This term is obsolete.

GO:0030520 JSON

estrogen receptor signaling pathway

Biological Process

Definition (GO:0030520 GONUTS page)

A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.

3,115 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
intracellular estrogen receptor signaling pathway exact
nuclear receptor-mediated estrogen signaling pathway exact
estrogen receptor signalling pathway broad

Ancestor Chart

Ancestor chart for GO:0030520
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030520

Child Term Relationship to
GO:0030520
regulation of intracellular estrogen receptor signaling pathway
regulates
positive regulation of intracellular estrogen receptor signaling pathway
positively_regulates
negative regulation of intracellular estrogen receptor signaling pathway
negatively_regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0030520 estrogen receptor signaling pathway Never in Taxon 4751 Fungi

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
InterPro IPR028355 Estrogen receptor beta/gamma

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030520 based on ALL annotations
The top 100 of 744 co-occurring terms
Co-occurring Term PR S% #Together #Compared
estrogen receptor signaling pathway
63,893.41 100.00 3,051 3,051
nuclear estrogen receptor activity
25,633.03 29.68 1,626 4,053
cellular response to estradiol stimulus
16,509.95 21.05 1,623 6,281
response to organic cyclic compound
12,172.45 16.00 1,526 8,010
regulation of androgen receptor signaling pathway
23,270.37 13.19 523 1,436
steroid binding
6,120.58 8.91 1,708 17,830
estrogen response element binding
23,556.66 6.39 219 594
response to lipid
3,874.25 5.72 1,525 25,150
nuclear estrogen receptor binding
5,093.18 5.63 490 6,147
androgen receptor signaling pathway
7,591.02 5.35 271 2,281
Totals 23498 244563
No co-occurrence statistics for GO:0030520 based on MANUAL annotations
The top 100 of 635 co-occurring terms
Co-occurring Term PR S% #Together #Compared
estrogen receptor signaling pathway
10,092.18 100.00 128 128
cellular response to estrogen stimulus
2,309.65 16.25 46 201
miRNA transcription
9,214.60 16.15 21 23
estrogen response element binding
1,856.96 13.86 46 250
regulation of skeletal muscle cell differentiation
4,189.21 13.84 22 53
androgen receptor signaling pathway
2,309.23 12.33 27 118
myoblast differentiation
1,964.85 10.05 22 113
nuclear estrogen receptor activity
2,354.84 8.05 14 60
positive regulation of DNA damage response, signal transduction by p53 class mediator
2,018.44 7.22 13 65
regulation of miRNA transcription
6,487.83 6.77 9 14
Totals 1037 15327

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-06-11 Deleted DEFINITION The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2024-06-11 Deleted SYNONYM estrogen receptor signaling pathway
2024-06-11 Updated TERM estrogen receptor signaling pathway
2024-06-11 Added SYNONYM intracellular estrogen receptor signaling pathway
2024-06-11 Added SYNONYM nuclear receptor-mediated estrogen signaling pathway
2024-06-11 Added DEFINITION A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
2024-04-13 Deleted DEFINITION The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
2024-04-13 Added DEFINITION The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Added DEFINITION The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Timestamp Action Category Detail
2024-06-11 Updated TERM estrogen receptor signaling pathway
2011-11-30 Updated TERM intracellular estrogen receptor signaling pathway
2002-01-19 Added TERM estrogen receptor signaling pathway
Timestamp Action Category Detail
2024-06-11 Deleted DEFINITION The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2024-06-11 Deleted SYNONYM estrogen receptor signaling pathway
2024-06-11 Added SYNONYM intracellular estrogen receptor signaling pathway
2024-06-11 Added SYNONYM nuclear receptor-mediated estrogen signaling pathway
2024-06-11 Added DEFINITION A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
2024-04-13 Deleted DEFINITION The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
2024-04-13 Added DEFINITION The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Added DEFINITION The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
2011-11-30 Deleted SYNONYM estrogen receptor signalling pathway
2011-11-30 Added SYNONYM estrogen receptor signalling pathway
2011-11-30 Added SYNONYM estrogen receptor signaling pathway
2011-11-30 Deleted DEFINITION Any series of molecular signals generated as a consequence of an estrogen binding to its receptor.
2011-11-30 Added DEFINITION Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of an estrogen binding to its receptor.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of an estrogen binding to its receptor.
2007-08-09 Added SYNONYM estrogen receptor signalling pathway
2007-08-09 Deleted SYNONYM estrogen receptor signalling pathway
2004-07-17 Updated DEFINITION Any series of molecular signals generated as a consequence of an estrogen binding to its receptor.
2004-04-19 Added SYNONYM estrogen receptor signalling pathway
2004-04-16 Deleted SYNONYM estrogen receptor signalling pathway
2003-11-13 Added SYNONYM estrogen receptor signalling pathway
2002-11-27 Added DEFINITION Signal transduction pathway mediated by an estrogen and its receptor.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0030518 (nuclear receptor-mediated steroid hormone signaling pathway)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
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