This term is obsolete.

GO:0030154 JSON

cell differentiation

Biological Process

Definition (GO:0030154 GONUTS page)

The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

2,270,876 annotations

Ancestor Chart

Ancestor chart for GO:0030154
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030154

Child Term Relationship to
GO:0030154
plant epidermal cell differentiation
is_a
cell development
part_of
endodermal cell differentiation
is_a
generative cell differentiation
is_a
synergid differentiation
is_a
neuroblast differentiation
is_a
pericyte cell differentiation
is_a
Malpighian tubule tip cell differentiation
is_a
sporocyte differentiation
is_a
transdifferentiation
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0030154 cell differentiation Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR003574 Interleukin-6-like
InterPro IPR008297 Notch
InterPro IPR009800 Coiled-coil alpha-helical rod protein 1
InterPro IPR010660 Notch, NOD domain
InterPro IPR011656 Notch, NODP domain
InterPro IPR026754 Pancreatic progenitor cell differentiation and proliferation factor
InterPro IPR033272 Hemogen
InterPro IPR039162 Homeodomain-only protein
UniProtKB-KW KW-0221 Differentiation
Wikipedia Cellular_differentiation

Cross-Ontology Relations

Relation Other Ontology ID Term
results_in_acquisition_of_features_of CL CL:0000000 cell

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030154 based on ALL annotations
The top 100 of 9,080 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell differentiation
434.63 100.00 448,520 448,520
nervous system development
128.44 10.60 63,581 215,157
anatomical structure morphogenesis
175.70 10.37 54,898 135,801
RNA polymerase II cis-regulatory region sequence-specific DNA binding
46.35 8.10 112,881 1,058,587
DNA-binding transcription factor activity, RNA polymerase II-specific
36.00 6.77 121,216 1,463,243
negative regulation of transcription by RNA polymerase II
69.39 6.65 45,922 287,649
positive regulation of transcription by RNA polymerase II
46.27 6.53 64,776 608,524
spermatogenesis
193.16 6.17 29,986 67,470
nuclear receptor activity
196.78 5.30 25,408 56,118
axon guidance
71.95 4.96 29,670 179,222
Totals 2583072 48748051
No co-occurrence statistics for GO:0030154 based on MANUAL annotations
The top 100 of 4,465 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell differentiation
237.90 100.00 5,430 5,430
nuclear receptor activity
137.34 12.44 743 1,287
anatomical structure morphogenesis
133.37 10.97 652 1,163
transcription cis-regulatory region binding
23.26 6.98 1,064 10,884
RNA polymerase II cis-regulatory region sequence-specific DNA binding
15.75 6.00 2,115 31,938
non-membrane spanning protein tyrosine kinase activity
124.19 5.79 332 636
positive regulation of transcription by RNA polymerase II
15.92 5.12 971 14,507
negative regulation of transcription by RNA polymerase II
18.24 4.91 653 8,516
BMP signaling pathway
76.93 4.52 271 838
regulation of transcription by RNA polymerase II
10.84 4.23 2,014 44,191
Totals 30665 637747

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_generic 141
goslim_plant 97
goslim_chembl 296
goslim_mouse 45
goslim_agr 53
goslim_drosophila 173
goslim_plant_ribbon 62

Change Log

Timestamp Action Category Detail
2024-03-21 Added SUBSET goslim_plant_ribbon
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2023-01-08 Added DEFINITION The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2023-01-08 Deleted DEFINITION The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2020-02-28 Deleted XREF MIPS_funcat:40.02
2019-11-09 Added SUBSET goslim_drosophila
2019-05-04 Added XREF MIPS_funcat:40.02
2017-07-08 Added SUBSET goslim_agr
2016-12-17 Added SUBSET goslim_mouse
2015-05-19 Added SUBSET goslim_chembl
Timestamp Action Category Detail
2004-09-29 Updated TERM cell differentiation
2001-08-22 Added TERM cell differentiation
Timestamp Action Category Detail
2023-01-08 Added DEFINITION The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2023-01-08 Deleted DEFINITION The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2010-12-17 Deleted DEFINITION The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2010-12-17 Added DEFINITION The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2010-05-02 Added DEFINITION The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
2010-05-02 Deleted DEFINITION The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2008-05-13 Added DEFINITION The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2008-05-12 Deleted DEFINITION The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2005-10-14 Updated DEFINITION The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.
2004-03-13 Updated DEFINITION The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
2003-10-18 Updated DEFINITION The process whereby relatively unspecialized cells, eg. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
2003-04-24 Updated DEFINITION The process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
2002-11-27 Added DEFINITION The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0048869 (cellular developmental process)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:40.02
2019-05-04 Added XREF MIPS_funcat:40.02
2009-03-29 Added XREF Wikipedia:Cellular_differentiation
Timestamp Action Category Detail
2024-03-21 Added SUBSET goslim_plant_ribbon
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2019-11-09 Added SUBSET goslim_drosophila
2017-07-08 Added SUBSET goslim_agr
2016-12-17 Added SUBSET goslim_mouse
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_generic
2013-04-18 Updated SUBSET goslim_plant
2011-03-18 Deleted SUBSET goslim_goa
2008-06-09 Added SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_goa
2008-06-09 Added SUBSET goslim_plant
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