This term is obsolete.

GO:0030297 JSON

transmembrane receptor protein tyrosine kinase activator activity

Molecular Function

Definition (GO:0030297 GONUTS page)

Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.

1,697 annotations

Ancestor Chart

Ancestor chart for GO:0030297
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0005155 obsolete epidermal growth factor receptor activating ligand activity consider GO:0030297

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030297 based on ALL annotations
The top 100 of 773 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transmembrane receptor protein tyrosine kinase activator activity
120,406.91 100.00 1,619 1,619
ERBB2-EGFR signaling pathway
88,028.59 28.82 522 714
ERBB2-ERBB4 signaling pathway
51,219.87 10.18 191 449
ERBB4-ERBB4 signaling pathway
45,338.41 9.52 183 486
mammary gland alveolus development
20,183.82 8.37 232 1,384
positive regulation of mitotic nuclear division
9,586.86 6.66 470 5,903
epidermal growth factor receptor binding
7,339.79 5.52 598 9,810
positive regulation of peptidyl-tyrosine phosphorylation
6,717.68 5.07 578 10,360
VEGF-A complex
120,406.90 4.88 79 79
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
118,901.82 4.88 79 80
Totals 13550 155205
No co-occurrence statistics for GO:0030297 based on MANUAL annotations
The top 100 of 691 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transmembrane receptor protein tyrosine kinase activator activity
15,378.56 100.00 84 84
ERBB2-EGFR signaling pathway
12,884.74 34.44 31 37
multivesicular body, internal vesicle lumen
14,097.01 12.94 11 12
negative regulation of cardiocyte differentiation
14,097.01 12.94 11 12
response to hydroxyisoflavone
14,097.01 12.94 11 12
positive regulation of prolactin secretion
13,012.63 12.79 11 13
ERBB4-ERBB4 signaling pathway
7,381.71 12.37 12 25
diterpenoid metabolic process
9,398.01 12.09 11 18
morphogenesis of an epithelial fold
7,354.96 11.46 11 23
response to cobalamin
5,126.19 10.38 11 33
Totals 1089 14601

Change Log

Timestamp Action Category Detail
2022-09-16 Deleted RELATION part of GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
2018-04-27 Deleted RELATION is a GO:0004871 (obsolete signal transducer activity)
2017-05-05 Deleted RELATION regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2017-05-01 Added RELATION regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2017-05-01 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2016-11-28 Deleted RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2016-03-02 Added RELATION is a GO:0004871 (obsolete signal transducer activity)
2015-07-11 Added DEFINITION Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
2015-07-11 Deleted DEFINITION Increases the activity of a transmembrane receptor protein tyrosine kinase.
2012-02-03 Added RELATION part of GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM transmembrane receptor protein tyrosine kinase activator activity
2001-10-01 Added TERM transmembrane receptor protein tyrosine kinase activator
Timestamp Action Category Detail
2015-07-11 Added DEFINITION Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
2015-07-11 Deleted DEFINITION Increases the activity of a transmembrane receptor protein tyrosine kinase.
2009-06-11 Added DEFINITION Increases the activity of a transmembrane receptor protein tyrosine kinase.
Timestamp Action Category Detail
2022-09-16 Deleted RELATION part of GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
2018-04-27 Deleted RELATION is a GO:0004871 (obsolete signal transducer activity)
2017-05-05 Deleted RELATION regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2017-05-01 Added RELATION regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2017-05-01 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2016-11-28 Deleted RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2016-03-02 Added RELATION is a GO:0004871 (obsolete signal transducer activity)
2012-02-03 Added RELATION part of GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
2010-06-15 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2010-06-14 Deleted RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2010-06-08 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2009-02-25 Deleted RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2009-02-22 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2008-05-01 Added RELATION is a GO:0030546 (signaling receptor activator activity)
2008-04-01 Updated RELATION is a GO:0030296 (protein tyrosine kinase activator activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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