This term is obsolete.

GO:0022004 JSON

midbrain-hindbrain boundary maturation during brain development

Biological Process

Definition (GO:0022004 GONUTS page)

A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. PMID:15541513

105 annotations

Ancestor Chart

Ancestor chart for GO:0022004
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0022004 midbrain-hindbrain boundary maturation during brain development Only in Taxon 7711 Chordata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q54NG5 44689 Q54NG5_DICDI GO:0007417 To remove over-annotation from InterPro entries. Reported by Typhaine from InterPro on 08/06/2020 IPR034968
IEA Review protein Q54NG6 44689 Q54NG6_DICDI GO:0007417 To remove over-annotation from InterPro entries. Reported by Typhaine from InterPro on 08/06/2020 IPR034968
NOT-qualified manual protein Q9VIP7 7227 ACASE_DROME GO:0007420 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:21148295

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0022004 based on ALL annotations
The top 85 of 85 co-occurring terms
Co-occurring Term PR S% #Together #Compared
midbrain-hindbrain boundary maturation during brain development
1,911,164.60 100.00 102 102
cerebellum formation
1,278,328.60 66.45 101 151
astrocyte-dopaminergic neuron signaling
804,281.75 41.91 101 240
positive regulation of dermatome development
674,921.70 35.19 101 286
metencephalon development
663,325.10 34.59 101 291
forebrain anterior/posterior pattern specification
569,403.00 29.71 101 339
diencephalon development
465,126.80 24.28 101 415
central nervous system morphogenesis
341,038.20 17.81 101 566
cell proliferation in midbrain
273,798.03 14.31 101 705
midbrain dopaminergic neuron differentiation
261,555.03 13.67 101 738
Totals 6471 94931152
No co-occurrence statistics for GO:0022004 based on MANUAL annotations
The top 78 of 78 co-occurring terms
Co-occurring Term PR S% #Together #Compared
midbrain-hindbrain boundary maturation during brain development
322,949.75 100.00 4 4
cerebellum formation
121,106.16 33.33 3 8
metencephalon development
96,884.93 27.27 3 10
positive regulation of dermatome development
58,718.13 15.38 2 11
forebrain anterior/posterior pattern specification
48,442.47 14.29 3 20
astrocyte-dopaminergic neuron signaling
80,737.44 14.29 1 4
negative regulation of apoptotic process involved in development
80,737.44 14.29 1 4
diencephalon development
34,601.76 10.34 3 28
cell proliferation in midbrain
34,601.76 10.34 3 28
neuron fate determination
32,294.98 9.68 3 30
Totals 191 372189

Change Log

Timestamp Action Category Detail
2024-08-16 Added CONSTRAINT in_taxon NCBITaxon:7711 (Chordata)
2024-08-16 Deleted CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2017-08-13 Deleted RELATION is a GO:0044707 (single-multicellular organism process)
2017-08-13 Added RELATION is a GO:0032501 (multicellular organismal process)
2016-06-22 Deleted RELATION is a GO:0044767 (single-organism developmental process)
2013-11-28 Deleted RELATION is a GO:0032502 (developmental process)
2013-11-28 Added RELATION is a GO:0044767 (single-organism developmental process)
2012-12-20 Added RELATION is a GO:0044707 (single-multicellular organism process)
2010-05-14 Deleted RELATION part of GO:0007420 (brain development)
Timestamp Action Category Detail
2007-01-15 Updated TERM midbrain-hindbrain boundary maturation during brain development
2006-08-17 Added TERM midbrain-hindbrain boundary maturation involved in brain development
Timestamp Action Category Detail
2010-05-14 Added DEFINITION A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2010-05-14 Deleted DEFINITION A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2008-05-13 Added DEFINITION A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2008-05-12 Deleted DEFINITION A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
2006-08-18 Added DEFINITION A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.
Timestamp Action Category Detail
2017-08-13 Deleted RELATION is a GO:0044707 (single-multicellular organism process)
2017-08-13 Added RELATION is a GO:0032501 (multicellular organismal process)
2016-06-22 Deleted RELATION is a GO:0044767 (single-organism developmental process)
2013-11-28 Deleted RELATION is a GO:0032502 (developmental process)
2013-11-28 Added RELATION is a GO:0044767 (single-organism developmental process)
2012-12-20 Added RELATION is a GO:0044707 (single-multicellular organism process)
2010-05-14 Deleted RELATION part of GO:0007420 (brain development)
2010-05-14 Added RELATION is a GO:0032502 (developmental process)
2010-05-14 Deleted RELATION is a GO:0071695 (anatomical structure maturation)
2010-03-04 Added RELATION is a GO:0071695 (anatomical structure maturation)
2010-03-04 Deleted RELATION is a GO:0021700 (developmental maturation)
2008-04-01 Updated RELATION part of GO:0021732 (midbrain-hindbrain boundary maturation)
2008-04-01 Updated RELATION part of GO:0007420 (brain development)
2008-04-01 Updated RELATION is a GO:0021700 (developmental maturation)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-08-16 Added CONSTRAINT in_taxon NCBITaxon:7711 (Chordata)
2024-08-16 Deleted CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
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