GO:0030748
JSON
amine N-methyltransferase activity
Molecular Function
Definition (GO:0030748 GONUTS page)
Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. Acts on primary, secondary and tertiary amines.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| tryptamine N-methyltransferase activity | narrow |
| nicotine N-methyltransferase activity | narrow |
| S-adenosyl-L-methionine:amine N-methyltransferase activity | related |
| arylamine N-methyltransferase activity | narrow |
| tryptamine methyltransferase | narrow |
Ancestor Chart
Ancestor chart for GO:0030748
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
| Annotating to catalytic activities using the IPI evidence code | Link |
| Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
| NOT-qualified manual | protein | A0A8I5YBY9 | 10116 | A0A8I5YBY9_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A2VDP2 | 9913 | PCMD1_BOVIN | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
| NOT-qualified manual | protein | A6JFH4 | 10116 | A6JFH4_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A6JFH5 | 10116 | A6JFH5_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | A7XRZ1 | 227321 | TDIE_EMENI | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17704773 | |
| NOT-qualified manual | protein | D3Z930 | 10116 | D3Z930_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | D4A629 | 10116 | D4A629_RAT | GO:0008757 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
| Database | ID | Description |
|---|---|---|
| EC | 2.1.1.49 | |
| MetaCyc | AMINE-N-METHYLTRANSFERASE-RXN | |
| RHEA | 23136 | |
| RHEA | 53924 | |
| RHEA | 53928 |
Replaces
This term can be used instead of these obsolete terms:
| GO Identifier | GO Term Name | Reason |
|---|---|---|
| GO:0102707 | obsolete S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity | replaced_by GO:0030748 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030748 based on ALL annotations
The top 18 of 18 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
|
1,329,898.40 | 100.00 | 149 | 149 |
|
|
1,329,898.40 | 22.82 | 34 | 34 |
|
|
1,329,898.50 | 0.67 | 1 | 1 |
|
|
25,574.97 | 0.50 | 1 | 52 |
|
|
24,627.75 | 0.50 | 1 | 54 |
|
|
2,329.59 | 0.17 | 39 | 22,264 |
|
|
833.73 | 0.06 | 144 | 229,698 |
|
|
133.33 | 0.01 | 61 | 608,428 |
|
|
74.60 | 0.01 | 4 | 71,305 |
|
|
54.40 | 0.00 | 149 | 3,642,626 |
| Totals | 894 | 102944577 | ||
No co-occurrence statistics for GO:0030748 based on MANUAL annotations
The top 8 of 8 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
|
117,627.75 | 100.00 | 12 | 12 |
|
|
117,627.75 | 25.00 | 3 | 3 |
|
|
117,627.76 | 8.33 | 1 | 1 |
|
|
5,017.30 | 4.21 | 9 | 211 |
|
|
1,917.84 | 1.60 | 6 | 368 |
|
|
291.52 | 0.25 | 6 | 2,421 |
|
|
15.76 | 0.01 | 12 | 89,580 |
|
|
2.81 | 0.00 | 1 | 41,833 |
| Totals | 50 | 134429 | ||
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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- Other
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-06-22 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| 2024-06-22 | Added | XREF | RHEA:23136 |
| 2024-06-22 | Added | XREF | RHEA:53928 |
| 2024-06-22 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. Acts on primary, secondary and tertiary amines. |
| 2024-06-22 | Added | XREF | RHEA:53924 |
| 2020-10-08 | Added | SYNONYM | S-adenosyl-L-methionine:amine N-methyltransferase activity |
| 2020-10-08 | Deleted | SYNONYM | S-adenosyl-L-methionine:amine N-methyltransferase activity |
| 2008-05-13 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| 2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| 2008-04-01 | Updated | RELATION | is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2003-08-12 | Added | TERM | amine N-methyltransferase activity |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-06-22 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| 2024-06-22 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. Acts on primary, secondary and tertiary amines. |
| 2020-10-08 | Added | SYNONYM | S-adenosyl-L-methionine:amine N-methyltransferase activity |
| 2020-10-08 | Deleted | SYNONYM | S-adenosyl-L-methionine:amine N-methyltransferase activity |
| 2008-05-13 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| 2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| 2007-12-14 | Added | SYNONYM | tryptamine methyltransferase |
| 2007-12-14 | Added | SYNONYM | S-adenosyl-L-methionine:amine N-methyltransferase activity |
| 2007-09-06 | Added | SYNONYM | tryptamine N-methyltransferase activity |
| 2007-09-06 | Added | SYNONYM | nicotine N-methyltransferase activity |
| 2007-09-06 | Added | SYNONYM | arylamine N-methyltransferase activity |
| 2004-04-28 | Added | DEFINITION | Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-04-01 | Updated | RELATION | is a GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-06-22 | Added | XREF | RHEA:23136 |
| 2024-06-22 | Added | XREF | RHEA:53928 |
| 2024-06-22 | Added | XREF | RHEA:53924 |
| 2003-10-27 | Added | XREF | MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN |
| 2003-08-12 | Added | XREF | EC:2.1.1.49 |
| Timestamp | Action | Category | Detail |
|---|
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