This term is obsolete.

GO:0019966 JSON

interleukin-1 binding

Molecular Function

Definition (GO:0019966 GONUTS page)

Binding to interleukin-1.

1,855 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
IL-1 binding exact

Ancestor Chart

Ancestor chart for GO:0019966
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019966

Child Term Relationship to
GO:0019966
interleukin-1 receptor antagonist activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0019966 interleukin-1 binding Never in Taxon 2 Bacteria
GO:0019966 interleukin-1 binding Never in Taxon 2157 Archaea
GO:0019966 interleukin-1 binding Never in Taxon 4751 Fungi

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P59823 10090 IRPL1_MOUSE GO:0019966 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P59824 10116 IRPL1_RAT GO:0019966 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein P60029 9598 IRPL1_PANTR GO:0019966 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q7YQL9 9600 IRPL1_PONPY GO:0019966 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein Q9NZN1 9606 IRPL1_HUMAN GO:0019966 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12783849

Cross-references

Database ID Description
InterPro IPR004078 Interleukin-1 binding protein

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0019966 based on ALL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-1 binding
154,836.20 100.00 1,259 1,259
interleukin-1, type II, blocking receptor activity
120,838.30 43.38 622 797
interleukin-1 receptor activity
40,182.27 24.43 1,016 3,915
interleukin-1, type I, activating receptor activity
34,153.17 12.15 268 1,215
interleukin-1-mediated signaling pathway
13,303.24 6.59 277 3,224
negative regulation of interleukin-1 alpha production
103,224.14 6.46 84 126
NACHT domain binding
121,538.10 5.71 73 93
negative regulation of protein processing
22,997.73 5.50 101 680
positive regulation of interleukin-1-mediated signaling pathway
154,836.20 5.32 67 67
response to organophosphorus
37,427.30 4.91 73 302
Totals 9027 3324453
No co-occurrence statistics for GO:0019966 based on MANUAL annotations
The top 100 of 132 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-1 binding
67,989.42 100.00 19 19
NACHT domain binding
54,391.54 20.00 4 5
positive regulation of retinoic acid receptor signaling pathway
15,997.51 12.50 4 17
response to organophosphorus
13,597.89 11.43 4 20
positive regulation of interleukin-1-mediated signaling pathway
67,989.42 10.53 2 2
interleukin-1 receptor activity
8,945.98 9.62 5 38
trans-synaptic signaling by trans-synaptic complex
11,998.13 9.09 3 17
interleukin-8 binding
22,663.14 8.70 2 6
negative regulation of exocytosis
7,390.16 8.33 5 46
negative regulation of complement activation, lectin pathway
19,425.55 8.33 2 7
Totals 230 48722

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with interleukin-1.
2021-05-24 Added DEFINITION Binding to interleukin-1.
2011-10-28 Added RELATION has part GO:0004908 (interleukin-1 receptor activity)
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with interleukin-1.
2009-07-03 Deleted DEFINITION Interacting selectively with interleukin-1.
2008-11-13 Deleted RELATION is a GO:0019965 (interleukin binding)
2008-11-13 Added RELATION is a GO:0019955 (cytokine binding)
Timestamp Action Category Detail
2003-06-10 Updated TERM interleukin-1 binding
2003-03-19 Updated TERM interleukin-1 binding activity
2002-01-10 Added TERM interleukin-1 binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with interleukin-1.
2021-05-24 Added DEFINITION Binding to interleukin-1.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with interleukin-1.
2009-07-03 Deleted DEFINITION Interacting selectively with interleukin-1.
2008-05-13 Added DEFINITION Interacting selectively with interleukin-1.
2008-05-12 Deleted DEFINITION Interacting selectively with interleukin-1.
2007-08-09 Added SYNONYM IL-1 binding
2007-08-09 Deleted SYNONYM IL-1 binding
2004-04-19 Added SYNONYM IL-1 binding
2004-04-16 Deleted SYNONYM IL-1 binding
2003-03-26 Updated DEFINITION Interacting selectively with interleukin-1.
2002-11-27 Added DEFINITION Interacting selectively and stoichiometrically with interleukin-1.
2002-08-24 Added SYNONYM IL-1 binding
Timestamp Action Category Detail
2011-10-28 Added RELATION has part GO:0004908 (interleukin-1 receptor activity)
2008-11-13 Deleted RELATION is a GO:0019965 (interleukin binding)
2008-11-13 Added RELATION is a GO:0019955 (cytokine binding)
2008-04-01 Updated RELATION is a GO:0019838 (growth factor binding)
2008-04-01 Updated RELATION is a GO:0019965 (interleukin binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
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