This term is obsolete.

GO:0031005 JSON

filamin binding

Molecular Function

Definition (GO:0031005 GONUTS page)

Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. PMID:11336782

Secondary IDs

GO:0031006, GO:0031007, GO:0031008

3,208 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
filamin-1 binding narrow
filamin-3 binding narrow
filamin-C binding narrow
ABP-278/276 binding narrow
ABPL binding narrow
gamma-filamin binding narrow
ABP-280 binding narrow
beta-filamin binding narrow
filamin-B binding exact
filamin A binding narrow

Ancestor Chart

Ancestor chart for GO:0031005
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684

Cross-references

Database ID Description
InterPro IPR028215 Refilin family

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0031005 based on ALL annotations
The top 100 of 468 co-occurring terms
Co-occurring Term PR S% #Together #Compared
filamin binding
61,806.84 100.00 3,154 3,154
regulation of chondrocyte development
57,217.94 48.63 1,596 1,724
actin filament bundle organization
56,432.34 48.28 1,596 1,748
negative regulation of bone mineralization involved in bone maturation
58,431.33 46.47 1,506 1,593
negative regulation of chondrocyte development
58,139.36 46.35 1,506 1,601
skeletal system morphogenesis
17,807.75 21.91 1,506 5,227
actin filament bundle
8,555.76 12.12 1,558 11,255
regulation of integrin activation
22,679.12 2.75 91 248
negative regulation of centrosome duplication
14,488.39 2.72 94 401
alpha-actinin binding
4,983.55 2.19 92 1,141
Totals 19932 2613007
No co-occurrence statistics for GO:0031005 based on MANUAL annotations
The top 100 of 401 co-occurring terms
Co-occurring Term PR S% #Together #Compared
filamin binding
14,848.27 100.00 87 87
negative regulation of bone mineralization involved in bone maturation
13,411.34 31.11 28 31
negative regulation of chondrocyte development
13,411.34 31.11 28 31
actin filament bundle organization
8,734.27 27.78 30 51
skeletal system morphogenesis
1,746.85 9.43 28 238
regulation of integrin activation
7,424.13 8.42 8 16
actin filament bundle
1,346.13 7.89 33 364
cardiac muscle thin filament assembly
1,349.84 5.35 10 110
cytoskeletal protein binding
690.62 3.42 10 215
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
832.61 3.19 6 107
Totals 488 10510

Change Log

Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2021-05-24 Added DEFINITION Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2012-03-24 Added SYNONYM beta-filamin binding
2012-03-24 Added SYNONYM filamin-B binding
2012-03-24 Added SYNONYM filamin A binding
2012-03-24 Added SYNONYM filamin-A binding
2012-03-24 Added SYNONYM alpha-filamin binding
2012-03-24 Added SYNONYM filamin C binding
2012-03-24 Added SYNONYM filamin B binding
2012-03-24 Added SYNONYM filamin-2 binding
Timestamp Action Category Detail
2004-09-25 Added TERM filamin binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2021-05-24 Added DEFINITION Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2012-03-24 Added SYNONYM beta-filamin binding
2012-03-24 Added SYNONYM filamin-B binding
2012-03-24 Added SYNONYM filamin A binding
2012-03-24 Added SYNONYM filamin-A binding
2012-03-24 Added SYNONYM alpha-filamin binding
2012-03-24 Added SYNONYM filamin C binding
2012-03-24 Added SYNONYM filamin B binding
2012-03-24 Added SYNONYM filamin-2 binding
2012-03-24 Added SYNONYM filamin-1 binding
2012-03-24 Added SYNONYM filamin-3 binding
2012-03-24 Added SYNONYM filamin-C binding
2012-03-24 Added SYNONYM ABP-278/276 binding
2012-03-24 Added SYNONYM ABPL binding
2012-03-24 Added SYNONYM gamma-filamin binding
2012-03-24 Added SYNONYM ABP-280 binding
2009-07-03 Deleted DEFINITION Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2008-05-13 Added DEFINITION Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2008-05-12 Deleted DEFINITION Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2004-10-08 Updated DEFINITION Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
2004-09-25 Added DEFINITION Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4?24, 100-residue repetitive segments including a carboxy-terminal dimerization domain.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008092 (cytoskeletal protein binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2012-03-24 Added SECONDARY GO:0031006 (filamin-A binding)
2012-03-24 Added SECONDARY GO:0031007 (filamin-B binding)
2012-03-24 Added SECONDARY GO:0031008 (filamin-C binding)
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