
2020-10-08 Added SYNONYM proline,2-oxoglutarate 3-dioxygenase activity
2020-10-08 Added SYNONYM procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
2020-10-08 Added SYNONYM procollagen-proline,2-oxoglutarate 3-dioxygenase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM procollagen-proline 3-dioxygenase activity
2001-11-15 Added TERM procollagen-proline 3-dioxygenase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM proline,2-oxoglutarate 3-dioxygenase activity
2020-10-08 Deleted SYNONYM prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity
2020-10-08 Deleted SYNONYM procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
2020-10-08 Deleted SYNONYM protocollagen proline 3-hydroxylase activity
2020-10-08 Added SYNONYM prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity
2020-10-08 Deleted SYNONYM procollagen-proline,2-oxoglutarate 3-dioxygenase activity
2020-10-08 Added SYNONYM protocollagen proline 3-hydroxylase activity
2020-10-08 Added SYNONYM proline,2-oxoglutarate 3-dioxygenase activity
2020-10-08 Added SYNONYM procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
2020-10-08 Added SYNONYM procollagen-proline,2-oxoglutarate 3-dioxygenase activity
2011-12-08 Deleted SYNONYM prolyl 3-hydroxylase activity
2011-12-08 Added SYNONYM prolyl 3-hydroxylase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.
2007-12-14 Added SYNONYM procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity
2007-12-14 Added SYNONYM prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity
2007-12-14 Added SYNONYM protocollagen proline 3-hydroxylase activity
2007-09-06 Added SYNONYM procollagen-proline,2-oxoglutarate 3-dioxygenase activity
2007-09-06 Added SYNONYM prolyl 3-hydroxylase activity
2007-09-06 Added SYNONYM proline,2-oxoglutarate 3-dioxygenase activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.
2002-11-27 Added DEFINITION Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + carbon dioxide.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0019798 (procollagen-proline dioxygenase activity)
2008-04-01 Updated RELATION is a GO:0031544 (peptidyl-proline 3-dioxygenase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:22872
2019-06-20 Added XREF KEGG_REACTION:R03218
2019-06-20 Deleted XREF KEGG:R03218
2019-04-01 Deleted XREF reactome:R-HSA-1980233
2019-04-01 Added XREF Reactome:R-HSA-1980233
2018-12-11 Added XREF reactome:R-HSA-1980233
2010-09-03 Added XREF KEGG:R03218
2003-10-27 Added XREF MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN
2001-11-15 Added XREF EC:1.14.11.7
Timestamp Action Category Detail
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