GO:0030122
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AP-2 adaptor complex
Cellular Component
Definition (GO:0030122 GONUTS page)
A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). PMID:10611976 PMID:21097499 PMID:22022230 PMID:24322426
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
HA2 | exact |
HA2 clathrin adaptor | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0030122 | AP-2 adaptor complex | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016020 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A022QST3 | 4155 | A0A022QST3_ERYGU | GO:0005886 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A022S0M6 | 4155 | A0A022S0M6_ERYGU | GO:0005886 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A059AQE2 | 71139 | A0A059AQE2_EUCGR | GO:0005886 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A059B0U9 | 71139 | A0A059B0U9_EUCGR | GO:0005886 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR017104 | Adaptor protein complex AP-2, alpha subunit |
InterPro | IPR027156 | AP-2 complex subunit sigma |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0005908 | obsolete HA2 clathrin adaptor | consider GO:0030122 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030122 based on ALL annotations
The top 100 of 435 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
AP-2 adaptor complex
|
18,293.81 | 100.00 | 10,656 | 10,656 |
clathrin adaptor activity
|
6,710.59 | 33.57 | 8,507 | 23,191 |
clathrin-dependent endocytosis
|
3,198.53 | 16.85 | 8,761 | 50,108 |
acetylcholine transmembrane transporter activity
|
16,091.50 | 15.11 | 1,644 | 1,869 |
acetate ester transport
|
17,646.54 | 14.51 | 1,554 | 1,611 |
organic cation transport
|
8,834.24 | 12.61 | 1,554 | 3,218 |
clathrin-coated pit
|
2,142.81 | 11.38 | 8,550 | 72,994 |
membrane coat
|
1,949.46 | 10.01 | 6,635 | 62,263 |
AP-1 adaptor complex
|
1,792.04 | 6.38 | 1,651 | 16,854 |
terminal bouton
|
1,036.19 | 4.32 | 1,646 | 29,060 |
Totals | 93992 | 8437544 |
No co-occurrence statistics for GO:0030122 based on MANUAL annotations
The top 100 of 223 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
AP-2 adaptor complex
|
4,075.08 | 100.00 | 317 | 317 |
clathrin adaptor activity
|
1,726.15 | 38.40 | 255 | 602 |
clathrin-dependent endocytosis
|
608.18 | 14.42 | 257 | 1,722 |
acetylcholine transmembrane transporter activity
|
2,445.05 | 8.06 | 27 | 45 |
synaptic vesicle endocytosis
|
451.17 | 7.61 | 62 | 560 |
postsynaptic neurotransmitter receptor internalization
|
1,901.70 | 6.16 | 21 | 45 |
regulation of endocytosis
|
394.94 | 6.05 | 44 | 454 |
AP-1 adaptor complex
|
436.08 | 5.19 | 29 | 271 |
postsynaptic endocytic zone
|
1,247.47 | 4.27 | 15 | 49 |
clathrin coat of coated pit
|
594.28 | 3.51 | 14 | 96 |
Totals | 1758 | 61631 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2019-09-12 | Deleted | RELATION | is a GO:0044433 (obsolete cytoplasmic vesicle part) |
2016-07-23 | Added | DEFINITION | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
2016-07-23 | Deleted | DEFINITION | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
2015-06-25 | Deleted | RELATION | is a GO:0044459 (obsolete plasma membrane part) |
2015-05-11 | Added | RELATION | is a GO:0098797 (plasma membrane protein complex) |
2011-01-27 | Added | DEFINITION | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
2011-01-27 | Deleted | DEFINITION | An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
2008-05-13 | Added | DEFINITION | An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
2008-05-12 | Deleted | DEFINITION | An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2001-08-21 | Added | TERM | AP-2 adaptor complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-07-23 | Added | DEFINITION | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
2016-07-23 | Deleted | DEFINITION | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
2011-01-27 | Added | DEFINITION | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
2011-01-27 | Deleted | DEFINITION | An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
2008-05-13 | Added | DEFINITION | An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
2008-05-12 | Deleted | DEFINITION | An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
2007-08-09 | Added | SYNONYM | HA2 |
2007-08-09 | Added | SYNONYM | HA2 clathrin adaptor |
2007-08-09 | Deleted | SYNONYM | HA2 |
2007-08-09 | Deleted | SYNONYM | HA2 clathrin adaptor |
2007-07-27 | Updated | DEFINITION | An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
2007-06-27 | Updated | DEFINITION | A membrane coat adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
2005-08-10 | Added | SYNONYM | HA2 clathrin adaptor |
2004-04-19 | Added | SYNONYM | HA2 |
2004-04-16 | Deleted | SYNONYM | HA2 |
2002-11-27 | Added | DEFINITION | An adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. |
2001-08-21 | Added | SYNONYM | HA2 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-09-12 | Deleted | RELATION | is a GO:0044433 (obsolete cytoplasmic vesicle part) |
2015-06-25 | Deleted | RELATION | is a GO:0044459 (obsolete plasma membrane part) |
2015-05-11 | Added | RELATION | is a GO:0098797 (plasma membrane protein complex) |
2008-04-01 | Updated | RELATION | part of GO:0030132 (clathrin coat of coated pit) |
2008-04-01 | Updated | RELATION | part of GO:0030128 (clathrin coat of endocytic vesicle) |
2008-04-01 | Updated | RELATION | is a GO:0044433 (obsolete cytoplasmic vesicle part) |
2008-04-01 | Updated | RELATION | is a GO:0044459 (obsolete plasma membrane part) |
2008-04-01 | Updated | RELATION | is a GO:0030131 (clathrin adaptor complex) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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