This term is obsolete.
Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'.

GO:0022850 JSON

serotonin-gated monoatomic cation channel activity

Molecular Function

Definition (GO:0022850 GONUTS page)

Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. PMID:12867984

Comments

Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'.

Secondary IDs

GO:0005232

561 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
serotonin-gated monoatomic cation-selective channel activity exact
serotonin-gated cation channel activity narrow
5-hydroxytryptamine-gated receptor-channel narrow
serotonin-activated cation-selective channel activity exact
serotonin-gated cation-selective channel activity broad

Ancestor Chart

Ancestor chart for GO:0022850
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0022850

Child Term Relationship to
GO:0022850
serotonin-activated cation-selective channel complex
capable_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0022850 serotonin-gated monoatomic cation channel activity Only in Taxon 33208 Metazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZLE9 10116 A0A8I5ZLE9_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZST4 10116 A0A8I5ZST4_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AI08 10116 A0A8I6AI08_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0PK00 9606 T120B_HUMAN GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6HVQ8 10116 A6HVQ8_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J168 10116 A6J168_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J4P5 10116 A6J4P5_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6QPF8 9913 T120B_BOVIN GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
Reactome R-HSA-9648983
Reactome R-HSA-975311

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:23906 monoatomic cation
has_small_molecule_activator CHEBI CHEBI:350546 serotonin(1+)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0022850 based on ALL annotations
The top 57 of 57 co-occurring terms
Co-occurring Term PR S% #Together #Compared
serotonin-gated monoatomic cation channel activity
388,538.97 100.00 510 510
serotonin-gated cation-selective signaling pathway
388,538.97 71.37 364 364
serotonin-activated cation-selective channel complex
387,474.47 71.23 364 365
excitatory extracellular ligand-gated monoatomic ion channel activity
106,298.39 17.90 174 636
serotonin receptor signaling pathway
37,791.65 9.38 370 3,804
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
21,843.55 5.07 174 3,095
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
23,590.88 4.63 83 1,367
regulation of presynaptic membrane potential
16,020.24 3.40 83 2,013
serotonin binding
8,671.95 2.04 97 4,346
transmembrane transporter complex
6,426.41 1.60 174 10,520
Totals 7211 91447142
No co-occurrence statistics for GO:0022850 based on MANUAL annotations
The top 43 of 43 co-occurring terms
Co-occurring Term PR S% #Together #Compared
serotonin-gated monoatomic cation channel activity
7,629.91 100.00 185 185
transmembrane transporter complex
2,514.40 32.28 174 528
excitatory extracellular ligand-gated monoatomic ion channel activity
2,158.71 27.80 174 615
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
1,062.08 13.80 174 1,250
monoatomic ion transmembrane transport
1,014.99 13.19 174 1,308
regulation of membrane potential
860.96 11.20 174 1,542
chemical synaptic transmission
447.00 5.84 174 2,970
serotonin receptor signaling pathway
869.23 5.54 18 158
serotonin-activated cation-selective channel complex
7,629.91 4.86 9 9
serotonin-gated cation-selective signaling pathway
7,629.91 3.78 7 7
Totals 1867 313145

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
2023-10-10 Added SYNONYM serotonin-gated monoatomic cation-selective channel activity
2023-10-10 Updated TERM serotonin-gated monoatomic cation channel activity
2022-12-02 Added SYNONYM serotonin-gated cation-selective channel activity
2022-12-02 Updated TERM serotonin-gated monoatomic cation-selective channel activity
2022-07-18 Added RELATION is a GO:0099589 (serotonin receptor activity)
2022-01-12 Added RELATION has part GO:0140227 (serotonin-gated cation-selective signaling pathway)
2020-07-19 Added XREF Reactome:R-HSA-9648983
2019-04-01 Deleted XREF reactome:R-HSA-975311
2019-04-01 Added XREF Reactome:R-HSA-975311
Timestamp Action Category Detail
2023-10-10 Updated TERM serotonin-gated monoatomic cation channel activity
2022-12-02 Updated TERM serotonin-gated monoatomic cation-selective channel activity
2017-01-02 Updated TERM serotonin-gated cation-selective channel activity
2007-07-11 Added TERM serotonin-gated cation channel activity
Timestamp Action Category Detail
2023-10-10 Added SYNONYM serotonin-gated monoatomic cation-selective channel activity
2022-12-02 Added SYNONYM serotonin-gated cation-selective channel activity
2017-01-02 Added SYNONYM serotonin-gated cation channel activity
2017-01-02 Added SYNONYM 5-hydroxytryptamine-gated receptor-channel
2017-01-02 Added SYNONYM serotonin-activated cation-selective channel activity
2015-05-11 Added DEFINITION Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.
2015-05-11 Deleted DEFINITION Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.
2008-05-13 Added DEFINITION Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.
2008-05-12 Deleted DEFINITION Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.
2007-07-27 Added DEFINITION Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.
Timestamp Action Category Detail
2022-07-18 Added RELATION is a GO:0099589 (serotonin receptor activity)
2022-01-12 Added RELATION has part GO:0140227 (serotonin-gated cation-selective signaling pathway)
2018-04-15 Added RELATION part of GO:0007210 (serotonin receptor signaling pathway)
2018-02-09 Deleted RELATION is a GO:0140135 (mechanosensitive monoatomic cation channel activity)
2018-02-09 Added RELATION is a GO:0099094 (ligand-gated monoatomic cation channel activity)
2017-11-19 Added RELATION is a GO:0140135 (mechanosensitive monoatomic cation channel activity)
2017-11-19 Deleted RELATION is a GO:0005261 (monoatomic cation channel activity)
2017-11-17 Deleted RELATION is a GO:0099589 (serotonin receptor activity)
2017-01-02 Added RELATION is a GO:0005261 (monoatomic cation channel activity)
2016-01-20 Added RELATION is a GO:0099589 (serotonin receptor activity)
2008-04-01 Updated RELATION is a GO:0022824 (transmitter-gated monoatomic ion channel activity)
Timestamp Action Category Detail
2020-07-19 Added XREF Reactome:R-HSA-9648983
2019-04-01 Deleted XREF reactome:R-HSA-975311
2019-04-01 Added XREF Reactome:R-HSA-975311
2018-12-11 Added XREF reactome:R-HSA-975311
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
2017-01-02 Added SECONDARY GO:0005232 (serotonin-activated cation-selective channel activity)
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