GO:0030695
JSON
GTPase regulator activity
Molecular Function
Definition (GO:0030695 GONUTS page)
Binds to and modulates the activity of a GTPase.
Secondary IDs
GO:0005083
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
small GTPase regulator activity | related |
small GTPase regulatory/interacting protein activity | related |
Ancestor Chart
Ancestor chart for GO:0030695
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0030695
Child Term | Relationship to GO:0030695 |
---|---|
GTPase inhibitor activity
|
is_a |
GTPase activator activity
|
is_a |
guanyl-nucleotide exchange factor activity
|
is_a |
guanyl-nucleotide exchange factor adaptor activity
|
is_a |
GDP-dissociation inhibitor activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR003109 | GoLoco motif |
InterPro | IPR037880 | RGS12, RGS domain |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030695 based on ALL annotations
The top 100 of 936 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
GTPase regulator activity
|
12,135.13 | 100.00 | 16,064 | 16,064 |
G-protein alpha-subunit binding
|
2,418.13 | 12.05 | 3,751 | 18,824 |
GDP-dissociation inhibitor activity
|
2,182.04 | 10.69 | 3,349 | 18,625 |
establishment of mitotic spindle orientation
|
1,428.14 | 7.97 | 3,184 | 27,055 |
regulation of G protein-coupled receptor signaling pathway
|
971.47 | 5.60 | 2,525 | 31,541 |
cell cortex
|
311.40 | 2.33 | 3,188 | 124,236 |
spindle organization
|
466.86 | 2.28 | 849 | 22,068 |
filamentous actin
|
424.94 | 1.83 | 594 | 16,963 |
muscle alpha-actinin binding
|
411.27 | 1.80 | 594 | 17,527 |
regulation of inflammatory response
|
352.39 | 1.39 | 419 | 14,429 |
Totals | 59407 | 5186533 |
No co-occurrence statistics for GO:0030695 based on MANUAL annotations
The top 100 of 409 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
GTPase regulator activity
|
16,561.53 | 100.00 | 78 | 78 |
IkappaB kinase complex binding
|
8,917.75 | 8.33 | 7 | 13 |
type II interferon receptor binding
|
8,280.76 | 8.24 | 7 | 14 |
activation-induced cell death of T cells
|
3,680.34 | 7.55 | 8 | 36 |
angiotensin-activated signaling pathway involved in heart process
|
11,829.66 | 6.25 | 5 | 7 |
regulation of ERK5 cascade
|
10,350.95 | 6.17 | 5 | 8 |
regulation of matrix metallopeptidase secretion
|
8,280.76 | 6.02 | 5 | 10 |
skeletal muscle acetylcholine-gated channel clustering
|
2,466.61 | 5.93 | 7 | 47 |
negative regulation of type II interferon-mediated signaling pathway
|
2,415.22 | 5.88 | 7 | 48 |
vascular associated smooth muscle contraction
|
5,520.51 | 4.65 | 4 | 12 |
Totals | 392 | 8928 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-17 | Deleted | DEFINITION | Modulates the rate of GTP hydrolysis by a GTPase. |
2021-02-17 | Added | DEFINITION | Binds to and modulates the activity of a GTPase. |
2015-02-13 | Added | SECONDARY | GO:0005083 (small GTPase regulator activity) |
2015-02-13 | Added | SYNONYM | small GTPase regulatory/interacting protein activity |
2015-02-13 | Added | SYNONYM | small GTPase regulator activity |
2010-06-15 | Added | RELATION | regulates GO:0003924 (GTPase activity) |
2010-06-14 | Deleted | RELATION | regulates GO:0003924 (GTPase activity) |
2010-06-08 | Added | RELATION | regulates GO:0003924 (GTPase activity) |
2009-05-11 | Added | RELATION | is a GO:0060589 (nucleoside-triphosphatase regulator activity) |
2009-05-11 | Deleted | RELATION | is a GO:0030234 (enzyme regulator activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-06-17 | Added | TERM | GTPase regulator activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-17 | Deleted | DEFINITION | Modulates the rate of GTP hydrolysis by a GTPase. |
2021-02-17 | Added | DEFINITION | Binds to and modulates the activity of a GTPase. |
2015-02-13 | Added | SYNONYM | small GTPase regulatory/interacting protein activity |
2015-02-13 | Added | SYNONYM | small GTPase regulator activity |
2008-05-13 | Added | DEFINITION | Modulates the rate of GTP hydrolysis by a GTPase. |
2008-05-12 | Deleted | DEFINITION | Modulates the rate of GTP hydrolysis by a GTPase. |
2003-06-17 | Added | DEFINITION | Modulates the rate of GTP hydrolysis by a GTPase. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-15 | Added | RELATION | regulates GO:0003924 (GTPase activity) |
2010-06-14 | Deleted | RELATION | regulates GO:0003924 (GTPase activity) |
2010-06-08 | Added | RELATION | regulates GO:0003924 (GTPase activity) |
2009-05-11 | Added | RELATION | is a GO:0060589 (nucleoside-triphosphatase regulator activity) |
2009-05-11 | Deleted | RELATION | is a GO:0030234 (enzyme regulator activity) |
2009-02-25 | Deleted | RELATION | regulates GO:0003924 (GTPase activity) |
2009-02-22 | Added | RELATION | regulates GO:0003924 (GTPase activity) |
2008-04-01 | Updated | RELATION | is a GO:0030234 (enzyme regulator activity) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-02-13 | Added | SECONDARY | GO:0005083 (small GTPase regulator activity) |
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