GO:0030870
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Mre11 complex
Cellular Component
Definition (GO:0030870 GONUTS page)
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. PMID:11988766 PMID:17674145
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
RAD50-MRE11-NBN complex | exact |
MRN complex | exact |
Rad50-Rad32-Nbs1 complex | exact |
Rad50 complex | exact |
RMX complex | exact |
MRX complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0030870 | Mre11 complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A0E5 | 10116 | A0A8I6A0E5_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR003701 | DNA double-strand break repair protein Mre11 |
InterPro | IPR004584 | DNA repair protein Rad50, eukaryotes |
InterPro | IPR016592 | Nibrin |
InterPro | IPR040227 | Nibrin-related |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030870 based on ALL annotations
The top 100 of 415 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Mre11 complex
|
13,143.73 | 100.00 | 15,076 | 15,076 |
mitochondrial double-strand break repair via homologous recombination
|
13,081.30 | 33.30 | 5,029 | 5,053 |
G-quadruplex DNA binding
|
8,246.47 | 31.74 | 5,897 | 9,399 |
telomere maintenance via recombination
|
6,267.37 | 26.80 | 5,722 | 12,000 |
mitotic G2 DNA damage checkpoint signaling
|
3,767.39 | 23.95 | 8,940 | 31,190 |
double-stranded telomeric DNA binding
|
4,996.68 | 23.88 | 5,897 | 15,512 |
chromosome organization involved in meiotic cell cycle
|
5,027.90 | 23.53 | 5,720 | 14,953 |
single-stranded telomeric DNA binding
|
4,750.17 | 23.13 | 5,897 | 16,317 |
telomere maintenance via telomerase
|
4,265.75 | 21.21 | 5,725 | 17,640 |
meiotic DNA double-strand break formation
|
4,032.03 | 19.03 | 5,034 | 16,410 |
Totals | 205647 | 20451934 |
No co-occurrence statistics for GO:0030870 based on MANUAL annotations
The top 100 of 173 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
Mre11 complex
|
4,032.95 | 100.00 | 350 | 350 |
mitochondrial double-strand break repair via homologous recombination
|
3,966.29 | 33.81 | 119 | 121 |
G-quadruplex DNA binding
|
2,455.82 | 25.95 | 109 | 179 |
double-stranded telomeric DNA binding
|
1,839.30 | 22.71 | 109 | 239 |
mitotic G2 DNA damage checkpoint signaling
|
1,038.00 | 22.27 | 218 | 847 |
telomere maintenance via recombination
|
1,456.72 | 19.96 | 108 | 299 |
single-stranded DNA endodeoxyribonuclease activity
|
1,217.87 | 19.30 | 122 | 404 |
chromosome organization involved in meiotic cell cycle
|
1,258.84 | 18.37 | 108 | 346 |
meiotic DNA double-strand break formation
|
842.81 | 14.98 | 121 | 579 |
condensed nuclear chromosome
|
563.47 | 10.64 | 108 | 773 |
Totals | 3178 | 47166 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2020-11-03 | Deleted | RELATION | is a GO:0032991 (protein-containing complex) |
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Added | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2012-06-01 | Deleted | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
2012-06-01 | Added | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-11-20 | Added | TERM | Mre11 complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-06-01 | Deleted | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
2012-06-01 | Added | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
2012-04-07 | Deleted | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
2012-04-07 | Added | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
2011-03-31 | Added | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
2011-03-31 | Deleted | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins. |
2009-03-23 | Added | SYNONYM | RAD50-MRE11-NBN complex |
2008-05-13 | Added | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins. |
2008-05-12 | Deleted | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins. |
2007-08-09 | Added | SYNONYM | MRX complex |
2007-08-09 | Added | SYNONYM | RMX complex |
2007-08-09 | Deleted | SYNONYM | Rad50-Rad32-Nbs1 complex |
2007-08-09 | Deleted | SYNONYM | Rad50 complex |
2007-08-09 | Deleted | SYNONYM | RMX complex |
2007-08-09 | Added | SYNONYM | Rad50 complex |
2007-08-09 | Deleted | SYNONYM | MRN complex |
2007-08-09 | Deleted | SYNONYM | MRX complex |
2007-08-09 | Added | SYNONYM | Rad50-Rad32-Nbs1 complex |
2007-08-09 | Added | SYNONYM | MRN complex |
2005-10-02 | Added | SYNONYM | Rad50 complex |
2005-10-02 | Added | SYNONYM | Rad50-Rad32-Nbs1 complex |
2005-03-26 | Added | SYNONYM | MRX complex |
2005-03-26 | Added | SYNONYM | RMX complex |
2004-04-19 | Added | SYNONYM | MRN complex |
2004-04-16 | Deleted | SYNONYM | MRN complex |
2003-11-25 | Added | SYNONYM | MRN complex |
2003-11-20 | Added | DEFINITION | Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-03 | Deleted | RELATION | is a GO:0032991 (protein-containing complex) |
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Added | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2008-04-01 | Updated | RELATION | is a GO:0044428 (obsolete nuclear part) |
2008-04-01 | Updated | RELATION | is a GO:0043234 (protein complex) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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