This term is obsolete.

GO:0030219 JSON

megakaryocyte differentiation

Biological Process

Definition (GO:0030219 GONUTS page)

The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.

3,604 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
megakaryocyte cell differentiation exact

Ancestor Chart

Ancestor chart for GO:0030219
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030219

Child Term Relationship to
GO:0030219
regulation of megakaryocyte differentiation
regulates
negative regulation of megakaryocyte differentiation
negatively_regulates
positive regulation of megakaryocyte differentiation
positively_regulates
megakaryocyte development
part_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0030219 megakaryocyte differentiation Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein E9PTS6 10116 E9PTS6_RAT GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P01127 9606 PDGFB_HUMAN GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P05622 10090 PGFRB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P12919 9685 PDGFB_FELCA GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P31240 10090 PDGFB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q05028 10116 PDGFB_RAT GO:0030097 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096

Cross-Ontology Relations

Relation Other Ontology ID Term
results_in_acquisition_of_features_of CL CL:0000556 megakaryocyte

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030219 based on ALL annotations
The top 100 of 268 co-occurring terms
Co-occurring Term PR S% #Together #Compared
megakaryocyte differentiation
130,132.70 100.00 1,498 1,498
basophil differentiation
130,132.70 11.62 174 174
erythrocyte differentiation
14,510.33 10.85 1,198 10,744
regulation of definitive erythrocyte differentiation
81,608.64 9.33 148 236
platelet formation
18,087.25 8.98 303 2,180
megakaryocyte development
18,378.50 8.82 285 2,018
primitive erythrocyte differentiation
22,923.10 6.17 130 738
positive regulation of macromolecule biosynthetic process
8,615.98 6.14 685 10,346
positive regulation of chromatin organization
130,132.70 5.87 88 88
regulation of mast cell differentiation
130,132.70 5.87 88 88
Totals 13746 444087
No co-occurrence statistics for GO:0030219 based on MANUAL annotations
The top 100 of 241 co-occurring terms
Co-occurring Term PR S% #Together #Compared
megakaryocyte differentiation
18,454.27 100.00 70 70
megakaryocyte development
2,516.49 9.78 18 132
regulation of definitive erythrocyte differentiation
9,936.92 9.21 7 13
peptidyl-cysteine S-nitrosylase activity
4,370.75 9.09 9 38
biliverdin reductase [NAD(P)+] activity
3,460.18 8.26 9 48
cellular response to cell-matrix adhesion
5,871.81 8.24 7 22
protein K69-linked ufmylation
3,785.49 7.92 8 39
enucleate erythrocyte differentiation
4,968.46 7.87 7 26
erythrocyte differentiation
1,511.34 7.66 38 464
positive regulation of megakaryocyte differentiation
2,460.57 7.41 10 75
Totals 631 12050

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2016-06-22 Deleted RELATION is a GO:0002244 (hematopoietic progenitor cell differentiation)
2013-10-24 Added RELATION is a GO:0002244 (hematopoietic progenitor cell differentiation)
2010-12-01 Added DEFINITION The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2010-12-01 Deleted DEFINITION The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2008-05-13 Added DEFINITION The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2008-05-12 Deleted DEFINITION The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2008-04-01 Updated RELATION is a GO:0030099 (myeloid cell differentiation)
2007-08-09 Added SYNONYM megakaryocyte cell differentiation
2007-08-09 Deleted SYNONYM megakaryocyte cell differentiation
Timestamp Action Category Detail
2005-02-21 Updated TERM megakaryocyte differentiation
2005-01-16 Updated TERM megakaryocyte cell differentiation
2001-09-05 Added TERM megakaryocyte differentiation
Timestamp Action Category Detail
2010-12-01 Added DEFINITION The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2010-12-01 Deleted DEFINITION The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2008-05-13 Added DEFINITION The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2008-05-12 Deleted DEFINITION The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2007-08-09 Added SYNONYM megakaryocyte cell differentiation
2007-08-09 Deleted SYNONYM megakaryocyte cell differentiation
2006-04-22 Updated DEFINITION The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2005-02-21 Added SYNONYM megakaryocyte cell differentiation
2005-01-21 Updated DEFINITION Processes by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
2002-11-27 Added DEFINITION The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte.
Timestamp Action Category Detail
2016-06-22 Deleted RELATION is a GO:0002244 (hematopoietic progenitor cell differentiation)
2013-10-24 Added RELATION is a GO:0002244 (hematopoietic progenitor cell differentiation)
2008-04-01 Updated RELATION is a GO:0030099 (myeloid cell differentiation)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
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