GO:0030154
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cell differentiation
Biological Process
Definition (GO:0030154 GONUTS page)
The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0030154
Child Term | Relationship to GO:0030154 |
---|---|
plant epidermal cell differentiation
|
is_a |
cell development
|
part_of |
endodermal cell differentiation
|
is_a |
generative cell differentiation
|
is_a |
synergid differentiation
|
is_a |
neuroblast differentiation
|
is_a |
pericyte cell differentiation
|
is_a |
Malpighian tubule tip cell differentiation
|
is_a |
sporocyte differentiation
|
is_a |
transdifferentiation
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0030154 | cell differentiation | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O16262 | 6239 | NIPI4_CAEEL | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR003574 | Interleukin-6-like |
InterPro | IPR008297 | Notch |
InterPro | IPR009800 | Coiled-coil alpha-helical rod protein 1 |
InterPro | IPR010660 | Notch, NOD domain |
InterPro | IPR011656 | Notch, NODP domain |
InterPro | IPR026754 | Pancreatic progenitor cell differentiation and proliferation factor |
InterPro | IPR033272 | Hemogen |
InterPro | IPR039162 | Homeodomain-only protein |
UniProtKB-KW | KW-0221 | Differentiation |
Wikipedia | Cellular_differentiation |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
results_in_acquisition_of_features_of | CL | CL:0000000 | cell |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030154 based on ALL annotations
The top 100 of 9,080 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cell differentiation
|
434.63 | 100.00 | 448,520 | 448,520 |
nervous system development
|
128.44 | 10.60 | 63,581 | 215,157 |
anatomical structure morphogenesis
|
175.70 | 10.37 | 54,898 | 135,801 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
46.35 | 8.10 | 112,881 | 1,058,587 |
DNA-binding transcription factor activity, RNA polymerase II-specific
|
36.00 | 6.77 | 121,216 | 1,463,243 |
negative regulation of transcription by RNA polymerase II
|
69.39 | 6.65 | 45,922 | 287,649 |
positive regulation of transcription by RNA polymerase II
|
46.27 | 6.53 | 64,776 | 608,524 |
spermatogenesis
|
193.16 | 6.17 | 29,986 | 67,470 |
nuclear receptor activity
|
196.78 | 5.30 | 25,408 | 56,118 |
axon guidance
|
71.95 | 4.96 | 29,670 | 179,222 |
Totals | 2583072 | 48748051 |
No co-occurrence statistics for GO:0030154 based on MANUAL annotations
The top 100 of 4,465 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cell differentiation
|
237.90 | 100.00 | 5,430 | 5,430 |
nuclear receptor activity
|
137.34 | 12.44 | 743 | 1,287 |
anatomical structure morphogenesis
|
133.37 | 10.97 | 652 | 1,163 |
transcription cis-regulatory region binding
|
23.26 | 6.98 | 1,064 | 10,884 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
15.75 | 6.00 | 2,115 | 31,938 |
non-membrane spanning protein tyrosine kinase activity
|
124.19 | 5.79 | 332 | 636 |
positive regulation of transcription by RNA polymerase II
|
15.92 | 5.12 | 971 | 14,507 |
negative regulation of transcription by RNA polymerase II
|
18.24 | 4.91 | 653 | 8,516 |
BMP signaling pathway
|
76.93 | 4.52 | 271 | 838 |
regulation of transcription by RNA polymerase II
|
10.84 | 4.23 | 2,014 | 44,191 |
Totals | 30665 | 637747 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_generic | 141 |
goslim_plant | 97 |
goslim_chembl | 296 |
goslim_mouse | 45 |
goslim_agr | 53 |
goslim_drosophila | 173 |
goslim_plant_ribbon | 62 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | SUBSET | goslim_plant_ribbon |
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2023-01-08 | Added | DEFINITION | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
2023-01-08 | Deleted | DEFINITION | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
2020-02-28 | Deleted | XREF | MIPS_funcat:40.02 |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2019-05-04 | Added | XREF | MIPS_funcat:40.02 |
2017-07-08 | Added | SUBSET | goslim_agr |
2016-12-17 | Added | SUBSET | goslim_mouse |
2015-05-19 | Added | SUBSET | goslim_chembl |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-09-29 | Updated | TERM | cell differentiation |
2001-08-22 | Added | TERM | cell differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-08 | Added | DEFINITION | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
2023-01-08 | Deleted | DEFINITION | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
2010-12-17 | Deleted | DEFINITION | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
2010-12-17 | Added | DEFINITION | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
2010-05-02 | Added | DEFINITION | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
2010-05-02 | Deleted | DEFINITION | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
2008-05-13 | Added | DEFINITION | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
2008-05-12 | Deleted | DEFINITION | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
2005-10-14 | Updated | DEFINITION | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
2004-03-13 | Updated | DEFINITION | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. |
2003-10-18 | Updated | DEFINITION | The process whereby relatively unspecialized cells, eg. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. |
2003-04-24 | Updated | DEFINITION | The process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. |
2002-11-27 | Added | DEFINITION | The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0048869 (cellular developmental process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:40.02 |
2019-05-04 | Added | XREF | MIPS_funcat:40.02 |
2009-03-29 | Added | XREF | Wikipedia:Cellular_differentiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | SUBSET | goslim_plant_ribbon |
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2017-07-08 | Added | SUBSET | goslim_agr |
2016-12-17 | Added | SUBSET | goslim_mouse |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2013-04-18 | Updated | SUBSET | goslim_generic |
2013-04-18 | Updated | SUBSET | goslim_plant |
2011-03-18 | Deleted | SUBSET | goslim_goa |
2008-06-09 | Added | SUBSET | goslim_generic |
2008-06-09 | Added | SUBSET | goslim_goa |
2008-06-09 | Added | SUBSET | goslim_plant |
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