This term is obsolete.
Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism.

GO:0030968 JSON

endoplasmic reticulum unfolded protein response

Biological Process

Definition (GO:0030968 GONUTS page)

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. PMID:12042763

Comments

Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism.

66,765 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
SREBP-mediated signalling pathway related
erUPR exact
ER unfolded protein response exact

Ancestor Chart

Ancestor chart for GO:0030968
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030968

Child Term Relationship to
GO:0030968
positive regulation of endoplasmic reticulum unfolded protein response
positively_regulates
negative regulation of endoplasmic reticulum unfolded protein response
negatively_regulates
regulation of endoplasmic reticulum unfolded protein response
regulates
ATF6-mediated unfolded protein response
is_a
PERK-mediated unfolded protein response
is_a
IRE1-mediated unfolded protein response
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A6HBA4 10116 A6HBA4_RAT GO:0034976 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZIA7 10116 D3ZIA7_RAT GO:0034976 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O43889-2 9606 CREB3_HUMAN GO:0034976 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15845366
NOT-qualified manual protein O95994 9606 AGR2_HUMAN GO:0034976 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25666625
NOT-qualified manual protein Q0WL81 3702 RNL_ARATH GO:0030968 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20844078
NOT-qualified manual protein Q61817 10090 CREB3_MOUSE GO:0034976 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q6FUI3 284593 Q6FUI3_CANGA GO:0030968 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:23382685
NOT-qualified manual protein Q8SQ19 9913 CREB3_BOVIN GO:0034976 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
InterPro IPR045133 Serine/threonine-protein kinase/endoribonuclease IRE1/2-like
InterPro IPR045149 Protein OS-9-like

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0006990 obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response consider GO:0030968

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0030968 based on ALL annotations
The top 100 of 1,679 co-occurring terms
Co-occurring Term PR S% #Together #Compared
endoplasmic reticulum unfolded protein response
3,575.28 100.00 54,524 54,524
IRE1-TRAF2-ASK1 complex
3,487.19 14.32 7,838 8,036
IRE1-mediated unfolded protein response
2,621.45 14.22 8,179 11,155
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
2,283.21 11.90 6,957 10,894
endoplasmic reticulum chaperone complex
2,982.27 11.52 6,427 7,705
retrograde protein transport, ER to cytosol
1,530.04 11.44 7,365 17,210
endoplasmic reticulum lumen
579.23 10.07 11,466 70,774
ERAD pathway
367.53 7.93 14,018 136,365
response to unfolded protein
802.00 7.73 5,756 25,660
protein O-linked mannosylation
393.93 5.99 6,320 57,360
Totals 337542 18658432
No co-occurrence statistics for GO:0030968 based on MANUAL annotations
The top 100 of 1,236 co-occurring terms
Co-occurring Term PR S% #Together #Compared
endoplasmic reticulum unfolded protein response
705.13 100.00 1,832 1,832
signal recognition particle binding
329.99 14.08 307 656
ERAD pathway
115.74 13.13 726 4,423
endoplasmic reticulum chaperone complex
416.99 11.69 233 394
ubiquitin-dependent glycoprotein ERAD pathway
698.18 10.96 201 203
mannoprotein catabolic process
694.71 10.90 200 203
endoplasmic reticulum lumen
143.65 8.69 241 1,183
calcium channel activity
101.58 7.67 258 1,791
heat shock protein binding
88.52 6.76 234 1,864
protein folding chaperone
63.12 5.56 234 2,614
Totals 8813 215139

Change Log

Timestamp Action Category Detail
2024-06-11 Added RELATION is a GO:0035556 (intracellular signal transduction)
2024-06-11 Deleted RELATION is a GO:0007165 (signal transduction)
2020-02-28 Deleted XREF MIPS_funcat:32.01.07
2019-05-04 Added XREF MIPS_funcat:32.01.07
2015-02-07 Added RELATION is a GO:0007165 (signal transduction)
2015-02-07 Deleted RELATION is a GO:0006984 (ER-nucleus signaling pathway)
2014-12-20 Deleted RELATION is a GO:0034620 (cellular response to unfolded protein)
2014-12-20 Added RELATION part of GO:0034620 (cellular response to unfolded protein)
2008-10-02 Deleted SYNONYM ER stress response
2008-10-02 Added RELATION is a GO:0034976 (response to endoplasmic reticulum stress)
Timestamp Action Category Detail
2008-06-16 Updated TERM endoplasmic reticulum unfolded protein response
2004-07-22 Added TERM unfolded protein response
Timestamp Action Category Detail
2008-10-02 Deleted SYNONYM ER stress response
2008-06-16 Added SYNONYM erUPR
2008-06-16 Deleted SYNONYM UPR
2008-06-16 Added SYNONYM ER unfolded protein response
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2007-08-09 Deleted SYNONYM SREBP-mediated signalling pathway
2007-08-09 Added SYNONYM ER stress response
2007-08-09 Added SYNONYM SREBP-mediated signalling pathway
2007-08-09 Added SYNONYM UPR
2007-08-09 Deleted SYNONYM ER stress response
2007-08-09 Deleted SYNONYM UPR
2007-05-13 Added SYNONYM SREBP-mediated signalling pathway
2004-07-24 Updated DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
2004-07-22 Added SYNONYM UPR
2004-07-22 Added DEFINITION The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of trancription and translation.
2004-07-22 Added SYNONYM ER stress response
Timestamp Action Category Detail
2024-06-11 Added RELATION is a GO:0035556 (intracellular signal transduction)
2024-06-11 Deleted RELATION is a GO:0007165 (signal transduction)
2015-02-07 Added RELATION is a GO:0007165 (signal transduction)
2015-02-07 Deleted RELATION is a GO:0006984 (ER-nucleus signaling pathway)
2014-12-20 Deleted RELATION is a GO:0034620 (cellular response to unfolded protein)
2014-12-20 Added RELATION part of GO:0034620 (cellular response to unfolded protein)
2008-10-02 Added RELATION is a GO:0034976 (response to endoplasmic reticulum stress)
2008-07-31 Added RELATION is a GO:0034620 (cellular response to unfolded protein)
2008-07-31 Deleted RELATION is a GO:0006986 (response to unfolded protein)
2008-04-01 Updated RELATION is a GO:0006984 (ER-nucleus signaling pathway)
2008-04-01 Updated RELATION is a GO:0006986 (response to unfolded protein)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:32.01.07
2019-05-04 Added XREF MIPS_funcat:32.01.07
Timestamp Action Category Detail
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