This term is obsolete.

GO:0030202 JSON

heparin proteoglycan metabolic process

Biological Process

Definition (GO:0030202 GONUTS page)

The chemical reactions and pathways involving heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin proteoglycans are stored selectively in the secretory granules of mammalian mast cells. PMID:22566225

6,893 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
heparin metabolism exact
heparan sulfate metabolic process related

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030202

Child Term Relationship to
GO:0030202
GO:0030211
heparin proteoglycan catabolic process
is_a
GO:0030210
heparin proteoglycan biosynthetic process
is_a

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030202 based on ALL annotations
The top 100 of 345 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0030202
heparin proteoglycan metabolic process
358,327.06 100.00 553 553
GO:0097018
renal albumin absorption
181,079.72 25.61 189 374
GO:0003220
left ventricular cardiac muscle tissue morphogenesis
179,641.30 25.41 188 375
GO:1905871
regulation of protein localization to cell leading edge
354,814.03 18.23 101 102
GO:1903210
podocyte apoptotic process
338,233.97 18.07 101 107
GO:0036339
lymphocyte adhesion to endothelial cell of high endothelial venule
358,327.03 15.91 88 88
GO:0061974
perichondral bone morphogenesis
358,327.03 15.91 88 88
GO:0002524
hypersensitivity
358,327.03 15.91 88 88
GO:0035645
enteric smooth muscle cell differentiation
358,327.03 15.91 88 88
GO:0060506
smoothened signaling pathway involved in lung development
358,327.03 15.91 88 88
Totals 10668 59738
No co-occurrence statistics for GO:0030202 based on MANUAL annotations
The top 100 of 317 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0030202
heparin proteoglycan metabolic process
70,576.65 100.00 20 20
GO:0034285
response to disaccharide
70,576.65 25.00 5 5
GO:0004561
alpha-N-acetylglucosaminidase activity
50,411.90 22.73 5 7
GO:1904389
rod bipolar cell differentiation
44,110.41 21.74 5 8
GO:0003220
left ventricular cardiac muscle tissue morphogenesis
24,701.83 21.21 7 20
GO:0036339
lymphocyte adhesion to endothelial cell of high endothelial venule
70,576.66 20.00 4 4
GO:0060792
sweat gland development
70,576.66 20.00 4 4
GO:0061974
perichondral bone morphogenesis
70,576.66 20.00 4 4
GO:0002524
hypersensitivity
70,576.66 20.00 4 4
GO:0060506
smoothened signaling pathway involved in lung development
70,576.66 20.00 4 4
Totals 426 3658

Change Log

Timestamp Action Category Detail
2025-02-22 Added DEFINITION The chemical reactions and pathways involving heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin proteoglycans are stored selectively in the secretory granules of mammalian mast cells.
2025-02-22 Deleted DEFINITION The chemical reactions and pathways involving heparin proteoglycans, which have glycosaminoglycan repeats consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. Heparin is similar to heparan sulfates but is of somewhat higher average Mr (6000-20000) and contains fewer N-acetyl groups and more N-sulfate and O-sulfate groups. They found mainly as an intracellular component of mast cells.
2025-02-04 Added RELATION is a GO:0006029 (proteoglycan metabolic process)
2025-02-04 Deleted RELATION is a GO:0030203 (glycosaminoglycan metabolic process)
2025-02-04 Deleted RELATION is a GO:0006790 (sulfur compound metabolic process)
2025-02-04 Updated TERM heparin proteoglycan metabolic process
2025-02-04 Added DEFINITION The chemical reactions and pathways involving heparin proteoglycans, which have glycosaminoglycan repeats consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. Heparin is similar to heparan sulfates but is of somewhat higher average Mr (6000-20000) and contains fewer N-acetyl groups and more N-sulfate and O-sulfate groups. They found mainly as an intracellular component of mast cells.
2025-02-04 Deleted DEFINITION The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2025-01-18 Added RELATION is a GO:0030203 (glycosaminoglycan metabolic process)
2025-01-18 Deleted RELATION is a GO:1903510 (obsolete mucopolysaccharide metabolic process)
Timestamp Action Category Detail
2025-02-04 Updated TERM heparin proteoglycan metabolic process
2007-01-15 Updated TERM heparin metabolic process
2001-09-01 Added TERM heparin metabolism
Timestamp Action Category Detail
2025-02-22 Added DEFINITION The chemical reactions and pathways involving heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin proteoglycans are stored selectively in the secretory granules of mammalian mast cells.
2025-02-22 Deleted DEFINITION The chemical reactions and pathways involving heparin proteoglycans, which have glycosaminoglycan repeats consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. Heparin is similar to heparan sulfates but is of somewhat higher average Mr (6000-20000) and contains fewer N-acetyl groups and more N-sulfate and O-sulfate groups. They found mainly as an intracellular component of mast cells.
2025-02-04 Added DEFINITION The chemical reactions and pathways involving heparin proteoglycans, which have glycosaminoglycan repeats consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. Heparin is similar to heparan sulfates but is of somewhat higher average Mr (6000-20000) and contains fewer N-acetyl groups and more N-sulfate and O-sulfate groups. They found mainly as an intracellular component of mast cells.
2025-02-04 Deleted DEFINITION The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2011-10-28 Added DEFINITION The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2011-10-28 Deleted DEFINITION The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2008-06-03 Added SYNONYM heparan sulfate metabolic process
2008-05-13 Added DEFINITION The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2007-08-09 Added SYNONYM heparin metabolism
2007-08-09 Deleted SYNONYM heparin metabolism
2007-01-29 Added SYNONYM heparin metabolism
2006-05-04 Updated DEFINITION The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2005-01-21 Updated DEFINITION The chemical reactions involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2002-11-27 Added DEFINITION The chemical reactions and physical changes involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
Timestamp Action Category Detail
2025-02-04 Added RELATION is a GO:0006029 (proteoglycan metabolic process)
2025-02-04 Deleted RELATION is a GO:0030203 (glycosaminoglycan metabolic process)
2025-02-04 Deleted RELATION is a GO:0006790 (sulfur compound metabolic process)
2025-01-18 Added RELATION is a GO:0030203 (glycosaminoglycan metabolic process)
2025-01-18 Deleted RELATION is a GO:1903510 (obsolete mucopolysaccharide metabolic process)
2020-11-03 Deleted RELATION is a GO:0043436 (oxoacid metabolic process)
2016-11-28 Added RELATION is a GO:0043436 (oxoacid metabolic process)
2016-06-22 Deleted RELATION is a GO:0043436 (oxoacid metabolic process)
2014-10-05 Deleted RELATION is a GO:0030203 (glycosaminoglycan metabolic process)
2014-10-05 Added RELATION is a GO:1903510 (obsolete mucopolysaccharide metabolic process)
2012-11-02 Added RELATION is a GO:0043436 (oxoacid metabolic process)
2009-07-06 Added RELATION is a GO:0006790 (sulfur compound metabolic process)
2008-04-01 Updated RELATION is a GO:0030203 (glycosaminoglycan metabolic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
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