This term is obsolete.

GO:0030122 JSON

AP-2 adaptor complex

Cellular Component

Definition (GO:0030122 GONUTS page)

A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). PMID:10611976 PMID:21097499 PMID:22022230 PMID:24322426

11,240 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
HA2 exact
HA2 clathrin adaptor exact

Ancestor Chart

Ancestor chart for GO:0030122
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0030122 AP-2 adaptor complex Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A022QST3 4155 A0A022QST3_ERYGU GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A022S0M6 4155 A0A022S0M6_ERYGU GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A059AQE2 71139 A0A059AQE2_EUCGR GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A059B0U9 71139 A0A059B0U9_EUCGR GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR017104 Adaptor protein complex AP-2, alpha subunit
InterPro IPR027156 AP-2 complex subunit sigma

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0005908 obsolete HA2 clathrin adaptor consider GO:0030122

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030122 based on ALL annotations
The top 100 of 427 co-occurring terms
Co-occurring Term PR S% #Together #Compared
AP-2 adaptor complex
17,981.39 100.00 11,020 11,020
clathrin adaptor activity
6,617.77 33.70 8,817 23,957
clathrin-dependent endocytosis
3,124.71 16.75 9,070 52,194
acetylcholine transmembrane transporter activity
15,853.85 15.10 1,699 1,927
acetate ester transport
17,365.44 14.51 1,607 1,664
organic cation transport
8,727.30 12.63 1,607 3,311
clathrin-coated pit
2,284.84 12.32 8,821 69,420
membrane coat
1,938.96 10.12 6,853 63,553
AP-1 adaptor complex
1,751.10 6.36 1,705 17,508
terminal bouton
1,024.67 4.34 1,701 29,850
Totals 97046 8438567
No co-occurrence statistics for GO:0030122 based on MANUAL annotations
The top 100 of 214 co-occurring terms
Co-occurring Term PR S% #Together #Compared
AP-2 adaptor complex
4,200.99 100.00 336 336
clathrin adaptor activity
1,695.47 36.73 270 669
clathrin-dependent endocytosis
626.46 14.41 272 1,824
synaptic vesicle endocytosis
556.95 8.82 70 528
acetylcholine transmembrane transporter activity
2,657.77 8.76 31 49
regulation of endocytosis
444.01 6.70 52 492
postsynaptic neurotransmitter receptor internalization
2,005.02 5.85 21 44
AP-1 adaptor complex
433.65 5.21 32 310
postsynaptic endocytic zone
1,286.02 4.05 15 49
synaptic vesicle
185.86 3.71 63 1,424
Totals 1801 57521

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2019-09-12 Deleted RELATION is a GO:0044433 (obsolete cytoplasmic vesicle part)
2016-07-23 Added DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2016-07-23 Deleted DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2015-06-25 Deleted RELATION is a GO:0044459 (obsolete plasma membrane part)
2015-05-11 Added RELATION is a GO:0098797 (plasma membrane protein complex)
2011-01-27 Added DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2011-01-27 Deleted DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2008-05-13 Added DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2008-05-12 Deleted DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
Timestamp Action Category Detail
2001-08-21 Added TERM AP-2 adaptor complex
Timestamp Action Category Detail
2016-07-23 Added DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2016-07-23 Deleted DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2011-01-27 Added DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2011-01-27 Deleted DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2008-05-13 Added DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2008-05-12 Deleted DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2007-08-09 Deleted SYNONYM HA2 clathrin adaptor
2007-08-09 Deleted SYNONYM HA2
2007-08-09 Added SYNONYM HA2
2007-08-09 Added SYNONYM HA2 clathrin adaptor
2007-07-27 Updated DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2007-06-27 Updated DEFINITION A membrane coat adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2005-08-10 Added SYNONYM HA2 clathrin adaptor
2004-04-19 Added SYNONYM HA2
2004-04-16 Deleted SYNONYM HA2
2002-11-27 Added DEFINITION An adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2001-08-21 Added SYNONYM HA2
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044433 (obsolete cytoplasmic vesicle part)
2015-06-25 Deleted RELATION is a GO:0044459 (obsolete plasma membrane part)
2015-05-11 Added RELATION is a GO:0098797 (plasma membrane protein complex)
2008-04-01 Updated RELATION is a GO:0030131 (clathrin adaptor complex)
2008-04-01 Updated RELATION is a GO:0044459 (obsolete plasma membrane part)
2008-04-01 Updated RELATION part of GO:0030132 (clathrin coat of coated pit)
2008-04-01 Updated RELATION part of GO:0030128 (clathrin coat of endocytic vesicle)
2008-04-01 Updated RELATION is a GO:0044433 (obsolete cytoplasmic vesicle part)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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