This term is obsolete.

GO:0031419 JSON

cobalamin binding

Molecular Function

Definition (GO:0031419 GONUTS page)

Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.

273,041 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
vitamin B12 binding exact

Ancestor Chart

Ancestor chart for GO:0031419
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Cross-references

Database ID Description
InterPro IPR002157 Cobalamin (vitamin B12)-binding protein
InterPro IPR003206 Diol/glycerol dehydratase, large subunit
InterPro IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic
InterPro IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic
InterPro IPR006158 Cobalamin (vitamin B12)-binding domain
InterPro IPR011822 Cobalamin-dependent methionine synthase
InterPro IPR012741 Methyltransferase cognate corrinoid protein
InterPro IPR013344 Ribonucleotide reductase, adenosylcobalamin-dependent
InterPro IPR013345 Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent
InterPro IPR014714 Glutamate mutase E subunit, C-terminal domain superfamily

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:30411 cobalamin

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0031419 based on ALL annotations
The top 100 of 611 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cobalamin binding
714.31 100.00 272,906 272,906
methylmalonyl-CoA mutase activity
713.64 16.17 44,125 44,166
homocysteine metabolic process
506.09 16.16 47,254 66,695
methionine synthase activity
465.46 15.99 47,711 73,219
tetrahydrofolate metabolic process
213.44 12.29 47,148 157,790
pteridine-containing compound metabolic process
520.93 10.85 30,853 42,306
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
178.31 9.13 34,337 137,553
propionate metabolic process, methylmalonyl pathway
714.31 7.30 19,922 19,922
methionine biosynthetic process
74.08 6.96 47,711 460,052
epoxyqueuosine reductase activity
309.90 5.34 15,650 36,073
Totals 1654015 195741287
No co-occurrence statistics for GO:0031419 based on MANUAL annotations
The top 83 of 83 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cobalamin binding
10,171.65 100.00 127 127
cobalamin transport
6,517.75 40.24 66 103
methylmalonyl-CoA mutase activity
10,171.65 35.43 45 45
propionate metabolic process, methylmalonyl pathway
10,171.65 33.07 42 42
cargo receptor ligand activity
7,911.28 5.43 7 9
cobalamin metabolic process
1,312.47 4.42 8 62
corrinoid adenosyltransferase activity
984.35 3.28 6 62
succinyl-CoA biosynthetic process
10,171.65 3.15 4 4
pivalyl-CoA mutase activity
8,137.32 3.13 4 5
transferase activity, transferring alkyl or aryl (other than methyl) groups
762.87 2.99 6 80
Totals 628 792030

Change Log

Timestamp Action Category Detail
2023-09-12 Added RELATION is a GO:1901363 (heterocyclic compound binding)
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2021-05-24 Added DEFINITION Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2020-06-02 Deleted RELATION is a GO:0008144 (obsolete drug binding)
2020-05-08 Deleted RELATION is a GO:0048037 (obsolete cofactor binding)
2020-02-28 Deleted XREF MIPS_funcat:16.21.09
2019-05-04 Added XREF MIPS_funcat:16.21.09
2017-11-29 Added RELATION is a GO:0008144 (obsolete drug binding)
2017-11-29 Added RELATION is a GO:0048037 (obsolete cofactor binding)
2009-07-06 Added RELATION is a GO:0046906 (tetrapyrrole binding)
Timestamp Action Category Detail
2005-05-16 Added TERM cobalamin binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2021-05-24 Added DEFINITION Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2009-07-03 Deleted DEFINITION Interacting selectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2008-10-02 Deleted DEFINITION Interacting lelectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2008-10-02 Added DEFINITION Interacting selectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2008-05-13 Added DEFINITION Interacting lelectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2008-05-12 Deleted DEFINITION Interacting lelectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2007-08-09 Added SYNONYM vitamin B12 binding
2007-08-09 Deleted SYNONYM vitamin B12 binding
2005-05-16 Added DEFINITION Interacting lelectively with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
2005-05-16 Added SYNONYM vitamin B12 binding
Timestamp Action Category Detail
2023-09-12 Added RELATION is a GO:1901363 (heterocyclic compound binding)
2020-06-02 Deleted RELATION is a GO:0008144 (obsolete drug binding)
2020-05-08 Deleted RELATION is a GO:0048037 (obsolete cofactor binding)
2017-11-29 Added RELATION is a GO:0008144 (obsolete drug binding)
2017-11-29 Added RELATION is a GO:0048037 (obsolete cofactor binding)
2009-07-06 Added RELATION is a GO:0046906 (tetrapyrrole binding)
2008-04-01 Updated RELATION is a GO:0019842 (vitamin binding)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:16.21.09
2019-05-04 Added XREF MIPS_funcat:16.21.09
Timestamp Action Category Detail
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