Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'.
GO:0022850
JSON
serotonin-gated monoatomic cation channel activity
Molecular Function
Definition (GO:0022850 GONUTS page)
Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. PMID:12867984
Comments
Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'.
Secondary IDs
GO:0005232
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
serotonin-gated monoatomic cation-selective channel activity | exact |
serotonin-gated cation channel activity | narrow |
5-hydroxytryptamine-gated receptor-channel | narrow |
serotonin-activated cation-selective channel activity | exact |
serotonin-gated cation-selective channel activity | broad |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0022850
Child Term | Relationship to GO:0022850 |
---|---|
serotonin-activated cation-selective channel complex
|
capable_of |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0022850 | serotonin-gated monoatomic cation channel activity | Only in Taxon | 33208 | Metazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5ZLE9 | 10116 | A0A8I5ZLE9_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZST4 | 10116 | A0A8I5ZST4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0PK00 | 9606 | T120B_HUMAN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HVQ8 | 10116 | A6HVQ8_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J168 | 10116 | A6J168_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J4P5 | 10116 | A6J4P5_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6QPF8 | 9913 | T120B_BOVIN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
Reactome | R-HSA-9648983 | |
Reactome | R-HSA-975311 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CHEBI | CHEBI:23906 | monoatomic cation |
has_small_molecule_activator | CHEBI | CHEBI:350546 | serotonin(1+) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0022850 based on ALL annotations
The top 57 of 57 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
serotonin-gated monoatomic cation channel activity
|
388,538.97 | 100.00 | 510 | 510 |
serotonin-gated cation-selective signaling pathway
|
388,538.97 | 71.37 | 364 | 364 |
serotonin-activated cation-selective channel complex
|
387,474.47 | 71.23 | 364 | 365 |
excitatory extracellular ligand-gated monoatomic ion channel activity
|
106,298.39 | 17.90 | 174 | 636 |
serotonin receptor signaling pathway
|
37,791.65 | 9.38 | 370 | 3,804 |
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
|
21,843.55 | 5.07 | 174 | 3,095 |
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
|
23,590.88 | 4.63 | 83 | 1,367 |
regulation of presynaptic membrane potential
|
16,020.24 | 3.40 | 83 | 2,013 |
serotonin binding
|
8,671.95 | 2.04 | 97 | 4,346 |
transmembrane transporter complex
|
6,426.41 | 1.60 | 174 | 10,520 |
Totals | 7211 | 91447142 |
No co-occurrence statistics for GO:0022850 based on MANUAL annotations
The top 43 of 43 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
serotonin-gated monoatomic cation channel activity
|
7,629.91 | 100.00 | 185 | 185 |
transmembrane transporter complex
|
2,514.40 | 32.28 | 174 | 528 |
excitatory extracellular ligand-gated monoatomic ion channel activity
|
2,158.71 | 27.80 | 174 | 615 |
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
|
1,062.08 | 13.80 | 174 | 1,250 |
monoatomic ion transmembrane transport
|
1,014.99 | 13.19 | 174 | 1,308 |
regulation of membrane potential
|
860.96 | 11.20 | 174 | 1,542 |
chemical synaptic transmission
|
447.00 | 5.84 | 174 | 2,970 |
serotonin receptor signaling pathway
|
869.23 | 5.54 | 18 | 158 |
serotonin-activated cation-selective channel complex
|
7,629.91 | 4.86 | 9 | 9 |
serotonin-gated cation-selective signaling pathway
|
7,629.91 | 3.78 | 7 | 7 |
Totals | 1867 | 313145 |
Change Log
- All changes
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
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- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2023-10-10 | Added | SYNONYM | serotonin-gated monoatomic cation-selective channel activity |
2023-10-10 | Updated | TERM | serotonin-gated monoatomic cation channel activity |
2022-12-02 | Added | SYNONYM | serotonin-gated cation-selective channel activity |
2022-12-02 | Updated | TERM | serotonin-gated monoatomic cation-selective channel activity |
2022-07-18 | Added | RELATION | is a GO:0099589 (serotonin receptor activity) |
2022-01-12 | Added | RELATION | has part GO:0140227 (serotonin-gated cation-selective signaling pathway) |
2020-07-19 | Added | XREF | Reactome:R-HSA-9648983 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-975311 |
2019-04-01 | Added | XREF | Reactome:R-HSA-975311 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-10-10 | Updated | TERM | serotonin-gated monoatomic cation channel activity |
2022-12-02 | Updated | TERM | serotonin-gated monoatomic cation-selective channel activity |
2017-01-02 | Updated | TERM | serotonin-gated cation-selective channel activity |
2007-07-11 | Added | TERM | serotonin-gated cation channel activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-10-10 | Added | SYNONYM | serotonin-gated monoatomic cation-selective channel activity |
2022-12-02 | Added | SYNONYM | serotonin-gated cation-selective channel activity |
2017-01-02 | Added | SYNONYM | serotonin-gated cation channel activity |
2017-01-02 | Added | SYNONYM | 5-hydroxytryptamine-gated receptor-channel |
2017-01-02 | Added | SYNONYM | serotonin-activated cation-selective channel activity |
2015-05-11 | Added | DEFINITION | Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. |
2015-05-11 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. |
2008-05-13 | Added | DEFINITION | Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. |
2007-07-27 | Added | DEFINITION | Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-18 | Added | RELATION | is a GO:0099589 (serotonin receptor activity) |
2022-01-12 | Added | RELATION | has part GO:0140227 (serotonin-gated cation-selective signaling pathway) |
2018-04-15 | Added | RELATION | part of GO:0007210 (serotonin receptor signaling pathway) |
2018-02-09 | Deleted | RELATION | is a GO:0140135 (mechanosensitive monoatomic cation channel activity) |
2018-02-09 | Added | RELATION | is a GO:0099094 (ligand-gated monoatomic cation channel activity) |
2017-11-19 | Added | RELATION | is a GO:0140135 (mechanosensitive monoatomic cation channel activity) |
2017-11-19 | Deleted | RELATION | is a GO:0005261 (monoatomic cation channel activity) |
2017-11-17 | Deleted | RELATION | is a GO:0099589 (serotonin receptor activity) |
2017-01-02 | Added | RELATION | is a GO:0005261 (monoatomic cation channel activity) |
2016-01-20 | Added | RELATION | is a GO:0099589 (serotonin receptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0022824 (transmitter-gated monoatomic ion channel activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-07-19 | Added | XREF | Reactome:R-HSA-9648983 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-975311 |
2019-04-01 | Added | XREF | Reactome:R-HSA-975311 |
2018-12-11 | Added | XREF | reactome:R-HSA-975311 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2017-01-02 | Added | SECONDARY | GO:0005232 (serotonin-activated cation-selective channel activity) |
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