This term is obsolete.

GO:0030122 JSON

AP-2 adaptor complex

Cellular Component

Definition (GO:0030122 GONUTS page)

A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). PMID:10611976 PMID:21097499 PMID:22022230 PMID:24322426

10,866 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
HA2 exact
HA2 clathrin adaptor exact

Ancestor Chart

Ancestor chart for GO:0030122
Chart options
Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0030122 AP-2 adaptor complex Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A022QST3 4155 A0A022QST3_ERYGU GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A022S0M6 4155 A0A022S0M6_ERYGU GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A059AQE2 71139 A0A059AQE2_EUCGR GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A059B0U9 71139 A0A059B0U9_EUCGR GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR017104 Adaptor protein complex AP-2, alpha subunit
InterPro IPR027156 AP-2 complex subunit sigma

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0005908 obsolete HA2 clathrin adaptor consider GO:0030122

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030122 based on ALL annotations
The top 100 of 435 co-occurring terms
Co-occurring Term PR S% #Together #Compared
AP-2 adaptor complex
18,293.81 100.00 10,656 10,656
clathrin adaptor activity
6,710.59 33.57 8,507 23,191
clathrin-dependent endocytosis
3,198.53 16.85 8,761 50,108
acetylcholine transmembrane transporter activity
16,091.50 15.11 1,644 1,869
acetate ester transport
17,646.54 14.51 1,554 1,611
organic cation transport
8,834.24 12.61 1,554 3,218
clathrin-coated pit
2,142.81 11.38 8,550 72,994
membrane coat
1,949.46 10.01 6,635 62,263
AP-1 adaptor complex
1,792.04 6.38 1,651 16,854
terminal bouton
1,036.19 4.32 1,646 29,060
Totals 93992 8437544
No co-occurrence statistics for GO:0030122 based on MANUAL annotations
The top 100 of 223 co-occurring terms
Co-occurring Term PR S% #Together #Compared
AP-2 adaptor complex
4,075.08 100.00 317 317
clathrin adaptor activity
1,726.15 38.40 255 602
clathrin-dependent endocytosis
608.18 14.42 257 1,722
acetylcholine transmembrane transporter activity
2,445.05 8.06 27 45
synaptic vesicle endocytosis
451.17 7.61 62 560
postsynaptic neurotransmitter receptor internalization
1,901.70 6.16 21 45
regulation of endocytosis
394.94 6.05 44 454
AP-1 adaptor complex
436.08 5.19 29 271
postsynaptic endocytic zone
1,247.47 4.27 15 49
clathrin coat of coated pit
594.28 3.51 14 96
Totals 1758 61631

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2019-09-12 Deleted RELATION is a GO:0044433 (obsolete cytoplasmic vesicle part)
2016-07-23 Added DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2016-07-23 Deleted DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2015-06-25 Deleted RELATION is a GO:0044459 (obsolete plasma membrane part)
2015-05-11 Added RELATION is a GO:0098797 (plasma membrane protein complex)
2011-01-27 Added DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2011-01-27 Deleted DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2008-05-13 Added DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2008-05-12 Deleted DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
Timestamp Action Category Detail
2001-08-21 Added TERM AP-2 adaptor complex
Timestamp Action Category Detail
2016-07-23 Added DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2016-07-23 Deleted DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2011-01-27 Added DEFINITION A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
2011-01-27 Deleted DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2008-05-13 Added DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2008-05-12 Deleted DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2007-08-09 Added SYNONYM HA2
2007-08-09 Added SYNONYM HA2 clathrin adaptor
2007-08-09 Deleted SYNONYM HA2
2007-08-09 Deleted SYNONYM HA2 clathrin adaptor
2007-07-27 Updated DEFINITION An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2007-06-27 Updated DEFINITION A membrane coat adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2005-08-10 Added SYNONYM HA2 clathrin adaptor
2004-04-19 Added SYNONYM HA2
2004-04-16 Deleted SYNONYM HA2
2002-11-27 Added DEFINITION An adaptor complex that links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles.
2001-08-21 Added SYNONYM HA2
Timestamp Action Category Detail
2019-09-12 Deleted RELATION is a GO:0044433 (obsolete cytoplasmic vesicle part)
2015-06-25 Deleted RELATION is a GO:0044459 (obsolete plasma membrane part)
2015-05-11 Added RELATION is a GO:0098797 (plasma membrane protein complex)
2008-04-01 Updated RELATION part of GO:0030132 (clathrin coat of coated pit)
2008-04-01 Updated RELATION part of GO:0030128 (clathrin coat of endocytic vesicle)
2008-04-01 Updated RELATION is a GO:0044433 (obsolete cytoplasmic vesicle part)
2008-04-01 Updated RELATION is a GO:0044459 (obsolete plasma membrane part)
2008-04-01 Updated RELATION is a GO:0030131 (clathrin adaptor complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.