Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.
GO:0019898
JSON
extrinsic component of membrane
Cellular Component
Definition (GO:0019898 GONUTS page)
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
Comments
Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.
Secondary IDs
GO:0030396
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
extrinsic to membrane | exact |
peripheral membrane protein | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0019898
Child Term | Relationship to GO:0019898 |
---|---|
extrinsic component of cell outer membrane
|
is_a |
extrinsic component of thylakoid membrane
|
is_a |
extrinsic component of organelle membrane
|
is_a |
extrinsic component of plasma membrane
|
is_a |
phosphatidylinositol 3-kinase complex
|
part_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Discerning the appropriate spatial relationship between a membrane and a gene product | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A8I6ARU6 | 10116 | A0A8I6ARU6_RAT | GO:0016020 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HKS9 | 10116 | A6HKS9_RAT | GO:0016020 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HKT1 | 10116 | A6HKT1_RAT | GO:0016020 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EZK6 | 10116 | F7EZK6_RAT | GO:0016020 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR002683 | PsbP, C-terminal |
InterPro | IPR008797 | Oxygen-evolving enhancer protein 3 |
InterPro | IPR010527 | Photosystem II PsbU, oxygen evolving complex |
InterPro | IPR030190 | Macrolide export protein MacA, alpha-hairpin domain superfamily |
Wikipedia | Peripheral_membrane_protein |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0000300 | obsolete peripheral to membrane of membrane fraction | consider GO:0019898 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0019898 based on ALL annotations
The top 100 of 844 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extrinsic component of membrane
|
6,308.09 | 100.00 | 30,903 | 30,903 |
macrolide transmembrane transporter complex
|
6,308.09 | 34.33 | 10,608 | 10,608 |
photosystem II oxygen evolving complex
|
4,574.21 | 30.59 | 10,695 | 14,749 |
xenobiotic detoxification by transmembrane export across the plasma membrane
|
792.20 | 10.13 | 10,623 | 84,588 |
axon guidance
|
274.92 | 3.86 | 7,811 | 179,222 |
photosystem II
|
257.75 | 3.82 | 11,414 | 279,342 |
efflux pump complex
|
205.42 | 2.97 | 7,809 | 239,804 |
photosynthetic electron transport chain
|
229.54 | 2.32 | 1,857 | 51,034 |
photosystem II stabilization
|
324.07 | 1.99 | 972 | 18,920 |
efflux transmembrane transporter activity
|
126.12 | 1.89 | 7,886 | 394,437 |
Totals | 210789 | 36765597 |
No co-occurrence statistics for GO:0019898 based on MANUAL annotations
The top 100 of 396 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extrinsic component of membrane
|
6,658.76 | 100.00 | 194 | 194 |
muscle cell projection
|
4,280.63 | 4.52 | 9 | 14 |
dendrite development
|
423.30 | 4.51 | 26 | 409 |
male genitalia morphogenesis
|
2,853.75 | 4.37 | 9 | 21 |
positive regulation of Rho protein signal transduction
|
428.94 | 4.21 | 21 | 326 |
regulation of vulval development
|
1,331.75 | 3.91 | 9 | 45 |
extrinsic component of cytoplasmic side of plasma membrane
|
681.01 | 3.30 | 9 | 88 |
mesodermal cell migration
|
673.36 | 3.28 | 9 | 89 |
positive regulation of Rac protein signal transduction
|
651.40 | 3.25 | 9 | 92 |
regulation of locomotion
|
605.34 | 3.17 | 9 | 99 |
Totals | 794 | 21937 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_metagenomics | 111 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:42.27.03 |
2019-09-12 | Added | RELATION | is a GO:0110165 (cellular anatomical structure) |
2019-09-12 | Deleted | RELATION | is a GO:0044425 (obsolete membrane part) |
2019-09-12 | Added | RELATION | part of GO:0016020 (membrane) |
2019-05-04 | Added | XREF | MIPS_funcat:42.27.03 |
2016-07-23 | Added | SUBSET | goslim_metagenomics |
2013-12-21 | Deleted | DEFINITION | Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. |
2013-12-21 | Updated | TERM | extrinsic component of membrane |
2013-12-21 | Added | SYNONYM | extrinsic to membrane |
2013-12-21 | Added | DEFINITION | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-12-21 | Updated | TERM | extrinsic component of membrane |
2002-12-17 | Updated | TERM | extrinsic to membrane |
2002-01-08 | Added | TERM | extrinsic membrane protein |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-12-21 | Deleted | DEFINITION | Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. |
2013-12-21 | Added | SYNONYM | extrinsic to membrane |
2013-12-21 | Added | DEFINITION | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
2008-05-13 | Added | DEFINITION | Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. |
2008-05-12 | Deleted | DEFINITION | Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. |
2007-10-16 | Deleted | SYNONYM | GPI-anchored membrane-bound receptor |
2007-08-09 | Deleted | SYNONYM | GPI-anchored membrane-bound receptor |
2007-08-09 | Deleted | SYNONYM | peripheral membrane protein |
2007-08-09 | Added | SYNONYM | peripheral membrane protein |
2007-08-09 | Added | SYNONYM | GPI-anchored membrane-bound receptor |
2005-08-10 | Added | SYNONYM | GPI-anchored membrane-bound receptor |
2005-03-05 | Updated | DEFINITION | Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. |
2005-02-25 | Updated | DEFINITION | Loosely bound, by ionic or covalent forces, to one surface of a membrane, but not integrated into the hydrophobic region. |
2004-04-30 | Updated | DEFINITION | Loosely bound, by ionic or covalent forces, to one or other surface of a membrane, but not integrated into the hydrophobic region. |
2004-04-19 | Added | SYNONYM | peripheral membrane protein |
2004-04-16 | Deleted | SYNONYM | peripheral membrane protein |
2003-03-26 | Updated | DEFINITION | Loosely bound, by ionic or covalent forces, to one or other surface of the cell membrane, but not integrated into the hydrophobic region. |
2002-11-27 | Added | DEFINITION | An operational term for any protein that can be dissociated unchanged from a cell membrane by a mild treatment such as increase in ionic strength of the medium or addition of a chelating agent to it. Such proteins are presumed to be loosely attached one or other surface of the cell membrane. |
2002-01-08 | Added | SYNONYM | peripheral membrane protein |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Added | RELATION | is a GO:0110165 (cellular anatomical structure) |
2019-09-12 | Deleted | RELATION | is a GO:0044425 (obsolete membrane part) |
2019-09-12 | Added | RELATION | part of GO:0016020 (membrane) |
2008-04-01 | Updated | RELATION | is a GO:0044425 (obsolete membrane part) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:42.27.03 |
2019-05-04 | Added | XREF | MIPS_funcat:42.27.03 |
2009-02-08 | Added | XREF | Wikipedia:Peripheral_membrane_protein |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-07-23 | Added | SUBSET | goslim_metagenomics |
2002-01-08 | Added | SECONDARY | GO:0030396 (peripheral membrane protein) |
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