GO:0019966
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interleukin-1 binding
Molecular Function
Definition (GO:0019966 GONUTS page)
Binding to interleukin-1.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
IL-1 binding | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0019966
Child Term | Relationship to GO:0019966 |
---|---|
interleukin-1 receptor antagonist activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0019966 | interleukin-1 binding | Never in Taxon | 2 | Bacteria | |
GO:0019966 | interleukin-1 binding | Never in Taxon | 2157 | Archaea | |
GO:0019966 | interleukin-1 binding | Never in Taxon | 4751 | Fungi |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P59823 | 10090 | IRPL1_MOUSE | GO:0019966 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | P59824 | 10116 | IRPL1_RAT | GO:0019966 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | P60029 | 9598 | IRPL1_PANTR | GO:0019966 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q7YQL9 | 9600 | IRPL1_PONPY | GO:0019966 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | Q9NZN1 | 9606 | IRPL1_HUMAN | GO:0019966 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12783849 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR004078 | Interleukin-1 binding protein |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0019966 based on ALL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
interleukin-1 binding
|
154,836.20 | 100.00 | 1,259 | 1,259 |
interleukin-1, type II, blocking receptor activity
|
120,838.30 | 43.38 | 622 | 797 |
interleukin-1 receptor activity
|
40,182.27 | 24.43 | 1,016 | 3,915 |
interleukin-1, type I, activating receptor activity
|
34,153.17 | 12.15 | 268 | 1,215 |
interleukin-1-mediated signaling pathway
|
13,303.24 | 6.59 | 277 | 3,224 |
negative regulation of interleukin-1 alpha production
|
103,224.14 | 6.46 | 84 | 126 |
NACHT domain binding
|
121,538.10 | 5.71 | 73 | 93 |
negative regulation of protein processing
|
22,997.73 | 5.50 | 101 | 680 |
positive regulation of interleukin-1-mediated signaling pathway
|
154,836.20 | 5.32 | 67 | 67 |
response to organophosphorus
|
37,427.30 | 4.91 | 73 | 302 |
Totals | 9027 | 3324453 |
No co-occurrence statistics for GO:0019966 based on MANUAL annotations
The top 100 of 132 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
interleukin-1 binding
|
67,989.42 | 100.00 | 19 | 19 |
NACHT domain binding
|
54,391.54 | 20.00 | 4 | 5 |
positive regulation of retinoic acid receptor signaling pathway
|
15,997.51 | 12.50 | 4 | 17 |
response to organophosphorus
|
13,597.89 | 11.43 | 4 | 20 |
positive regulation of interleukin-1-mediated signaling pathway
|
67,989.42 | 10.53 | 2 | 2 |
interleukin-1 receptor activity
|
8,945.98 | 9.62 | 5 | 38 |
trans-synaptic signaling by trans-synaptic complex
|
11,998.13 | 9.09 | 3 | 17 |
interleukin-8 binding
|
22,663.14 | 8.70 | 2 | 6 |
negative regulation of exocytosis
|
7,390.16 | 8.33 | 5 | 46 |
negative regulation of complement activation, lectin pathway
|
19,425.55 | 8.33 | 2 | 7 |
Totals | 230 | 48722 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2157 (Archaea) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2 (Bacteria) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with interleukin-1. |
2021-05-24 | Added | DEFINITION | Binding to interleukin-1. |
2011-10-28 | Added | RELATION | has part GO:0004908 (interleukin-1 receptor activity) |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with interleukin-1. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with interleukin-1. |
2008-11-13 | Deleted | RELATION | is a GO:0019965 (interleukin binding) |
2008-11-13 | Added | RELATION | is a GO:0019955 (cytokine binding) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-06-10 | Updated | TERM | interleukin-1 binding |
2003-03-19 | Updated | TERM | interleukin-1 binding activity |
2002-01-10 | Added | TERM | interleukin-1 binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with interleukin-1. |
2021-05-24 | Added | DEFINITION | Binding to interleukin-1. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with interleukin-1. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with interleukin-1. |
2008-05-13 | Added | DEFINITION | Interacting selectively with interleukin-1. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with interleukin-1. |
2007-08-09 | Added | SYNONYM | IL-1 binding |
2007-08-09 | Deleted | SYNONYM | IL-1 binding |
2004-04-19 | Added | SYNONYM | IL-1 binding |
2004-04-16 | Deleted | SYNONYM | IL-1 binding |
2003-03-26 | Updated | DEFINITION | Interacting selectively with interleukin-1. |
2002-11-27 | Added | DEFINITION | Interacting selectively and stoichiometrically with interleukin-1. |
2002-08-24 | Added | SYNONYM | IL-1 binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-10-28 | Added | RELATION | has part GO:0004908 (interleukin-1 receptor activity) |
2008-11-13 | Deleted | RELATION | is a GO:0019965 (interleukin binding) |
2008-11-13 | Added | RELATION | is a GO:0019955 (cytokine binding) |
2008-04-01 | Updated | RELATION | is a GO:0019838 (growth factor binding) |
2008-04-01 | Updated | RELATION | is a GO:0019965 (interleukin binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2157 (Archaea) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2 (Bacteria) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
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