This term is obsolete.

GO:0030695 JSON

GTPase regulator activity

Molecular Function

Definition (GO:0030695 GONUTS page)

Binds to and modulates the activity of a GTPase.

Secondary IDs

GO:0005083

1,000,887 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
small GTPase regulator activity related
small GTPase regulatory/interacting protein activity related

Ancestor Chart

Ancestor chart for GO:0030695
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030695

Child Term Relationship to
GO:0030695
GTPase inhibitor activity
is_a
GTPase activator activity
is_a
guanyl-nucleotide exchange factor activity
is_a
guanyl-nucleotide exchange factor adaptor activity
is_a
GDP-dissociation inhibitor activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Cross-references

Database ID Description
InterPro IPR003109 GoLoco motif
InterPro IPR037880 RGS12, RGS domain

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030695 based on ALL annotations
The top 100 of 936 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GTPase regulator activity
12,135.13 100.00 16,064 16,064
G-protein alpha-subunit binding
2,418.13 12.05 3,751 18,824
GDP-dissociation inhibitor activity
2,182.04 10.69 3,349 18,625
establishment of mitotic spindle orientation
1,428.14 7.97 3,184 27,055
regulation of G protein-coupled receptor signaling pathway
971.47 5.60 2,525 31,541
cell cortex
311.40 2.33 3,188 124,236
spindle organization
466.86 2.28 849 22,068
filamentous actin
424.94 1.83 594 16,963
muscle alpha-actinin binding
411.27 1.80 594 17,527
regulation of inflammatory response
352.39 1.39 419 14,429
Totals 59407 5186533
No co-occurrence statistics for GO:0030695 based on MANUAL annotations
The top 100 of 409 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GTPase regulator activity
16,561.53 100.00 78 78
IkappaB kinase complex binding
8,917.75 8.33 7 13
type II interferon receptor binding
8,280.76 8.24 7 14
activation-induced cell death of T cells
3,680.34 7.55 8 36
angiotensin-activated signaling pathway involved in heart process
11,829.66 6.25 5 7
regulation of ERK5 cascade
10,350.95 6.17 5 8
regulation of matrix metallopeptidase secretion
8,280.76 6.02 5 10
skeletal muscle acetylcholine-gated channel clustering
2,466.61 5.93 7 47
negative regulation of type II interferon-mediated signaling pathway
2,415.22 5.88 7 48
vascular associated smooth muscle contraction
5,520.51 4.65 4 12
Totals 392 8928

Change Log

Timestamp Action Category Detail
2021-02-17 Deleted DEFINITION Modulates the rate of GTP hydrolysis by a GTPase.
2021-02-17 Added DEFINITION Binds to and modulates the activity of a GTPase.
2015-02-13 Added SECONDARY GO:0005083 (small GTPase regulator activity)
2015-02-13 Added SYNONYM small GTPase regulatory/interacting protein activity
2015-02-13 Added SYNONYM small GTPase regulator activity
2010-06-15 Added RELATION regulates GO:0003924 (GTPase activity)
2010-06-14 Deleted RELATION regulates GO:0003924 (GTPase activity)
2010-06-08 Added RELATION regulates GO:0003924 (GTPase activity)
2009-05-11 Added RELATION is a GO:0060589 (nucleoside-triphosphatase regulator activity)
2009-05-11 Deleted RELATION is a GO:0030234 (enzyme regulator activity)
Timestamp Action Category Detail
2003-06-17 Added TERM GTPase regulator activity
Timestamp Action Category Detail
2021-02-17 Deleted DEFINITION Modulates the rate of GTP hydrolysis by a GTPase.
2021-02-17 Added DEFINITION Binds to and modulates the activity of a GTPase.
2015-02-13 Added SYNONYM small GTPase regulatory/interacting protein activity
2015-02-13 Added SYNONYM small GTPase regulator activity
2008-05-13 Added DEFINITION Modulates the rate of GTP hydrolysis by a GTPase.
2008-05-12 Deleted DEFINITION Modulates the rate of GTP hydrolysis by a GTPase.
2003-06-17 Added DEFINITION Modulates the rate of GTP hydrolysis by a GTPase.
Timestamp Action Category Detail
2010-06-15 Added RELATION regulates GO:0003924 (GTPase activity)
2010-06-14 Deleted RELATION regulates GO:0003924 (GTPase activity)
2010-06-08 Added RELATION regulates GO:0003924 (GTPase activity)
2009-05-11 Added RELATION is a GO:0060589 (nucleoside-triphosphatase regulator activity)
2009-05-11 Deleted RELATION is a GO:0030234 (enzyme regulator activity)
2009-02-25 Deleted RELATION regulates GO:0003924 (GTPase activity)
2009-02-22 Added RELATION regulates GO:0003924 (GTPase activity)
2008-04-01 Updated RELATION is a GO:0030234 (enzyme regulator activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
2015-02-13 Added SECONDARY GO:0005083 (small GTPase regulator activity)
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