GO:0030520
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estrogen receptor signaling pathway
Biological Process
Definition (GO:0030520 GONUTS page)
A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
intracellular estrogen receptor signaling pathway | exact |
nuclear receptor-mediated estrogen signaling pathway | exact |
estrogen receptor signalling pathway | broad |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0030520
Child Term | Relationship to GO:0030520 |
---|---|
regulation of intracellular estrogen receptor signaling pathway
|
regulates |
positive regulation of intracellular estrogen receptor signaling pathway
|
positively_regulates |
negative regulation of intracellular estrogen receptor signaling pathway
|
negatively_regulates |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0030520 | estrogen receptor signaling pathway | Never in Taxon | 4751 | Fungi |
More information on taxon constraints in GO is available here
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR028355 | Estrogen receptor beta/gamma |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030520 based on ALL annotations
The top 100 of 744 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
estrogen receptor signaling pathway
|
63,893.41 | 100.00 | 3,051 | 3,051 |
nuclear estrogen receptor activity
|
25,633.03 | 29.68 | 1,626 | 4,053 |
cellular response to estradiol stimulus
|
16,509.95 | 21.05 | 1,623 | 6,281 |
response to organic cyclic compound
|
12,172.45 | 16.00 | 1,526 | 8,010 |
regulation of androgen receptor signaling pathway
|
23,270.37 | 13.19 | 523 | 1,436 |
steroid binding
|
6,120.58 | 8.91 | 1,708 | 17,830 |
estrogen response element binding
|
23,556.66 | 6.39 | 219 | 594 |
response to lipid
|
3,874.25 | 5.72 | 1,525 | 25,150 |
nuclear estrogen receptor binding
|
5,093.18 | 5.63 | 490 | 6,147 |
androgen receptor signaling pathway
|
7,591.02 | 5.35 | 271 | 2,281 |
Totals | 23498 | 244563 |
No co-occurrence statistics for GO:0030520 based on MANUAL annotations
The top 100 of 635 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
estrogen receptor signaling pathway
|
10,092.18 | 100.00 | 128 | 128 |
cellular response to estrogen stimulus
|
2,309.65 | 16.25 | 46 | 201 |
miRNA transcription
|
9,214.60 | 16.15 | 21 | 23 |
estrogen response element binding
|
1,856.96 | 13.86 | 46 | 250 |
regulation of skeletal muscle cell differentiation
|
4,189.21 | 13.84 | 22 | 53 |
androgen receptor signaling pathway
|
2,309.23 | 12.33 | 27 | 118 |
myoblast differentiation
|
1,964.85 | 10.05 | 22 | 113 |
nuclear estrogen receptor activity
|
2,354.84 | 8.05 | 14 | 60 |
positive regulation of DNA damage response, signal transduction by p53 class mediator
|
2,018.44 | 7.22 | 13 | 65 |
regulation of miRNA transcription
|
6,487.83 | 6.77 | 9 | 14 |
Totals | 1037 | 15327 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-06-11 | Deleted | DEFINITION | The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2024-06-11 | Deleted | SYNONYM | estrogen receptor signaling pathway |
2024-06-11 | Updated | TERM | estrogen receptor signaling pathway |
2024-06-11 | Added | SYNONYM | intracellular estrogen receptor signaling pathway |
2024-06-11 | Added | SYNONYM | nuclear receptor-mediated estrogen signaling pathway |
2024-06-11 | Added | DEFINITION | A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription. |
2024-04-13 | Deleted | DEFINITION | The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2024-04-13 | Added | DEFINITION | The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-11 | Updated | TERM | estrogen receptor signaling pathway |
2011-11-30 | Updated | TERM | intracellular estrogen receptor signaling pathway |
2002-01-19 | Added | TERM | estrogen receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-11 | Deleted | DEFINITION | The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2024-06-11 | Deleted | SYNONYM | estrogen receptor signaling pathway |
2024-06-11 | Added | SYNONYM | intracellular estrogen receptor signaling pathway |
2024-06-11 | Added | SYNONYM | nuclear receptor-mediated estrogen signaling pathway |
2024-06-11 | Added | DEFINITION | A nuclear receptor-mediated signaling pathway initiated by an estrogen binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription. |
2024-04-13 | Deleted | DEFINITION | The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2024-04-13 | Added | DEFINITION | The series of molecular signals initiated by estrogen binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). |
2011-11-30 | Deleted | SYNONYM | estrogen receptor signalling pathway |
2011-11-30 | Added | SYNONYM | estrogen receptor signalling pathway |
2011-11-30 | Added | SYNONYM | estrogen receptor signaling pathway |
2011-11-30 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of an estrogen binding to its receptor. |
2011-11-30 | Added | DEFINITION | Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). |
2008-05-13 | Added | DEFINITION | Any series of molecular signals generated as a consequence of an estrogen binding to its receptor. |
2008-05-12 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of an estrogen binding to its receptor. |
2007-08-09 | Added | SYNONYM | estrogen receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | estrogen receptor signalling pathway |
2004-07-17 | Updated | DEFINITION | Any series of molecular signals generated as a consequence of an estrogen binding to its receptor. |
2004-04-19 | Added | SYNONYM | estrogen receptor signalling pathway |
2004-04-16 | Deleted | SYNONYM | estrogen receptor signalling pathway |
2003-11-13 | Added | SYNONYM | estrogen receptor signalling pathway |
2002-11-27 | Added | DEFINITION | Signal transduction pathway mediated by an estrogen and its receptor. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0030518 (nuclear receptor-mediated steroid hormone signaling pathway) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
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