GO:0031005
JSON
filamin binding
Molecular Function
Definition (GO:0031005 GONUTS page)
Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. PMID:11336782
Secondary IDs
GO:0031006, GO:0031007, GO:0031008
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
filamin-1 binding | narrow |
filamin-3 binding | narrow |
filamin-C binding | narrow |
ABP-278/276 binding | narrow |
ABPL binding | narrow |
gamma-filamin binding | narrow |
ABP-280 binding | narrow |
beta-filamin binding | narrow |
filamin-B binding | exact |
filamin A binding | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR028215 | Refilin family |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0031005 based on ALL annotations
The top 100 of 468 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
filamin binding
|
61,806.84 | 100.00 | 3,154 | 3,154 |
regulation of chondrocyte development
|
57,217.94 | 48.63 | 1,596 | 1,724 |
actin filament bundle organization
|
56,432.34 | 48.28 | 1,596 | 1,748 |
negative regulation of bone mineralization involved in bone maturation
|
58,431.33 | 46.47 | 1,506 | 1,593 |
negative regulation of chondrocyte development
|
58,139.36 | 46.35 | 1,506 | 1,601 |
skeletal system morphogenesis
|
17,807.75 | 21.91 | 1,506 | 5,227 |
actin filament bundle
|
8,555.76 | 12.12 | 1,558 | 11,255 |
regulation of integrin activation
|
22,679.12 | 2.75 | 91 | 248 |
negative regulation of centrosome duplication
|
14,488.39 | 2.72 | 94 | 401 |
alpha-actinin binding
|
4,983.55 | 2.19 | 92 | 1,141 |
Totals | 19932 | 2613007 |
No co-occurrence statistics for GO:0031005 based on MANUAL annotations
The top 100 of 401 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
filamin binding
|
14,848.27 | 100.00 | 87 | 87 |
negative regulation of bone mineralization involved in bone maturation
|
13,411.34 | 31.11 | 28 | 31 |
negative regulation of chondrocyte development
|
13,411.34 | 31.11 | 28 | 31 |
actin filament bundle organization
|
8,734.27 | 27.78 | 30 | 51 |
skeletal system morphogenesis
|
1,746.85 | 9.43 | 28 | 238 |
regulation of integrin activation
|
7,424.13 | 8.42 | 8 | 16 |
actin filament bundle
|
1,346.13 | 7.89 | 33 | 364 |
cardiac muscle thin filament assembly
|
1,349.84 | 5.35 | 10 | 110 |
cytoskeletal protein binding
|
690.62 | 3.42 | 10 | 215 |
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
|
832.61 | 3.19 | 6 | 107 |
Totals | 488 | 10510 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2021-05-24 | Added | DEFINITION | Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2012-03-24 | Added | SYNONYM | beta-filamin binding |
2012-03-24 | Added | SYNONYM | filamin-B binding |
2012-03-24 | Added | SYNONYM | filamin A binding |
2012-03-24 | Added | SYNONYM | filamin-A binding |
2012-03-24 | Added | SYNONYM | alpha-filamin binding |
2012-03-24 | Added | SYNONYM | filamin C binding |
2012-03-24 | Added | SYNONYM | filamin B binding |
2012-03-24 | Added | SYNONYM | filamin-2 binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-09-25 | Added | TERM | filamin binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2021-05-24 | Added | DEFINITION | Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2012-03-24 | Added | SYNONYM | beta-filamin binding |
2012-03-24 | Added | SYNONYM | filamin-B binding |
2012-03-24 | Added | SYNONYM | filamin A binding |
2012-03-24 | Added | SYNONYM | filamin-A binding |
2012-03-24 | Added | SYNONYM | alpha-filamin binding |
2012-03-24 | Added | SYNONYM | filamin C binding |
2012-03-24 | Added | SYNONYM | filamin B binding |
2012-03-24 | Added | SYNONYM | filamin-2 binding |
2012-03-24 | Added | SYNONYM | filamin-1 binding |
2012-03-24 | Added | SYNONYM | filamin-3 binding |
2012-03-24 | Added | SYNONYM | filamin-C binding |
2012-03-24 | Added | SYNONYM | ABP-278/276 binding |
2012-03-24 | Added | SYNONYM | ABPL binding |
2012-03-24 | Added | SYNONYM | gamma-filamin binding |
2012-03-24 | Added | SYNONYM | ABP-280 binding |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2008-05-13 | Added | DEFINITION | Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2004-10-08 | Updated | DEFINITION | Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
2004-09-25 | Added | DEFINITION | Interacting selectively with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4?24, 100-residue repetitive segments including a carboxy-terminal dimerization domain. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008092 (cytoskeletal protein binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-03-24 | Added | SECONDARY | GO:0031006 (filamin-A binding) |
2012-03-24 | Added | SECONDARY | GO:0031007 (filamin-B binding) |
2012-03-24 | Added | SECONDARY | GO:0031008 (filamin-C binding) |
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