This term is obsolete.

GO:0030870 JSON

Mre11 complex

Cellular Component

Definition (GO:0030870 GONUTS page)

Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. PMID:11988766 PMID:17674145

15,432 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
RAD50-MRE11-NBN complex exact
MRN complex exact
Rad50-Rad32-Nbs1 complex exact
Rad50 complex exact
RMX complex exact
MRX complex exact

Ancestor Chart

Ancestor chart for GO:0030870
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0030870 Mre11 complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A0E5 10116 A0A8I6A0E5_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR003701 DNA double-strand break repair protein Mre11
InterPro IPR004584 DNA repair protein Rad50, eukaryotes
InterPro IPR016592 Nibrin
InterPro IPR040227 Nibrin-related

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030870 based on ALL annotations
The top 100 of 415 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Mre11 complex
13,143.73 100.00 15,076 15,076
mitochondrial double-strand break repair via homologous recombination
13,081.30 33.30 5,029 5,053
G-quadruplex DNA binding
8,246.47 31.74 5,897 9,399
telomere maintenance via recombination
6,267.37 26.80 5,722 12,000
mitotic G2 DNA damage checkpoint signaling
3,767.39 23.95 8,940 31,190
double-stranded telomeric DNA binding
4,996.68 23.88 5,897 15,512
chromosome organization involved in meiotic cell cycle
5,027.90 23.53 5,720 14,953
single-stranded telomeric DNA binding
4,750.17 23.13 5,897 16,317
telomere maintenance via telomerase
4,265.75 21.21 5,725 17,640
meiotic DNA double-strand break formation
4,032.03 19.03 5,034 16,410
Totals 205647 20451934
No co-occurrence statistics for GO:0030870 based on MANUAL annotations
The top 100 of 173 co-occurring terms
Co-occurring Term PR S% #Together #Compared
Mre11 complex
4,032.95 100.00 350 350
mitochondrial double-strand break repair via homologous recombination
3,966.29 33.81 119 121
G-quadruplex DNA binding
2,455.82 25.95 109 179
double-stranded telomeric DNA binding
1,839.30 22.71 109 239
mitotic G2 DNA damage checkpoint signaling
1,038.00 22.27 218 847
telomere maintenance via recombination
1,456.72 19.96 108 299
single-stranded DNA endodeoxyribonuclease activity
1,217.87 19.30 122 404
chromosome organization involved in meiotic cell cycle
1,258.84 18.37 108 346
meiotic DNA double-strand break formation
842.81 14.98 121 579
condensed nuclear chromosome
563.47 10.64 108 773
Totals 3178 47166

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2020-11-03 Deleted RELATION is a GO:0032991 (protein-containing complex)
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2019-09-12 Added RELATION part of GO:0005634 (nucleus)
2019-09-12 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2012-06-01 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-06-01 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
Timestamp Action Category Detail
2003-11-20 Added TERM Mre11 complex
Timestamp Action Category Detail
2012-06-01 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-06-01 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-04-07 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2012-04-07 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2011-03-31 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
2011-03-31 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2009-03-23 Added SYNONYM RAD50-MRE11-NBN complex
2008-05-13 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2008-05-12 Deleted DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
2007-08-09 Added SYNONYM MRX complex
2007-08-09 Added SYNONYM RMX complex
2007-08-09 Deleted SYNONYM Rad50-Rad32-Nbs1 complex
2007-08-09 Deleted SYNONYM Rad50 complex
2007-08-09 Deleted SYNONYM RMX complex
2007-08-09 Added SYNONYM Rad50 complex
2007-08-09 Deleted SYNONYM MRN complex
2007-08-09 Deleted SYNONYM MRX complex
2007-08-09 Added SYNONYM Rad50-Rad32-Nbs1 complex
2007-08-09 Added SYNONYM MRN complex
2005-10-02 Added SYNONYM Rad50 complex
2005-10-02 Added SYNONYM Rad50-Rad32-Nbs1 complex
2005-03-26 Added SYNONYM MRX complex
2005-03-26 Added SYNONYM RMX complex
2004-04-19 Added SYNONYM MRN complex
2004-04-16 Deleted SYNONYM MRN complex
2003-11-25 Added SYNONYM MRN complex
2003-11-20 Added DEFINITION Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins.
Timestamp Action Category Detail
2020-11-03 Deleted RELATION is a GO:0032991 (protein-containing complex)
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2019-09-12 Added RELATION part of GO:0005634 (nucleus)
2019-09-12 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044428 (obsolete nuclear part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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