Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism.
GO:0030968
JSON
endoplasmic reticulum unfolded protein response
Biological Process
Definition (GO:0030968 GONUTS page)
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. PMID:12042763
Comments
Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
SREBP-mediated signalling pathway | related |
erUPR | exact |
ER unfolded protein response | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0030968
Child Term | Relationship to GO:0030968 |
---|---|
positive regulation of endoplasmic reticulum unfolded protein response
|
positively_regulates |
negative regulation of endoplasmic reticulum unfolded protein response
|
negatively_regulates |
regulation of endoplasmic reticulum unfolded protein response
|
regulates |
ATF6-mediated unfolded protein response
|
is_a |
PERK-mediated unfolded protein response
|
is_a |
IRE1-mediated unfolded protein response
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A6HBA4 | 10116 | A6HBA4_RAT | GO:0034976 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZIA7 | 10116 | D3ZIA7_RAT | GO:0034976 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O43889-2 | 9606 | CREB3_HUMAN | GO:0034976 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15845366 | |
NOT-qualified manual | protein | O95994 | 9606 | AGR2_HUMAN | GO:0034976 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25666625 | |
NOT-qualified manual | protein | Q0WL81 | 3702 | RNL_ARATH | GO:0030968 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:20844078 | |
NOT-qualified manual | protein | Q61817 | 10090 | CREB3_MOUSE | GO:0034976 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q6FUI3 | 284593 | Q6FUI3_CANGA | GO:0030968 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:23382685 | |
NOT-qualified manual | protein | Q8SQ19 | 9913 | CREB3_BOVIN | GO:0034976 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR045133 | Serine/threonine-protein kinase/endoribonuclease IRE1/2-like |
InterPro | IPR045149 | Protein OS-9-like |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0006990 | obsolete positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response | consider GO:0030968 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0030968 based on ALL annotations
The top 100 of 1,679 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
endoplasmic reticulum unfolded protein response
|
3,575.28 | 100.00 | 54,524 | 54,524 |
IRE1-TRAF2-ASK1 complex
|
3,487.19 | 14.32 | 7,838 | 8,036 |
IRE1-mediated unfolded protein response
|
2,621.45 | 14.22 | 8,179 | 11,155 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
2,283.21 | 11.90 | 6,957 | 10,894 |
endoplasmic reticulum chaperone complex
|
2,982.27 | 11.52 | 6,427 | 7,705 |
retrograde protein transport, ER to cytosol
|
1,530.04 | 11.44 | 7,365 | 17,210 |
endoplasmic reticulum lumen
|
579.23 | 10.07 | 11,466 | 70,774 |
ERAD pathway
|
367.53 | 7.93 | 14,018 | 136,365 |
response to unfolded protein
|
802.00 | 7.73 | 5,756 | 25,660 |
protein O-linked mannosylation
|
393.93 | 5.99 | 6,320 | 57,360 |
Totals | 337542 | 18658432 |
No co-occurrence statistics for GO:0030968 based on MANUAL annotations
The top 100 of 1,236 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
endoplasmic reticulum unfolded protein response
|
705.13 | 100.00 | 1,832 | 1,832 |
signal recognition particle binding
|
329.99 | 14.08 | 307 | 656 |
ERAD pathway
|
115.74 | 13.13 | 726 | 4,423 |
endoplasmic reticulum chaperone complex
|
416.99 | 11.69 | 233 | 394 |
ubiquitin-dependent glycoprotein ERAD pathway
|
698.18 | 10.96 | 201 | 203 |
mannoprotein catabolic process
|
694.71 | 10.90 | 200 | 203 |
endoplasmic reticulum lumen
|
143.65 | 8.69 | 241 | 1,183 |
calcium channel activity
|
101.58 | 7.67 | 258 | 1,791 |
heat shock protein binding
|
88.52 | 6.76 | 234 | 1,864 |
protein folding chaperone
|
63.12 | 5.56 | 234 | 2,614 |
Totals | 8813 | 215139 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-11 | Added | RELATION | is a GO:0035556 (intracellular signal transduction) |
2024-06-11 | Deleted | RELATION | is a GO:0007165 (signal transduction) |
2020-02-28 | Deleted | XREF | MIPS_funcat:32.01.07 |
2019-05-04 | Added | XREF | MIPS_funcat:32.01.07 |
2015-02-07 | Added | RELATION | is a GO:0007165 (signal transduction) |
2015-02-07 | Deleted | RELATION | is a GO:0006984 (ER-nucleus signaling pathway) |
2014-12-20 | Deleted | RELATION | is a GO:0034620 (cellular response to unfolded protein) |
2014-12-20 | Added | RELATION | part of GO:0034620 (cellular response to unfolded protein) |
2008-10-02 | Deleted | SYNONYM | ER stress response |
2008-10-02 | Added | RELATION | is a GO:0034976 (response to endoplasmic reticulum stress) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-06-16 | Updated | TERM | endoplasmic reticulum unfolded protein response |
2004-07-22 | Added | TERM | unfolded protein response |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-10-02 | Deleted | SYNONYM | ER stress response |
2008-06-16 | Added | SYNONYM | erUPR |
2008-06-16 | Deleted | SYNONYM | UPR |
2008-06-16 | Added | SYNONYM | ER unfolded protein response |
2008-05-13 | Added | DEFINITION | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. |
2008-05-12 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. |
2007-08-09 | Deleted | SYNONYM | SREBP-mediated signalling pathway |
2007-08-09 | Added | SYNONYM | ER stress response |
2007-08-09 | Added | SYNONYM | SREBP-mediated signalling pathway |
2007-08-09 | Added | SYNONYM | UPR |
2007-08-09 | Deleted | SYNONYM | ER stress response |
2007-08-09 | Deleted | SYNONYM | UPR |
2007-05-13 | Added | SYNONYM | SREBP-mediated signalling pathway |
2004-07-24 | Updated | DEFINITION | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. |
2004-07-22 | Added | SYNONYM | UPR |
2004-07-22 | Added | DEFINITION | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of trancription and translation. |
2004-07-22 | Added | SYNONYM | ER stress response |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-11 | Added | RELATION | is a GO:0035556 (intracellular signal transduction) |
2024-06-11 | Deleted | RELATION | is a GO:0007165 (signal transduction) |
2015-02-07 | Added | RELATION | is a GO:0007165 (signal transduction) |
2015-02-07 | Deleted | RELATION | is a GO:0006984 (ER-nucleus signaling pathway) |
2014-12-20 | Deleted | RELATION | is a GO:0034620 (cellular response to unfolded protein) |
2014-12-20 | Added | RELATION | part of GO:0034620 (cellular response to unfolded protein) |
2008-10-02 | Added | RELATION | is a GO:0034976 (response to endoplasmic reticulum stress) |
2008-07-31 | Added | RELATION | is a GO:0034620 (cellular response to unfolded protein) |
2008-07-31 | Deleted | RELATION | is a GO:0006986 (response to unfolded protein) |
2008-04-01 | Updated | RELATION | is a GO:0006984 (ER-nucleus signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0006986 (response to unfolded protein) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:32.01.07 |
2019-05-04 | Added | XREF | MIPS_funcat:32.01.07 |
Timestamp | Action | Category | Detail |
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