This term is obsolete.
Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.

GO:0019898 JSON

extrinsic component of membrane

Cellular Component

Definition (GO:0019898 GONUTS page)

The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

Comments

Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.

Secondary IDs

GO:0030396

259,676 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
extrinsic to membrane exact
peripheral membrane protein exact

Ancestor Chart

Ancestor chart for GO:0019898
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019898

Child Term Relationship to
GO:0019898
extrinsic component of cell outer membrane
is_a
extrinsic component of thylakoid membrane
is_a
extrinsic component of organelle membrane
is_a
extrinsic component of plasma membrane
is_a
phosphatidylinositol 3-kinase complex
part_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Discerning the appropriate spatial relationship between a membrane and a gene product Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A8I6ARU6 10116 A0A8I6ARU6_RAT GO:0016020 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HKS9 10116 A6HKS9_RAT GO:0016020 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HKT1 10116 A6HKT1_RAT GO:0016020 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EZK6 10116 F7EZK6_RAT GO:0016020 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR002683 PsbP, C-terminal
InterPro IPR008797 Oxygen-evolving enhancer protein 3
InterPro IPR010527 Photosystem II PsbU, oxygen evolving complex
InterPro IPR030190 Macrolide export protein MacA, alpha-hairpin domain superfamily
Wikipedia Peripheral_membrane_protein

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0000300 obsolete peripheral to membrane of membrane fraction consider GO:0019898

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0019898 based on ALL annotations
The top 100 of 844 co-occurring terms
Co-occurring Term PR S% #Together #Compared
extrinsic component of membrane
6,308.09 100.00 30,903 30,903
macrolide transmembrane transporter complex
6,308.09 34.33 10,608 10,608
photosystem II oxygen evolving complex
4,574.21 30.59 10,695 14,749
xenobiotic detoxification by transmembrane export across the plasma membrane
792.20 10.13 10,623 84,588
axon guidance
274.92 3.86 7,811 179,222
photosystem II
257.75 3.82 11,414 279,342
efflux pump complex
205.42 2.97 7,809 239,804
photosynthetic electron transport chain
229.54 2.32 1,857 51,034
photosystem II stabilization
324.07 1.99 972 18,920
efflux transmembrane transporter activity
126.12 1.89 7,886 394,437
Totals 210789 36765597
No co-occurrence statistics for GO:0019898 based on MANUAL annotations
The top 100 of 396 co-occurring terms
Co-occurring Term PR S% #Together #Compared
extrinsic component of membrane
6,658.76 100.00 194 194
muscle cell projection
4,280.63 4.52 9 14
dendrite development
423.30 4.51 26 409
male genitalia morphogenesis
2,853.75 4.37 9 21
positive regulation of Rho protein signal transduction
428.94 4.21 21 326
regulation of vulval development
1,331.75 3.91 9 45
extrinsic component of cytoplasmic side of plasma membrane
681.01 3.30 9 88
mesodermal cell migration
673.36 3.28 9 89
positive regulation of Rac protein signal transduction
651.40 3.25 9 92
regulation of locomotion
605.34 3.17 9 99
Totals 794 21937

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_metagenomics 111

Change Log

Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:42.27.03
2019-09-12 Added RELATION is a GO:0110165 (cellular anatomical structure)
2019-09-12 Deleted RELATION is a GO:0044425 (obsolete membrane part)
2019-09-12 Added RELATION part of GO:0016020 (membrane)
2019-05-04 Added XREF MIPS_funcat:42.27.03
2016-07-23 Added SUBSET goslim_metagenomics
2013-12-21 Deleted DEFINITION Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region.
2013-12-21 Updated TERM extrinsic component of membrane
2013-12-21 Added SYNONYM extrinsic to membrane
2013-12-21 Added DEFINITION The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
Timestamp Action Category Detail
2013-12-21 Updated TERM extrinsic component of membrane
2002-12-17 Updated TERM extrinsic to membrane
2002-01-08 Added TERM extrinsic membrane protein
Timestamp Action Category Detail
2013-12-21 Deleted DEFINITION Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region.
2013-12-21 Added SYNONYM extrinsic to membrane
2013-12-21 Added DEFINITION The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2008-05-13 Added DEFINITION Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region.
2008-05-12 Deleted DEFINITION Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region.
2007-10-16 Deleted SYNONYM GPI-anchored membrane-bound receptor
2007-08-09 Deleted SYNONYM GPI-anchored membrane-bound receptor
2007-08-09 Deleted SYNONYM peripheral membrane protein
2007-08-09 Added SYNONYM peripheral membrane protein
2007-08-09 Added SYNONYM GPI-anchored membrane-bound receptor
2005-08-10 Added SYNONYM GPI-anchored membrane-bound receptor
2005-03-05 Updated DEFINITION Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region.
2005-02-25 Updated DEFINITION Loosely bound, by ionic or covalent forces, to one surface of a membrane, but not integrated into the hydrophobic region.
2004-04-30 Updated DEFINITION Loosely bound, by ionic or covalent forces, to one or other surface of a membrane, but not integrated into the hydrophobic region.
2004-04-19 Added SYNONYM peripheral membrane protein
2004-04-16 Deleted SYNONYM peripheral membrane protein
2003-03-26 Updated DEFINITION Loosely bound, by ionic or covalent forces, to one or other surface of the cell membrane, but not integrated into the hydrophobic region.
2002-11-27 Added DEFINITION An operational term for any protein that can be dissociated unchanged from a cell membrane by a mild treatment such as increase in ionic strength of the medium or addition of a chelating agent to it. Such proteins are presumed to be loosely attached one or other surface of the cell membrane.
2002-01-08 Added SYNONYM peripheral membrane protein
Timestamp Action Category Detail
2019-09-12 Added RELATION is a GO:0110165 (cellular anatomical structure)
2019-09-12 Deleted RELATION is a GO:0044425 (obsolete membrane part)
2019-09-12 Added RELATION part of GO:0016020 (membrane)
2008-04-01 Updated RELATION is a GO:0044425 (obsolete membrane part)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:42.27.03
2019-05-04 Added XREF MIPS_funcat:42.27.03
2009-02-08 Added XREF Wikipedia:Peripheral_membrane_protein
Timestamp Action Category Detail
2016-07-23 Added SUBSET goslim_metagenomics
2002-01-08 Added SECONDARY GO:0030396 (peripheral membrane protein)
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