This term is obsolete.

GO:0030297 JSON

transmembrane receptor protein tyrosine kinase activator activity

Molecular Function

Definition (GO:0030297 GONUTS page)

Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.

1,722 annotations

Ancestor Chart

Ancestor chart for GO:0030297
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0005155 obsolete epidermal growth factor receptor activating ligand activity consider GO:0030297

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030297 based on ALL annotations
The top 100 of 686 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transmembrane receptor protein tyrosine kinase activator activity
120,678.97 100.00 1,642 1,642
ERBB2-EGFR signaling pathway
86,368.28 27.70 511 714
ERBB2-ERBB4 signaling pathway
51,335.60 10.05 191 449
ERBB4-ERBB4 signaling pathway
45,440.85 9.41 183 486
mammary gland alveolus development
20,185.67 8.29 232 1,387
positive regulation of mitotic nuclear division
9,559.13 6.63 474 5,984
epidermal growth factor receptor binding
7,162.49 5.37 595 10,025
VEGF-A complex
120,678.96 4.81 79 79
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
119,170.48 4.81 79 80
regulation of cortisol biosynthetic process
56,271.65 4.78 83 178
Totals 13030 148874
No co-occurrence statistics for GO:0030297 based on MANUAL annotations
The top 100 of 631 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transmembrane receptor protein tyrosine kinase activator activity
18,820.44 100.00 75 75
ERBB2-EGFR signaling pathway
10,173.21 21.74 20 37
ERBB4-ERBB4 signaling pathway
9,033.81 13.64 12 25
positive regulation of mitotic nuclear division
1,845.14 7.72 20 204
ERBB2-ERBB4 signaling pathway
9,410.22 7.41 6 12
mammary gland alveolus development
3,072.73 6.90 8 49
epidermal growth factor receptor binding
1,299.91 5.97 23 333
receptor ligand activity
1,019.95 5.20 42 775
negative regulation of epithelial cell apoptotic process
1,804.70 4.96 7 73
positive regulation of cerebellar granule cell precursor proliferation
7,528.18 4.94 4 10
Totals 556 7927

Change Log

Timestamp Action Category Detail
2022-09-16 Deleted RELATION part of GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
2018-04-27 Deleted RELATION is a GO:0004871 (obsolete signal transducer activity)
2017-05-05 Deleted RELATION regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2017-05-01 Added RELATION regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2017-05-01 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2016-11-28 Deleted RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2016-03-02 Added RELATION is a GO:0004871 (obsolete signal transducer activity)
2015-07-11 Added DEFINITION Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
2015-07-11 Deleted DEFINITION Increases the activity of a transmembrane receptor protein tyrosine kinase.
2012-02-03 Added RELATION part of GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM transmembrane receptor protein tyrosine kinase activator activity
2001-10-01 Added TERM transmembrane receptor protein tyrosine kinase activator
Timestamp Action Category Detail
2015-07-11 Added DEFINITION Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
2015-07-11 Deleted DEFINITION Increases the activity of a transmembrane receptor protein tyrosine kinase.
2009-06-11 Added DEFINITION Increases the activity of a transmembrane receptor protein tyrosine kinase.
Timestamp Action Category Detail
2022-09-16 Deleted RELATION part of GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
2018-04-27 Deleted RELATION is a GO:0004871 (obsolete signal transducer activity)
2017-05-05 Deleted RELATION regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2017-05-01 Added RELATION regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2017-05-01 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2016-11-28 Deleted RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2016-03-02 Added RELATION is a GO:0004871 (obsolete signal transducer activity)
2012-02-03 Added RELATION part of GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
2010-06-15 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2010-06-14 Deleted RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2010-06-08 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2009-02-25 Deleted RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2009-02-22 Added RELATION positively regulates GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
2008-05-01 Added RELATION is a GO:0030546 (signaling receptor activator activity)
2008-04-01 Updated RELATION is a GO:0030296 (protein tyrosine kinase activator activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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